Recently added articles from Alcohol Research & Health:
Who is at risk? Population characterization of alcohol self-administration in nonhuman primates helps identify pathways to dependence.
Dec 22, 2008; ... Alcohol addiction--or alcohol Dependence--is a chronic and progressive disorder that has a significant detrimental impact on the drinker, his or her family and community, and society as a whole. Accordingly, it is important to identify the mechanisms contributing to the development of ...
The molecular basis of Tolerance.
Dec 22, 2008; ... Tolerance to a drug, including alcohol, was first described as a form of behavioral plasticity and was defined as a decreased response to repeated drug exposures (Kalant 1998). Tolerance can be described at different levels of biological complexity--molecular, cellular, and behavioral--or ...
How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective.
Dec 22, 2008; ... The development of dependence on alcohol (as well as on other drugs of abuse) is posited to involve changes in brain chemistry that lead not only to signs of withdrawal upon abstention from alcohol (i.e., to physical or physiological dependence) (Ritzmann and Tabakoff 1976) but also, in ...
From actions to habits: neuroadaptations leading to dependence.
Dec 22, 2008; ... Addiction is a series of misguided actions. Yet how the brain selects and generates actions has received surprisingly little attention in addiction research. In recent years, considerable progress has been made in identifying the neural circuits responsible for the control of goal-directed ...
Glossary.
Dec 22, 2008 ... [gamma]-Aminobutyric acid (GABA): A neurotransmitter that in the brain acts to reduce the activity of the signal-receiving neuron. Action potential: A rapid change in cell membrane potential (the electrical potential difference across the cell membrane) followed by a return to ...