Recently added articles from American Journal of Respiratory Cell and Molecular Biology:

Cigarette Smoke Triggers Code Red: p21^sup CIP1/WAF1/SDI1^ Switches on Danger Responses in the Lung

Jul 01, 2008; Tuder, Rubin M; Yun, Jeong H; Graham, Brian B ... The article by Yao and coworkers in this issue (Am. J. Respir. Cell Mol. Biol. 2008;39:7-18) reveals that the cyclin-dependent kinase inhibitor p21CIP1/WAF1/SDI1 (designated hereafter as p21), which has been linked to cell cycle growth arrest due to stress or danger cell responses, may modulate ...

Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice

Jul 01, 2008; Yao, Hongwei; Yang, Se-Ran; Edirisinghe, Indika; Rajendrasozhan, Saravanan; Caito, Samuel; Adenuga, David; O'Reilly, Michael A; Rahman, Irfan ... The cyclin-dependent kinase inhibitor p21^sup CIP1/WAF1/SDI1^ (p21) is an important inhibitory checkpoint regulator of cell cycle progression in response to oxidative and genotoxic stresses. It is known that p21 potentiates inflammatory response and inhibits apoptosis and proliferation, leading ...

Nasal Abnormalities in Cystic Fibrosis Mice Independent of Infection and Inflammation

Jul 01, 2008; Hilliard, Tom N; Zhu, Jie; Farley, Ray; Escudero-Garcia, Sara; Wainwright, Brandon J; Jeffery, Peter K; Griesenbach, Uta; Bush, Andrew; Davies, Jane C; Alton, Eric W F W ... It is not known whether the progressive airway changes in cystic fibrosis (CF) are all secondary to infection and inflammation. The CF mouse nose shares electrophysiologic and cellular properties with human CF airway epithelium. In the present work, we tested the hypothesis that structural ...

Adenovirus IL-13-Induced Airway Disease in Mice: A Corticosteroid-Resistant Model of Severe Asthma

Jul 01, 2008; Therien, Alex G; Bernier, Virginie; Weicker, Sean; Tawa, Paul; Falgueyret, Jean-Pierre; Mathieu, Marie-Claude; Honsberger, Jeanne; Pomerleau, Véronique; Robichaud, Annette; Stocco, Rino; Dufresne, Lynn; Houshyar, Hani; Lafleur, Josiane; Ramachandran, Chidambaram ... Interleukin 13 (IL-13) is considered to be a key driver of the development of airway allergic inflammation and remodeling leading to airway hyperresponsiveness (AHR). How precisely IL-13 leads to the development of airway inflammation, AHR, and mucus production is not fully understood. In order ...

Electrophysiological Characterization of Rat Type II Pneumocytes in Situ

Jul 01, 2008; Shlyonsky, Vadim; Goolaerts, Arnaud; Mies, Frédérique; Naeije, Robert ... Optimal aeration of the lungs is dependent on an alveolar fluid clearance, a process that is governed by Na+ and Cl2 transport. However, the specific contribution of various ion channels in different alveolar cell types under basal or stimulated conditions is not exactly known. We established a ...

Male Sex Hormones Exacerbate Lung Function Impairment after Bleomycin-Induced Pulmonary Fibrosis

Jul 01, 2008; Voltz, James W; Card, Jeffrey W; Carey, Michelle A; DeGraff, Laura M; Ferguson, Catherine D; Flake, Gordon P; Bonner, James C; Korach, Kenneth S; Zeldin, Darryl C ... The roles of sex hormones as modulators of lung function and disease have received significant attention as differential sex responses to various lung insults have been recently reported. The present study useda bleomycin-inducedpulmonaryfibrosismodel inC57BL/6 mice to examine potential sex ...

Neutrophil Elastase Is Needed for Neutrophil Emigration into Lungs in Ventilator-Induced Lung Injury

Jul 01, 2008; Kaynar, A Murat; Houghton, A McGarry; Lum, Esther H; Pitt, Bruce R; Shapiro, Steven D ... Mechanical ventilation, often required to maintain normal gas exchange in critically ill patients, may itself cause lung injury. Lungprotective ventilatory strategies with low tidal volume have been a major success in the management of acute respiratory distress syndrome(ARDS). Volutrauma causes ...

Induction of Vascular Remodeling in the Lung by Chronic House Dust Mite Exposure

Jul 01, 2008; Rydell-Törmänen, Kristina; Johnson, Jill R; Fattouh, Ramzi; Jordana, Manel; Erjefält, Jonas S ... Structural changes to the lung are associated with chronic asthma. In addition to alterations to the airway wall, asthma is associated with vascular modifications, although this aspect of remodeling is poorly understood. We sought to evaluate the character and kinetics of vascular remodeling in ...

MARCKS Regulation of Mucin Secretion by Airway Epithelium in Vitro: Interaction with Chaperones

Jul 01, 2008; Park, Joungjoa; Fang, Shijing; Crews, Anne L; Lin, Ko-Wei; Adler, Kenneth B ... We have reported previously that myristoylated alanine-rich C kinase substrate (MARCKS) is a key regulatory molecule controlling mucin secretion by airway epithelial cells in vitro and in vivo. The results of those studies supported a mechanism whereby MARCKS, upon phosphorylation by protein ...

Macrophage Migration Inhibitory Factor Governs Endothelial Cell Sensitivity to LPS-Induced Apoptosis

Jul 01, 2008; Damico, Rachel L; Chesley, Alan; Johnston, Laura; Bind, Eric P; Amaro, Eric; Nijmeh, Julie; Karakas, Bedri; Welsh, Laura; Pearse, David B; Garcia, Joe G N; Crow, Michael T ... Human endothelial cells (EC) are typically resistant to the apoptotic effects of stimuli associated with lung disease. The determinants of this resistance remain incompletely understood. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine produced by human pulmonary artery ...

SHP-1 Inhibition by 4-Hydroxynonenal Activates Jun N-Terminal Kinase and Glutamate Cysteine Ligase

Jul 01, 2008; Rinna, Alessandra; Forman, Henry Jay ... 4-Hydroxy-2-nonenal (HNE), a major lipid peroxidation product, is toxic at high concentrations, but at near-physiological concentrations it induces detoxifying enzymes. Previous data established that in human bronchial epithelial (HBE1) cells, both genes for glutamate cysteine ligase (GCL) are ...

Cyclic Stretch Affects Pulmonary Endothelial Cell Control of Pulmonary Smooth Muscle Cell Growth

Jul 01, 2008; Ochoa, Cristhiaan D; Baker, Haven; Hasak, Stephen; Matyal, Robina; Salam, Aleya; Hales, Charles A; Hancock, William; Quinn, Deborah A ... Endothelial cells are subjected to mechanical forces in the form of cyclic stretch resulting from blood pulsatility. Pulmonary artery endothelial cells (PAECs) produce factors that stimulate and inhibit pulmonary artery smooth muscle cell (PASMC) growth. We hypothesized that PAECs exposed to ...

Carbonic Anhydrase and Alveolar Fluid Absorption/From the Authors

Jul 01, 2008; Effros, Richard M; Chen, Jiwang; Briva, Arturo; Lecuona, Emilia; Sznajder, Jacob I ... To the Editor: The recent article by Chen and coworkers (1) reports that carbonic anhydrase II (CAII) is found in both type I and type II alveolar epithelial cells. Although inhibition of CAII with acetazolamide or methazolamide delayed intracellular acidification during hypercapnia in ...

Transcription Factor Oligodeoxynucleotides to NF-[kappa]B Inhibit Transcription of IL-8 in Bronchial Cells

Jul 01, 2008; Bezzerri, Valentino; Borgatti, Monica; Nicolis, Elena; Lampronti, Ilaria; Dechecchi, Maria Cristina; Mancini, Irene; Rizzotti, Paolo; Gambari, Roberto; Cabrini, Giulio ... Chronic pulmonary inflammation in patients affected by cystic fibrosis (CF) is characterized by massive bronchial infiltrates of neutrophils, which is sustained by the interaction of pathogens (e.g., Pseudomonas aeruginosa) with surface bronchial cells. To explore new treatment options focused ...

Asbestos-Induced MKP-3 Expression Augments TNF-[alpha] Gene Expression in Human Monocytes

Jul 01, 2008; Tephly, Linda A; Carter, A Brent ... TNF-α is associated with the development of interstitial fibrosis. We have demonstrated that the p38 mitogen-αctivated protein (MAP) kinase regulates TNF-α expression in monocytes exposed to asbestos. In this report, we asked if extracellular signal-regulated kinase (ERK) was also ...