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Amyloid articles

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An overview of high-dose melphalan and stem cell transplantation in the treatment of AL amyloidosis

Dec 01, 2007; ... Keywords: AL amyloidosis, treatment, stem cell transplantation, melphalan Abbreviations: HDM/SCT= high-dose melphalan and stem cell transplantation; CR = hematologic complete response; FLC=serum free light chain concentration; TRM = treatment-related mortality Abstract AL ...

Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis

Dec 01, 2007; ... Keywords: Rheumatoid arthritis, secondary amyloidosis, SAA1 alleles Abbreviations: R = rheumatoid arthritis; FMF=familial Mediterranean fever; SAA = serum amyloid A protein Abstract Objective. To address whether or not the rarity of amyloidosis in Greek patients with ...

Progression of cardiac amyloid deposition in hereditary transthyretin amyloidosis patients after liver transplantation

Dec 01, 2007; ... Keywords: Transthyretin, amyloidosis, liver transplantation, cardiomyopathy Abbreviations: TTR = transthyretin; OLT = orthotopic liver transplantation; ASO = antisense oligonucleotides; SDS-PAGE=sodium dodecyl sulfate polyacrylamide gel electrophoresis; CHF= congestive heart ...

Transthyretin valine-94-alanine, a novel variant associated with late-onset systemic amyloidosis with cardiac involvement

Dec 01, 2007; ... Keywords: Dilated cardiomyopathy, cardiac amyloidosis, transthyretin Abbreviations: cTnT= cardiac troponin T; FAP= familial amyloid polyneuropathy; HIEF= hybrid isoelectric focusing; LV= left ventricular; NT-proBNP= N-terminal pro-natriuretic peptide; NYHA = New York Heart Association ...

A new ATTR Phe64Ile mutation with late-onset multiorgan involvement

Dec 01, 2007; ... Keywords: Amyloidosis, transthyretin, cardiomyopathy, polyneuropathy Abbreviations: TTR= transthyretin; FAP=familial amyloid polyneuropathy; NYHA = New York Heart Association; NT-proBNP= N-terminal pro-brain natriuretic peptide; LVEF=left ventricular ejection fraction; IVRT=isovolumetric ...

Identification of a novel TTR Gly67Glu mutant and the first case series of familial transthyretin amyloidosis in Hong Kong Chinese

Dec 01, 2007; ... Keywords: Familial transthyretin amyloidosis, Hong Kong Chinese, TTR gene Abbreviations: ATTR = Familial transthyretin amyloidosis Abstract Familial transthyretin amyloidosis (ATTR), caused by mutant transthyretin deposition, is mainly characterized by peripheral ...

Lambda II immunoglobulin light chain protein in primary localized rectal amyloidosis

Dec 01, 2007; ... Keywords: Amyloid protein, λ light chain, localized rectal amyloidosis Abbreviations: λ^sub II^ = lambda II; Ig = immunoglobulin; LC=light chain; PVDF=polyvinylidine difluoride; AL=amyloid light chain; AA = amyloid A; SAA = serum amyloid A; ApoAI = apolipoprotein A-I; ApoAII = ...

Immunoglobulin D lambda multiple myeloma and amyloidosis with predominant soft tissue involvement

Dec 01, 2007; ... Keywords: IgD lambda myeloma, AL amyloidosis, amyloid arthropathy, mucocutaneous amyloidosis Abbreviations: MM = multiple myeloma; IgD = immunoglobulin D Abstract Multiple myeloma (MM) is associated with amyloidosis in approximately 15% of the patients. The most frequent ...

Systemic reactive (AA) amyloidosis in a patient with Glanzmann thrombasthenia

Dec 01, 2007; ... Keywords: Amyloidosis, Glanzmann thrombasthenia, nephrotic syndrome, renal biopsy Abbreviations: GT = Glanzmann thrombasthenia; Ig = immunoglobulin; MEFN = Mediterranean fever; AA = (Apo)serumAA; gp = glycoprotein To the Editor, A 34-year-old woman with Glanzmann ...

Brain Trust. The Hidden Connection Between Mad Cow Disease and Alzheimer's Disease/Dying for a Hamburger. Modern meat Processing and the Epidemic of Alzheimer's Disease

Dec 01, 2007; ... Brain Trust. The Hidden Connection Between Mad Cow Disease and Alzheimer's Disease Colm A. Kelleher Paraview: Pocket Books, 2004 312 pp., $22.00 ISBN 0-7434-9935-2 Dying for a Hamburger. Modern meat Processing and the Epidemic of Alzheimer's Disease Murray Waldman and Marjorie Lamb ...

Cutaneous Manifestations of Rheumatic Diseases (2nd Edition)

Dec 01, 2007; ... Cutaneous Manifestations of Rheumatic Diseases (2nd Edition) Richard D. Sontheimer and Thomas T. Provost (Eds.) Lippincott Williams and Wilkins, Philadelphia, USA, 2004 318 pp., $149.00 ISBN 0-7817-3478-9 This 25 authored textbook is a valuable addition to the literature on rheumatic ...

Harrison's Rheumatology

Dec 01, 2007; ... Harrison's Rheumatology Andiony S. Fauci (Ed.) McGraw Hill Co., 2006 359 pp., $67.95 ISBN 0-07-145743-7 This soft cover 359 page work is essentially die updated rheumatology component of Harrison's Principles of Internal Medicine (16th Edition). It is a multiauthored (30 authors) text ...

Erratum

Dec 01, 2007; ... In the article "Diagnostic performance of amyloid A protein quantification in fat tissue of patients with clinical AA amyloidosis" by Hazenberg, B. P. C, et al., ...

Heparan sulfate as a therapeutic target in amyloidogenesis: prospects and possible complications

Sep 01, 2007; ... Keywords: Amyloidogenesis, glycosaminoglycans, heparan sulfate, biosynthesis inhibition, therapy, complications, sulfotransferases Abbreviations: AA = amyloid A; AD = Alzheimer's disease; ECM = extracellular matrix; GAG = glycosaminoglycan; HS = heparan sulfate; HSPG = heparan sulfate ...

Structural analyses of fibrinogen amyloid fibrils

Sep 01, 2007; ... Keywords: Fibrinogen, amyloid, protein structure, fiber diffraction, electron microscopy Abbreviations: HRA = hereditary renal amyloidosis Abstract Hereditary fibrinogen amyloidosis is characterized by deposition of amyloid fibrils in renal glomeruli. The subunit protein ...

A primer of amyloid nomenclature

Sep 01, 2007; ... Keywords: Amyloidosis, amyloid protein, nomenclature Abbreviations: AβPP = Aβ peptide precursor; FAC = familial amyloidotic cardiomyopathy; FAP = familial amyloidotic polyneuropathy Abstract The increasing knowledge of the exact biochemical nature of the ...

Polyanion induced fibril growth enables the development of a reproducible assay in solution for the screening of fibril interfering compounds, and the investigation of the prion nucleation site

Sep 01, 2007; ... Keywords: CJD, BSE, amyloid, prion, GAG Abbreviations: Aβ = amyloid β protein; BSE = bovine spongiform encephalopathy; CJD = Creutzfeldt-Jacob disease; Fmoc =fluorenylmethoxycarbonyl; GAG = glycosaminoglycan; huPrP = human prion protein; moPrP = mouse prion protein; PrP = ...

Familial amyloidotic polyneuropathy: long-term follow-up of abdominal fat tissue aspirate in patients with and without liver transplantation

Sep 01, 2007; ... Keywords: Transthyretin, inherited amyloidosis, abdominal fat aspirate, liver transplantation Abbreviations: FAP= familial amyloidotic polyneuropathy; TTR = transthyretin; Gly = glycine; Glu = glutamic acid; Va l= valine; Met = methionine; Tx = liver transplantation; NT-ProBNP = ...

In vivo stabilization of mutant human transthyretin in transgenic mice

Sep 01, 2007; ... Keywords: Transthyretin, amyloidosis, FAP, transgenics, diflunisal, heterotetramers Abbreviations: TTR = transthyretin; L55P TTR = transthyretin mutation leucine [arrow right] proline at position 55; V30M TTR = transthyretin mutation valine [arrow right] methionine at position 30; T119M ...

Amyloid fibril formation by human stefin B: influence of pH and TFE on fibril growth and morphology

Sep 01, 2007; ... Keywords: Amyloid fibrils, cystatins, flow cytometry, lag phase oligomers, morphology by AFM, TFE effect on the kinetics Abbreviations: FSC= forward scatter; SSC=side scatter; C.R.=Congo red; AFM=atomic force microscopy; TEM=transmission electron microscopy; GA=glutaraldehyde; ...