Recently added articles from Archives of Pathology & Laboratory Medicine:

Computer-Assisted Grading of Neuroblastic Differentiation/In Reply

Jun 01, 2008; Kong, Jun; Sertel, Olcay; Boyer, Kim L; Saltz, Joel H; Gurcan, Metin N; Shimada, Hiroyuki; Qualman, Stephen J ... To the Editor.-We read with great interest the protocols for the examination of specimens from patients with neuroblastoma and related neuroblastic tumors by Qualman et al.1 The authors suggested that pathologists follow the presented protocols when writing pathology reports on neuroblastoma and ...

Poster Presentation: An Observation

Jun 01, 2008; Zarrin-Khameh, Neda ... To the Editor.-Preparing a poster, especially for the first time, can be quiet challenging. I thought my observations could serve as a guideline for the number of columns, figures, tables, and charts/algorithms that could be included in a poster. These observations were made during the poster ...

The WHO Classification of Tumours of the Central Nervous System, 4th Edition

Jun 01, 2008; Fuller, Gregory N ... The recently revised WHO Classifi- cation of Tumours of the Central Nervous System (4th edition, 2007) follows in the highly successful footsteps of previous editions of this widely used reference.1-3 The latest version is the product of the combined efforts of an international group of ...

Protocol for the Examination of Specimens From Patients With Tumors of the Brain/Spinal Cord

Jun 01, 2008; Parisi, Joseph E; Miller, Dylan V; Boyer, Philip J; Brat, Daniel J; Cochran, Elizabeth J; Cohen, Mark L; DeMasters, Bette K; Dolinak, David; McComb, Rodney D; McLendon, Roger E; Powell, Suzanne Z; Prayson, Richard A; Vinters, Harry V; Yachnis, Anthony T ... The College of American Pathologists offers these protocols to assist pathologists in providing clinically useful and relevant information when reporting results of surgical specimen examinations. The College regards the reporting elements in the ''Surgical Pathology Cancer Case Summary ...

Urine Culture Contamination: A College of American Pathologists Q-Probes Study of 127 Laboratories

Jun 01, 2008; Bekeris, Leonas G; Jones, Bruce Allen; Walsh, Molly K; Wagar, Elizabeth A ... * Context.-While urine culture contamination may not be completely avoidable, some laboratories have lower contamination rates than others. A College of American Pathologists (CAP) 1998 Q-Probes study showed that many interventions commonly assumed to reduce contamination were not demonstrably ...

Longitudinal Clinical Evaluation of a Novel Antibody Cocktail for Detection of High-Grade Squamous Intraepithelial Lesions on Cervical Cytology Specimens

Jun 01, 2008; Tambouret, Rosemary H; Misdraji, Joseph; Wilbur, David C ... * Context.-Although cervical cancer screening by cytology is successful, the test continues to show relatively poor operating characteristics. Cell cycle markers may enhance detection of high-grade squamous intraepithelial lesions. Objective.-To determine the clinical usefulness of ...

Evidence-Based Pathology and the Pathologic Evaluation of Thymomas: Transcapsular Invasion Is Not a Significant Prognostic Feature

Jun 01, 2008; Gupta, Ruta; Marchevsky, Alberto M; McKenna, Robert J; Wick, Mark; Moran, Cesar; Zakowski, Maureen F; Suster, Saul ... * Context.-Evaluation of transcapsular invasion is currently considered very important in the pathologic examination of thymomas. However, recent studies have questioned the prognostic value of stratifying thymoma patients into stage I and II disease. Evidence-based pathology promotes the use of ...

Metastatic Patterns of Cancers: Results From a Large Autopsy Study

Jun 01, 2008; diSibio, Guy; French, Samuel W ... * Context.-Many studies have addressed metastatic patterns seen among various cancers. No recent studies, however, provide quantitative analyses of such patterns arising from a broad range of cancers based primarily on postmortem tissue analyses. Objective.-To provide a quantitative ...

Clinicopathologic Significance of Nuclear Grooves and Inclusions in Renal Cell Carcinoma: Image Database Construction and Quantitative Scoring

Jun 01, 2008; Lee, Ju-Han; Han, Eun Mee; Lin, Zhen-Hua; Wu, Zheng-Sheng; Lee, Eung-Seok; Kim, Young-Sik ... * Context.-Nuclear grooves and inclusions are major features of cancer. However, the nuclear irregularities in renal cell carcinoma (RCC) have not yet been well characterized. Objective.-To determine the clinicopathologic significance of nuclear grooves and inclusions in ...

The Informed Consent Process in Whole Blood Donation

Jun 01, 2008; Alaishuski, Lindsay A; Grim, Rodney D; Domen, Ronald E ... * Context.-Informed consent in transfusion medicine has been an area lacking of significant research and it is unknown if donors fully comprehend the risks associated with whole blood donation. Objective.-To assess the adequacy of the informed consent process in whole blood ...

Translocations and Amplifications of Chromosome 12 in Liposarcoma Demonstrated by the LSI CHOP Breakapart Rearrangement Probe

Jun 01, 2008; Willmore-Payne, Carlynn; Holden, Joseph; Turner, Kristi C; Proia, Alan; Layfield, Lester J ... * Context.-Liposarcomas display a number of molecular abnormalities involving chromosome 12. Myxoid and round cell liposarcomas are characterized by t(12;16)(q13; p11) or t(12;22)(q13;q12) translocations. Amplifications occur within the 12q13-15 region of atypical lipomatous tumors and ...

Clinicopathologic Characteristics, CpG Island Methylator Phenotype, and BRAF Mutations in Microsatellite-Stable Colorectal Cancers Without Chromosomal Instability

Jun 01, 2008; Kakar, Sanjay; Deng, Guoren; Sahai, Vaibhav; Matsuzaki, Koji; Tanaka, Hirofumi; Miura, Soichuro; Kim, Young S ... * Context.-The 2 chief pathways implicated in colorectal carcinogenesis, microsatellite instability and chromosomal instability, are not present in 20% to 37% of cases. Objective.-To determine whether the CpG island methylator phenotype (CIMP) pathway, characterized by simultaneous ...

Cytogenetic Studies of 24 Renal Epithelial Tumors With von Hippel-Lindau and Fragile Histidine Triad Protein Expression Correlation

Jun 01, 2008; Gayrard, Nathalie; Cacheux, Valère; Iborra, François; Mourad, Georges; Argilés, Àngel ... * Context.-Deletion of the short arm of chromosome 3 (3p deletion) is a cytogenetic abnormality generally associated with clear cell renal cell carcinoma, the most aggressive form of renal epithelial tumor. Objective.-To cytogenetically characterize 24 renal tumors in order to check the ...

Touch Imprint Cytology in Tumor Tissue Banks for the Confirmation of Neoplastic Cellularity and for DNA Extraction

Jun 01, 2008; Mangia, Anita; Chiriatti, Annalisa; Chiarappa, Patrizia; Incalza, Maria Angela; Antonaci, Giovanni; Pilato, Brunella; Simone, Giovanni; Tommasi, Stefania; Paradiso, Angelo ... * Context.-Learning the characteristics of frozen tissue samples stored in tumor banks for biological studies remains a problem. Objective.-To assess the use of touch imprint cytology on fresh tissue samples as a rapid and reliable method of determining the presence and quantity of ...

Is Surgical Excision Necessary for the Management of Atypical Lobular Hyperplasia and Lobular Carcinoma In Situ Diagnosed on Core Needle Biopsy? A Report of 38 Cases and Review of the Literature

Jun 01, 2008; Cangiarella, Joan; Guth, Amber; Axelrod, Deborah; Darvishian, Farbod; Singh, Baljit; Simsir, Aylin; Roses, Daniel; Mercado, Cecilia ... * Context.-Both atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) have traditionally been considered to be risk factors for the development of invasive carcinoma and are followed by close observation. Recent studies have suggested that these lesions may represent true ...

Glial Choristoma in the Oral and Maxillofacial Region: A Clinicopathologic Study of 6 Cases

Jun 01, 2008; Sun, Li-Sha; Sun, Zhi-Peng; Ma, Xu-Chen; Li, Tie-Jun ... * Context.-Glial choristoma is an uncommon developmental abnormality typically presenting at birth or in early childhood. The nasal region is most frequently affected. Palate, tongue, cheek, scalp, and orbit can also be affected but these occurrences are relatively rare. Objective.-To ...

The Effect of the Number of Biopsy Cores on the Concordance Between Prostate Biopsy and Prostatectomy Gleason Score: A Prostate Volume-Controlled Study

Jun 01, 2008; Antunes, Alberto A; Leite, Katia Ramos; Dall'Oglio, Marcos F; Cury, Jose; Srougi, Miguel ... * Context.-Studies analyzing the concordance of biopsy and radical prostatectomy (RP) Gleason scores have limitations. Some included 2 or more centers, used historical controls from the early prostate specific antigen era or lacked a clear definition of the biopsy schemes. Furthermore, most did ...

Surgical Neuropathology Update: A Review of Changes Introduced by the WHO Classification of Tumours of the Central Nervous System, 4th Edition

Jun 01, 2008; Brat, Daniel J; Parisi, Joseph E; Kleinschmidt-DeMasters, Bette K; Yachnis, Anthony T; Montine, Thomas J; Boyer, Philip J; Powell, Suzanne Z; Prayson, Richard A; McLendon, Roger E ... * Context.-The World Health Organization (WHO) recently published its 4th edition of the classification of tumors of the central nervous system, incorporating a substantial number of important changes to the previous version (WHO 2000). The new WHO classification introduces 7 changes in the ...

Trastuzumab as Adjuvant Therapy for Early Breast Cancer: The Importance of Accurate Human Epidermal Growth Factor Receptor 2 Testing

Jun 01, 2008; Hicks, David G; Kulkarni, Swati ... * Context.-Overexpression of human epidermal growth factor receptor 2 (HER2) is an adverse prognostic parameter for patients with breast cancer. Patients with HER2- positive tumors are, however, likely to gain significant benefit from targeted therapy with trastuzumab. Four largescale trials ...

Tumor-to-Tumor Metastasis: Report of 2 Cases of Metastatic Carcinoma to Angiomyolipoma of the Kidney

Jun 01, 2008; Ricketts, Reva; Tamboli, Pheroze; Czerniak, Bogdan; Guo, Charles C ... * Tumor-to-tumor metastasis is a rare phenomenon. Renal cell carcinoma is the most common recipient of tumor-totumor metastasis in malignant tumors. However, renal angiomyolipoma has not been reported to be a recipient. Here we report 2 cases of tumor-to-tumor metastasis to renal angiomyolipoma ....