Recently added articles from Archives of Pathology & Laboratory Medicine:
Evidence-Based Pathology and the Pathologic Evaluation of Thymomas/In Reply
Dec 01, 2008; ... To the Editor.-I would like to correct a piece of misinformation contained in the article by Gupta et al "Evidence-Based Pathology and the Pathologic Evaluation of Thymomas: Transcapsular Invasion Is Not a Significant Prognostic Feature," published in Archives of Pathology & Laboratory ...
A New Liver Explant Fixation Technique
Dec 01, 2008; ... To the Editor.-Surgical intervention, including orthotopic liver transplantation, is a common modality used in the treatment of hepatocellular carcinoma. Accurate pathologic information is important to clinicians for appropriate staging and prognostication of such patients, particularly the ...
In Remembrance of William Christopherson, MD
Dec 01, 2008; ... To the Editor.-The death of Dr William Christopherson (December 21, 2007) represents a genuine loss to the national and international medical community. His pioneering contributions in the field of gynecologic pathology, especially cervical cytopathology, brought worldwide recognition to him ...
Notification of Critical Results: A College of American Pathologists Q-Probes Study of 121 Institutions
Dec 01, 2008; ... Context.-Hospital accreditors are placing increased emphasis on the timeliness with which critical laboratory results are reported to caregivers. Objective.-To measure the speed of critical result notification at a group of laboratories, identify factors associated with faster reporting, ...
The Rate of Manual Microscopic Examination of Urine Sediment: A College of American Pathologists Q-Probes Study of 11 243 Urinalysis Tests From 88 Institutions
Dec 01, 2008; ... Context.-The manual microscopic examination (MME) of the urine sediment is an imprecise and labor-intensive procedure. Many laboratories have developed rules from clinical parameters or urinalysis results to limit the number of these examinations. Objective.-To determine the rate of ...
Adjunctive Human Papillomavirus DNA Testing Is a Useful Option in Some Clinical Settings for Disease Risk Assessment and Triage of Females With ASC-H Papanicolaou Test Results
Dec 01, 2008; ... Context.-Recent guidelines recommend colposcopy for women with atypical squamous cells, cannot exclude highgrade squamous intraepithelial lesion (ASC-H). Objective.-To determine whether adjunctive high-risk human papillomavirus (hrHPV) testing is useful for disease risk assessment in ...
Lymphatic Vessel Density Is Not Associated With Lymph Node Metastasis in Non-Small Cell Lung Carcinoma
Dec 01, 2008; ... Context.-Angiogenesis is essential for tumors to grow and metastasize. Lymphatic metastasis is also an important means of tumor spread. In non-small cell lung carcinoma, the relationship of lymphangiogenesis with lymph node metastasis and, ultimately, patient prognosis is ...
Immunohistochemical Expression of Estrogen and Progesterone Receptors in Primary Pulmonary Neuroendocrine Tumors
Dec 01, 2008; ... Context.-Lung and breast carcinomas are among the most prevalent cancers. Advances in cancer therapies can provide survival benefit and be potentially curative, even in metastatic disease. Due to the high prevalence of these carcinomas, it is not unusual to encounter lung nodule(s) in a patient ...
Telomerase Activity in Effusions: A Comparison Between Telomere Repeat Amplification Protocol In Situ and Conventional Telomere Repeat Amplification Protocol Assay
Dec 01, 2008; ... Context.-We previously found telomere repeat ampli- fication protocol (TRAP) in situ helpful in the diagnosis of malignancy in effusions, whereas varying sensitivities and specificities for malignancy were reported by investigators using extract-based TRAP. Objective.-To compare the 2 ...
The Relationship of Drug Abuse to Unexplained Sudden Death
Dec 01, 2008; ... Context.-Forensic pathologists regularly investigate the deaths of individuals with a history of drug abuse. Autopsy, including toxicology testing, reveals no cause for death in a subset of this cohort. Objective.-To determine whether deaths with an undetermined cause and manner of death ...
Immunohistochemical Evaluation of Androgen Receptor, HER-2/neu, and p53 in Benign Pleomorphic Adenomas
Dec 01, 2008; ... Context.-Immunohistochemical stains for androgen receptor (AR), HER-2/neu, and p53 are used as diagnostic markers associated with malignancy in several histologic types of salivary gland tumors. These markers may be useful in differentiating pleomorphic adenoma with cytologic atypia from ...
Fascin Determination in Urothelial Carcinomas of the Urinary Bladder: A Marker of Invasiveness
Dec 01, 2008; ... Context.-Invasion and the depth of invasion affect significantly the prognosis in urothelial carcinomas. The histopathologic evaluation of invasion may be problematic in some cases. Application of new immunohistochemical markers may facilitate the assessment of invasion. Fascin, one of these ...
Reduction of Blood Loss From Laboratory Testing in Hospitalized Adult Patients Using Small-Volume (Pediatric) Tubes
Dec 01, 2008; ... Context.-Blood loss from laboratory testing (BLLT) can be significant in hospitalized patients. It is a common practice to draw full large-volume tubes of blood from adults. Objective.-To determine whether BLLT occurred when a small-volume (pediatric) blood collection tube (SVT) was ...
What Is Adequate Sampling of Extraplacental Membranes? A Randomized, Prospective Analysis
Dec 01, 2008; ... Context.-It is the generally accepted practice to submit 1 or 2 membrane rolls when examining placentas. Objective.-To determine whether obtaining additional sections would increase diagnostic yield and, if so, to what degree. Design.-A membrane roll section was prospectively ...
Definition of Reference Limits for Autoantibodies to Thyroid Peroxidase and Thyroglobulin in a Large Population of Outpatients Using an Indirect Method Based on Current Data
Dec 01, 2008; ... Context.-The reference limits for thyroid antibodies are generally made by measuring thyroid peroxidase and thyroglobulin antibody values in a group of healthy subjects (direct method), as proposed by the National Academy of Clinical Biochemistry. Objective.-To define the upper reference ...
Tissue Handling and Specimen Preparation in Surgical Pathology: Issues Concerning the Recovery of Nucleic Acids From Formalin-Fixed, Paraffin-Embedded Tissue
Dec 01, 2008; ... Context.-Expression profiling by microarrays and realtime polymerase chain reaction-based assays is a powerful tool for classification and prognostication of disease; however, it remains a research tool, largely reliant on frozen tissue. Limiting the utility of expression profiling is the ...
A Brief History of the Formation and Transformation of the College of American Pathologists House of Delegates
Dec 01, 2008; ... The College of American Pathologists (CAP) was officially founded in Chicago on December 13, 1946, during the second day of a 2-day ad hoc meeting of about 140 board-certified pathologists. They had assembled largely by the efforts of Frank W. Hartman, MD, who was elected the CAP's first ...
Intraductal Carcinoma Arising in Intraductal Papilloma in an Axillary Lymph Node: Review of the Literature and Proposed Theories of Evolution
Dec 01, 2008; ... We report a case of an axillary lymph node containing benign glandular lesions, intraductal papilloma with florid and atypical duct hyperplasia, and ductal carcinoma in situ. We propose 2 theories for the development of the intraductal papilloma: from adjacent benign glandular inclusions, or ...
Sister Mary Joseph Nodule as a First and Only Sign of Extraovarian Carcinoma: A Case Report and Review of the Literature
Dec 01, 2008; ... Sister Mary Joseph nodule is one of the less well-known signs of intra-abdominal metastatic disease. The primary tumor site is nearly always detected because of specific morphologic and immunohistochemical features of the umbilical tumor.We describe a case of a 74-year-old woman with a Sister ...
Granular Cell Astrocytoma
Dec 01, 2008; ... Granular cell astrocytoma (GCA) is a rare type of malignant brain tumor with distinct morphologic features and aggressive clinical behavior. Almost all GCAs occur in the cerebral hemispheres. It is characterized by a prominent component of bland-looking granular cells. The tumor cells are ...