Archives of Pathology & Laboratory Medicine back issues from July 2007:
Resolving Dilemmas in Lung Cancer Staging and Histologic Typing
Jul 01, 2007; ... With the recent lung cancer deaths of two high-profile individuals, Peter Jennings and Dana Reeve, the public has come to learn what physicians know all too well-most patients with lung cancer present at an inoperable stage, and the vast majority of them die of their disease. Pathologists ...
Commonly Encountered Difficulties in Pathologic Staging of Lung Cancer
Jul 01, 2007; ... * Context.-Lung cancer is the leading cause of cancer mortality worldwide. Despite technological, therapeutic, and scientific advances, most patients present with incurable disease and a poor chance of long-term survival. For those with potentially curable disease, lung cancer staging greatly ...
Bronchioloalveolar Carcinoma: A Review of Current Concepts and Evolving Issues
Jul 01, 2007; ... * Context.-The concept of bronchioloalveolar carcinoma underwent considerable refinement between the publications of the 1981 and 1999 World Health Organization classifications of lung tumors. Both pathologic and clinical aspects of this carcinoma are the subject of considerable ...
Accuracy and Cost-Effectiveness of Core Needle Biopsy in the Evaluation of Suspected Lymphoma: A Study of 101 Cases
Jul 01, 2007; ... * Context.-Lymphomas have traditionally been diagnosed on excisional biopsies of lymph nodes in order to evaluate tissue architecture and cytomorphology. Recent lymphoma classification schemes emphasize immunophenotypic, genetic, and molecular aspects in addition to morphology as diagnostic ...
Primary Testicular and Paratesticular Lymphoma: A Retrospective Clinicopathologic Study of 34 Cases With Emphasis on Differential Diagnosis
Jul 01, 2007; ... * Context.-Recent reports indicate the rate of primary testicular lymphomas is on the rise and misdiagnosis can still occur. Objective.-To review and investigate the clinicopathologic features of primary testicular lymphoma with emphasis on the differential diagnosis. Discussion about ...
The Contribution of Bifunctional SkipDewax Pretreatment Solution, Rabbit Monoclonal Antibodies, and Polymer Detection Systems in Immunohistochemistry
Jul 01, 2007; ... * Context.-In immunohistochemistry, nonstandardized antigen retrieval protocols and fluids, poor-quality antibodies, and the presence of endogenous biotin frequently lead to incorrect results. Recently, advanced reagents including bifunctional SkipDewax pretreatment solution (BSPS), rabbit ...
Cytodiagnosis in the Autopsy Suite: A Tool for Improving Autopsy Quality and Resident Education
Jul 01, 2007; ... * Context.-Despite several publications attesting to its accuracy and value, cytology is rarely used for preliminary autopsy diagnosis in the United States. Postmortem cytodiagnosis has the potential to increase the accuracy and specificity of the provisional and final autopsy diagnoses, ...
Selecting Automation for the Clinical Chemistry Laboratory
Jul 01, 2007; ... * Context.-Laboratory automation proposes to improve the quality and efficiency of laboratory operations, and may provide a solution to the quality demands and staff shortages faced by today's clinical laboratories. Several vendors offer automation systems in the United States, with both subtle ...
Major Histocompatibility Complex Class I and II Detection as a Diagnostic Tool in Idiopathic Inflammatory Myopathies
Jul 01, 2007; ... * Context.-Muscle biopsy is at present the gold standard for the diagnosis of idiopathic inflammatory myopathies (IIMs), which include dermatomyositis, polymyositis, and inclusion body myositis. Currently, there is no definite diagnostic marker that helps in the discrimination of different ...
An Evaluation of the Performance of Sysmex XE-2100 in Enumerating Nucleated Red Cells in Peripheral Blood
Jul 01, 2007; ... * Context.-Automated methods of enumerating nucleated red blood cells (NRBCs) in blood are gaining acceptance in many laboratories. Objective.-To evaluate the performance of Sysmex XE- 2100 in enumerating NRBCs in peripheral blood. Design.-Automated relative number of NRBCs per ...
Grading of Follicular Lymphoma: Comparison of Routine Histology With Immunohistochemistry
Jul 01, 2007; ... * Context.-Follicular lymphoma (FL) grading is based on the average number of large transformed cells in 10 neoplastic follicles at ×40 high-power field (×10-40 highpower field) examination (grade 1, 0-5 centroblasts per high-power field; grade 2, 6-15 centroblasts per high-power field; grade 3, ...
Utility of MIB-1 (Ki-67) in Evaluating Diminutive Colorectal Polyps With Cautery Artifact
Jul 01, 2007; ... * Context.-Accurate interpretation of colorectal polyp histology is essential in the decision-making process during treatment and surveillance following polypectomies. However, interpretation of diminutive colorectal polyps removed by thermal electrocoagulation (hot biopsy technique) is often ...
Drug-Herb Interaction: Effect of St John's Wort on Bioavailability and Metabolism of Procainamide in Mice
Jul 01, 2007; ... * Context.-St John's wort induces the activity of the cytochrome P450 enzyme system causing treatment failure because of increased metabolism of many drugs. Procainamide is metabolized by a different pathway to N-acetyl procainamide. Objective.-To study St John's wort-procainamide ...
Expression of p63 Differs in Peritoneal Endometriosis, Endometriomas, Adenomyosis, Rectovaginal Septum Endometriosis, and Abdominal Wall Endometriosis
Jul 01, 2007; ... * Context.-Although there is evidence that endometriosis results from basal endometrium dislocation, the underlying biology is not fully understood. One protein that plays an important role in regulating epithelial proliferation and differentiation is the 63-kDa membrane protein (p63), which is ...
A Proposal on the Identification, Histologic Reporting, and Implications of Intraductal Prostatic Carcinoma
Jul 01, 2007; ... * Context.-Prostatic adenocarcinoma growing within acinar- ductal spaces (intraductal carcinoma) in contrast to highgrade prostatic intraepithelial neoplasia (HG-PIN) impacts negatively on patient outcome.There is currently no generally accepted definition of this lesion nor is it classified in ...
Myelodysplastic Syndromes in Children: A Critical Review of Issues in the Diagnosis and Classification of 887 Cases From 13 Published Series
Jul 01, 2007; ... * Context.-Pediatric myelodysplastic syndromes (MDSs) are uncommon disorders, which may be difficult to diagnose, particularly in the absence of increased blasts. Pediatric MDSs have several unique features including their association with inherited/constitutional disorders in approximately one ...
Multifocal, Extranodal Sinus Histiocytosis With Massive Lymphadenopathy: An Overview
Jul 01, 2007; ... * Context.-This article provides an overview of the major pathologic manifestations of sinus histiocytosis with massive lymphadenopathy, including patient characteristics and current knowledge about its pathogenesis, with an emphasis on multifocal and extranodal presentation. Sinus histiocytosis ...
Intraductal Carcinoma of the Prostate Gland With Transmucosal Spread to the Seminal Vesicle: A Lesion Distinct From High-Grade Prostatic Intraepithelial Neoplasia
Jul 01, 2007; ... * Intraductal carcinoma of the prostate (IDC-P) gland represents an intraluminal neoplastic proliferation that is distinct from high-grade prostatic intraepithelial neoplasia (HG-PIN) and almost always coexists with large-volume, high-stage, and high-grade invasive carcinoma. We document an ...
Bilateral Presentation of Fibroadenoma With Digital Fibroma-like Inclusions in the Male Breast
Jul 01, 2007; ... * Fibroepithelial lesions are uncommon in the male breast. Most published reports describe phyllodes tumors. Fibroadenomas are very common in female breasts, but are exceedingly rare in the male breast. Gynecomastia and/or lobular differentiation have been known to coexist in both types of ...
Enterocolic Lymphocytic Phlebitis: Clinicopathologic Features and Review of the Literature
Jul 01, 2007; ... * Enterocolic lymphocytic phlebitis (ELP) is a recently described entity and is of unknown etiology and pathogenesis. It is characterized by phlebitis of the bowel wall and mesentery, without arterial involvement or evidence of systemic vasculitis. The clinical presentation of ELP is varied, but ...
Plexiform Fibrohistiocytic Tumor: A Brief Review
Jul 01, 2007; ... * Plexiform fibrohistiocytic tumor is a rare mesenchymal neoplasm of intermediate malignancy, first reported by Enzinger and Zhang in 1988. It has a predilection for children and young adults but can occur at any age. The tumor usually involves the upper limbs as a slow-growing, painless mass ....
A Review of Articles From Last Month's Archives of Pathology & Laboratory Medicine
Jul 01, 2007; ... Listed below are questions based on articles that appeared in last month's print edition of the ARCHIVES. Registered continuing medical education participants should answer these questions either online or use the July 2007 answer sheet. 1. Among the results of the Norwegian Vitamin ...