Recently added articles from Biophysical Journal:
Packaging Double-Helical DNA into Viral Capsids: Structures, Forces, and Energetics
Jul 15, 2008; ... ABSTRACT Small, icosahedral double-stranded DNA bacteriophage pack their genomes tightly into preformed protein capsids using an ATP-driven motor. Coarse-grain molecular-mechanics models provide a detailed picture of DNA packaging in bacteriophage, revealing how conformation depends on ...
Synthetic Nanopores as a Test Case for Ion Channel Theories: The Anomalous Mole Fraction Effect without Single Filing
Jul 15, 2008; ... ABSTRACT The predictions of a theory for the anomalous mole fraction effect (AMFE) are tested experimentally with synthetic nanopores in plastic. The negatively charged synthetic nanopores under consideration are highly cation selective and 50 [Angstrom] in diameter at their smallest ...
Part I: An X-Ray Scattering Study of Cholera Toxin Penetration and Induced Phase Transformations in Lipid Membranes
Jul 15, 2008; ... ABSTRACT Cholera toxin is a highly efficient biotoxin, which is frequently used as a tool to investigate protein-membrane interactions and as a reporter for membrane rafts. Cholera toxin binds selectively to gangliosides with highest affinity to GM^sub 1^. However, the mechanism by which ...
Atomistic Simulations of the HIV-1 Protease Folding Inhibition
Jul 15, 2008; ... ABSTRACT Biochemical experiments have recently revealed that the p-S8 peptide, with an amino-acid sequence identical to the conserved fragment 83-93 (S8) of the HIV-1 protease, can inhibit catalytic activity of the enzyme by interfering with protease folding and dimerization. In this ...
Gating Mechanisms of Mechanosensitive Channels of Large Conductance, I: A Continuum Mechanics-Based Hierarchical Framework
Jul 15, 2008; ... ABSTRACT A hierarchical simulation framework that integrates information from molecular dynamics (MD) simulations into a continuum model is established to study the mechanical response of mechanosensitive channel of large-conductance (MscL) using the finite element method (FEM). The ...