Blood Weekly back issues from June 1998:
Viral Inactivation Technology Kills Hard-to-Eliminate Parvo Virus
Jun 01, 1998 ... New technology may soon inactivate viruses present in blood samples, right in blood collection tubes.Pentose Pharmaceuticals, Inc., Cambridge, Massachusetts, plans to submit a 510K regulatory application to the U.S. Food and Drug administration (FDA) some time during 1998 for the ...
Conference Coverage (ASCO) PBPC Transplantation Supports Dose Intensive Chemo in Children
Jun 01, 1998 ... Peripheral blood progenitor cell (PBPC) transplantation reduces the number of hospital days for children and young adults who receive dose intensive chemotherapy (CT) for metastatic sarcomas.Douglas Hawkins, representing colleagues from the Children's Hospital and Regional Medical ...
Conference Coverage (ASCO) Risks Associated with Chemotherapy-Based Transfusion Requirements are Quantified
Jun 01, 1998 ... In the never-ending saga of chemotherapy induced complications, a new study provides hope that platinum-based chemotherapy-induced anemia in ovarian cancer patients can be prevented before it occurs.David Heddens, representing colleagues from the Arizona Cancer Center, the ...
Desmopressin Vasopressin Analog Does Not Significantly Prevent Blood Loss
Jun 01, 1998 ... A vasopressin analog decreased blood loss only by 19 percent in patients undergoing spinal surgery.Desmopressin acetate (DDAVP, Upjohn Co. of Toronto, Ontario, Canada) has been used to improve bleeding times and to provide surgical hemostasis in patients with platelet disorders ...
Epstein-Barr Virus CD8+ Activation Could Be Immune Response to Active Viral Replication
Jun 01, 1998 ... Expression of CD38 and HLA-DR on CD8(+) cells might be a marker for ongoing viral replication in both HIV and Epstein-Barr virus (EBV) infections.Jonathan E. Lynne, UCLA School of Medicine, Los Angeles, California, and colleagues studied the temporal pattern of CD8(+) cell ...
Hematopoiesis High Level of Leukemic Cells Engrafted in NOD/SCID Mice
Jun 01, 1998 ... An in vivo model of human chronic myeloid leukemia (CML) may enable further investigation and the development of more effective therapies.The model involves the intravenous injection of patient peripheral blood (PB) or bone marrow (BM) cells into sublethally irradiated nonobese ...
Human Papillomavirus Topical Antiviral Compound Reduces Cutaneous and Genital Warts
Jun 01, 1998 ... A topical compound that mimics the effects of interferon shows promise for the treatment of cutaneous and genital warts caused by human papilloma virus (HPV) infections.The initial results of two early clinical studies of PEN203 for treating HPV were reported by Pentose ...
Plasmodium vivax Malaria Should Be Considered in Symptomatic Patients Returning from Korea
Jun 01, 1998 ... A case of malaria acquired by a U.S. Army soldier while in Korea highlights how an infectious disease, uncommon in certain countries, can lead to misdiagnosis.The soldier probably was infected with Plasmodium vivax during 1995, and presented with symptoms to Madigan Army Medical ...
AIDS Immunity Transient HIV Infection a Myth
Jun 01, 1998 ... Intensive evaluation has failed to corroborate transient HIV infection.There have been several reports of infants apparently infected with HIV who were later found to be uninfected. Because these studies used highly accurate tests for the virus - viral isolation or polymerase ...
Conference Coverage (ECPI Combination Vaccines) Tips on Vaccine Licensing from Wyeth-Lederle
Jun 01, 1998 ... Not everything comes from the R&D department.Modern pharmaceutical firms are constantly on the lookout for sources of technology that they can acquire or license. The trick, of course, is to spot relevant technologies before one's competitors: and this is perhaps nowhere more ...
Virology (HCV) Serum Viral Level Measures Liver Viral Burden
Jun 01, 1998 ... Serum viral level is an accurate measurement of intrahepatic viral burden during chronic hepatitis C virus infection, according to a report from Spain.Since the natural history of hepatitis C associated liver disease and therapeutic responsiveness might vary according to liver and ...
Blood Donation 17-Year-Olds Now Can Donate Blood in the U.K.
Jun 01, 1998 ... Baroness Jay, Minister for Health for the United Kingdom, announced May 15, 1998, that the British government has introduced new blood donor age limits so that people aged between 17-70 may now give blood.The new age range, replacing the previous 18-65 age limit, means that the ...
Blood Safety U.K. Committee on Safety of Medicines Completes Review of Blood Products
Jun 01, 1998 ... The United Kingdom's Committee on Safety of Medicines (CSM) has completed its review of the sourcing of blood products.A number of precautionary measures to protect patients against the theoretical risk of contracting new variant Creutzfeldt-Jacob Disease (nvCJD) were announced in ...
Blood Safety Viral Inactivation Method To Improve Safety of Blood Products Presented
Jun 01, 1998 ... Pentose Pharmaceuticals, Inc., Cambridge, Massachusetts, presented preclinical results demonstrating that Inactine blood-derived products and biopharmaceuticals, is active against all major classes of contaminating viruses.Inactine is a method for eliminating viral pathogens in ...
Blood Vessels In Vivo Measurement of Real-Time Aortic Segmental Volume
Jun 01, 1998 ... The conductance catheter technique for chamber volume measurement has been applied in vivo to determine real-time phasic aortic segmental volume.D.A. Hettrick et al. used a four-electrode conductance catheter to measure time-varying resistance of the descending thoracic aorta in ...
Cord Blood Transplantation New Life From Afterbirth
Jun 01, 1998 ... Five years ago, umbilical cord blood was a shot-in-the-dark last chance for one young leukemia patient who couldn't find a matching donor for a bone marrow transplant.Today, Duke University researchers in North Carolina think it holds promise for a broader spectrum of patients who ...
Drug Development Class of Cancer Drugs May Also Help Leukemia
Jun 01, 1998 ... A class of cancer drugs that has had an impact on tumors in mice may also work against leukemia, their discoverer said.Dr. Judah Folkman, Harvard University and Boston Children's Hospital, Cambridge, Massachusetts, whose anti-angiogenesis compounds have made front-page news and ...
Hemophilia A (Therapy) FDA, EMEA to Review Applications for New Hemophilia A Treatment
Jun 01, 1998 ... Genetics Institute and Wyeth-Ayerst have announced that the U.S. Food and Drug Administration (FDA) and the European Medicines Evaluation Agency (EMEA) have accepted for review a Biologics License Application (BLA) and a Marketing Authorization Application (MAA) for ReFactoR Antihemophilic ...
Industry News (Hemophilia) Company Announces Formation of Hemophilia Group
Jun 01, 1998 ... Genetics Institute, Inc., a wholly-owned subsidiary of American Home Products Corporation, announced the formation of the Genetics Institute Hemophilia Group, a group within the company dedicated to advancing care for people with hemophilia and their caregivers through advanced technologies ...
Legal Issues Canadian Government Reopens Talks On Blood Scandal
Jun 01, 1998 ... Canadian Health Minister Allan Rock failed to resolve a crisis that has virtually paralyzed the federal government as it struggles to deal with the outrage of patients of a tainted blood scandal.No consensus was reached in seven hours of talks with provincial health ministers which ...
Transfusions 510(k) Filing for FDA Clearance of r/LS System Announced
Jun 01, 1998 ... HemaSure Inc., Marlborough, Massachusetts, announced that it has filed a 510(k) Pre-Market Notification application with the U.S. Food and Drug Administration (FDA) for the company's r/LS System.The r/LS System is designed to increase the safety of donated blood by reducing ...
Conference News . . . June 1, 1998 Information About Research Worldwide . . . Compiled by Michelle Marble
Jun 01, 1998 ... Transfusion Medicine "A Clinical Prediction Rule to Guide the Use of Prophylactic Platelet Growth Factors (PGF) and Platelet (PLT) Transfusions." L. Elting, C. Martin, S. Cantor, D. Kurtin, E. Rubenstein, E. Laiho, S. Rodriguez, K. Kanesan and R. Benjamin. M.D. Anderson Cancer Center, ...
Cancer Vaccines "Vaccination with Peptide to the Heparin Binding Domain of bFGF Conjugated to Liposomes Inhibits bFGF Induced Neovascularization." S.M. Plum, A. Ruiz, J. Madsen, W.E. Fogler and A.H. Fortier. EntreMed, Inc., Rockville, Maryland.
Jun 01, 1998 ... According to an abstract submitted by the authors to the 89th Annual Meeting of the American Association for Cancer Research, held March 28 - April 1, 1998, in New Orleans, Louisiana, "Basic fibroblast growth factor (bFGF) is an important stimulator of angiogenesis implicated in neoplastic ...
Platelet Recovery "Comparison of the Use of G-CSF-Stimulated Peripheral Blood Stem Cells (PBSC) or G-CSF-Stimulated Bone Marrow (BM) in Six Antigen-Matched Sibling Transplantation."
Jun 01, 1998 ... J.S. Serody, J.M. Wiley, D.A. Gabriel, E. Powell, C. Scott, P. Lawrence, S.A. Bentley, M.E. Brecher, J. Folds and T.C. Shea. University of North Carolina, Departments of Medicine, Pediatrics, Pathology and Laboratory Medicine and the Lineberger Comprehensive Cancer Center, Chapel Hill, North ...
Stem Cell Mobilization "Development of a Method for Monitoring Blood Dendritic Cell Numbers: Comparison of Normal Individuals and Patients Undergoing Stem Cell Mobilization."
Jun 01, 1998 ... D.N.J. Hart, D.B. Fearnley L. Whyte, S. Carnoutsos and A. Cook. Haematology/lmmunology Research Group & Dept. of Haematology Christchurch Hospital, Christchurch, New Zealand.According to an abstract submitted by the authors to the 34th Annual Meeting of the American Society of ...
Journal News . . . June 1, 1998 Reviews and Information From Periodicals and Journals Worldwide . . . Compiled by Alan D. Henderson
Jun 01, 1998 ... Bone Marrow Radford, S.A.; Johnson, E.M.; Leeming, J.P.; Millar, M.R.; Cornish, J.M.; Foot, A.B.M.; Warnock, D.W. "Molecular Epidemiological Study of Aspergillus fumigatus in a Bone Marrow Transplantation Unit by PCR Amplification of Ribosomal Intergenic Spacer Sequences." Journal of ...
Cornea Banking Engelmamn, K.; Ventura, A.S.; Drexler, D.; Staude, H.J. "A Sensitive Method for Testing the Quality of Organ Culture Media and of Individual Medium Components in a Cornea Bank."
Jun 01, 1998 ... Graefes Archive for Clinical and Experimental Ophthalmology, April 1998;236(4):312-319.According to the authors' abstract of an article published in Graefes Archive for Clinical and Experimental Ophthalmology, "BACKGROUND: It has been suggested that variations in the quality of ...
Diagnostics Waite, R.T.; Woods, G.L. "Evaluation of BACTEC MYCO/F Lytic Medium for Recovery of Mycobacteria and Fungi From Blood." Journal of Clinical Microbiology, May 1998;36(5):1176-1179.
Jun 01, 1998 ... According to the authors' abstract of an article published in Journal of Clinical Microbiology, "The reliability of MYCO/F Lytic medium in the BACTEC 9240 blood culture system was evaluated by comparing its performance to that of the Isolator system for the recovery of fungi and to that of ...
Diagnostics Tortoli, E.; Cichero, P.; Chirillo, M.G.; Gismondo, M.R.; Bono, L.; Gesu, G.; Simonetti, M.T.; Volpe, G.; Nardi, G.; Marone, P.
Jun 01, 1998 ... "Multicenter Comparison of ESP Culture System II With BACTEC 460TB and With Lowenstein-Jensen Medium for Recovery of Mycobacteria From Different Clinical Specimens, Including Blood." Journal of Clinical Microbiology, May 1998;36(5):1378-1381.According to the authors' abstract of an ...
Diagnostics (HCV) Lepogam, S.; Dubois, F.; Christen, R.; Raby, C.; Cavicchini, A.; Goudeau, A. "Comparison of DNA Enzyme Immunoassay and Line Probe Assays (Inno-LiPA HCV I and II) for Hepatitis C Virus Genotyping."
Jun 01, 1998 ... Journal of Clinical Microbiology, May 1998;36(5):1461-1463.According to the authors' abstract of an article published in Journal of Clinical Microbiology, "Two methods for genotyping hepatitis C virus (DNA enzyme immunoassay [DEIA] and line probe assay [Inno-LiPA HCV I and II]) ...
Immunosuppression Mathew, J.M.; Carreno, M.; Zucker, K.; Fuller, L.; Kenyon, N.; Esquenazi, V.; Ricordi, C.; Tzakis, A.G.; Miller, J.
Jun 01, 1998 ... "Cellular Immune Responses of Human Cadaver Donor Bone Marrow Cells and Their Susceptibility to Commonly Used Immunosuppressive Drugs in Transplantation." Transplantation, April 15, 1998;65(7):947-955.According to the authors' abstract of an article published in Transplantation, ...
Blood Banking No Difference in GBV-C/HGV Viremia in Donors with Normal or Elevated ALT
Jun 08, 1998 ... Infection with GB virus C (GBV-C) and its strain variant hepatitis G virus (HGV) is common in the Swedish blood donor population.No significant difference in the prevalence of GBV-C/HGV infection between donors with normal alanine aminotransferase (ALT) levels and those with ...
Chagas' Disease PCR Method Detects T. cruzi in Blood
Jun 08, 1998 ... The 220-bp DNA fragment may be a useful tool for the detection of Trypanosoma cruzi in blood.The protozoan parasite T. cruzi is the causative agent of Chagas' disease, a major public health problem in Latin America.Carlota Susana Carriazo of Argentina's Universidad ...
Pancreas Transplantation Organs from Older Donors Result in More Premature Graft Loss
Jun 08, 1998 ... Pancreas grafts from donors older than 45 years adversely affect transplantation outcome, study findings show.Multivariate analysis demonstrated that increasing donor age was the only donor variable that correlated with poorer short-term pancreas (Px) graft survival, reported ...
Renal Transplantation KS and Lymphoma Found in Same Biopsy Specimen
Jun 08, 1998 ... A patient simultaneously developed Kaposi's sarcoma (KS) and lymphoma 15 months after renal transplantation.Although KS and non-Hodgkin's lymphoma frequently occur after renal transplantation, the complications usually occur as separate entities."To our knowledge, this ...
Thrombocytopenia HIV Infected Marrow Megakaryocytes May Cause Ineffective Platelet Production
Jun 08, 1998 ... Ineffective platelet production in HIV infected patients may be the result of HIV infected marrow megakaryocytes directly impairing platelet formation.James L. Cole, Emory University School of Medicine, Atlanta, Georgia, and colleagues characterized platelet production in a cohort ...
Blood Safety (HBV) Transgenic Tobacco Plants Provide Cheap Source of Antigen for Blood Testing
Jun 08, 1998 ... Genetically engineered tomatoes may have made a brief media splash, but closely-related transgenic tobacco plants may have a more lasting impact.Japanese researchers have engineered tobacco plants to express hepatitis B virus core antigen (HBcAg) less expensively and with ...
Hematopoiesis Key Role for Mesenchymal Stem Cells Demonstrated in Bone Marrow
Jun 08, 1998 ... Osiris Therapeutics, Inc., Baltimore, Maryland, announced the publication of key research findings demonstrating the important role of human mesenchymal stem cells (hMSCs) in supporting blood cell formation (hematopoiesis) in bone marrow.The research findings, published in the ...
Industry News (Joint Venture) Agreement Provided Greater Access To Virus Inactivated Plasma Product
Jun 08, 1998 ... The American Red Cross and Blood Centers of America (BCA)/hemerica have announced the signing of an agreement to make PLAS+SD (Pooled Plasma, Solvent/Detergent Treated) available to BCA-affiliated blood centers throughout the United States.V.I. Technologies, Inc. (VITEX) received ...
Occupational Safety FDA Clearance for CoverTip Safety Syringe Announced
Jun 08, 1998 ... Medisys Technologies, Inc., Baton Rouge, Louisiana, announced it has received U.S. Food and Drug Administration (FDA) 510K clearance to market the CoverTip Safety Syringe into the billion dollar U.S. syringe market.The CoverTip Safety Syringe is indicated for use in the ...
Treatment (Hemophilia B) Gene Therapy Approach Shows Promise with Single Intramuscular Administration
Jun 08, 1998 ... Scientists at Avigen, Inc., Seattle, Washington, and The Children's Hospital of Philadelphia, Pennsylvania, have developed a gene therapy approach for the treatment of hemophilia B using a single intramuscular administration of an adeno-associated virus (AAV) vector containing the gene for ...
Transfusion Medicine "A Transfusion Protocol (TP) and a 100% Computerized System for the Prescription and the Follow-Up of Transfusions Has Allowed a Major Improvement of the Quality of Transfusion in a Medical Oncology Department of a Comprehensive Cancer Center."
Jun 08, 1998 ... D. Spadth, O. Agulles, F. Viry-Babel, J.P. Marquis and P. Bey. Centre Alexis, Vautrin Vandaeuvre-les-Nancy, France.According to an abstract submitted by the authors to the 34th Annual Meeting of the American Society of Clinical Oncology, held May 16-19, 1998, in Los Angeles, ...
Platelets (Shelf Life) "Buffy Coat Derived Platelet Concentrates: Progressive Decrease in Platelet Function During the Shelf Life."
Jun 08, 1998 ... A. Botchwav, N.A. Flores, D.J. Sheridan and H. Cohen. Academic Cardiology Unit, Department of Haematology, Imperial College School of Medicine at St. Mary's, London, United Kingdom.According to an abstract submitted by the authors to the Royal College of Physicians of Edinburgh ...
Platelets (Storage) "Microvesiculation of Platelet Concentrates During Storage."
Jun 08, 1998 ... P. Krailadsiri, M.J. Seghatchian, M. Contreras, I.J. Mackie and S.J. Machin. National Blood Service-London and the South East, University College Hospital.According to an abstract submitted by the authors to the Royal College of Physicians of Edinburgh Consensus Conference on ...
Transfusion Medicine "Transfusion Support with Filtered Washed Red Cells to Prevent Relapse of Post Transfusion Purpura."
Jun 08, 1998 ... N. Win and C. Humphries. NBS-South, Thames, London and SE Zone.According to an abstract submitted by the authors to the Royal College of Physicians of Edinburgh Consensus Conference on Platelet Transfusion, held November 27-28, 1997, in Edinburgh, United Kingdom, "Post-transfusion ...
Transfusion Reactions "Comparison of Effect of Blood Bank Versus Bedside Filtration on Platelet Transfusion Reactions."
Jun 08, 1998 ... K.G. Morris and C. Bharucha. Northern Ireland Blood Transfusion Service, Belfast, Northern Ireland.According to an abstract submitted by the authors to the Royal College of Physicians of Edinburgh Consensus Conference on Platelet Transfusion, held November 27-28, 1997, in ...
Blood Gene Therapy "Efficient Retroviral-Mediated Gene Transfer to Human Cord Blood Stem Cells With in vivo Repopulating Potential."
Jun 08, 1998 ... Conneally, E.; Eaves, C.J.; Humphries, R.K. Blood, May 1, 1998;91(9):3487-3493.According to the authors' abstract of an article published in Blood, "Recent studies have shown efficient gene transfer to primitive progenitors in human cord blood (CB) when the cells are incubated in ...
Coagulation Testing "Minimum Specimen Volume Requirements for Routine Coagulation Testing - Dependence on Citrate Concentration."
Jun 08, 1998 ... Adcock, D.M.; Kressin, D.C.; Marlar, R.A. American Journal of Clinical Pathology, May 1998;109(5):595-599.According to the authors' abstract of an article published in American Journal of Clinical Pathology, "We evaluated the effect of sample volume and citrate concentration on ...
Cytomegalovirus "Evaluation of Murex CMV DNA Hybrid Capture Assay for Detection and Quantitation of Cytomegalovirus Infection in Patients Following Allogeneic Stem Cell Transplantation."
Jun 08, 1998 ... Hebart, H.; Gamer, D.; Loeffler, J.; Mueller, C.; Sinzger, C.; Jahn, G.; Bader, P.; Klingebiel, T.; Kanz, L.; Einsele, H. Journal of Clinical Microbiology, May 1998;36(5):1333-1337.According to the authors' abstract of an article published in Journal of Clinical Microbiology, ...
Diagnostics "Detection and Characterization of Carcinoma Cells in the Blood."
Jun 08, 1998 ... Racila, E.; Euhus, D.; Weiss, A.J.; Rao, C.; Mcconnell, J.; Terstappen, L.W.M.M.; Uhr, J.W. Proceedings of the National Academy of Sciences of the United States of America, April 14, 1998;95(8):4589-4594.According to the authors' abstract of an article published in Proceedings of ...
Diagnostics "Panfungal PCR Assay for Detection of Fungal Infection in Human Blood Specimens."
Jun 08, 1998 ... Vanburik, J.A.; Myerson, D.; Schreckhise, R.W.; Bowden, R.A. Journal of Clinical Microbiology, May 1998;36(5):1169-1175.According to the authors' abstract of an article published in Journal of Clinical Microbiology, "A novel panfungal PCR assay which detects the small-subunit rRNA ...
Diagnostics (HCV) "Evaluation of a Membrane Filter Assay System, Ortho HCV Ab Quik Pack, for Detection of Anti-Hepatitis C Virus Antibody."
Jun 08, 1998 ... Kodama, T.; Ichiyama, S.; Sato, K.; Nada, T.; Nakashima, N. Journal of Clinical Microbiology, May 1998;36(5):1439-1440.According to the authors' abstract of an article published in Journal of Clinical Microbiology, "A simple membrane immunoassay assay system, Quik Pack, for the ...
Diagnostics (HCV) "Factors Associated With Serum Alanine Transaminase Activity in Healthy Subjects: Consequences for the Definition of Normal Values, for Selection of Blood Donors, and for Patients With Chronic Hepatitis C."
Jun 08, 1998 ... Piton, A.; Poynard, T.; Imbertbismut, F.; Khalil, L.; Delattre, J.; Pelissier, E.; Sansonetti, N.; Opolon, P. Hepatology, May 1998;27(5):1213-1219.According to the authors' abstract of an article published in Hepatology, "In clinical research, the definition of the upper limit of ...
Hemophilia "Sustained Phenotypic Correction of Murine Hemophilia A by in vivo Gene Therapy."
Jun 08, 1998 ... Connelly, S.; Andrews, J.L.; Gallo, A.M.; Kayda, D.B.; Qian, J.H.; Hoyer, L.; Kadan, M.J.; Gorziglia, M.I.; Trapnell, B.C.; Mcclelland, A.; Kaleko, M. Blood, May 1, 1998;91(9):3273-3281.According to the authors' abstract of an article published in Blood, "Hemophilia A is caused by ...
Screening (HAV) "Use of Three Recommended Criteria for Anti-Hepatitis A Antibody Testing in Travellers."
Jun 08, 1998 ... Landry, P.; Darioli, R. Schweizerische Medizinische Wochenschrift, April 11, 1998;128(15):581-585.According to the authors' abstract of an article published in Schweizerische Medizinische Wochenschrift, "To select the travellers most likely to benefit from anti-hepatitis A (HA) ...
HIV-1 Modified Assays Screen Large Numbers of Serum Samples
Jun 22, 1998 ... It is possible to use certain assays efficiently in screening large numbers of serum samples for the presence of HIV, study results show.To detect antibody-negative HIV-1 RNA positive samples among sera sent to microbiological laboratories, Pierre-Alain Morandi of Switzerland's ...
VITAXIN: Another Anti-Angiogenic Agent In The News
Jun 22, 1998 ... Results from a phase I clinical trial demonstrated the safety of the anti-angiogenic agent VITAXIN.John Gutheil represented colleagues from the Sidney Kimmel Cancer Center, California, with trial results at the 34th Annual Meeting of the American Society of Clinical Oncology, held ...
Cytomegalovirus Virus Infection Inhibits BM Engraftment
Jun 22, 1998 ... Cytomegalovirus infection inhibits the engraftment of donor bone marrow cells in the recipient stroma.Stromal hemopoietin downregulation may explain the deficient hematopoietic reconstitution, reported Hans-Peter Steffens and colleagues of Germany's Johannes Gutenberg University ...
Epstein-Barr Virus BARF1 May Modulate Host Immune Response to Viral Infection
Jun 22, 1998 ... The BARF1 protein may modulate the host immune response to Epstein-Barr virus infection.The BARF1 gene is transcribed early after Epstein-Barr virus (EBV) infection from the BamHI A fragment of the EBV genome. The gene is reported to confer tumorigenic capacity onto human B cell ...
HHV-8 CDC Researchers Develop Peptide-Based EIA
Jun 22, 1998 ... An enzyme immunoassay (EIA) has been developed to detect human herpesvirus 8 (HHV-8) antibodies.U.S. Centers for Disease Control and Prevention (CDC) researchers Chou-Pong Pau and colleagues mapped a dominant epitope within the HHV-8 ORF 65-encoded protein to an 8-amino-acid (aa) ...
Hematopoiesis CD34+ Cell Reinfusion in High Numbers Reduces Platelet Requirements
Jun 22, 1998 ... Reinfusion of high doses of CD34(+) cells after chemotherapy shortens the time for hematopoietic engraftment, study results show.The optimal numbers of CD34(+) cells required for reinfusion in patients undergoing peripheral blood progenitor cell (PBPC) transplantation after ...
Hematopoiesis Fibronectin May Support Stem Cells Growth In Vivo
Jun 22, 1998 ... Fibronectin may support the growth of hematopoietic stem and progenitor cells both in vitro and in vivo.Fibronectin (FN) is believed to play important roles in certain aspects of hematopoiesis through binding to very late antigen 4 (VLA4) and VLA5. The effects of FN on ...
AIDS Pathogenesis Ho's "Raging Fire" Put Out
Jun 22, 1998 ... A new theory of AIDS pathogenesis supersedes the "raging fire" and "tap-and-drain" models put forward by David Ho.Instead of a constant systemic battle between a horde of HIV virions and a constantly surging supply of new T cells, the new model suggests that localized cells ...
Bleeding Disorders (Prevention) Initiative Aims to Prevent Bloodborne Disease Transmission and Bleeding Disorder
Jun 22, 1998 ... The National Prevention Awareness Campaign is a new National Hemophilia Foundation (NHF)/U.S. Centers for Disease Control and Prevention initiative to promote the prevention or reduction of the complications of bleeding disorders.These prevention messages include exercise and early ...
Overview of 12th World AIDS Conference
Jun 22, 1998 ... Bang the drum, slowly.The 12th World AIDS Conference will put up its tents in Geneva, Switzerland, from June 28 through July 3, 1998.It's been two years since the last conference in Vancouver, Canada: two years since highly active antiretroviral therapy (HAART) became ...