Blood Weekly back issues from August 2008:
Water-diffusion technology identifies brain regions damaged by prenatal alcohol exposure.
Aug 07, 2008 ... Scientists know that children with Fetal Alcohol Spectrum Disorder (FASD) often have structural brain damage. Yet little is known about how white matter connections, and deep gray matter structures that act as relay stations, are affected in children with FASD. A new study has used ...
'Statins' linked to improved survival in kidney transplant recipients.
Aug 07, 2008 ... For patients receiving kidney transplants, treatment with cholesterol-lowering "statin" drugs may lead to longer survival, reports a study in the November 2008 Journal of the American Society of Nephrology (JASN) (see also American Society of Nephrology). "Statin therapy is well ...
Discovery of a mechanism that regulates cell movement.
Aug 07, 2008 ... A study performed by researchers at the Institute for Research in Biomedicine (IRB Barcelona), in collaboration with researchers at the Instituto de Biologia Molecular of the CSIC, reveal a mechanism that controls the movement of cells in a tissue by regulating cell adhesion. This same ...
Male kidneys for men only?
Aug 07, 2008 ... The gender of donor and recipient plays a larger role in kidney transplants than previously assumed. Female donor kidneys do not function as well in men u due to their smaller size. Women have a higher risk of rejecting a male donor kidney. Therefore, in the future, gender should be ...
Discovery of a new signaling mechanism may lead to novel anti-inflammatory therapy.
Aug 07, 2008 ... A team of researchers at the University of California, San Diego School of Medicine has uncovered a new signaling mechanism used to activate protein kinases that are critical for the body's inflammatory response. Their work will be published in the July 18 online edition of Science ...
Study results from K. Sai et al provide new insights into cancer.
Aug 07, 2008 ... According to recent research from Tokyo, Japan, "Background and purpose Cytochrome P450 3A4 (CYP3A4) converts an anticancer prodrug, irinotecan, to inactive metabolites such as APC. However, the contribution of CYP3A4 genetic polymorphisms to irinotecan pharmacokinetics (PK) and ...
Research from R. Soundravally and co-researchers yields new findings on dengue fever.(Report)
Aug 07, 2008 ... According to a study from Pondicherry, India, "Antigen peptides are actively transported across the endoplasmic reticulum by the transporters associated with antigen presentation (TAP). TAP genes polymorphism could influence the selection process that determines which antigen peptides play ...
Studies in the area of dialysis reported from P.M. Palevsky and co-researchers.
Aug 07, 2008 ... According to a study from the United States, "The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial. We randomly assigned critically ill patients with acute kidney injury and failure of at least one nonrenal organ or sepsis ...
New drug resistance study findings recently were published by researchers at Kyushu University.(Report)
Aug 07, 2008 ... According to recent research from Fukuoka, Japan, "Stenotrophomonas maltophilia (previously named Xanthomonas maltophilia) is an aerobic, nonfermentive, Gram-negative bacillus that is widespread in the environment. It is considered to be an organism with a limited pathogenic potential, ...
Research reports on enzyme research from A.A. Birukova and colleagues provide new insights.
Aug 07, 2008 ... "Acute lung injury, sepsis, lung inflammation, and ventilator-induced lung injury are life-threatening conditions associated with lung vascular barrier dysfunction, which may lead to pulmonary edema. Increased levels of atrial natriuretic peptide (ANP) in lung circulation reported in these ...
Research from University of Leipzig in the area of life sciences published.
Aug 07, 2008 ... "The antimicrobial activity of new tetracationic and water-soluble meso-substituted tetrahydroporphyrin tetratosylat (BL1065) and of dicationic water-soluble chlorine e6 Photolon (TM) (BLC1013) is described. The dark toxicity and photosensitizing potentials of both photosensitizers were ...
Simple flow-based total nucleated cell differential.
Aug 07, 2008 ... A new method published in Cytometry part B uses DRAQ5 to gate all nucleated cells, FlowCount beads, a panel of 6 antibodies in 4 clusters and the 5 fluorescence channels plus forward and side scatter on the Beckman Coulter FC500 flow cytometer to get a comprehensive analysis of both ...
Studies from Novo Nordisk in the area of life sciences published.
Aug 07, 2008 ... "Recombinant activated factor VIIa (rFVIIa) is indicated for on-demand treatment of bleeding and the prevention and treatment of surgical bleeding in patients with hemophilia A or B who have antibodies to coagulation factors VIII or IX. The currently approved single-use formulation of ...
Report summarizes mesothelioma study findings from University of Rochester.
Aug 07, 2008 ... "Malignant pleural mesothelioma (MPM) is a rare cancer that rnetastasizes to mediastinal lymph nodes (MLNs). The diagnosis of MPM metastatic to MLNs may not be straightforward," researchers in the United States report (see also Mesothelioma). "We describe 3 cases to highlight ...
New findings from Nagoya University in the area of myelodysplastic syndrome published.
Aug 07, 2008 ... "P53 mutation has been reported in various solid tumors, acute leukemia and myelodysplastic syndrome (MDS), but the diagnostic significance of p53 in MDS remains to be determined. The purpose of the present paper was to examine p53 mutation and immunostaining of the same patients, because ...
Study findings on myeloma are outlined in reports from M.S. Bhandari and colleagues.
Aug 07, 2008 ... "Multiple malignancies in the same patient are unusual. This is particularly true for patients with hematologic malignancies who have a concomitant solid tumor," researchers in the United States report (see also Myeloma). "We report the unexpectedly higher frequency of renal ...
Studies from Showa University provide new data on neutropenia.(Report)
Aug 07, 2008 ... According to recent research published in the journal Cancer Chemotherapy and Pharmacology, " Fever occurring in a neutropenic patient remains a common life-threatening complication of cancer chemotherapy, and febrile neutropenia (FN) is recognized as a dose-limiting factor (DLF) in cancer ...
New Parkinson disease research from Z. Ganor et al outlined.
Aug 07, 2008 ... "Mutations in GBA and LRRK2 genes have been implicated in Parkinson disease (PD), particularly in Ashkenazi Jews. An Israeli Ashkenazi cohort of 420 patients with PD, 333 elderly controls, and 3,805 young controls was screened for eight GBA mutations, which are associated with mild (N370S, ...
Research on pharmacokinetics detailed by P.M. Lorusso and co-authors.
Aug 07, 2008 ... According to a study from the United States, " This phase I study assessed the safety, optimally tolerated regimen (OTR), pharmacokinetics, pharmacodynamics, and preliminary clinical activity of lapatinib and docetaxel in patients with advanced solid tumors. Patients and Methods Doses of ...
Telescope Embedded in Spectacle Lens Promises to Make Driving Easier for Visually Impaired.
Aug 07, 2008 ... Glasses embedded with a telescope promise to make it easier for people with impaired vision to drive and do other activities requiring sharper distance vision. Schepens Eye Research Institute scientists describe the advantages of these innovative glasses over earlier devices in an article ...
Studies from University of Milan in the area of sepsis described.
Aug 07, 2008 ... According to recent research published in the journal Transplantation Proceedings, "Severe sepsis in transplant recipients results in an extremely high morbidity mortality rate. Microvascular alterations play an important role in the development of sepsis-induced organ dysfunction." ...
Studies from W.C. Cirocco and colleagues reveal new findings on sepsis.
Aug 07, 2008 ... "Stapled hemorrhoidopexy (SH) was conceived and developed in Europe. Over the past decade, there have been reports of severe, life-threatening complications and 2 deaths," researchers in the United States report (see also Sepsis). "These are the first such cases from the ...
Study data from University of Tennessee provide new insights into sepsis.
Aug 07, 2008 ... "Intra-abdominal sepsis (IAS) following pancreatectomy is associated with the need for therapeutic intervention and may result in mortality. We retrospectively reviewed patients developing IAS following elective pancreatectomy," researchers in the United States report (see also Sepsis). ...
New sickle cell anemia data have been reported by K.B. Taori and co-authors.
Aug 07, 2008 ... According to recent research published in the American Journal of Roentgenology, "The purpose of our study was to detect changes in renovascular resistance through renal Doppler indexes in young sickle cell disease patients with normal routine urine laboratory tests." "Renal ...
Research from University of Vermont, Medical Department provide new insights into subarachnoid hemorrhage.
Aug 07, 2008 ... According to recent research published in the journal Stroke, "Cerebral vasospasm after subarachnoid hemorrhage ( SAH) is a major contributor to mortality and morbidity after aneurysm rupture. Recently, R-type voltage-dependent Ca2+ channel ( VDCC) expression has been associated with ...
Reports outline surgery research from St. Joseph University.(Report)
Aug 07, 2008 ... According to a study from Beirut, Lebanon, "The purpose of this study was to evaluate the safety of femoral arterial pressure monitoring in cardiac surgery. Prospective, observational study." "Cardiac surgery unit (CSU) in a university hospital. Of a total of 2,350 consecutive ...
Data on thrombocytopenic purpura reported by researchers at Monash University.(Report)
Aug 07, 2008 ... "Receptors on platelets that contain immunoreceptor tyrosine-based activation motifs (ITAMs) include collagen receptor glycoprotein (GP) VI, and Fc gamma RIIa, a low affinity receptor for immunoglobulin (Ig) G. We examined the function of GPVI and Fc gamma RIIa in a patient diagnosed with ...
Studies by T. Yuri and co-authors describe new findings in thrombocytopenic purpura.
Aug 07, 2008 ... "A 64-year-old Japanese woman suffering from idiopathic thrombocytopenic purpura was treated with prednisolone. During the course of steroid withdrawal she developed parotid gland enlargement and cervical lymph node swelling with multiple dome-shaped red papules on her trunk and upper ...
Studies from S. Shetty et al provide new data on thrombophilia.
Aug 07, 2008 ... According to a study from Bombay, India, "The clinical phenotype in hemophilia generally cot-relates with the type of mutations." "We studied 16 patients with severe hemophilia A (factor VIII and factor VIII:Ag <1%) with intron 22 inversions of the factor VIII gene and 6 ...
New transplantation data have been reported by J. Junginger and co-authors.
Aug 07, 2008 ... According to recent research from Tubingen, Germany, "The short cold ischemic tolerance of the gut is a major problem in small bowel transplantation. We have shown that intestinal lipid administration is beneficial during systemic inflammation like sepsis." "Rats were ...
Findings from St. Thomas' Hospital provide new insights into vasculitis.
Aug 07, 2008 ... According to recent research from London, the United Kingdom, "Cardiovascular disease may be increased in patients with systemic vasculitides (SV). The Ankle-Brachial Pressure Index (ABPI) is a non-invasive tool for the assessment of cardiovascular risk (CV)." "Our aim was to ...
New findings from University of Texas, M. D. Anderson Cancer Center in the area of acute lymphoblastic leukemia therapy published.(Report)
Aug 07, 2008 ... Research findings, 'Secondary myelodysplastic syndrome in a patient with Philadelphia-positive acute lymphoblastic leukemia after achieving a major molecular response with hyperCVAD plus imatinib mesylate,' are discussed in a new report. "The addition of imatinib to high-intensity ...
Scientists at Scientific Institute, Division of Pediatrics describe research in autoinflammatory disease.
Aug 07, 2008 ... A new study, 'Diagnosis and management of autoinflammatory diseases in childhood,' is now available. "Autoinflammatory diseases are a group monogenic inflammatory conditions characterized by an early onset during childhood. Under the term 'periodic fevers' are gathered some monogenic ...
Studies from M.L. Slovak and colleagues yield new information about life sciences.(Conference notes)
Aug 07, 2008 ... Current study results from the report, 'International Working Group on MDS cytogenetics: October 2007 meeting report,' have been published. According to recent research from the United States, "The inaugural meeting of the International Working Group on MDS cytogenetics convened 22-23 ...
Study data from National Medical Center update understanding of myelodysplastic syndrome cell biology.
Aug 07, 2008 ... Investigators publish new data in the report 'Functional analysis of myelodysplastic syndromes-derived mesenchymal stem cells.' According to recent research from Mexico, "Two different reports, including one from our own group, have recently demonstrated the presence of severe chromosomal ...
Researchers from University of Rochester detail findings in myelodysplastic syndrome risk factors.
Aug 07, 2008 ... Scientists discuss in 'Is there an entity of chemically induced BCR-ABL-positive chronic myelogenous leukemia' new findings in myelodysplastic syndrome. According to recent research from the United States, "Advances in the therapy of malignancy have been accompanied by an increased ...
Recent studies from Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins add new data to myelodysplastic syndrome therapy.
Aug 07, 2008 ... Data detailed in 'Myeloablative allogeneic bone marrow transplant using T cell depleted allografts followed by post-transplant GM-CSF in high-risk myelodysplastic syndromes' have been presented. According to recent research from the United States, "Allogeneic blood and marrow ...
Researchers from Cedars-Sinai Medical Center, Division of Hematology detail new studies and findings in the area of myeloid leukemia therapy.(Report)
Aug 07, 2008 ... Scientists discuss in 'Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells' new findings in myeloid leukemia. "Cucurbitacins have long been utilized for their abortifacient and anti-inflammatory effects; however, little is ...
Scientists at University of North Texas describe research in acute hypotension.(Report)
Aug 07, 2008 ... According to a study from the United States, "The effect of antihypertensive drugs on autonomic neural control of the cerebral circulation remains unclear. This study was designed to compare middle cerebral artery mean blood velocity responses to acute hypotension with and without ...
New acute leukemia data have been reported by W. Stock and co-authors.
Aug 07, 2008 ... "A phase I study was performed to determine the safety and pharmacokinetics of XK469R in patients with refractory acute leukemia. The study aimed to determine the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of XK469R given intravenously over 30 to 60 min on days 1, 3, and ...
Data on anesthesia described by J. Fazakas et al.
Aug 07, 2008 ... "Although the contraindications for thoracic epidural anesthesia (TEA) are well defined, the debate continues about whether TEA improves outcomes. Pro and con trials and a metaanalysis in the past have yielded equivocal results; they did not deal with new vascular intervention or drugs," ...
New data from Army illuminate research in aneurysm.
Aug 07, 2008 ... According to recent research from Beijing, People's Republic of China, " Due to their location, large and giant intracavernous and paraclinoid aneurysms remain a challenge for vascular neurosurgeons. We identified characteristics, surgical indications and treatment strategies of large and ...
Study findings from University of Washington broaden understanding of aneurysm.
Aug 07, 2008 ... According to recent research from the United States, "Bronchial artery aneurysms occur rarely, but they are potentially life threatening and require treatment to avoid rupture and other complications. A 37-year-old man, who was otherwise healthy, presented with chest discomfort and was ...
Data on angiology discussed by M.L. Antonova and colleagues.
Aug 07, 2008 ... According to recent research published in the journal Annals of Biomedical Engineering, "The arterial wall viscoelasticity plays an essential role in the vascular responsiveness to vasoactive drugs or pathologies. The aim of this investigation was to derive and compare resonance curve ...
New research on angiology from M.A.D. Vente and co-authors summarized.(Report)
Aug 07, 2008 ... " The aim of this study is to evaluate the toxicity of holmium-166 poly(L-lactic acid) microspheres administered into the hepatic artery in pigs. Healthy pigs (20-30 kg) were injected into the hepatic artery with holmium-165-loaded microspheres ((HoMS)-Ho-165; n= 5) or with ...
Studies from Miyazaki University, Medical Department provide new data on angiology.
Aug 07, 2008 ... "Smooth muscle cell (SMC)-rich intima is a morphological feature of atherosclerotic lesions that is observed in eroded plaque and spastic arteries. Arteries with SMC-rich intima are susceptible to vasoconstriction or vasospasm against some vasoactive agents," investigators in Kihara, Japan ...
Studies from W.C. Methodiusngwodo and colleagues provide new data on angiology.(Report)
Aug 07, 2008 ... According to recent research from the United States, "We have replaced aortography and open thoracic surgery to diagnose and treat blunt traumatic thoracic aortic disruption (TTAD) in favor of CT angiography (CTA) and endovascular repair. The purpose of this study is to review our ...
Recent findings from D.M. Rabi and co-authors highlight research in angiotensins.
Aug 07, 2008 ... "Clinical practice recommendations for hypertension do not make recommendations specific to men or women. However, the sex hormones appear to modulate differently the renin-angiotensin system (RAS), which plays a central role in the regulation of blood pressure," investigators in Calgary, ...
Reports outline antibiotics study results from S. Roy et al.
Aug 07, 2008 ... According to a study from Calcutta, India, "Development of biomaterials, which are inherently antibacterial having broad-spectrum activity against both Gram-positive and Gram-negative bacteria with considerable biocompatibility, is of tremendous importance in biomedicinal chemistry ....
Research from Leiden University yields new findings on antibiotics.(Report)
Aug 07, 2008 ... According to recent research from Netherlands, "Chitosan, a biodegradable and biocompatible polymer, has attracted great attention in the pharmaceutical and biomedical fields especially due to its properties to reversibly open the tight junctions of the epithelial tissues and to allow for ...
Research from University of Pennsylvania reveals new findings on aortic dissection.(Report)
Aug 07, 2008 ... "Conventional open repair of acute complicated type B aortic dissection is associated with significant morbidity and mortality. This study examined the results of thoracic endovascular aortic repair (TEVAR) in acute type B aortic dissection complicated with rupture or malperfusion ...
Nihon University publishes research in apoptosis.(Report)
Aug 07, 2008 ... "Cerebral ischemia followed by oxygen reperfusion induced apoptosis in hippocampal neurons in the stroke-prone spontaneously hypertensive rat (SHRSP) but not in Wistar Kyoto rats (WKY). We investigated whether 2-phenyl-1,2-benzisoselenazol-3(2H)-one, also called PZ51 (ebselen), useful for ...
Research findings from W. Pickering et al update understanding of apoptosis.
Aug 07, 2008 ... "Coagulation has an absolute requirement for macromolecular complexes to be assembled on a negatively charged phospholipid (PL) surface. Previously, we reported that malignant T-lymphoblastoid cells have the ability to support procoagulant activity (PCA) independently of tissue factor by ...
Studies from Hong Kong University of Science & Technology reveal new findings on apoptosis.
Aug 07, 2008 ... According to recent research from Hong Kong, People's Republic of China, "Accumulating evidence indicates that deregulation of cyclin-dependent kinase 5 (Cdk5) activity is associated with apoptosis in various neurodegenerative disease models. Interestingly, recent studies suggest that Cdk5 ...
Findings in artificial chromosomes reported from University of Leeds.
Aug 07, 2008 ... According to recent research from Leeds, the United Kingdom, "Genome scans using large numbers of randomly selected markers have revealed a small proportion of loci that deviate from neutral expectations and so may mark genomic regions that contribute to local adaptation. Measurements of ...
Researchers from University of Liege describe findings in artificial chromosomes.
Aug 07, 2008 ... "Koi herpesvirus (KHV) is the causative agent of a lethal disease in koi and common carp. In the present study, we describe the cloning of the KHV genome as a stable and infectious bacterial artificial chromosome (BAC) clone that can be used to produce KHV recombinant strains," scientists ...
Research reports on atherosclerosis from M. Mayr and colleagues provide new insights.
Aug 07, 2008 ... "We have recently demonstrated that stem cell antigen 1-positive (Sca-1(+)) progenitors exist in the vascular adventitia of apolipoprotein E-deficient (apoE(-/-)) mice and contribute to smooth muscle cell (SMC) accumulation in vein graft atherosclerosis. Using a combined proteomic and ...
Research on autoimmune disease published by scientists at University of Basel.
Aug 07, 2008 ... "Many of the clinical, histological and serological manifestations of chronic graft-versus-host disease (GVHD) resemble autoimmune disease (AD), and although the differences are significant, they may be more semantic than biological. Indeed, studies suggest that some ADs may represent a ...
New data from X. Mao et al illuminate research in B-cell lymphoma.(Report)
Aug 07, 2008 ... " Primary cutaneous B-cell lymphoma (PCBCL) consists mainly of primary cutaneous marginal zone B-cell lymphoma (PCMZL), primary cutaneous follicle centre lymphoma (PCFCL) and primary cutaneous large B-cell lymphoma, leg type (PCLBCL-LT). The activator protein 1 (AP-1) transcription factor ...
Research findings from University of California update understanding of B-cell lymphoma.
Aug 07, 2008 ... "In an initial epigenetic characterization of diffuse large B-cell lymphoma (DLBCL), we evaluated the DNA methylation levels of over 500 CpG islands. Twelve CpG islands (AR, CDKN1C, DLC1, DRD2, GATA4, GDNF, GRIN2B, MTHFR, MYOD1, NEUROD1, ONECUT2 and TFAP2A) showed significant methylation ...
Research from Showa University in B-cell lymphoma provides new insights.
Aug 07, 2008 ... "Described herein is a case of thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Using immunohistochemical double staining it was found that most of the thymic lymphoid follicles in this case possessed cytokeratin-positive and follicular dendritic cell ...
Researchers at University of Melbourne target B-cell lymphoma.
Aug 07, 2008 ... According to recent research from Parkville, Australia, "Primary breast lymphoma is a rare entity. Furthermore, extranodal marginal zone B-cell lymphoma affecting the breast is exceedingly rare." "We report a unique case of invasive lobular carcinoma diagnosed simultaneously ...
Study findings from C. Demirkesen et al provide new insights into Behcet disease.
Aug 07, 2008 ... According to a study from Istanbul, Turkey, "Adhesion molecules have a role in many vasculitic disorders. Our aim was to evaluate the status of adhesion molecules in nodular lesions of Behcet syndrome (BS) and compare them with results,for the 2 most common types of panniculitis, erythema ...
New biomedicine research from C.M. Chanaud and colleagues discussed.(Conference notes)
Aug 07, 2008 ... According to recent research from the United States, "Clinical Investigators conducting biomedical research involving human participants in the U.S. are responsible for the content of the consent document(s) and for the conduct of the informed consent conference(s) with the human ...
Reports summarize blood pressure research from University of Florence.(Report)
Aug 07, 2008 ... "Objectives The present study investigated whether central blood pressure (BP) predicts cardiovascular (CV) events better than brachial BP in a cohort of normotensive and untreated hypertensive elderly individuals. Limited and conflicting data have been reported on the prognostic ...