Blood Weekly back issues from March 2009:
Study indicates some MRSA infections in ICU patients have been decreasing in recent years.
Mar 05, 2009 ... In contrast to the perception that methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections associated with use of a catheter is an increasing problem in intensive care unit (ICU) patients, the incidence of this type of infection decreased by nearly 50 percent from 1997 - ...
McMaster researchers discover new mode of how diseases evolve.
Mar 05, 2009 ... Researchers of the Michael G. DeGroote Institute for Infectious Disease Research have discovered a new way that bacteria evolve into something that can make you sick (see also McMaster University). The finding, published in the Feb. 16 issue of the Proceedings of the National ...
Air-filled bones helped prehistoric reptiles take first flight.
Mar 05, 2009 ... In the Mesozoic Era, 70 million years before birds first conquered the skies, pterosaurs dominated the air with sparrow- to Cessna-sized wingspans. Researchers suspected that these extinct reptiles sustained flight through flapping, based on fossil evidence from the wings, but had little ...
Cementless cup device developed for hip replacements shows durability after more than 20 years.
Mar 05, 2009 ... When a first hip replacement fails, patients may be concerned that their options for a durable hip replacement are limited and that the prognosis is poor. However, a research study to be published in the February issue of the Journal of Bone and Joint Surgery suggests that this may not be ...
Help for liver transplant patients with small-for-size syndrome.
Mar 05, 2009 ... Blocking off the splenic artery, either through surgical ligation or radiological coiling, helped six out of seven patients suffering from small-for-size syndrome after a partial liver transplant. This finding is in the February issue of Liver Transplantation, a journal published by John ...
New cardiology study findings recently were reported by J. Jabot and co-researchers.(Clinical report)
Mar 05, 2009 ... According to recent research published in the journal Intensive Care Medicine, "For predicting fluid responsiveness by passive leg raising (PLR), the lower limbs can be elevated at 45A degrees either from the 45A degrees semi-recumbent position (PLRSEMIREC) or from the supine position ...
New findings reported from Tufts University describe advances in cat scratch disease.
Mar 05, 2009 ... "Cat-scratch disease (CSD) is largely due to infection with Bartonella henselae. Microbiologic detection is difficult, and molecular testing is not readily available," scientists in the United States report (see also Cat Scratch Disease). "A monoclonal antibody (mAB) to B ...
Findings from H. Ruschulte and co-authors provide new insights into central venous catheter.(Clinical report)
Mar 05, 2009 ... "The objective of the study was to evaluate the effectiveness of chlorhexidine-impregnated sponges for reducing catheter-related infections of central venous catheters inserted for cancer chemotherapy. The method used was a randomized, prospective, open, controlled clinical study ...
Study results from J.D. Arthur and colleagues broaden understanding of clinical trial research.(Clinical report)
Mar 05, 2009 ... "Treatment of chronic anal fissure (CAF) by fissurectomy with botulinum toxin A (BTA) injection results in a healing rate of greater than 90%. BTA injection, however, can cause incontinence and perianal sepsis," scientists in Manchester, the United Kingdom report (see also Clinical Trial ...
New coagulation study findings have been reported from University of Verona, World Health Organization.(Report)
Mar 05, 2009 ... According to a study from Verona, Italy, "This study assessed the risk of any bleeding abnormalities, including the risk of gastrointestinal bleeding, associated with antidepressant exposure. We used a case-control methodology." "Case patients were individuals admitted with a ...
Research on coagulation reported by A. Eskild et al.
Mar 05, 2009 ... In this recent report, researchers in Trondheim, Norway conducted a study "To study the association of preeclampsia with abnormal bleeding in the first trimester and after delivery. Register-based population study. The Medical Birth Registry of Norway." "A total of 315,085 women ...
Studies from M. Vijapurkar et al further understanding of coagulation.
Mar 05, 2009 ... "At this centre, 130 women with rare bleeding disorders (RBD) were investigated over the past 15 years. Fifty patients were above the age of menarche (age of menarche in India is 10 years)," investigators in Mumbai, India report (see also Coagulation). "Of these 44 presented ...
New research on drug resistance from P.M. Vidal and co-authors summarized.
Mar 05, 2009 ... In this recently published article, scientists in Sao Paulo, Brazil conducted a study "To identify risk factors associated with nosocomial bloodstream infections caused by multiple clones of the staphylococcal cassette chromosome mec (SCCmec) type IV strain of methicillin-resistant ...
Research from St. Mary's Hospital has provided new information about drug resistance.
Mar 05, 2009 ... "The prevalence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains causing bloodstream infection (BSI) has not been studied in Korea. We sought to determine the prevalence of CA-MRSA strains among isolates recovered from patients with MRSA BSIs and to ...
Recent findings from Medical College of Wisconsin, Medical College highlight research in enzyme research.
Mar 05, 2009 ... According to recent research from the United States, "Ca2+-calmodulin (Ca2+-CaM) activates erythrocyte adenosine monophosphate deaminase (AMPD) in conditions of disturbed calcium homeostasis, prompting us to investigate adenine nucleotide metabolic dysregulation in sickle cell disease ...
Findings in Guillain-Barre syndrome reported from Tufts University.(Clinical report)
Mar 05, 2009 ... According to recent research from the United States, "In this study we sought to determine whether axonal damage in severe Guillain-Barre syndrome (GBS) was secondary to critical illness polyneuropathy (CIP) in the intensive care unit (ICU) by reviewing comorbidities in patients who had ...
Studies from University of Basel yield new information about hematologic disease.
Mar 05, 2009 ... " The risk for donors of allogeneic hematopoietic stem cells transplants is generally considered negligible. Scattered reports of severe complications and a recent controversy on hematopoietic malignancies after granulocyte colony-stimulating factor administration have challenged this ...
Escalon(R) Reports Second Quarter Fiscal 2009 Results.(Financial report)
Mar 05, 2009 ... Escalon Medical Corp. (Nasdaq Capital Market: ESMC) announced results for its fiscal second quarter ended December 31, 2008 (see also Hematology). For the second quarter of fiscal 2009, the Company reported increased net revenue of $8,099,000, compared with $7,495,000 in the ...
Scientists at University of Catania publish research in hemophilia a.(Clinical report)
Mar 05, 2009 ... "The introduction of recombinant factor VIII (rFVIII) clotting factor concentrates nearly 20 years ago represented a significant advance in the treatment of hemophilia A. The major advantage of rFVIII products compared with plasma-derived FVIII products is related to product safety, with ...
Studies from K. Kakihana et al have provided new data on leukemia.
Mar 05, 2009 ... According to recent research from Tokyo, Japan, "Pulmonary leukemic infiltration (PLI) is more common than generally recognized, but accurate antemortem diagnosis with pathological proof is rarely achieved. We describe herein the clinical courses of two patients with PLI following ...
Research conducted at Louisiana State University has updated our knowledge about life sciences.
Mar 05, 2009 ... "We report three sickle cell patients with recent cocaine abuse who presented with typical symptoms of vaso-occlusion rapidly progressing to major organ dysfunction," scientists writing in the Southern Medical Journal report (see also Life Sciences). "Our experience suggests ...
Research on life sciences reported by N.N. Li et al.
Mar 05, 2009 ... "Host dendritic cells (DCs) play a critical role in initiating graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL), and separation of GVL from GVHD remains a major challenge in the treatment of hematologic malignancies by allogeneic hematopoietic cell transplantation (HCT) ....
Research results from S. Kanaji and co-authors update knowledge of life sciences.(Report)
Mar 05, 2009 ... According to recent research from Saga, Japan, "Coagulation factor V (FV) deficiency is a rare bleeding disorder characterized by low coagulant and antigen levels of FV with bleeding symptoms ranging from mild to severe. Only a limited number of mutations have been reported because of the ...
Study findings from F.B. Machado et al broaden understanding of life sciences.(Report)
Mar 05, 2009 ... According to a study from Brazil, "Haemophilia A, the most common severe hereditary bleeding disorder in humans, is chiefly caused by mutations in the coagulation factor VIII F8 gene, which maps on chromosome band Xq28. Linkage analysis with F8 intragenic and/or closely located extragenic ...
Reports on lymphadenopathy findings from Gazi University, Medical Department provide new insights.
Mar 05, 2009 ... According to recent research from Ankara, Turkey, "Rosai-Dorfman disease (RDD) or ''sinus histiocytosis with massive lymphadenopathy'' is a rare lymphoproliferative disorder of unknown etiology. The disease usually presents with painless lymphadenopathy with occasional extranodal ...
Researchers at Tokai University, Medical Department target lymphadenopathy.
Mar 05, 2009 ... According to recent research published in the International Journal of Hematology, "We report a case of age-related EBV-associated B-cell lymphoproliferative disorder (age-related EBV+ B-cell LPD) metachronously showing two distinct morphologic appearances: one of a polymorphic disease ...
New research on myelodysplastic syndrome from University of Texas summarized.
Mar 05, 2009 ... According to a study from the United States, " The presence of paroxysmal nocturnal hemoglobinuria clones in the setting of aplastic anemia or myelodysplastic syndrome has been shown to have prognostic and therapeutic implications. However, the status of paroxysmal nocturnal hemoglobinuria ...
Researchers at University of Turin release new data on myelodysplastic syndrome.
Mar 05, 2009 ... "The efficacy of human recombinant erythropoietin (rEPO) in myelodysplastic syndromes (MDS) has generally been best in untransfused patients with 'refractory anaemia' according to the World Health Organization (WHO). We treated 63 MDS patients [excluding refractory anaemia with excess ...
Data on neutropenia described by researchers at University of Washington.
Mar 05, 2009 ... "Of Recommendations: The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group found that the evidence is currently insufficient to recommend for or against the routine use of UGT1A1 genotyping in patients with metastatic colorectal cancer who are to be ...
Findings from University of Nijmegen advance knowledge in neutropenia.
Mar 05, 2009 ... "We undertook a retrospective analysis of a cohort of 67 patients with multiple myeloma who had received an autologous haematopoietic SCT (HSCT) following high-dose melphalan to explore the impact of mucositis on the systemic inflammatory response. A homogenous group of 16 patients without ...
Reports from Emory University, Medical Department advance knowledge in neutropenia.
Mar 05, 2009 ... In this recent article published in the journal Laryngoscope, scientists in the United States conducted a study "To evaluate a multidisciplinary early intervention protocol for invasive fungal sinusitis (IFS) in neutropenic patients and its effect on degree of tissue involvement at time ...
Researchers' work from University of Manchester focuses on neutropenia.(Report)
Mar 05, 2009 ... "This study aimed to critically appraise the current level of economic evidence available for thiopurine S-methyltransferase (TPMT) testing of thiopurine drugs, such as azathioprine. Six economic evaluations of testing were identified, which all recommended that TPMT testing is a ...
Studies from M. Germeshausen and co-researchers update current data on neutropenia.
Mar 05, 2009 ... "Severe congenital neutropenia (CN) is a rare bone marrow failure syndrome with a high incidence of acute leukemia. In previous studies, we could show that point mutations in the gene for the granulocyte colony-stimulating factor (G-CSF) receptor CSF3R are a highly predictive marker for ...
Studies from J. Frey et al add new findings in the area of papillary cancer.
Mar 05, 2009 ... According to a study from the United States, "Aggressive digital papillary adenocarcinoma (ADPAca) is a rare, underreported, and often misdiagnosed malignant tumor of the sweat glands most commonly Occurring in males in their fifties to seventies. We report two cases of ADPAca with ...
Recent studies from University of Copenhagen add new data to peptic ulcers.(Report)
Mar 05, 2009 ... "The overall mortality for patients undergoing surgery for perforated peptic ulcer has increased despite improvements in perioperative monitoring and treatment. The objective of this study was to identify and describe perioperative risk factors in order to identify ways of optimizing the ...
Study data from G. Gualco and colleagues update understanding of peripheral t-cell lymphoma.
Mar 05, 2009 ... According to a study from Sao Paulo, Brazil, "Composite lymphomas are rare and defined as hematopoietic neoplasms with more than I malignant lymphomatous clone showing different phenotypic features. Of all possible combinations between non-Hodgkin lymphomas, B cell or T cell, and Hodgkin ...
Research from D.P. Rossignol and co-researchers provides new data on pharmacodynamics.(Report)
Mar 05, 2009 ... According to recent research from the United States, "Eritoran tetrasodium (E5564), a structural analogue of the lipid A portion of endotoxin lipopolysaccharide or LPS). is in antagonist of LPS and other Toll-like receptor 4 (TLR4) ligands. Eritoran tetrasodium quantitatively blocks LPS ...
Data on relapsing fever detailed by researchers at State University of New York.
Mar 05, 2009 ... According to a study from the United States, "T cell-independent Abs are protective against Lyme disease and relapsing fever, illnesses caused by Borrelia spirochetes with distinct blood-borne phases of infection. To understand this protective response, we characterized splenic and ...
Study results from Wayne State University provide new insights into sarcoidosis.(Report)
Mar 05, 2009 ... " Objectives Nodular sarcoidosis is an uncommon presentation of sarcoidosis. Our objective was to describe the clinical characteristics of a large cohort of patients with nodular sarcoidosis," scientists in the United States report (see also Sarcoidosis). " We performed a ...
New sepsis study findings reported from J.Y. Rhee and co-authors.(Report)
Mar 05, 2009 ... "This study compares the effectiveness of the Pitt bacteremia score, the Charlson weighted index of comorbidity, and the Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring systems for the prediction of mortality in intensive care unit (ICU) patients with sepsis using the ...
Reports outline sepsis study findings from H. Komura and colleagues.
Mar 05, 2009 ... "Phagocytosis prevents the release of potentially harmful or immunogenic materials from dying cells. Milk fat globule epidermal growth factor (EGF)-factor VIII (MFG-E8) mediates the clearance of apoptotic cells," scientists in the United States report (see also Sepsis). "We ...
Researchers from University of Washington report recent findings in sepsis.
Mar 05, 2009 ... "Genetic variation contributes to risk and outcomes of sepsis. We sought to determine whether variation in inflammation related genes is associated with severity of sepsis in trauma patients," investigators in the United States report (see also Sepsis). "A cohort of severely ...
Scientists at Radboud University target sepsis.
Mar 05, 2009 ... "Because severe sepsis is frequently complicated by multiple organ failure, it is of importance to monitor organ function. Unfortunately, conventional liver function markers are either relatively unspecific or have a long half-life, which make them poor predictors of acute liver injury," ...
Studies in the area of sepsis reported from Chang-Gung University.(Report)
Mar 05, 2009 ... "Severe sepsis and septic shock, often complicated by acute kidney injury (AKI), are the most common causes of mortality in noncoronary intensive care units (ICUs). This study investigates the outcomes of critically ill patients with sepsis and elucidates the association between prognosis ...
Study findings from T. Rimmele et al provide new insights into sepsis.(Report)
Mar 05, 2009 ... According to recent research from Lyon, France, "High-volume haemofiltration (HVHF) has been suggested as an adjuvant treatment of septic shock due to its capacities to remove from blood both pro- and anti-inflammatory mediators involved in the sepsis syndrome. Adsorption properties of ...
High-Throughput Genotyping of AML Patients for a Key Immune Receptor May Significantly Improve Treatment Outcome.
Mar 05, 2009 ... Sequenom, Inc. (NASDAQ:SQNM), a leading provider of genetic analysis solutions, announced results of a large, multicenter retrospective study from the ChildrenEs Hospital Oakland Research Institute and the University of Minnesota Cancer Center showing that donors with more stimulatory ...
New stem cell research study findings reported from London Metropolitan University.
Mar 05, 2009 ... "Tissue derived from the aborted fetus is considered 'the right tool for the job' in some stem cell laboratories. Relatively little is known of the arrangements in Britain for sourcing aborted fetuses for research purposes," researchers in London, the United Kingdom report (see also Stem ...
Research conducted at University of Toronto has provided new information about telomerase.
Mar 05, 2009 ... "Functional proteins of complex eukaryotes within the same species are rather invariant. A single catalytic component of telomerase TERT is essential for an active telomerase complex that maintains telomeres," investigators in Toronto, Canada report (see also Telomerase). ...
Researchers' work from University of Oklahoma focuses on thrombocytopenic purpura.(Report)
Mar 05, 2009 ... According to a study from the United States, "Health-related quality of life (HRQoL) is a major concern for adults with chronic immune thrombocytopenic purpura (ITP) due to the symptoms associated with the disease and its treatment. This study utilized the ITP-patient assessment ...
Studies in the area of vasculitis reported from C. Tosoni and co-researchers.
Mar 05, 2009 ... According to a study from Brescia, Italy, "Urticarial vasculitis (UV) is an uncommon type of chronic urticaria (CU), which exhibits leucocytoclastic vasculitis. Painful and long-lasting (> 24 h) weals associated with purpura or bruising are considered indicative of UV." "It is ...
Findings in acute lymphocytic leukemia reported from University of Freiburg, Department of Medicine I.(Report)
Mar 05, 2009 ... Research findings, 'Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect ...
Investigators at Athens University zero in on hematologic disease genetics.
Mar 05, 2009 ... New investigation results, 'Is there an association with constitutional structural chromosomal abnormalities and hematologic neoplastic process? A short review,' are detailed in a study published in Annals of Hematology. "The occasional observation of constitutional chromosomal ...
New hematologic disease therapy research from University of Florida described.
Mar 05, 2009 ... Current study results from the report, 'Jak2 inhibitors: rationale and role as therapeutic agents in hematologic malignancies,' have been published. According to a study from the United States, "Although the Jak2-V617F mutation has generated strong awareness because of its causative role ...
Researchers at Shiraz University of Medical Sciences, Prof. Alborzi Clinical Microbiology Research Center have published new data on hematologic disease therapy.(Report)
Mar 05, 2009 ... A new study, 'Molecular detection of invasive aspergillosis in hematologic malignancies,' is now available. "Aspergillus species are the most frequent causes of invasive mold infections in immunocompromised patients, particularly those who underwent chemotherapy for hematologic ...
Research on hemophilia a published by scientists at Cardiff University, Department of Haematology.
Mar 05, 2009 ... Scientists discuss in 'Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A' new findings in hemophilia a. According to recent research from Cardiff, the United Kingdom, "The role of prophylactic factor VIII ...
King George Medical University, Department of Pathology reports research in hemophilia a therapy.
Mar 05, 2009 ... Data detailed in 'Screening for hemophilia A carriers: utility of PCR-RFLP--based polymorphism analysis' have been presented. "Health schemes are promoting application of molecular diagnosis and screening in peripheral diagnostics labs. Intragenic restriction fragment length polymorphisms ...
Investigators at University of Heidelberg publish new data on iron overload prevention.(Clinical report)
Mar 05, 2009 ... New investigation results, 'Deferasirox in MDS patients with transfusion-caused iron overload--a phase-II study,' are detailed in a study published in Annals of Hematology. According to a study from Mannheim, Germany, "Blood transfusions represent a main component of supportive care in ...
Research from Teikyo University, Department of Pediatrics provide new insights into kidneys.(Report)
Mar 05, 2009 ... Researchers detail in 'Renal beta(2)-adrenoceptor modulates the lipopolysaccharide transport system in sepsis-induced acute renal failure,' new data in kidneys. According to a study from Tokyo, Japan, "The aim of this study was to define the contribution of renal beta(2)-adrenoceptor ...
Researchers from Shiraz University, Research Center describe findings in life sciences.
Mar 05, 2009 ... Researchers detail in 'Factor XI deficiency in Southern Iran: identification of a novel missense mutation,' new data in life sciences. "Factor XI (FXI)-deficiency is a rare coagulation disorder inherited as an autosomal recessive trait, which is most common in Ashkenazi Jews, but also ...
New malt lymphoma immunology research has been reported by scientists at Namseoul University.(Report)
Mar 05, 2009 ... New research, 'Pediatric mucosa-associated lymphoid tissue (MALT) lymphoma of lip: a case report and literature review,' is the subject of a report. "Mucosa-associated lymphoid tissue (MALT) lymphoma is listed in the new World Health Organization classification as extranodal marginal zone ...
New myelodysplastic syndrome immunology study findings have been reported from Gunma University.(Clinical report)
Mar 05, 2009 ... Current study results from the report, 'Clinical significance of regulatory T cells in patients with myelodysplastic syndrome,' have been published. "Foxp3(+) regulatory T cells (Tregs) play a central role in maintaining immune tolerance. Their expansion in malignant diseases leads to the ...
New necrosis study findings have been published by scientists at Shanghai Jiao Tong University, Department of Anesthesiology.
Mar 05, 2009 ... Scientists discuss in 'Different effect of glutamine on macrophage tumor necrosis factor-alpha release and heat shock protein 72 expression in vitro and in vivo' new findings in necrosis. According to a study from Shanghai, People's Republic of China, "Macrophage plays a vital role in ...
Researchers from School of Medicine provide details of new studies and findings in the area of necrotizing enterocolitis therapy.(Report)
Mar 05, 2009 ... New research, 'Lactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Enterobacter sakazakii-induced nitric oxide both in vitro and in the newborn rat model of necrotizing enterocolitis,' is the subject of a report. "Enterobacter sakazakii is an emerging pathogen ...
Medical College, Department of Immunology describes research in sepsis therapy.(Report)
Mar 05, 2009 ... Fresh data on sepsis are presented in the report 'Loss of hepatic B cells following lipopolysaccharide injection and polymicrobial sepsis.' According to recent research from Tokorozawa, Japan, "B cells possess pleiotropic functions and are important for both humoral as well as cellular ...
Reports summarize thrombocytopenic purpura therapy study results from Keio University, Department of Internal Medicine.
Mar 05, 2009 ... Data detailed in 'Splenic macrophages maintain the anti-platelet autoimmune response via uptake of opsonized platelets in patients with immune thrombocytopenic purpura' have been presented. "Immune thrombocytopenic purpura (ITP) is an autoimmune disease primarily caused by IgG ...