Blood Weekly back issues from May 2009:
Remote or rural residence not associated with increased time to kidney transplantation.
May 07, 2009 ... Contrary to what may be a common perception, researchers found no evidence that the likelihood of kidney transplantation is lower among remote- or rural-dwelling patients treated for kidney failure in the United States, according to a study in the April 22/29 issue of JAMA (see also JAMA ...
'Nature vs. nurture' study of deceased donor pairs in kidney transplantation.(Obituary)
May 07, 2009 ... The implications of a new study could improve the outcomes, and potentially survival rates, for some of the thousands of individuals who undergo kidney transplants each year. The study concluded that donor-related risk factors, yet to be identified, make a measurable contribution to the ...
Study findings from K. Petrie et al provide new insights into acute myeloid leukemia.
May 07, 2009 ... According to recent research published in the journal Current Opinion in Hematology, "Purpose of review Since the 1970s, the concept of differentiation therapy has been viewed as a promising and revolutionary approach for the treatment of acute myeloid leukemia (AML) and other cancers ....
Studies from Shanghai Jiao Tong University have provided new data on acute promyelocytic leukemia.
May 07, 2009 ... "All-trans retinoic acid (ATRA)/arsenic trioxide (ATO) combination-based therapy has benefitted newly diagnosed acute promyelocytic leukemia (APL) in short-term studies, but the long-term efficacy and safety remained unclear. From April 2001, we have followed 85 patients administrated ...
Study results from Children's Hospital update understanding of apoptosis.
May 07, 2009 ... According to a study from the United States, "Extensive apoptosis of leukocytes during sepsis and endotoxic shock constitutes an important mechanism linked to the excessive mortality associated with these disorders. Caspase inhibitors confer protection from endotoxin-induced lymphocyte ...
Researchers' work from University of Fukui focuses on drug development.
May 07, 2009 ... According to recent research from Fukui, Japan, "Myelotoxicity, a major toxicity of vinorelbine. may be related to the degree of one's exposure to vinorelbine. In theory, clarithromycin has the potential to alter vinorelbine's pharmacokinetics by inhibiting CYP3A and/or P-glycoprotein; ...
Study findings on endometriosis are outlined in reports from L. Kang and colleagues.
May 07, 2009 ... In this recently published study, investigators in Shanghai, People's Republic of China conducted a study "To examine the clinical application of laparoscopic partial resection of symptomatic adenomyosis combined with uterine artery Occlusion (UAO). Retrospective cohort Study (Canadian ...
Study results from C. Cordonnier and colleagues in the area of fungal disease published.
May 07, 2009 ... "Empirical antifungal therapy is the standard of care for neutropenic patients with hematological malignancies who remain febrile despite broad-spectrum antibacterial treatment. Recent diagnostic improvements may ensure the early diagnosis of potentially invasive fungal disease," ...
Studies from Kyoto University, Medical Department yield new information about hematologic disease.
May 07, 2009 ... "The impact of donor-recipient ABO matching on outcomes after allogeneic stem cell transplantation has been a matter of controversy. Individual patient data-based meta-analysis was conducted with a pooled data set provided through six published and one unpublished cohorts," researchers in ...
Study data from T. Kawase and colleagues update understanding of hematologic disease.
May 07, 2009 ... "The finding that the risk of relapse in hematologic malignancy decreases after allogeneic hematopoietic stem cell transplantation (HSCT) has lead to the concept of a graft-versus-leukemia (GVL) effect. However, this beneficial effect is considered to be frequently offset by ...
Findings in hemophilia reported from E.I.B. Peerschke and co-researchers.
May 07, 2009 ... According to a study from the United States, "Quantification of inhibitory antibodies against infused factor VIII (FVIII) has an important role in the management of patients with hemophilia A. This article summarizes results from the largest North American FVIII inhibitor proficiency ...
Research in the area of insulin resistance reported from T. Grau and colleagues.
May 07, 2009 ... According to recent research from Madrid, Spain, "Purpose of review Despite increasing evidence that critically ill patients have lower energy requirements than expected, most guidelines continue to recommend elevated caloric requirements in h patients, particularly in septic patients ....
New Klebsiella pneumoniae study results from S.G. Stahlhut et al described.
May 07, 2009 ... "FimH is an adhesive subunit of type 1 fimbriae expressed by different enterobacterial species. The enteric bacterium Klebsiella pneumoniae is an environmental organism that is also a frequent cause of sepsis, urinary tract infection (UTI), and liver abscess," scientists writing in the ...
Research on legionnaire disease published by scientists at St. Antonius Hospital.
May 07, 2009 ... According to recent research from Nieuwegein, Netherlands, "Polymorphisms leading to deficiency of mannose-binding lectin (MBL) are associated with predisposition to infection. However, MBL deficiency can be protective against intracellular pathogens that use MBL to enter host cells." ...
Findings from M. Goldman et al in life sciences reported.
May 07, 2009 ... "In August 2005, the Canadian Blood Services decreased the deferral period for tattooing and ear or body piercing from 12 to 6 months. This study assessed the impact of this change on blood safety and availability," scientists in Ottawa, Canada report (see also Life Sciences). ...
New findings from Taipei Veterans General Hospital in the area of life sciences published.
May 07, 2009 ... According to recent research from Taipei, Taiwan, "A 50-year-old man presented with an asymptomatic, 1.5 x 1.5 cm, dark-brown noduloplaque with a rubbery consistency (Fig. 1) on the lateral aspect of the left lower leg of uncertain duration. His general condition was healthy, and he did ...
New life sciences study findings recently were published by researchers at Vanderbilt University.
May 07, 2009 ... "Tuon and colleagues have developed an animal model to examine the impact of sepsis on memory in rats," researchers in the United States report (see also Life Sciences). "They report important data that expand the understanding of the cognitive consequences of critical illness ....
Findings in lupus reported from K. Anam and co-researchers.(Report)
May 07, 2009 ... "Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease ...
Researchers at University of Medicine and Dentistry of New Jersey target lymphangioma.
May 07, 2009 ... According to recent research from the United States, " Attributed to congenital malformation of lymphatic duets, diffuse retroperitoneal cystic has it distribution that often corresponds to the location. of primitive fetal lymphatic sacs. Three recognized types are capillary, cavernous ...
Studies from Osaka University, Medical Department in the area of lymphoma described.
May 07, 2009 ... " Because recognizable lesions are often absent, selection of biopsy sites for diagnosis of intravascular large B-cell lymphoma (IVL) is frequently problematic. A 59-year-old woman was admitted with fever and general fatigue," scientists in Suita, Japan report (see also Lymphoma). ...
New myelodysplastic syndrome study findings have been reported by P.K. Eplingburnette and colleagues.
May 07, 2009 ... According to recent research from the United States, "Purpose of review Myelodysplastic syndrome is an important hematological malignancy affecting the expanding aged population. Our understanding of the biology of this disease has been limited by the heterogeneous clinicopathological ...
Researchers from University of Paris detail new studies and findings in the area of myelodysplastic syndrome.
May 07, 2009 ... " Drug treatments for patients with high-risk myelodysplastic syndromes provide no survival advantage. In this trial, we aimed to assess the effect of azacitidine on overall survival compared with the three commonest conventional care regimens," investigators in Bobigny, France report (see ...
Researchers from University of Paris report details of new studies and findings in the area of myelodysplastic syndrome.
May 07, 2009 ... According to recent research from Bobigny, France, "Purpose of review Myelodysplastic syndromes (MDS) are characterized by chronic cytopenias and a high risk of transformation to acute myeloid leukemia, To date, only allogeneic stem cell transplantation has shown curative potential in MDS ....
Study data from Celgene Corporation update knowledge of myelodysplastic syndrome.(Report)
May 07, 2009 ... "Multiple myeloma treatment with lenalidomide-based regimens is associated with risk of venous thromboembolism (VTE), particularly during concomitant use with erythropoiesis-stimulating agents (ESAs). The risk of VTE in myelodysplastic syndrome (MDS) patients treated with lenalidomide is ...
New pancreatitis research reported from P.D. Hardt and co-authors.
May 07, 2009 ... According to a study from Giessen, Germany, "Purpose of review To learn about the prevalence, pathophysiology, and treatment of exocrine pancreatic involvement in critically ill patients. Recent findings Elevations in the levels of pancreatic enzymes are observed in up to 80% of intensive ...
Findings from University of Giessen in sepsis reported.
May 07, 2009 ... " One of the main causes of death in European and US intensive care units is sepsis. It involves a network of pro-inflammatory cytokines such as TNF-alpha, IL-1 beta and IL-6," investigators in Giessen, Germany report (see also Sepsis). "Furthermore, there is an up regulation of ...
New sepsis findings from E.N. Deal and co-authors described.(Report)
May 07, 2009 ... According to a study from the United States, "Various dosing strategies for cefepime have been developed in an effort to maximize pharmacodynamic exposure of this agent against gram-negative infections. An assessment of cefepime dosing strategies is warranted given recent reports of poorer ...
New sepsis research from Emory University discussed.
May 07, 2009 ... "In the previous issue of Critical Care, Blanco and colleagues contributed to a growing body of literature on the international epidemiology of severe sepsis. Taken together, these studies confirm that the sepsis incidence is high, that the development of organ dysfunction is a major ...
New sepsis study results from M. Sanzgarcia et al described.
May 07, 2009 ... "Patients with recurrent episodes of Escherichia coli bloodstream infection (REC-BSI) have been described previously only in small studies. We report on the incidence, clinical significance, and predisposing conditions of REC-BSI in a general hospital from 1992 to 2005," scientists in ...
Reports from University of Colorado advance knowledge in sepsis.
May 07, 2009 ... " Septic encephalopathy secondary to a breakdown of the blood-brain barrier (BBB) is a known complication of sepsis. However, its pathophysiology remains unclear," scientists in the United States report (see also Sepsis). "The present study investigated the effect of complement ...
Reports outline sepsis study findings from University of California.
May 07, 2009 ... According to recent research from the United States, " Sepsis is the 10th leading cause of death in the United States. The National Center for Health Statistics' multiple-cause-of-death (MCOD) dataset is a large, publicly available, population-based source of information on disease burden ...
Research conducted at Emory University has provided new information about sepsis.
May 07, 2009 ... " Diabetes mellitus (DM) is one of the most common chronic co-morbid medical conditions in the USA and is frequently present in patients with sepsis. Previous studies reported that people with DM and severe sepsis are less likely to develop acute lung injury (ALI)," investigators in the ...
Research on sepsis published by F. Venet et al.
May 07, 2009 ... "Sepsis syndrome represents the leading cause of death in intensive care unit. Patients present features consistent with a decline in immune responsiveness potentially contributing to mortality," scientists in Lyon, France report (see also Sepsis). "We investigated whether ...
Research on sepsis published by scientists at Washington University, Medical Department.(Report)
May 07, 2009 ... According to recent research from the United States, "Sepsis is a severe, life-threatening infection and a leading cause of death in hospitals. A hallmark of sepsis is the profound apoptosis-induced depletion of lymphocytes generating a lymphopenic environment." "As lymphopenia ...
Researchers from Cooper University provide details of new studies and findings in the area of sepsis.
May 07, 2009 ... "Current murine models of sepsis do not account for the effects of aggressive fluid resuscitation on hemodynamics and mortality. Evaluate the impact of fluid resuscitation regimens on cardiovascular performance and survival in a murine model of sepsis," scientists in the United States ...
Researchers from University of Washington detail new studies and findings in the area of sepsis.
May 07, 2009 ... According to recent research from the United States, "Sepsis is an important clinical problem with a mortality rate of 20% to 30%." "Lymphocyte apoptosis has been recognized as an important step in the pathogenesis of experimental sepsis, by inducing a state of 'immune ...
Studies from University of Queensland have provided new information about sepsis.(Clinical report)
May 07, 2009 ... According to a study from Brisbane, Australia, "A lack of published pharmacokinetic data on statins in sepsis has prompted concerns about their safety and toxicity. This study determined single dose pharmacokinetics of Atorvastatin administered orally to acutely ill patients." ...
Studies from University of Texas in the area of sepsis described.
May 07, 2009 ... According to recent research published in the journal Critical Care, "Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Treatment with recombinant human activated protein C (rhAPC) has been reported to increase survival from severe sepsis." ...
Study Finds Blood Cells Can Be Reprogrammed to Act as Embryonic Stem Cells.
May 07, 2009 ... In a recent study, U.S. researchers have reprogrammed cells found in circulating blood into cells that are molecularly and functionally indistinguishable from embryonic stem cells, a revolutionary achievement that provides a readily accessible source of stem cells and an alternative to ...
Research from Central South University, Institute of Molecular Hematology reveals new findings on acute promyelocytic leukemia therapy.
May 07, 2009 ... A new study, 'Use of all-trans retinoic acid in combination with arsenic trioxide for remission induction in patients with newly diagnosed acute promyelocytic leukemia and for consolidation/maintenance in CR patients,' is now available. According to recent research from Changsha, People's ...
New alpha-thalassemia research reported from N. Sardon Estevez and co-authors.
May 07, 2009 ... New investigation results, 'Diagnostic value of zinc protoporphyrin in a screening strategy for alpha-thalassemia,' are detailed in a study published in European Journal of Haematology. "The definitive diagnosis of alpha-thalassemia involves detection of a deletion of one or more ...
Data from Wayne State University, Department of Pediatrics advance knowledge in epilepsy.(Clinical report)
May 07, 2009 ... Research findings, 'Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery,' are discussed in a new report. "Since prediction of long-term seizure outcome using preoperative diagnostic modalities remains suboptimal in epilepsy surgery, we ...
New hematologic disease study findings recently were reported by researchers at Emory University, Winship Cancer Institute.
May 07, 2009 ... New investigation results, 'Detection of respiratory viruses with a multiplex polymerase chain reaction assay (MultiCode-PLx Respiratory Virus Panel) in patients with hematologic malignancies,' are detailed in a study published in Leukemia & Lymphoma. According to recent research from the ...
Study results from Shinshu University, Department of Pediatrics update understanding of pediatric in children.
May 07, 2009 ... Investigators publish new data in the report 'High incidence of meropenem resistance among alpha-hemolytic streptococci in children with cancer.' According to recent research published in the journal Pediatrics International, "Infections caused by antibiotics-resistant Gram-positive ...
Study findings on lymphoma immunology are outlined in reports from Center for Cancer Research.(Report)
May 07, 2009 ... New research, 'Autoimmunity and hematologic malignancies: associations and mechanisms,' is the subject of a report. According to recent research from the United States, "Although the true prevalence of autoimmune diseases remains to be better defined, in Western countries the current ...
New myelodysplastic syndrome therapy study findings have been published by scientists at Medical University of Vienna.
May 07, 2009 ... A report, 'Deferasirox induces regression of iron overload in patients with myelodysplastic syndromes,' is newly published data in European Journal of Clinical Investigation. According to a study from Vienna, Austria, "Transfusion-related morbidity is an emerging problem in chronically ...
New neutropenia therapy research reported from University of Texas, M.D. Anderson Cancer Center.
May 07, 2009 ... A new study, 'The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Fever and neutropenia: the early years,' is now available. According to a study from the United States, "The importance of neutropenia as a predisposing factor for infection in patients with ...
Research conducted at University of Pittsburgh, Department of Dermatology has provided new information about purpura.
May 07, 2009 ... Scientists discuss in 'Periumbilical purpura prior to gastrointestinal involvement in Henoch-Schönlein purpura' new findings in purpura. According to a study from the United States, "Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving the skin, joints, ...
Study findings from Dicle University, Department of Hematology broaden understanding of purpura therapy.(Report)
May 07, 2009 ... Scientists discuss in 'The efficacy of rituximab in patients with splenectomized refractory chronic idiopathic thrombocythopenic purpura' new findings in purpura. "The most difficult problem a physician encounters is the management of patients with idiopathic thrombocytopenic purpura ...
Scientists at National Heart, Lung, & Blood Institute publish research in sickle cell anemia.(Report)
May 07, 2009 ... New research, 'Near-infrared spectra absorbance of blood from sickle cell patients and normal individuals,' is the subject of a report. "Limited data are available regarding the physicochemical dynamics of tissue hypoxia in sickle cell disease. Studies using near-infrared spectroscopy ...
Studies in the area of acute myeloid leukemia reported from J.E. Lancet and co-researchers.
May 07, 2009 ... According to a study from the United States, "Purpose of review Given the high rates of relapse in acute myeloid leukemia (AML), there is tremendous opportunity for the development of new therapeutic strategies in the postremission state. Unfortunately, the currently available modalities ...
New alloimmunization data have been reported by A. Franco and co-authors.
May 07, 2009 ... According to recent research from the United States, "To determine whether prenatal management using guidelines established for anti-D is applicable to anti-Jka. A computerized database containing the records of all alloimmunized pregnancies at The Ohio State University Medical Center with ...
New anaphylactic shock study results from J. Chen et al described.
May 07, 2009 ... "To report a rare but severe adverse effect of intravenous itraconazole, anaphylactic shock with hypotension and hypoxemia, in a female patient with acute lymphoblastic leukemia (ALL). SUMMARY: A 36-year-old woman with ALL received antifungal therapy for pulmonary fungal infections," ...
Researchers at Catholic University, Medical Department release new data on angiology.
May 07, 2009 ... According to a study from Santiago, Chile, "Vascular calcification has been widely recognized as a significant contributor to cardiovascular risk in patients with chronic kidney disease. Recent evidence suggests that BMP-7 decreases the vascular calcification observed in uraemic rats, ...
Data from J. Minami and colleagues advance knowledge in angiotensins.
May 07, 2009 ... According to recent research from Mibu, Japan, "Among angiotensin receptor blockers (ARBs), telmisartan is suggested to function as a partial agonist of peroxisome proliferator-activated receptor-gamma (PPAR gamma) and to improve lipid and glucose metabolism. Clinical benefits of ...
Research on angiotensins described by R.D. Feldman and colleagues.
May 07, 2009 ... "Notwithstanding the availability of antihypertensive drugs and practice guidelines, blood pressure control remains suboptimal. The complexity of current treatment guidelines may contribute to this problem," investigators in London, Canada report (see also Angiotensins). "To ...
Researchers from Ehime University, Medical Department report recent findings in angiotensins.
May 07, 2009 ... "Recently we have cloned angiotensin II type 2 receptor-interacting protein 1 (ATIP1) as a novel protein that interacts specifically with the C-terminal tail of the angiotensin II type 2 receptor; however, the pathophysiological roles of ATIP1 in vascular remodeling are still unknown ....
Researchers from Harvard University detail new studies and findings in the area of angiotensins.
May 07, 2009 ... According to a study from the United States, "Stennett AK, Qiao X, Falone AE, Koledova VV, Khalil RA. Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats." "Am J Physiol Heart Circ Physiol 296: H745-H755, ...
Investigators at National University have published new data on antimicrobials.
May 07, 2009 ... "Antimicrobial peptides constitute an important part of the innate immune defense and are promising new candidates for antibiotics. Naturally occurring antimicrobial peptides often possess hemolytic activity and are not suitable as drugs," researchers in Singapore, Singapore report (see ...
New apoptosis research from Ruhr University outlined.
May 07, 2009 ... According to a study from Bochum, Germany, "Meridional rhodium(III) polypyridyl complexes of the type mer-[RhX3(DMSO)(pp)] (X = Cl, pp = phen 1, dpq 2, dppz 3, X = Br, pp = phen 4) represent a promising class of potent cytostatic agents for the treatment of lymphoma and leukemia. Exposure ...
Research on arteriovenous fistula detailed by J. Chew and co-authors.
May 07, 2009 ... In this recently published study, investigators in Vancouver, Canada conducted a study "To present our experience with the endovascular management of intracranial dural arteriovenous fistulas with direct cortical venous drainage by trans-arterial embolisation Using Onyx. Between January ...
Study findings on arteritis are outlined in reports from G. Canaud and colleagues.
May 07, 2009 ... According to a study from Paris, France, "Fungal contamination of kidney allograft preservative fluid can lead to renal arteritis and arterial wall rupture. We have evaluated a conservative management strategy based onearly antifungal therapy, rigorous morphological monitoring of the graft ...
Reports outline arthroplasty research from S. Tarasevicius and colleagues.
May 07, 2009 ... "Background and purpose We have previously reported that the first 10 years of hip arthroplasty in Lithuania resulted in a higher cumulative revision rate than that observed in Sweden. We thus compared the corresponding results after introduaction of total knee replacement in Lithuania," ...
Studies conducted at F. Consolo et al on artificial liver recently published.
May 07, 2009 ... "A comprehensive computational study modelling the operation of a rotating hollow-fiber bioreactor for artificial liver (BAL) was performed to explore the interactions between the oxygenated culture medium and the cultured hepatocytes. Computational fluid dynamics investigations were ...
New atherosclerosis study findings have been published by M.C. Guisasola and colleagues.(Report)
May 07, 2009 ... According to a study from Madrid, Spain, "Atherosclerosis is a disease whose pathogenesis involves inflammatory and immunological mechanisms, including an autoimmune reaction against heat shock proteins (Hsps). The purpose of this study was to analyze whether the antiatherogenic effect of ...