Recently added articles from Canadian Journal of Physiology and Pharmacology:
Use of voltage clamp fluorimetry in understanding potassium channel gating: a review of Shaker fluorescence data.(Report)
Jun 01, 2009; ... Introduction The ability of voltage-gated ion channels to sense and modulate cellular membrane potentials, and in doing so influence virtually all essential cellular processes, underscores their importance in all physiological systems (Hille 2001). Many of the details of channel ...
URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats.(Report)
Jun 01, 2009; ... Introduction Neuropathy, often expressed as hypersensitivity to painful stimuli (hyperalgesia), is among the most common complication of diabetes mellitus (Young et al. 1993; Tentolouris et al. 2001; Obrosova 2003). Diabetic rats display a range of abnormal behavioral responses ...
Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures.(Report)
Jun 01, 2009; ... Introduction The glucocorticoid (GC) steroid hormones released from the adrenal cortex are the principal effectors in the stress response (Sapolsky et al. 2000). Although short-term elevation of GCs can be protective against stress, chronic elevation of GCs caused by sustained ...
Chunghyuldan attenuates brain microglial inflammatory response.(Report)
Jun 01, 2009; ... Introduction Microglial cells play pivotal roles in immune and inflammatory responses in the central nervous system (CNS) and are activated during neuropathological conditions, restoring CNS homeostasis (Glezer et al. 2007). Microglial activation involves proliferation, ...
Evaluation of the antidiabetic potential of selected medicinal plant extracts from the Canadian boreal forest used to treat symptoms of diabetes: part II.(Report)
Jun 01, 2009; ... Introduction Type 2 diabetes is a global health problem. In Canada alone, the prevalence of diabetes has increased by 65% between 1995 and 2005 (Lipscombe and Hux 2007) to approximately 2 million cases, and it is projected that by 2030 this number will rise to over 3 million ...