Cancer Weekly back issues from April 2003:
NIST, UW-Madison research may lead to new breast cancer detection methods.(National Institute of Standards and Technology)(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Other than skin cancer, breast cancer is the most common type of cancer among women in the United States. More than 180,000 women are diagnosed with breast cancer each year. Research has led to progress against breast cancer - better ...
Thrombin generation correlates with biomarkers in advanced prostate cancer.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Thrombin generation correlates with biomarkers in advanced prostate cancer. According to recent research from the United States, "thrombin generation is increased in men with advanced prostate cancer. Thrombin has the ability to ...
Pulmonary metastasis can arise after surgery for osteosarcoma.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Pulmonary metastasis can arise after surgery for osteosarcoma. According to recent research from Japan, "early relapse with distant metastasis often is observed in patients with cancer after resection of the primary tumor." ...
Disruption of the HIC1 gene may predispose mice to gender-specific malignancy.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Disruption of the HIC1 gene may predispose mice to gender-specific malignancy "The gene hypermethylated in cancer-1 (HIC1) encodes a zinc-finger transcription factor that belongs to a group of proteins known as the POZ family. HIC1 is ...
Potential blood test could predict risk.(for colorectal cancer)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Johns Hopkins scientists have found a way to predict, with a simple blood test, which people may be at higher-than-normal risk for the most common form of colon cancer. The research, described in the March 14, 2003, issue of Science, ...
Gene that drives apoptosis also plays key role in development of skeletal muscle.(rhabdomyosarcoma development)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Investigators at St. Jude Children's Research Hospital have discovered that a protein causing mature cells to commit suicide also helps primitive muscle cells called myoblasts fuse together, allowing them to develop into muscles. The ...
Bone marrow grafts may be best option with matched unrelated donors.(acute lymphoblastic leukemia )
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Bone marrow grafts may be the best choice for acute lymphoblastic leukemia (ALL) patients with HLA-identical but unrelated stem cell donors. Researchers from France "analyzed data for 213 patients with ALL and AML who received either ...
An unusual case of microcystic adnexal carcinoma described.(skin cancer)(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- An unusual case of microcystic adnexal carcinoma is described. According to recent research from England, "Microcystic adnexal carcinoma (MAC) is an uncommon, recently described cutaneous adnexal malignant neoplasm, associated with ...
Anthrapyridazone derivatives are active, even on multidrug resistant cells.(leukemia treatment)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Anthrapyridazone derivatives are active, even on multidrug resistant cells. According to recent research from Poland, "A series of anthrapyridazone derivatives with 1-2 basic side chains at various positions in tile tetracyclic ...
CTLA-4 exon 1 polymorphism G was found in leukemic hemolytic anemia patients.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- CTLA-4 exon 1 polymorphism G was found in leukemic hemolytic anemia patients. "CTLA-4 is a CD28 homologue that plays an important role in negative regulation of T-cell responses. Its transient expression on the surface of activated T ...
CMV disease can mimic an acute B-precursor lymphoblastic leukemia.(cytomegalovirus)(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- CMV disease can mimic an acute B-precursor lymphoblastic leukemia. "Hematogones (B-lymphocyte progenitor-precursor cells) are normal bone marrow constituents which are morphologically distinct lymphoid cells with homogeneous, condensed ...
A serum test is more consistently reliable than the standard urine test.(multiple myeloma diagnosis)(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- A serum test is more consistently reliable than the standard urine test. "Bence Jones protein in urine (immunoglobulin free light-chains) is characteristic of light-chain multiple myeloma. We aimed to compare a quantitative immunoassay ...
The alcaloid swainsonine has a significant stimulatory effect on bone marrow.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- The alcaloid swainsonine has a significant stimulatory effect on bone marrow. "The immunomodulatory alkaloid swainsonine (8alphabeta-indolizidine-1alpha,2alpha,8beta-triol) has potential for overcoming the bone marrow suppressive effects ...
Migration of mutagens/carcinogens from PET bottles to water found.(polyethylene terephthalate )
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Migration of mutagens/carcinogens from polyethylene terephthalate bottles to the water they contain has been found. According to a study from Italy, "This study monitored the release of mutagenic/carcinogenic compounds into mineral water ...
Injection of DTI-015, a mix of BCNU in ethanol, stabilized active gliomas.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Injection of DTI-015, a mix of BCNU in ethanol, stabilized active gliomas. "DTI-015 (BCNU in 100% ethanol) utilizes solvent facilitated perfusion for the intratumoral treatment of gliomas. The ethanol solvent vehicle facilitates a rapid ...
Differentiating demyelinating lesion from neoplasm requires caution.(brain tumor)(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Differentiating demyelinating lesion from neoplasm requires caution. According to recent research from the United States, "Tumefactive demyelinating lesions can present with features similar, clinically and radiologically, to those of ...
Data provide evidence of how to conduct web-based interventions.(breast cancer risk notification)(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Data provide evidence of how to conduct web-based interventions. "The Internet might transform the way in which health information is communicated to patients and general populations. Understanding differences in usage patterns will be ...
Doppler imaging may have value for differentiating focal breast lesions.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Doppler imaging may have value for differentiating focal breast lesions. "The purpose of this article is to demonstrate the diagnostic impact of ultrasound (US) in differentiating focal breast lesions with special regard on power Doppler ...
Incidence of "lobular" disease increasing.(lobular breast cancer)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- The incidence of lobular breast cancer has increased steadily from 1987 to 1999, according to a new report. Previous studies have shown that ever use or current use of combined estrogen and progestin hormone replacement therapy (CHRT) ...
Local recurrence before 2 years following surgery predicts the worst outcome.(breast cancer)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Local recurrence before 2 years following surgery predicts the worst outcome. According to a study from England, "Local recurrence of cancer in the treated breast following breast conserving surgery and radiotherapy occurs in a minority ...
Metastasis and tumor growth suppression achieved with propolis in mouse model.(breast cancer with lung metastasis)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Metastasis and tumor growth suppression achieved with propolis in mouse model. According to recent research from Croatia, "The antimetastatic efficacy of a water soluble derivative of propolis (WSDP) was studied. Tumor was a ...
New technologies improve ability to diagnose and excise breast cancer.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- New technologies have improved the ability to diagnose and excise breast cancer. According to a study from the United States, "Until recently little advance in the diagnosis and excision of breast cancer has been made since the inception ...
Researchers call for better studies on environmental links.(breast cancer)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- A much broader net needs to be cast in the search for environmental links to breast cancer, concludes a new report that stems from a landmark gathering last year of researchers, public health officials, and activists. According to the ...
State variation in mortality rates due to later stage at presentation.(breast cancer)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- State variation in mortality rates was due to later stage at presentation. "In 2001 approximately 40000 deaths from breast cancer will occur in the United States. Although some estimates suggest possible state-to-state variations in ...
Tamoxifen and a farnesyl transferase inhibitor can have synergistic effects.(breast cancer)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Tamoxifen and a farnesyl transferase inhibitor can have synergistic effects. "Farnesyl transferase inhibitors (FTIs) serve to specifically inhibit farnesyl isoprenoid lipid modification of proteins. Although originally developed as ...
The biology of breast cancer genes will impact disease management.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- The biology of breast cancer genes will impact disease management. According to recent research from the United States, "The biology of breast carcinoma is complex, with multiple factors contributing to its development and progression." ...
Thymidylate synthase and thymidine are valid markers for selecting therapy.(for breast cancer)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Thymidylate synthase and thymidine are valid markers for selecting breast cancer therapy. According to a study from Japan, "thymidine phosphorylase (dThdPase) is identical to platelet-derived endothelial cell growth factor, and has an ...
Axillary lymph node drainage appears to be an important prognostic factor.(breast cancer)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Axillary lymph node drainage appears to be an important prognostic factor. According to recent research from Hungary, "Axillary lymph node staging is an important prognostic factor in patients with breast cancer. The longterm survival is ...
Case report: Metastatic metamorphopsia of the right eye.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- According to recent research from France, "We report the case of a 46-year-old woman, with no prior medical history, who developed a metamorphopsia of the right eye, followed by visual impairment." Ophthalmological examination revealed ...
Lung transplantation for bronchogenic carcinoma is not supported.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Lung transplantation for bronchogenic carcinoma is not supported. "Experience with lung transplantation for bronchogenic carcinoma is limited. In our experience, three of six patients died of recurrent carcinoma within 5 to 35 months ...
Expression of BCA-1 may influence tumor development and localization to CNS.(central nervous system )
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Expression of BCA-1 may influence tumor development and localization to the central nervous system. According to a study from the United States, "Primary central nervous system lymphoma (PCNSL) is a rare but often rapidly fatal form of ...
The estrogen product 2-methoxyestradiol is a promising anticancer agent.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- The estrogen product 2-methoxyestradiol is a promising anticancer agent. "Estrogens occurring naturally in the body are metabolized to catecholestrogens (2- and 4-hydroxyestradiol) by the cytochrome P450 enzymes. 2-Hydroxy ...
Peptide fusion improves the efficacy of thymidine kinase suicide gene therapy.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Peptide fusion improves the efficacy of thymidine kinase suicide gene therapy. According to recent research from Italy, "suicide gene therapy using herpes simplex virus type-1 (HSV-1) thymidine kinase (TK) is a widely exploited approach ...
Docetaxel enhances the effect of the angiogenesis inhibitor TNP-470.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Docetaxel enhances the effect of the angiogenesis inhibitor TNP-470. "We demonstrated recently that chronic frequent administration of an adequate biological dose of the angiogenesis inhibitor TNP-470 (AGM-1470, O-chloracetyl-carbamoyl ...
Neck lymph node metastasis risk relates to ill defined extracapsular spread.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Neck lymph node metastasis risk relates to ill defined extracapsular spread. According to recent research from England, "The prognostic significance of extracapsular spread of cervical metastases in oral cancer is still controversial. ...
Behavior changes could sharply cut cancer death rates.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Stepped-up efforts to help people quit smoking, lose weight, and change other unhealthy behaviors could lead to a 29% decline in U.S. cancer death rates by 2015, according to a report issued by the Institute of Medicine. Behavior ...
Thromboembolism precedes cancer; should be considered risk marker.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Thromboembolism precedes cancer; it should be considered a marker for risk. According to a study from the United States, "Thromboembolic (TE) events preceding cancer have been observed. Some studies failed to find this correlation. We ...
CD40-directed gene therapy shows prospects for treating human cancers.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- CD40-directed gene therapy shows prospects for treating human cancers. According to a study from the United States, "CD40, a member of the tumor necrosis factor receptor (TNF-R) family, is a surface receptor best known for its capacity ...
Fruit fly metalloproteinase controls tissue remodeling, not embryo development.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Fruit fly matrix metalloproteinase fosters tissue remodeling, not embryo development. "The matrix metalloproteinase (MMP) family is heavily implicated in many diseases, including cancer. The developmental functions of these genes are ...
Men more likely to be screened for prostate than for colorectal cancer.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Prostate cancer screening is more common than colorectal screening for men in the United States, according to a new study. But if practice were in accordance with evidence of screening-related benefits, colorectal cancer screening would be more ...
Cyclooxygenase inhibitors decrease the angiogenic potential of tumor cells.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Cyclooxygenase inhibitors decrease the angiogenic potential of tumor cells. "It seems certain that cyclooxygenase-2(COX-2) is related to tumor and some data suggest that COX-2 might have relation to tumor malignance and angiogenesis," ...
Plasminogen activators and captopril combine to diminish angiogenesis in tumors.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Plasminogen activators, when combined with captopril, increase antiangiogenic activity in the plasma of cancer patients, according to medical investigators at Beth Israel Deaconess Medical Center. Researchers at the Harvard affiliated ...
South Africa approves natural interferon.(hairy cell leukemia treatment)(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Viragen, Inc., (VRA) and Viragen International, Inc., (VGNI) announced the approval of its natural human alpha interferon for sale in South Africa. The South African regulatory authorities approved an application filed by Viragen's ...
Cancer treated using vaccines in mixed allogeneic bone marrow chimeras.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Successful therapy of metastatic cancer was achieved using tumor vaccines in mixed allogeneic bone marrow chimeras. According to a study from the United States, "A frequent outcome of allogeneic stem cell transplantation (alloSCT) in the ...
Researchers report a thymic carcinoid mimicking acute aortic dissection.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Researchers report a thymic carcinoid mimicking acute aortic dissection. According to recent research from England, "Thymic carcinoids are extremely rare." "We present an 80-year-old hypertensive patient who presented as an ...
Nuclear phosphatase and tensin homologue is associated with G0-G1.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Nuclear phosphatase and tensin homologue is associated with G0-G1. According to recent research from the United States, "Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that causes cell cycle ...
A rare case of metastasis to the scalp from carcinoma of the cervix is presented.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- A rare case of metastasis to the scalp from carcinoma of the cervix is presented. According to a study from South Korea, "Carcinoma of the cervix is a common neoplasm. Early detection and improved treatment techniques have resulted in ...
Common cell lines were analyzed cytogenetically for all aberrations.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Common cell lines were analyzed cytogenetically for all aberrations. According to a study from the United States, "We applied a combination of molecular cytogenetic methods, including comparative genomic hybridization (CGH), spectral ...
Dendritic cell vaccine shows promise against cervical cancer.(Ampligen)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Vaccination with dendritic cells pulsed with tumor lysate and matured with a novel synthetic clinically nontoxic, double-stranded RNA analogue poly [I]:poly[C[subscript]12U] (Ampligen) induced a strong immune response against cervical cancer. ...
Growth of HeLa cells enhanced by H[subscript]2O[subscript]2 at relatively low concentrations.(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- The growth of HeLa cells was enhanced by H[subscript]2O[subscript]2 at relatively low concentrations. "In this paper, the effects of H[subscript]2O[subscript]2, a typical reactive oxygen species (ROS), on cell proliferation or death ...
Antinausea drug will likely get approval in U.S.(Emend)(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Merck and Co.'s experimental treatment for preventing nausea and vomiting in chemotherapy patients won key support from a group of government advisers, meaning the drug will likely be approved for sale in the United States. The group of ...
Older, younger febrile neutropenic patients have similar infection rates.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Febrile neutropenic patients over age 60 have similar infection rates as younger patients. "We prospectively evaluated 131 consecutive episodes of fever and chemotherapy-induced neutropenia in 85 adults with hematological malignancies to ...
Medical journal editorial dubs Gleevec "gold standard".(chronic myeloid leukemia treatment)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Gleevec is the new "gold standard" for treatment of chronic myeloid leukemia (CML), according to an editorial published in a leading medical journal. The editorial cites a study published in the same issue (March 13, 2003, New England ...
Major study shows aspirin can reduce polyp return in GI cancer patients.(gastrointestinal cancer)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Patients who have had colorectal cancer may reduce their risk of suffering a recurrence by taking an aspirin daily, according to a new study conducted by a University of North Carolina at Chapel Hill physician and colleagues around the United ...
Reduced syndecan-2 expression correlates with lower colon cancer tumorigenicity.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Reduced syndecan-2 expression correlates with lower colon cancer tumorigenicity. "The inhibition of histone deacetylase activity is known to induce morphological changes of transformed cells. In this study, we investigated the effect of ...
Study explores genetic counseling in families with hereditary disease.(colon cancer genetics)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Among family members of patients with a certain type of hereditary colon cancer, only approximately half chose to undergo genetic testing, and many cited psychological and family issues as reasons for not participating in genetic counseling. ...
Tea complements drugs in treatment.(of colon tumors)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- A new study from the Linus Pauling Institute at Oregon State University (OSU) suggests that consumption of green and white tea can be just about as effective as use of the prescription drug sulindac in preventing colon tumors in a certain type of ...
Western diet a chief culprit.(increased risk of colon cancer)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Women who fill their diets with red or processed meats, french fries, white bread, and sugary desserts may have an increased risk of colon cancer, according to a new study. Researchers followed more than 76,000 women for 12 years to ...
Patients prefer "virtual" colonoscopy but dislike preparation.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Surveying patients who were screened for colorectal cancer, investigators at the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis found that most prefer "virtual" colonoscopy to traditional ...
CDC study finds colorectal cancer screening rates remain low.(Centers for Disease Control and Prevention)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Although scientific evidence shows that more than one-third of deaths from colorectal cancer could be avoided if people aged 50 and older were screened regularly, American's screening rates remain low, the U.S. Centers for Disease Control and ...
Markers of susceptibility to some meat and caffeine carcinogens are found.
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Markers of susceptibility to some meat and caffeine carcinogens are found. According to a study from the United States, "Red meats cooked at high temperatures generate mutagenic heterocyclic amines, which undergo metabolic activation by ...
Screening tests effective and can save lives.(colorectal cancer screening)(Brief Article)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- A review of available scientific evidence supports the recommendation that all men and women aged 50 years or older undergo screening for colorectal cancer, but it does not support choosing one test over another, according to findings from the ...
Preparations can lead to kidney failure and the need for dialysis or transplant.(Chinese herb nephropathy)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- Herbal preparations can lead to kidney failure and the need for dialysis or transplant. "A new renal disease called Chinese herb nephropathy (CHN) has been reported to occur in women who have ingested slimming pills containing powdered ...
A protein cluster links UVB and the induction of growth factor in skin cells.(ultraviolet B radiation)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- A protein cluster links UVB and the induction of growth factor in skin cells. "Chronic sun exposure of the skin has long been postulated to enhance cutaneous angiogenesis, resulting in highly vascularized skin cancers. As the UVB ...
New program to study possible environmental causes of cancer.(UCLA's Jonsson Cancer Center and the School of Public Health program)
Apr 01, 2003 ... 2003 APR 1 - (NewsRx.com & NewsRx.net) -- A new program at UCLA's Jonsson Cancer Center and the School of Public Health will seek to discover subtle variations in the human genetic blueprint that predispose some individuals to develop cancer after contact with environmental pollutants. ...