Cancer Weekly back issues from December 2004:
Topoisomerase II alpha is a prognostic indicator in breast cancer.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Topoisomerase II alpha is a prognostic indicator in breast cancer, pathologists at Tel Aviv University report. "Topoisomerase II-alpha (Topo II-alpha) is a nuclear enzyme. Its expression rises rapidly at the end of the S to G2/M phase ...
Study: Shorter, more aggressive treatments better control disease.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Women receiving care at small, local radiation therapy facilities are less likely to receive shorter, more aggressive treatments for their cervical cancer, according to a study by M.D. Anderson Cancer Center researchers. The findings ...
Genetic markers of tumorogenic aberrant crypt foci identified.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Genetic markers of tumorogenic aberrant crypt foci (ACF) have been identified in a murine marker of colon cancer. In a recent study from the United States, conducted to "determine whether cancer risk is related to histopathological ...
Dendritic cell-tumor fusion vaccines being developed for renal cell carcinoma.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Dendritic cell-tumor fusion vaccines are being developed for renal cell carcinoma. "Renal cell carcinoma is a malignant disease that demonstrates resistance to standard chemotherapeutic agents. A promising area of investigation is the ...
Allogeneic stem-cell transplantation for renal-cell cancer reviewed.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Researchers review allogeneic stem-cell transplantation for renal-cell cancer in a recent issue of Lancet Oncology. "Metastatic renal-cell carcinoma (RCC) is resistant to chemotherapy, and patients with this disease have a poor outlook. ...
Corrections being made to Louisiana abortion brochure.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Less than a week after learning that a state brochure incorrectly said abortions could increase the risk of breast cancer, health officials had a new version up on the Internet. It will take a bit longer to fix the paper version, Bob ...
Oral etoposide has a cytoreductive effect in relapsed ALL.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Oral etoposide has a cytoreductive effect in relapsed acute lymphoblastic leukemia. According to a study from the United States, "We evaluated the clinical response to low-dose etoposide in relapsed acute lymphoblastic leukemia (ALL). Of ...
L-ascorbic acid represses NF-kappa B/COX-2 expression in acute myeloid leukemia.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- L-ascorbic acid represses NF-kappa B/COX-2 expression in acute myeloid leukemia. "There is increasing evidence that L-ascorbic acid (LAA) is selectively toxic to some types of cancer cells at pharmacological concentrations, functioning ...
Nuclear localization of adenovirus E4orf4 protein correlates with cell death.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Nuclear localization of adenovirus E4orf4 protein correlates with cell death. "The adenovirus E4orf4 protein induces p53-independent death of human cancer cells by a mechanism requiring interactions with the Balpha subunit of protein ...
Scientists successful in "death clock" gene hunt.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Medical scientists at the University of Leicester have narrowed the search for the "death clock" gene in humans. Their study relates to a hunt for a gene that has important implications for aging and cancer as well as other age-related ...
Intracellular SAH removal may be therapeutic option in alcoholic liver disease.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Intracellular S-adenosylhomocysteine removal may be a therapeutic option in alcoholic liver disease. According to a study from the United States, "In alcoholic liver disease, tumor necrosis factor-alpha (TNF-alpha) is a critical ...
Study: FG-2216 increases endogenous EPO production in humans.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- FibroGen, Inc., announced that oral administration of FG-2216, the company's investigational therapy for anemia, was safe and well-tolerated and significantly increased production of endogenous erythropoietin (EPO) in healthy human subjects. ...
GAD 67KD antisense leaves colon cancer cells susceptible to cancer therapy.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- GAD 67KD antisense leaves colon cancer cells susceptible to cancer therapy. According to a study from South Korea, "in eukaryotes, glutamate decarboxylase (GAD) expression was found in brain, kidney, and several kinds of tumor tissues ....
Intratumoral CCL5 overexpression delays tumor growth.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Intratumoral CCL5 overexpression delays tumor growth. According to recent research from France, "Chemokines participate in the antitumor immune response by regulating the movement and positioning of lymphocytes as well as effector ...
NF-kappa B activation by API2/MALT1 fusions inhibits p53 dependant apoptosis.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- NF-kappa B activation by API2/MALT1 fusions inhibits p53 dependant apoptosis. According to published research from the United States, "Interactions between survival pathways and apoptotic cascades play a determinant role in the ...
High incidence of autoimmune hemolytic anemia complicating SCT in children.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- There is a high incidence of autoimmune hemolytic anemia complicating stem cell transplantation in pediatric patients. "Hemolytic anemia is a recognized complication of hematopoietic cell transplantation (HCT) and can result from ...
Cancer reference laboratory named to Deloitte's Fast 500 list.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- US LABS announced that it has ranked 181 on the 2004 Deloitte Technology Fast 500, a ranking of the 500 fastest-growing technology companies in North America. The company also ranked sixth on the Orange County, California, Fast 50, one ...
Scott Hawley named American Cancer Society research professor, awarded $300,000.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Scott Hawley, PhD, investigator at the Stowers Institute for Medical Research, has been named an American Cancer Society (The Society) Research Professor. The designation carries an award of $300,000 over 5 years with the possibility of an ...
Plasma elements deem VEGF a biomarker for intestinal cancer transformation.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Plasma elements deem VEGF a biomarker for intestinal cancer transformation. "Vascular endothelial growth factor (VEGF) is known to play a key role in tumor angiogenesis. Our preliminary published data suggest that plasma-activated ...
Type-1 innate and acquired immunity play crucial roles in tumor immunotherapy.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Type-1 innate and acquired immunity play crucial roles in tumor immunotherapy. According to a study from Japan, "the discovery of a large array of tumor antigens has demonstrated that host lymphocytes can indeed recognize and destroy ...
Promising data presented on phase 2 trial drug for superficial bladder cancer.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Spectrum Pharmaceuticals, Inc. (SPPI) announced encouraging efficacy and safety data from the ongoing multi-center phase 2 trial of EOquin as a single agent in patients with recurrent superficial bladder cancer refractory to at least one prior ...
Novel technique isolates/tracks rare lymphoid stem cell that facilitates BMT.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- A novel technique was developed that isolates and tracks a rare lymphoid stem cell that facilitates bone marrow transplantation. "Bone marrow cells are composed of pluripotent stem cells to terminally differentiated cells, with a wide ...
Trisacryl gelatin microspheres effective for preoperative embolization.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Trisacryl gelatin microspheres are highly effective for embolization of bone neoplasms prior to surgical removal. Radiologists in Austria conducted a study "to compare the efficacy of trisacryl gelatin microspheres versus polyvinyl ...
Post-therapy damage in medulloblastoma patients can be mistaken for new tumors.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Irradiation and high-dose chemotherapy used to treat two types of brain tumors - medulloblastoma and supratentorial PNET - can cause changes in the brain's white matter that look like tumors when seen on MRI scans. This finding, by a ...
"Knowledge management" system could "revolutionize" treatment.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Scientists in the U.K. have designed a knowledge management system that they think could enable medical practitioners to make speedy, informed decisions about breast cancer patients. The project pulls together information previously held ...
GATA3 mutations identified in breast tumors.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- A number of breast tumor GATA3 mutations have been identified and characterized. "GATA3 is an essential transcription factor that was first identified as a regulator of immune cell function," scientists in the United States explained ....
Accelerated partial breast irradiation new option for breast cancer patients.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Women diagnosed with breast cancer must weigh the options between old tried- and-true and next-generation breast cancer treatments An estimated 216,000 American women will be diagnosed with breast cancer this year, according to the ...
Apoptotic response of tamoxifen-resistant breast tumor cells clarified.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Expression of apoptosis-related genes has been characterized in tamoxifen (TAM)-resistant breast tumor cells. In a recent study, oncologists in Germany "examined alterations in the apoptotic response" of TAM-resistant breast cancer ...
Breast cancer study examines new radiofrequency ablation assisted lumpectomy.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- The University of Arkansas for Medical Sciences (UAMS), and RITA Medical Systems, Inc., (RITA) announced that the first patient in a planned series of 30 received a radiofrequency ablation-assisted lumpectomy procedure. According to ...
Chemotherapies have varied effects on menopausal symptoms of cancer patients.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Oncologists in Belgium have studied "the changes in frequency and severity of menopausal symptoms in patients receiving tamoxifen or aromatase inhibitors and identified factors influencing these symptoms." They noted, "Endocrine ...
Data on radiation dose from digital mammography reported from large study.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Radiologists in Spain have reported the mean and range of radiation dose from digital mammography calculated from data on over 5,000 patients. M. Chevalier, of the University of Complutense Madrid, and colleagues, "[analyzed] the dose of ...
Elizabeth Edwards's diagnosis encourages others to get check-ups.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Elizabeth Edwards said she is glad her breast cancer diagnosis is encouraging people to stop neglecting their own health, as she admits she did. "I didn't test myself as often," and didn't get yearly mammograms, the wife of former vice ...
Endogenous BRCA1-IRIS may influence DNA replication initiation machinery.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Endogenous BRCA1-IRIS may positively influence the DNA replication initiation machinery. According to published research from the United States, "Breast cancer is the most common malignancy among women, and mutations in the BRCA genes ...
Enhancing cancerous area on MR mammography compared with pathological exam.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- According to a study from Belgium, "The enhancing area surrounding breast carcinoma on magnetic resonance (MR) mammography is correlated with findings from pathological examination. "We studied 194 patients with breast cancer who ...
Genes linked to breast tumor progression and/or metastasis identified.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- A number of novel breast tumor genes linked to progressive disease and/or metastasis have been identified. "Breast carcinoma is a complex disease characterized by accumulation of multiple genetic alterations, and the understanding of ...
HER2-positive disease invades organs due to fatal chemical attraction.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Researchers at The University of Texas M.D. Anderson Cancer Center have solved the mystery of why an aggressive form of HER2-positive breast cancer travels readily to a few key organs - lungs, liver, and bone -where it then establishes new tumors. ...
Hierarchical clustering of breast tumor immunomarkers has high prognostic value.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Hierarchical clustering analysis of breast tumor immunohistochemical data has high prognostic value. "Prognostically relevant cluster groups, based on gene expression profiles, have been recently identified for breast cancers, lung ...
In BRCA1/2 mutation carriers, cancer may mimic benign lesions on mammogram.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- A study involving BRCA 1/2 gene mutation carriers found that a significant number of circumscribed non-calcified mammographic masses found in these patients were malignant. "Breast cancers in gene mutation carriers may escape ...
New surgical technique determines if cancer has spread.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Women in Britain with breast cancer will soon benefit from a pioneering surgical technique developed in Wales. Robert Mansel and his team at Cardiff University, Wales College of Medicine, recently launched the "New Start" training ...
Obesity, lymph node status, and prognosis in breast cancer explored.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the associations of obesity, lymph node status, and prognosis in breast cancer patients. According to recent research from Norway, "Breast cancer patients who are obese have a higher risk of lymph node ...
Patients receiving taxane-based chemotherapy not at higher risk of pneumonitis.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Researchers at The University of Texas M.D. Anderson Cancer Center have shown that breast cancer patients treated with taxane-based chemotherapies and radiation are not at increased risk of developing pneumonitis, a dangerous lung condition ...
Phage display library from lymph nodes of breast cancer patients constructed.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Researchers have constructed phage display libraries from reactive lymph nodes of breast carcinoma patients. According to a study from Germany, "The display of recombinant antibody fragments on the surface of filamentous phage mimics B ...
Plasma prolactin levels associated with increased postmenopausal disease risk.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Study findings suggest that plasma prolactin levels are associated with increased postmenopausal risk of breast cancer. "Prolactin is important in human breast development, and substantial laboratory and in vitro data suggest a role in ...
Private practice in Munich, Germany, selects mammography system.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- A new private practice in Munich, Germany, has chosen Sectra's revolutionary digital mammography system, Sectra MicroDose Mammography. The new practice will focus on the low-dose concept and will offer its customers a significant ...
Saudi Arabia: National guidelines on breast cancer management needed.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Data revealing variability and/or deficiencies in breast cancer management among surgeons and hospitals in Saudi Arabia have at least one group of surgeons there calling for national guidelines to set the standard of care for this disease. ...
Trial evaluates supplemental screening sonography in dense breasts.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- A clinical trial is evaluating use of supplemental screening sonography to detect cancer in dense breasts. "In single-center trials across 42,838 examinations, 150 (0.35%) cancers were identified only sonographically in average-risk ...
Women willing to deal with negative aspects of screening to gain benefit.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- There is nothing pleasant about getting a mammogram done, but overall, women are willing to put up with the discomfort and potential anxiety for the benefit of early detection of breast cancer. "The main risks and other adverse ...
Biopharma reports third quarter 2004 results, clinical achievements.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Progenics Pharmaceuticals, Inc., (NASDAQ: PGNX) announced its results of operations for the third quarter ended September 30, 2004, and for the first 9 months of 2004. Revenues for the third quarter ended September 30, 2004, totaled ...
Biopharmaceuticals company announces third quarter results, progress made.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Keryx Biopharmaceuticals announced its financial results for the third quarter ended Sept. 30, 2004. At Sept. 30, 2004, Keryx announced cash, cash equivalents, interest receivable and investment securities of $51.4 million, compared to ...
Biotech company announces restructured agreement for cancer drug.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Ligand Pharmaceuticals announced that it has restructured its agreement with Eli Lilly and Company with respect to the royalties payable to Lilly on sales of Ligand's marketed cancer drug Ontak (denileukin diftitox) in the United States. Ligand ...
Dermatology pharmaceutical company announces financing, new hires.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Neosil Incorporated announced that it closed a $32 million placement of series A Preferred Stock to a group of investors led by MPM Capital and Burrill & Company. The financing will enable Neosil to complete preclinical work on existing ...
Developer of surgical and diagnostic products announces financial results.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Neoprobe Corporation (OTCBB:NEOP) announced consolidated operating results for the third quarter of 2004. Third quarter results included revenues of $1.7 million, representing increases of 46% compared to $1.2 million for the third ...
Pharmaceutical firm reports loss of $0.18 per share.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Ariad Pharmaceuticals, Inc., (ARIA) announced consolidated financial results for the quarter ended September 30, 2004, and provided an overview of the clinical development of AP23573. "In the third quarter, we continued to move forward ...
Biotech establishes new business units for pain and oncology.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Ligand Pharmaceuticals announced that it has established separate therapeutically focused business units for its pain and oncology products. Patrick M. Shea, formerly vice president of marketing, has been promoted to vice president of ...
ComfortScan agreements inked in Canada, Italy, and Russia.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- DOBI Medical International, Inc., (DBMI) announced that it signed distribution agreements for the ComfortScan system with several leading medical suppliers including Horizon Medical Services, Ltd., in Ontario, Canada; Technologic, srl, in Torino, ...
IUN and Theragenics Corporation sign 3-year strategic alliance agreement.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- International Physician Networks dba International Urology Network (IUN) has entered into a 3-year exclusive, strategic alliance agreement with Theragenics Corporation (TGX). This agreement will provide group purchasing services to over ...
Molecular diagnostics company announces expansion of diagnostic pipeline.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Third Wave Technologies Inc. (TWTI) provided new details about the expansion of the company's molecular diagnostic pipeline and issued preliminary guidance for 2005 clinical molecular diagnostic revenue. Products to be released during ...
New company to develop, produce patient-specific cancer vaccines.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Baylor Health Care System announced its formation of a cancer immunotherapy company, known as ODC Therapy, Inc. ODC will develop, produce and distribute customized cancer vaccines, including a melanoma vaccine, to individual patients and ...
BRCA1 missense variant thwarts transcriptional activity.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- One of two BRCA1 missense variants identified by researchers in the U.S. has deleterious effects on gene transcription. "Many families with multiple cases of ovarian cancer, breast cancer, or both segregate inherited mutations in one ...
Clinical studies needed to evaluate role of BRCA1 in chemotherapy response.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Prospective clinical studies are needed to evaluate the role of BRCA1 in response to taxane-based chemotherapy, researchers say. Loss of BRCA1 function is associated with sensitivity to DNA-damaging chemotherapy and may also be ...
SOCS1 and 2 genes suppress growth of ovarian and breast carcinoma cells.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Suppressor of cytokine signaling genes 1 and 2 suppress the growth of ovarian and breast carcinoma cells, researchers in Australia have shown. "Suppressor of cytokine signaling (SOCS) proteins have emerged as critical attenuators of ...
Fused cell vaccination and CpG oligodeoxynucleotides reject tumor recurrence.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Fused cell vaccination and CpG oligodeoxynucleotides reject tumor recurrence. "Immunization with dendritic cells (DCs) using various antigen (Ag)-loading approaches has shown promising results in tumor-specific immunotherapy and ...
Standardized reviews of glioblastoma vascular patterns assist treatment choice.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Standardized reviews of glioblastoma vascular patterns assist treatment choice. "In a recent study, the existence of distinct vascular patterns with prognostic impact has been described in glioblastomas. The bizarre angiogenic subtype ...
Vascular targeting agent, radiation reduces tumor growth by 98% in animals study.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Peregrine Pharmaceuticals, Inc. (PPHM) announced that Philip Thorpe, PhD, a member of its scientific advisory board, gave the keynote presentation at the Vascular Targeting Agents conference in Cambridge, Massachusetts. Thorpe's address ...
Hepatitis C infection encourages liver cancer recurrence after resection.
Dec 07, 2004 ... 2004 DEC 7 - (NewsRx.com & NewsRx.net) -- Hepatitis C infection encourages liver cancer recurrence after resection. "Hepatocellular carcinoma (HCC) is closely associated with chronic hepatitis B or C virus (HBV, HCV) infection. Tumor recurrence frequently occurs after surgical ...