Cancer Weekly back issues from September 2008:
Why a common treatment for prostate cancer ultimately fails.
Sep 02, 2008 ... Some of the drugs given to many men during their fight against prostate cancer can actually spur some cancer cells to grow, researchers have found. The findings were published online this week in a pair of papers in the Proceedings of the National Academy of Sciences (see also University ...
CEL-SCI Announces Exclusive Licensing Agreement with Teva for Cancer Drug Multikine.
Sep 02, 2008 ... CEL-SCI Corporation (AMEX:CVM) announced that it has entered into an exclusive licensing agreement with Teva Pharmaceutical Industries Ltd. (Teva), a leading global pharmaceutical company, under which CEL-SCI has granted Teva an exclusive license to market and distribute the Company's ...
Hero Police Dog Succumbs to Cancer - Morris Animal Foundation Honors 'Rocky' - Also Honored 'Rocky' Six Years Ago When He Was Shot.
Sep 02, 2008 ... Cancer has claimed a hero police dog, and Morris Animal Foundation (MAF) is now honoring "Rocky," a canine member of the Lakewood Police Department in Colorado. MAF first honored Rocky six years ago when his bravery resulted in being shot, but in still catching a criminal (see also ...
Prescription Sleeping Pill Use Tied to Cancer.
Sep 02, 2008 ... The next time you consider popping a pill when you have trouble nodding off, it might be worth counting sheep instead. A senior psychiatrist at the Scripps Clinic Sleep Center in San Diego, Calif. has found evidence that taking sleeping pills regularly can increase the risk of skin cancer ...
Study data from University of Cambridge update knowledge of cancer vaccines.
Sep 02, 2008 ... "Prophylactic vaccination with human papillomavirus (HPV) virus-like particle (VLP) vaccines against HPV 16 and HPV 18, which are the cause of 70% or more of cervical cancers in women, has transformed our prospects for reducing the incidence of this disease on a global scale. HPV VLP ...
Research from University of Yamanashi, Medical Department provides new data about adenocarcinoma.
Sep 02, 2008 ... "Lobular endocervical glandular hyperplasia (LEGH) is a cervical lesion with pyloric gland metaplasia. Minimal deviation adenocarcinoma (MDA) is an extremely well differentiated form of endocervical adenocarcinoma (AC)," investigators in Yamanashi, Japan report (see also Adenocarcinoma). ...
Researchers at Washington University target adenocarcinoma.
Sep 02, 2008 ... "This is a phase II, single-center, single-arm study of patients with resectable adenocarcinoma of the pancreas who were treated with adjuvant interferon-based chemoradiation followed by gemcitabine. The primary end point was 2-year overall survival, with secondary endpoints being 2-year ...
Scientists at University of Alabama describe research in adenocarcinoma.
Sep 02, 2008 ... According to a study from the United States, "A 64-year-old man presented with symptoms of a lung infection. Radiologic work-up revealed opacity in the upper lobe of right lung." "A computer tomographic (CT) guided fine-needle aspiration biopsy revealed sheets and clusters of ...
Studies from Royal Liverpool University yield new data on adenocarcinoma.(Report)
Sep 02, 2008 ... " The objective of this study was to evaluate whether preoperative CA19-9 levels and the platelet-lymphocyte ratio (PLR) might reflect prognostic indices for resected ampullary adenocarcinoma. Materials and Methods Data were collected prospectively over a 10-year period for consecutive ...
Study data from M. Dank et al provide new insights into adenocarcinoma.
Sep 02, 2008 ... "We aimed to establish the superiority (or noninferiority if superiority was not achieved) in terms of time to progression (TTP) of irinotecan/5-fluorouracil (IF) over cisplatin/5-fluorouracil (CF) in chemonaive patients with adenocarcinoma of the stomach/esophagogastric junction. Patients ...
Study findings from Shiga University provide new insights into adenocarcinoma.
Sep 02, 2008 ... "Myxoid adrenocortical tumors are extremely rare neoplasms with only nine adenomas and eleven carcinomas reported in the literature. They occasionally have a pseudoglandular component resembling metastatic mucinous adenocarcinoma in the adrenal gland," scientists writing in the journal ...
Study findings from University of Texas broaden understanding of adenocarcinoma.
Sep 02, 2008 ... According to recent research from the United States, " We conducted a phase II trial of preoperative gemcitabine and cisplatin chemotherapy in addition to chemoradiation (Gem-Cis-XRT) and pancreaticoduodenectomy (PD) for patients with stage I/II pancreatic adenocarcinoma. Patients and ...
Study data from A. Advani and colleagues update understanding of adrenocortical cancer.(Report)
Sep 02, 2008 ... "Structured multicentre efforts are needed if the prognosis of adrenocortical carcinoma (ACC) is to be improved. Data collection may be enhanced through standardised histopathological reporting using criteria such as the recently published Royal College of Pathologists' (UK) minimum ...
Reports outline apoptosis research from J. Bakhshi and colleagues.
Sep 02, 2008 ... According to recent research from the United States, "The microenvironment of cancerous cells includes endoplasmic reticulum ( ER) stress the resistance to which is required for the survival and growth of tumors. Acute ER stress triggers the induction of a family of ER stress proteins that ...
Research findings from Tzu Chi University update understanding of apoptosis.(Report)
Sep 02, 2008 ... "The objective of this study was to evaluate the cardiac toxicity induced by carboplatin, a second generation platinum-containing anti-cancer drug, and to test whether pravastatin can reduce this cardio-toxicity. In the present study, infusion of carboplatin (100 mg/kg) to mice resulted in ...
Research on apoptosis published by K. Omata et al.(Report)
Sep 02, 2008 ... "DNA fragmentation factor is a heterodimer complex of the nuclease CAD and its specific inhibitor ICAD, which can be activated during apoptosis to induce DNA fragmentation. Although ICAD expression levels have been quantified in a variety of human cancer cells, the mechanism of ICAD gene ...
Investigators at University of Dublin, Trinity College release new data on autoimmune disease.(Report)
Sep 02, 2008 ... According to a study from Dublin, Ireland, "Hashimoto Thyroiditis (H.T.) is a destructive autoimmune thyroid condition whose precise molecular pathogenesis remains unclear. ret/PTC-1 is a chimeric transcript which has been described in autoimmune thyroid disease (AITD) and thyroid ...
New basal cell cancer research from University of Rochester described.(Report)
Sep 02, 2008 ... According to recent research published in the journal Clinical Cancer Research, "In superficial basal cell carcinomas treated with photodynamic therapy with topical delta-aminolevulinic acid, we examined effects of light irradiance on photodynamic efficiency and pain. The rate of ...
Reports outline basal cell cancer study results from A. Konstantinidis et al.
Sep 02, 2008 ... "An 80-year-old woman presented with a lump in her left lower eyelid," investigators in Coventry, the United Kingdom report (see also Basal Cell Cancer). "Histopathology of the lesion supported the diagnosis of basal cell carcinoma with osteosarcomatous changes. The lesion was ...
Studies from General Hospital yield new information about biopsy.(Report)
Sep 02, 2008 ... According to recent research from Barcelona, Spain, "To review the relationship between the Gleason grade and prostate volume in biopsy and radical prostatectomy (RP) specimens, and thus assess the hypothesis that smaller prostates have a greater incidence of high-grade tumours. We ...
Data from F. Demirel and colleagues advance knowledge in bladder cancer.(Report)
Sep 02, 2008 ... " In this study, we analyzed the effect of Turkish coffee and black tea consumption, alcohol intake and smoking on bladder cancer. A total of 164 patients with bladder tumors and 324 individuals without primary tumors were included in the study," researchers in Ankara, Turkey report (see ...
Research from Mayo Clinic yields new findings on bladder cancer.
Sep 02, 2008 ... According to a study from the United States, "To assess the reproducibility of the UroVysion fluorescence in situ hybridization (FISH) bladder cancer detection assay. Thirteen specimens (2 negative, 3 low-level positive [1-10% abnormal cells], 5 mid-level positive [11-75%], and 3 ...
Studies from G. Braud et al provide new data on bladder cancer.
Sep 02, 2008 ... According to a study from France, "- The objective of this retrospective study was to analyse the impact of Lymph node invasion on survival after radical cystectomy for bladder cancer. - From 1988 to 2002, 192 patients underwent radical cystectomy for bladder cancer." "Lymph ...
Scientists at Shandong University describe research in bone cancer.
Sep 02, 2008 ... "Twenty-six patients with bone tumors in a proximal tibia underwent limb-salvage surgery with custom prosthesis. The soft tissue reconstruction included gastrocnemius flap transposition to cover the upper part of the prosthesis and to reconstruct the extensor mechanism with its muscle ...
Reports by F. Camnasio and co-researchers describe recent advances in bone disease.
Sep 02, 2008 ... " Metastatic bone disease is the most common cause of malignancies to the skeleton in adults. The treatment of bone metastases is frequently palliative aiming to achieve a satisfactory control of pain and to prevent or to treat pathological fractures," scientists in Milan, Italy report ...
Research results from Gifu University, Medical Department update understanding of brachytherapy.
Sep 02, 2008 ... In this recent study, researchers in Gifu, Japan conducted a study "To compare the dosimetric results between MRI-based and TRUS-based preplanning in permanent prostate brachytherapy, and to estimate the accuracy of MRI-based preplanning by comparing with CT/MRI fusion-based postimplant ...
Studies from University of Amsterdam yield new information about brachytherapy.
Sep 02, 2008 ... "The two main modalities to deliver high dose to the prostate and prevent high doses to neighboring organs are intensity modulated radiotherapy (IMRT) or external beam radiotherapy combined with brachytherapy. Because of the different biological effectiveness the physical dose ...
Studies from University of California have provided new information about brachytherapy.
Sep 02, 2008 ... In this recently published article, scientists in the United States conducted a study "To establish an inverse planning set of parameters (class solution) to boost dominant intra-prostatic lesion (DIL) defined by MRI/MRSI. For 15 patients, DIL were contoured on CT or MR images and a class ...
Reports summarize brain cancer study results from University of California.(Report)
Sep 02, 2008 ... According to a study from the United States, "The goal of this study was to examine the sensitivity and specificity in preoperative localization of hand motor cortex by imaging regional event-related desynchronization (ERD) of brainwaves in the P frequency band (15-25 Hz) involved in ...
Erasmus University details research in breast cancer.
Sep 02, 2008 ... " Data on distant disease-free interval (DDFI) and the localization of the first distant metastasis (DM) in BRCA1- and BRCA2-associated breast cancer (BC) patients are as yet scarcely available. Patients and methods We identified 57 BRCA1-associated and 31 BRCA2-associated BC patients, ...
Findings from Dalhousie University provide new insights into breast cancer.
Sep 02, 2008 ... " Adjuvant 5-flurouracil, epirubicin and cyclophosphamide-docetaxel (FEC-D) has been shown to improve disease-free and overall survival (DFS and OS), compared to FEC 100, for node-positive breast cancer. An economic evaluation was undertaken to examine the cost-utility (CU) of FEC-D ...
Findings from M. Lansdown and co-researchers advance knowledge in breast cancer.
Sep 02, 2008 ... In this recent report, researchers in Brighton, the United Kingdom conducted a study "To examine, via an international survey, the impact of positive and negative interactions on the patient-physician relationship. Research design and methods: This online survey was conducted in five ...
Findings from Ohio State University in breast cancer reported.
Sep 02, 2008 ... "Preclinical studies show that mitomycin-C (MMC) followed by irinotecan (CPT-11) is synergistic. Therefore, we evaluated the toxicity and efficacy of sequentially administered low-dose MMC and CPT-11 in patients (pts) with pretreated metastatic breast cancer (MBC)," researchers in the ...
Findings in breast cancer reported from D.J. Hughes and co-researchers.
Sep 02, 2008 ... According to recent research from Dublin, Ireland, "Though much progress has been made in understanding the role of two major high-risk breast cancer (BC) susceptibility genes, BRCA1 and BRCA2, it remains unclear what causes the observed variation in risk between mutation carriers. This ...
Findings in breast cancer reported from E.Y. Oh and co-researchers.
Sep 02, 2008 ... " Human breast cancer incidence, histopathologic grade, invasiveness, and mortality risk vary significantly throughout each year. In order to better understand this seasonal cancer biology, we investigated the circannual pattern of post-resection breast cancer metastasis, under genetically ...
Indiana University details research in breast cancer.
Sep 02, 2008 ... "Taxanes (paclitaxel and docetaxel) comprise a class of mitotic inhibitors which considered highly active chemotherapeutic agents against cancer cells, and have become a cornerstone in the treatment of patients with early and advanced breast cancer," investigators in the United States ...
Investigators at Nanjing Medical University zero in on breast cancer.
Sep 02, 2008 ... According to a study from Nanjing, People's Republic of China, "Epidermal growth factor (EGF), a potent mitogenic peptide, plays an important role in the development of cancers, including breast cancer. Previous studies showed that plasma EGF levels may influence the risk of cancer." ...
New breast cancer data have been reported by L. Li and co-authors.
Sep 02, 2008 ... According to recent research from Stockholm, Sweden, "The role of genomic instability and proliferative activity for development of distant metastases in breast cancer was analysed, and the relative contribution of these two risk factors was quantified. A detailed quantitative comparison ...
New breast cancer research from Kagoshima University described.(Report)
Sep 02, 2008 ... According to recent research from Kagoshima, Japan, "To investigate the aetiological role of human papillomavirus (HPV) in breast cancer, we examined the presence, genotype, viral load, and physical status of HPV in 124 Japanese female patients with breast carcinoma. Human papillomavirus ...
New breast cancer research from McGill University discussed.(Report)
Sep 02, 2008 ... "High-risk human papillomaviruses (HPVs) could be important risk factors for breast carcinogenesis and metastasis. Based on this hypothesis, we recently studied the effect of E6/E7 onco-proteins of high-risk HPV type 16 in two non-invasive human breast cancer cell lines, BT20 and MCF7; we ...
New breast cancer research from University of Urbino discussed.
Sep 02, 2008 ... According to recent research from Urbino, Italy, "Arachidonic acid, a bioactive molecule metabolized into prostaglandins and leukotrienes, contributes to cellular proliferation and tumor progression. Group IIa secretory phospholipase A2 (sPLA2-IIa) can facilitate arachidonate release from ...
New breast cancer study findings have been published by scientists at Erasmus University.(Report)
Sep 02, 2008 ... " Breast cancer incidence continuous to increase. We examined at population level the association between the relative excess risk of breast cancer and previous age of mother at first birth," scientists in Netherlands report (see also Breast Cancer). " Incidence of breast cancer ...
New findings reported from E. Kellen and co-authors describe advances in breast cancer.
Sep 02, 2008 ... " To assess the occurrence of interval breast cancers among those women who attended the mammography screening programme in the Belgian province of Limburg. Interval cancers are tumours that are being diagnosed before the next scheduled screening round and are related to the sensitivity ...
New findings reported from University of Basel describe advances in breast cancer.(Report)
Sep 02, 2008 ... According to recent research from Basel, Switzerland, "Previous research evaluating the use of adjuvant endocrine therapy among postmenopausal breast cancer patients showed with 15-50% wide ranges of non-adherence rates. We evaluated this issue by analysing an unselected study group ...
Recent findings from G. Gruber and co-authors highlight research in breast cancer.(Report)
Sep 02, 2008 ... According to a study from Zurich, Switzerland, "Extracapsular tumor spread (ECS) has been identified as a possible risk factor for breast cancer recurrence, but controversy exists regarding its role in decision making for regional radiotherapy. This study evaluates ECS as a predictor of ...
Recent findings from Ohio State University, Medical Department highlight research in breast cancer.
Sep 02, 2008 ... "Inflammatory breast carcinoma (IBC) is a particularly lethal form of breast cancer characterized by exaggerated lymphovascular invasion, which is a phenotype recapitulated in our human xenograft MARY-X. MARY-X generated spheroids in vitro that resemble the embryonal blastocyst," ...
Reports from Indiana University advance knowledge in breast cancer.
Sep 02, 2008 ... According to recent research published in the Journal of Clinical Oncology, " The combination of lapatinib and trastuzumab has been observed to have a synergistic, antiproliferative effect against ErbB2-positive breast cancer cells in vitro. This phase I study assessed the safety, clinical ...
Reports outline breast cancer study findings from T. Dorjgochoo and colleagues.(Report)
Sep 02, 2008 ... " The influence of vitamin supplements on breast cancer risk is unclear and the interactive effects of dietary and supplemental sources are unknown. This study investigated (1) the association between self-reported vitamin supplement use (multivitamin, A, B, C, and E) and breast cancer and ...
Reports outline breast cancer study results from University of London, Imperial College.
Sep 02, 2008 ... "Breast cancer is the leading cause of cancer deaths among women worldwide. The theory of targeting both cancer cells directly and their blood supply has significant therapeutic potential," scientists in London, the United Kingdom report (see also Breast Cancer). "However, to ...
Research data from M.L. Scotti and colleagues update understanding of breast cancer.(Report)
Sep 02, 2008 ... According to recent research from the United States, "Breast cancers overexpressing human epidermal growth factor receptor 2 (HER2) have been reported to have higher proliferative and metastatic activity in the presence of autocrine prolactin (PRL), indicating potential cooperation between ...
Research from C.K. Gwede and co-researchers provides new data on breast cancer.
Sep 02, 2008 ... According to recent research published in the journal Supportive Care in Cancer, " Cancer patients experience multiple concurrent symptoms. This exploratory analysis assessed symptom burden among patients undergoing chemotherapy for breast cancer to identify distinct subgroups of patients ...
Research from J. Wang and co-authors yields new data on breast cancer.
Sep 02, 2008 ... According to recent research from the United States, "Our objective was to examine the association between dietary fat intake, cooking fat usage, and breast cancer risk in a population-based, multiethnic, case-control study conducted in the San Francisco Bay area. Intake of total fat and ...
Research from J.F. Cheng and colleagues has provided new data on breast cancer.(Report)
Sep 02, 2008 ... According to recent research published in the journal Breast Cancer Research and Treatment, " Benign breast biopsies with concurrent multiple benign lesions with different histopathologic diagnoses were termed heterogeneous benign breast disease (HBBD). Multiplicity of benign breast ...
Research from Lund University in the area of breast cancer described.
Sep 02, 2008 ... "High prolactin levels have been associated with increased breast cancer risk. Prolactin is essential for breast-feeding," investigators in Lund, Sweden report (see also Breast Cancer). "Prolactin is lowered primarily by the first full-term pregnancy and not by subsequent ...
Research from M.J. Hassett and co-researchers yields new findings on breast cancer.
Sep 02, 2008 ... "Although many quality measures have been created, there is no consensus regarding which are the most important. We sought to develop a simple, explicit strategy for prioritizing breast cancer quality measures based on their potential to highlight areas where quality improvement efforts ...
Research from N. Honma and co-researchers provides new data on breast cancer.
Sep 02, 2008 ... According to recent research published in the Journal of Clinical Oncology, " The clinicopathologic importance of a second estrogen receptor (ER), ER-beta, in breast cancers has been intensely studied; however, there is still no real consensus regarding the clinical utility of an ER-beta ...
Research from University of Michigan reveals new findings on breast cancer.(Survey)
Sep 02, 2008 ... In this recent study, researchers in the United States conducted a study "To evaluate the association between provider characteristics and treatment location and racial/ethnic minority patients' knowledge of breast cancer treatment risks and benefits. Data Sources/Data Collection. Survey ...
Research from University of Toronto broadens understanding of breast cancer.
Sep 02, 2008 ... According to a study from Toronto, Canada, "The contribution of BRCA1 and BRCA2 to breast cancer incidence in Cuba has not yet been explored. In order to estimate the proportion of breast cancers due to BRCA1 and BRCA2 mutations in Cuba, and to identify possible Cuban founder mutations, we ...
Research from W.G.E. Direcks and colleagues has provided new data on breast cancer.(Report)
Sep 02, 2008 ... "Increased 2'-deoxy-2'-[F-18]fluoro-D-glucose (FDG) uptake is the most commonly used marker for positron emission tomography in oncology. However, a proliferation tracer such as 3'-deoxy-3'-[F-18]fluorothymidine (FLT) might be more specific for cancer. 3'-deoxy-3'-[F-18] fluorothymidine ...
Research in the area of breast cancer reported from M.T. Epping and colleagues.
Sep 02, 2008 ... According to a study from Netherlands, "The tumour antigen PReferentially expressed Antigen of MElanoma ( PRAME) is expressed in a variety of malignancies, including breast cancer. We have analysed PRAME gene expression in relation to clinical outcome for 295 primary breast cancer ...
Research on breast cancer described by scientists at University of Michigan.(Clinical report)
Sep 02, 2008 ... According to a study from the United States, " Aromatase inhibitors (AIs) are increasingly used as adjuvant treatment of postmenopausal women with hormone receptor-positive breast cancer. AIs are commonly associated with musculoskeletal symptoms." "The primary objective of this ...
Research on breast cancer discussed by G. Rappa and co-researchers.
Sep 02, 2008 ... "Malignant tumors comprise a small proportion of cancer-initiating cells (CIC), capable of sustaining tumor formation and growth. CIC are the main potential target for anticancer therapy," scientists writing in the journal Experimental Cell Research report (see also Breast Cancer). ...
Research reports from University of Marburg provide new insights into breast cancer.
Sep 02, 2008 ... According to recent research published in the journal Annals of Oncology, "Recent studies indicate that women with breast cancer are at increased risk of fracture compared with their age-matched peers. Current treatment guidelines are inadequate for averting fractures in osteopenic women, ...
Research reports on breast cancer from Duke University provide new insights.
Sep 02, 2008 ... " Breast cancer arising in young women is correlated with inferior survival and higher incidence of negative clinicopathologic features. The biology driving this aggressive disease has yet to be defined," investigators in the United States report (see also Breast Cancer). ...
Research results from P. Abboud and colleagues update understanding of breast cancer.(Report)
Sep 02, 2008 ... "This study was designed to evaluate a cell proliferation marker, including the percentage of cycling cells (MIB1), and the duration of the cell cycle (assessed by argyrophilic nucleolar organizer regions proteins [AgNORs]measurement). We included 90 patients with invasive node-negative ...