Cancer Weekly back issues from December 2008:
New Patient Study Suggests Siemens Non-Invasive Blood Test May Have a Role in Monitoring Breast Cancer Patients' Response to Herceptin* (trastuzumab) Therapy.
Dec 02, 2008 ... Siemens Healthcare (www.siemens.com/diagnostics) announced that data from a new study published in the American Cancer Society journal Cancer, supports using the Siemens Serum HER-2/neu test to monitor patients with an aggressive type of metastatic breast cancer. This non-invasive blood ...
Studies from J. Fourcade and co-authors have provided new information about cancer vaccines.
Dec 02, 2008 ... According to recent research from the United States, "Analog peptides represent a promising tool to further optimize peptide-based vaccines in promoting the expansion of tumor antigen-specific cytotoxic T lymphocytes. Here, we report the results of a pilot trial designed to study the ...
Study findings on cancer vaccines are outlined in reports from K. Kronenberger and colleagues.
Dec 02, 2008 ... According to recent research from Munich, Germany, "B cell-derived chronic lymphocytic leukemia (CLL) is an incurable disease that requires innovative therapeutic regimens. Experimental approaches of immunotherapy aiming at induction of systemic T-cell responses have been developed." ...
Rexin-G Controls Tumor Growth and Improves Survival in Chemotherapy-Resistant Soft Tissue Sarcoma and Osteosarcoma: Phase I/II & Confirmatory Phase II Studies.
Dec 02, 2008 ... Epeius Biotechnologies announced the results of Phase I/II and II studies of Rexin-G in chemotherapy-resistant metastatic soft tissue sarcoma and osteosarcoma, as presented by Dr. Sant P. Chawla, principal investigator, at the CTOS 14th annual meetings held in London UK on November 13-15, ...
Research findings from Mayo Clinic update understanding of life sciences.(Report)
Dec 02, 2008 ... According to a study from the United States, "Lymphocyte differentiation from naive CD4(+) T cells into mature Th1, Th2, Th17, or T regulatory cell (Treg) phenotypes has been considered end stage in character. In this study, we demonstrate that dendritic cells (DCs) activated with a novel ...
New adenocarcinoma findings from Technical University of Munich described.
Dec 02, 2008 ... "Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with an innate resistance to therapy. Pancreatic stellate cells (PSCs) produce this excessively desmoplastic microenvironment," scientists in Munich, Germany report (see also Adenocarcinoma). "The impact of ...
Research data from R.L. Barclay and colleagues update understanding of adenoma.
Dec 02, 2008 ... "Screening colonoscopy can prevent cancer by removal of adenomatous polyps. Recent evidence suggests that insufficient time for inspection during overly rapid colonoscope withdrawal may compromise adenoma detection," scientists in the United States report (see also Adenoma). ...
Studies from E.S. Cankurtaran and co-researchers yield new data on anxiety disorders.(Report)
Dec 02, 2008 ... "Goals of the work This study aimed to compare the effectiveness of mirtazapine and imipramine on not only the distressing symptoms of cancer patients such as pain, nausea, vomiting, appetite loss, and sleep disturbances but also depressive and anxiety symptoms. Materials and methods ...
Research from C. Chu and co-authors provides new data about apoptosis.
Dec 02, 2008 ... According to a study from the United States, "Addition of a 5' cap to RNA polymerase II transcripts, the first step of pre-mRNA processing in eukaryotes from yeasts to mammals, is catalyzed by the sequential action of RNA triphosphatase, guanylyltransferase, and (guanine-N-7) ...
Research on apoptosis reported by D.M. Kuang et al.
Dec 02, 2008 ... According to recent research from Guangzhou, People's Republic of China, "Defects in the CD3/TCR complex and impairment of T cell function are necessary for tumor evasion, but the underlying mechanisms are incompletely understood. We found that culture supernatants from several types of ...
Researchers from Rockefeller University describe findings in apoptosis.
Dec 02, 2008 ... "The proapoptotic factors Reaper, Hid, Grim, and Sickle regulate apoptosis in Drosophila by inhibiting the antiapoptotic factor DIAP1 (Drosophila inhibitor of apoptosis 1). Heat, UV light, x-rays, and developmental signals can all increase the proapoptotic factors, but the control of ...
Research from University of Florence yields new data on basal cell cancer.
Dec 02, 2008 ... According to a study from Florence, Italy, "Basal cell carcinoma is the most common skin tumor in humans which can be removed in a variety of ways (depending on the type of the lesion, the affected area, and depth of the lesion). Laser therapy offers another option to the traditional ...
Research findings from University of Minnesota update understanding of biopsy.
Dec 02, 2008 ... According to a study from the United States, "Isolated rib lesions detected on bone scanning can pose a diagnostic challenge, particularly in patients with a known primary cancer. The purpose of our study was to assess the diagnostic value of radionuclide-guided rib biopsy with an ...
Study results from University of Aberdeen, Medical Department broaden understanding of heterotopic ossification.(Report)
Dec 02, 2008 ... According to a study from Scotland, "During a study of bone mineral density changes around cemented femoral implants, we recognized heterotopic ossification occurring regularly in a position anterior to the greater trochanter and proximal femur. The aim of this study was to describe the ...
Data on BMC cancer published by researchers at University of Munich.
Dec 02, 2008 ... According to recent research from Munich, Germany, "The intermediate filament forming protein keratin 8 (K8) is a tumour-associated antigen, which was shown to be over-expressed in a variety of malignancies. Here, we present a study of K8 expression in squamous epithelia of the head and ...
Study results from D.A. Campanacci and colleagues broaden understanding of bone cancer.
Dec 02, 2008 ... "Treatment of distal tibial tumors is challenging due to the scarce soft tissue coverage of this area. Ankle arthrodesis has proven to be an effective treatment in primary and post-traumatic joint arthritis, but few papers have addressed the feasibility and techniques of ankle arthrodesis ...
Study findings on brachytherapy are outlined in reports from RWTH Aachen University.
Dec 02, 2008 ... In this recent report, researchers in Aachen, Germany conducted a study "To evaluate seed displacements after permanent prostate brachytherapy considering different prostate Levels. In 61 patients, postimplant CT scans were performed 1 day and 1 month after an implant with stranded seeds." ...
Recent studies from University of Regensburg add new data to brain cancer.
Dec 02, 2008 ... In this recent study, researchers in Regensburg, Germany conducted a study "To demonstrate the feasibility of a biologically adapted dose-escatation approach to brain tumors. Due to the specific accumulation of fluoroethyltyrosine (FET) in brain tumors, F-18-FET-PET imaging is used to ...
Findings from R.A. Olson and co-researchers advance knowledge in brain metastasis.(Report)
Dec 02, 2008 ... "Goal of work Detection of cognitive impairment in patients with brain metastases is important for both patient management and clinical trials. The most commonly used cognitive screen, the Mini Mental State Examination (MMSE), though convenient, is not sensitive in these patients," ...
Findings from Erasmus University in breast cancer reported.
Dec 02, 2008 ... "Breast cancer accounts for over 20% of all female cancers. A positive family history remains one of the most important risk factors for the disease, with first-degree relatives of patients having a twofold elevated risk," investigators in Netherlands report (see also Breast Cancer). ...
Findings from National Cancer Institute advance knowledge in breast cancer.(Clinical report)
Dec 02, 2008 ... "Most risk factors for male breast cancer have been derived from retrospective studies that may reflect selective recall. In the prospective National Institutes of Health AARP Diet and Health Study, we studied 324 920 men, among whom 121 developed breast cancer," scientists in the United ...
Findings from University of Texas broaden understanding of breast cancer.
Dec 02, 2008 ... According to a study from the United States, " Tamoxifen's effect of reducing the risk of estrogen receptor (ER)-positive breast cancer is well established. Its effect on the time to first diagnosis of breast cancer has not been reported." "We used information from the ...
Investigators at University of Dundee have published new data on breast cancer.
Dec 02, 2008 ... "As the prevalence of breast cancer increases, survival improves and short stay or outpatient care become the norm, greater numbers of men will be involved in providing care and support for their partners at home. This qualitative study explored the experiences of 26 male partners of women ...
New breast cancer findings from Linkoping University described.
Dec 02, 2008 ... "The guideline for postmastectomy radiotherapy (PMRT), which is prescribed to reduce recurrence of breast cancer in the chest wall and improve overall survival, is not always followed. Identifying and extracting important patterns of non-compliance are crucial in maintaining the quality of ...
New breast cancer research from Erasmus University described.(Report)
Dec 02, 2008 ... "In this study, we quantified 249 mature micro-RNA (miRNA) transcripts in estrogen receptor-positive (ER+) primary breast tumors of patients with lymph node-negative (LNN) disease to identify miRNAs associated with metastatic capability. In addition, the prognostic value of the candidate ...
New breast cancer research has been reported by scientists at Dalhousie University, Medical Department.(Report)
Dec 02, 2008 ... "Carboxypeptidase-D (CPD) and carboxypeptidase-M (CPM) release C-terminal arginine (Arg) from polypeptides, and both are present in the plasma membrane. Cell-surface CPD increases intracellular Arg, which is converted to nitric oxide ( NO)," investigators in Halifax, Canada report (see ...
New breast cancer study findings recently were published by C. Dewolf and co-researchers.
Dec 02, 2008 ... According to recent research from Netherlands, "We have studied the potential contribution of ABCG2 (breast cancer resistance protein) to resistance to nucleoside analogues. In cells transfected with DNA constructs resulting in overexpression of human or mouse ABCG2, we found resistance ...
Reports from Baylor College of Medicine, College of Medicine add new data to research in breast cancer.
Dec 02, 2008 ... According to a study from the United States, "Interactions between mitochondrial deoxyribonucleic acid (mtDNA) variants and the risk of developing breast cancer were investigated using DNA samples collected from non-Jewish European American breast cancer patients and ethnically age-matched ...
Reports from University Hospital add new data to research in breast cancer.(Report)
Dec 02, 2008 ... According to recent research from the United States, "Although sentinel lymph node (SLN) biopsy is the standard technique for staging the axilla of clinically node-negative breast cancer, the optimal number of radioactive SLNs to remove to ensure accuracy and minimize morbidity is still ...
Reports from University of Gothenburg highlight recent research in breast cancer.
Dec 02, 2008 ... According to a study from Gothenburg, Sweden, "It is of great significance to find better markers to correctly distinguish between high-risk and low-risk breast cancer patients since the majority of breast cancer cases are at present being overtreated. 46 tumours from node-negative breast ...
Reports outline breast cancer study results from Rush University.(Report)
Dec 02, 2008 ... According to recent research published in the journal Surgery, "Isosulfan Blue dye (BD) allergic drug reactions (ADR) occur in up to 2% of patients undergoing SLN biopsy (SLNB). We sought to determine if BD enhances the performance of SLNB such that this risk is justified." "A ...
Research conducted at S. Dellapasqua and co-researchers has updated our knowledge about breast cancer.
Dec 02, 2008 ... According to a study from Milan, Italy, " Metronomic chemotherapy has shown efficacy in patients with metastatic breast cancer. When used in association with targeted antiangiogenic drugs, it was more active than metronomic therapy alone in preclinical and clinical studies." ...
Research from Kwandong University, Medical Department yields new findings on breast cancer.(Report)
Dec 02, 2008 ... "We performed this study to evaluate the chronological changes in Korean breast cancer characteristics and reproductive factors from 1996 to 2006. We analyzed the chronological changes among newly diagnosed primary breast cancer patients recruited at 102 general hospitals," scientists in ...
Research from University of Nancy provides new data on breast cancer.
Dec 02, 2008 ... According to recent research from France, "Generalized skin sensitization is a main drawback of photodynamic therapy with systemic administration of photosensitizers. We have evaluated the potential use of an intratumoral injection of a liposomal formulation of mTHPC (Foslip) in a mouse ...
Research from University of Naples reveals new findings on breast cancer.
Dec 02, 2008 ... According to recent research from Naples, Italy, "Overexpression of the ErbB2 receptor is associated with the progression of breast cancer, and is a sign of a poor prognosis. Herceptin, a humanized antibody directed to the ErbB2 receptor, has been proven to be effective in the ...
Research on breast cancer described by scientists at Shinshu University, Medical Department.(Report)
Dec 02, 2008 ... According to recent research from Asahi, Japan, "Breast-conserving surgery (BCS) has been carried out as desirable choice for patients with early-stage breast cancer. However, many patients obliged to abandon BCS because of tumours accompanied by extended intraductal components or multiple ...
Research on breast cancer discussed by scientists at New York University, Medical Department.(Report)
Dec 02, 2008 ... "Recruitment of effector T cells to inflamed peripheral tissues is regulated by chemokines and their receptors, but the factors regulating recruitment to tumors remain largely undefined. Ionizing radiation (IR) therapy is a common treatment modality for breast and other cancers," ...
Research reports from University of Montreal provide new insights into osteoarthritis.
Dec 02, 2008 ... "Overproduction of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) plays an important role in the pathogenesis of osteoarthritis (OA). In the present study. we determined the effect of trichostatin A (TSA) and butyric acid (BA), two histone deacetylase (HDAC) inhibitors, on NO and PGE2 ...
Researchers from Baylor College of Medicine, College of Medicine report details of new studies and findings in the area of breast cancer.
Dec 02, 2008 ... According to a study from the United States, "Amplified-in-breast cancer 1 (AIB1) is an overexpressed transcriptional coactivator in breast cancer. Although overproduced AIB1 is oncogenic, its role and underlying mechanisms in metastasis remain unclear." "Here, mammary ...
Researchers from University of Oxford discuss findings in breast cancer.(Clinical report)
Dec 02, 2008 ... " Active smoking has little or no effect on womens risk of developing breast cancer, but it has been suggested that passive exposure to tobacco smoke may increase this risk among women who have never smoked. To evaluate the possible relationship between passive smoking and breast cancer ...
Researchers' work from University of Washington focuses on breast cancer.
Dec 02, 2008 ... "We sought to (1) describe associations between measures of tumor perfusion by dynamic contrast-enhanced breast magnetic resonance imaging (DCE-MRI), blood flow by O-15-water positron emission tomography (PET) and metabolism by F-18-fluorodeoxyglucose (F-18)-FDG PET and (2) improve our ...
Scientists at Nanyang Technological University discuss research in breast cancer.(Report)
Dec 02, 2008 ... According to a study from Singapore, Singapore, "Tetratricopeptide repeat domain 9A (TTC9A) protein is a recently identified protein which contains three tetratricopeptide repeats (TPRs) on its C-terminus. In our previous studies, we have shown that TTC9A was a hormonally-regulated gene in ...
Scientists at University of Leuven target breast cancer.
Dec 02, 2008 ... According to recent research from Louvain, Belgium, " This phase III randomized open-label clinical trial was designed to evaluate the efficacy and safety of the steroidal aromatase inactivator exemestane versus the antiestrogen tamoxifen as first-line treatment for metastatic breast ...
Scientists at University of Santiago report research in breast cancer.
Dec 02, 2008 ... According to a study from Spain, " Breast cancer is one of the leading causes of mortality among women. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with reduced risk for breast cancer, but results from these studies of the association have been inconsistent." ...
Studies from F. Leelin et al in the area of breast cancer described.
Dec 02, 2008 ... "Disparities in breast cancer outcomes persist among Asian American women. Breast cancer is the most commonly diagnosed cancer among Chinese American women," investigators in the United States report (see also Breast Cancer). "This article describes the psychometric evaluation ...
Studies from G.K. Ellis and co-authors have provided new information about breast cancer.
Dec 02, 2008 ... According to a study from the United States, " Adjuvant aromatase inhibitor therapy is well established in postmenopausal women with hormone receptor-positive breast cancer, but such therapy is complicated by accelerated bone loss and increased fracture risk. We investigated the ability of ...
Studies from S. Dawood and co-researchers yield new data on breast cancer.(Report)
Dec 02, 2008 ... " Overall, breast cancer mortality has been declining in the United States, but survival studies of patients with stage IV disease are limited. The aim of this study was to evaluate trends in and factors affecting survival in a large population-based cohort of patients with newly diagnosed ...
Study findings from University of Louvain provide new insights into breast cancer.
Dec 02, 2008 ... " Polysomy 17 is frequently found in breast cancer and may complicate the interpretation of HER-2 testing results. We investigated the impact of polysomy 17 on HER-2 testing and studied its clinicopathologic significance in relation to HER2 gene amplification," researchers in Louvain, ...
Data from J.D. Keen et al provide new insights into breast cancer screening.
Dec 02, 2008 ... "In order to promote consumer- oriented informed medical decision- making regarding screening mammography, we created a decision model to predict the age dependence of the cancer detection rate, the recall rate and the secondary performance measures (positive predictive values, total ...
Data from Ondokuz Mayis University, Nursing Department advance knowledge in breast cancer screening.
Dec 02, 2008 ... "The second leading cause of cancer death in Turkey, breast cancer accounts for 24% of female cancers, with a crude incidence rate of 7.2 per 100,000 women in 1999. It was determined that breast self-examination (BSE) is carried out effectively if it is taught by a physician or a ...
Findings from P.J. Campbell and co-authors provide new insights into cancer.
Dec 02, 2008 ... According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "During the clonal expansion of cancer from an ancestral cell with an initiating oncogenic mutation to symptomatic neoplasm, the occurrence of somatic ...
Findings in cancer reported from K.L. Gorringe and co-researchers.
Dec 02, 2008 ... According to a study from Melbourne, Australia, "High-resolution techniques for analysis of genome copy number (CN) enable the analysis of complex cancer somatic genetics. However, the analysis of these data is difficult, and failure to consider a number of issues in depth may result in ...
New cancer research from L. Tessonnier et al outlined.
Dec 02, 2008 ... According to recent research from Marseille, France, " The widespread use of high-resolution cross-sectional imaging such as computed tomography (CT) and magnetic resonance imaging (MRI) for the investigation of the abdomen is associated with an increasing detection of incidental adrenal ...
New cancer study findings have been reported by H. Wang and colleagues.
Dec 02, 2008 ... "Fenretinide [N-(4-hydroxyphenyl)retinamide (4-HPR)] is cytotoxic in many cancer cell types. Studies have shown that elevation of ceramide species plays a role in 4-HPR cytotoxicity," scientists in the United States report (see also Cancer). "To determine 4-HPR activity in a ...
Reports from G. Sanclemente and co-researchers add new data to research in cancer.
Dec 02, 2008 ... According to a study from Medellin, Colombia, "Sun exposure and skin phototype are the most relevant risk factors for skin cancer. Colombia has high levels of ultraviolet radiation during the whole year, therefore, both, high UVI's and outdoor worker's daily activities, in our country are ...
Reports from University of Manitoba highlight recent research in cancer.
Dec 02, 2008 ... According to a study from Winnipeg, Canada, "Prostate cancer is the second most common type of cancer in men living in the United States and the most common type of malignancy in Canadian men, accounting for 186,320 new cases in the United States and 24,700 in Canada in 2008." ...
Reports on cancer findings from Johann Wolfgang Goethe University provide new insights.
Dec 02, 2008 ... "Despite the improvements in cancer therapy during the past years, high-grade gliomas and many other types of cancer are still extremely resistant to current forms of therapy. Boron neutron capture therapy (BNCT) provides a promising way to destroy cancer cells without damaging healthy ...
Reports outline cancer research from M. Sanchezcespedes and colleagues.(Report)
Dec 02, 2008 ... "Context.-The development of targeted therapies creates a need to accurately classify tumors. Among the more pressing needs are the identification of the complete catalog of genes that are altered in cancer and the accurate discrimination of tumors based on their genetic background," ...
Research conducted at A.J. Folkes and co-researchers has updated our knowledge about cancer.
Dec 02, 2008 ... According to a study from Slough, the United Kingdom, "Phosphatidylinositol-3-kinase (PI3K) is an important target in cancer due to the deregulation of the PI3K/Akt signaling pathway in a wide variety of tumors." "A series of thieno[3.2-d]pyrimidine derivatives were prepared ...
Research from University of Ulm reveals new findings on cancer.
Dec 02, 2008 ... " Adenocarcinomas of the pancreas are characterized by a rapid progression, an early metastasis, a limited response to chemo- and radiotherapy, and an intense fibrotic reaction known as tumor desmoplasia. Carcinoma cells are surrounded by a dense stroma consisting of myofibroblast-like ...
Research reports from Duke University provide new insights into cancer.
Dec 02, 2008 ... "Nutritional care is an integral component of quality cancer treatment. Patients undergoing cancer therapy are at risk for developing a variety of side effects that impact their intake, absorption, and nutritional status," scientists writing in the Clinical Journal of Oncology Nursing ...
Research reports from F. Bailey and co-authors provide new insights into cancer.
Dec 02, 2008 ... According to recent research published in the journal Palliative Medicine, "Cyclizine is an antihistamine, which is frequently used to manage nausea and vomiting in cancer patients." "Antihistamines can be drugs of misuse/abuse, and the article describes four cancer patients who ...
Researchers from Innsbruck Medical University detail new studies and findings in the area of cancer.
Dec 02, 2008 ... According to a study from Innsbruck, Austria, "Although several epidemiologic studies have shown that gamma-glutamyltransferase (GGT) is associated with cardiovascular disease and all-cause mortality, its relationship with cancer incidence remains widely unexplored. In experimental models ...
Researchers from Oxford Outcomes Ltd. provide details of new studies and findings in the area of cancer.(Report)
Dec 02, 2008 ... "Fatigue is recognized as the most serious complication of chemotherapy for the majority of patients. This study aims to determine preferences and utility values for health state descriptions of anemia associated with cancer treatment," scientists writing in the journal Value in Health ...
Researchers from University of Stirling report on findings in cancer.
Dec 02, 2008 ... According to a study from Scotland, "Many people diagnosed with cancer will receive chemotherapy as a core component of their care." "Recent changes in the delivery of cancer services mean that patients frequently receive care on an out-patient basis and are therefore often ...