Cancer Weekly back issues from March 2009:
Newly discovered gene could be a prime target in the most lethal brain cancer.
Mar 03, 2009 ... Scientists at Duke University Medical Center and Johns Hopkins University have discovered mutations in two genes that could become therapeutic targets in malignant glioma, a dangerous class of brain tumors (see also Duke University Medical Center). "The fact that the defective ...
Nothin' but Try: the Shane Drury Story - Inspirational New Biography Pays Loving Tribute to Professional Bull Rider Shane Drury.
Mar 03, 2009 ... In his new book, "Nothin' But Try: The Shane Drury Story" (published by AuthorHouse), Tall Paul sets out to chronicle the life and times of his son, professional bull rider Shane Drury (1979-2006), combining detailed, illuminating biographical information with loving tributes to the ...
Agendia Publishes Direct Evidence That MammaPrint Predicts Benefit of Chemotherapy in Breast Cancer.
Mar 03, 2009 ... Agendia, a world leader in molecular cancer diagnostics, announced that a study demonstrating the direct predictive ability of its breast cancer recurrence test, MammaPrint(R), has been published in Breast Cancer Research and Treatment. Additionally, the study authors have been invited to ...
New cancer gene therapy study findings reported from Virginia Commonwealth University, Medical Department.
Mar 03, 2009 ... According to recent research from the United States, "We describe a novel basic leucine zipper containing type I IFN-inducible early response gene SARI (Suppressor of AP-1, Regulated by IFN). Steady-state SARI mRNA expression was detected in multiple lineage-specific normal cells, but not ...
New research on cancer gene therapy from Technical University summarized.
Mar 03, 2009 ... "Recent studies demonstrate that recombinant adeno-associated virus (rAAV)-based antigen loading of dendritic cells (DCs) generates, in vitro, significant and rapid cytotoxic T-lymphocyte (CTL) responses against viral antigens. We used the rAAV system to induce specific CTLs against tumor ...
Pro-Pharmaceuticals Postpones Rights Offering.(Report)
Mar 03, 2009 ... Pro-Pharmaceuticals, Inc. (OTCBB: PRWP) (the "Company"), announced that it has postponed its previously announced rights offering. Subject to market conditions, the Company will determine whether it will proceed with the rights offering after it files its Annual Report on Form 10-K with ...
University Clinic Heidelberg Explores Advanced TomoTherapy[R] Delivery Technique.
Mar 03, 2009 ... TomoTherapy Incorporated (NASDAQ: TOMO) announced that research partner University Clinic Heidelberg, Germany, has demonstrated the ability to dramatically reduce treatment times for the TomoTherapy[R] Hi*Art[R] system, while at the same time improving plan quality by further reducing ...
New adenocarcinoma data have been reported by L. Egevad and co-authors.
Mar 03, 2009 ... "This report presents two cases of urachal signet-cell adenocarcinoma (USCA). Two men, aged 53 and 51 years, presented with haematuria," investigators in Lyon, France report (see also Adenocarcinoma). "Cystoscopy showed tumours in the dome of the bladder and transurethral ...
New adenocarcinoma research reported from N. Nose and co-authors.(Report)
Mar 03, 2009 ... According to recent research from Kitakyushu, Japan, " Adenocarcinoma of the lung unrelated to a smoking habit occurs more frequently in women than men, thus suggesting an association between female hormones and development of these tumors. The aim of this study was to elucidate the ...
Research in the area of adenocarcinoma reported from K.J. Park and colleagues.(Report)
Mar 03, 2009 ... "Primary mucinous tumors of the female genital tract have morphologic features similar to primary gastrointestinal adenocarcinomas, and distinguishing these malignancies may be extremely difficult. The purpose of this study was to characterize the immunostaining patterns Of tumors of the ...
New adenoma data have been reported by A.K. Gupta and co-authors.
Mar 03, 2009 ... According to recent research from the United States, "Purpose of review There is a wealth of literature, both from epidemiological and molecular studies, which support the role of aberrant crypt foci (ACF) as a putative precursor to colorectal adenomas and a potential biomarker for ...
Study results from University of Milan update understanding of ameloblastic cancer.
Mar 03, 2009 ... "Ameloblastic carcinoma is a very rare malignant odontogenic neoplasm of the mandible and maxilla, accounting for some 66 reported cases. The case of a 68-year-old man who presented a fistula with orosinus communication of 14-year duration that, after anti-aggregant therapy, began bleeding ...
New findings from Aarhus University describe advances in anal cancer.(Report)
Mar 03, 2009 ... According to recent research from Aarhus, Denmark, "Salvage surgery of recurrent or persistent anal cancer following radiotherapy is often followed by perineal wound complications. We examined survival and perineal wound complications in anal cancer salvage surgery during a 10-year period ...
Study findings from Z. Ali et al provide new insights into anesthesia.
Mar 03, 2009 ... According to recent research published in the Journal of Neurosurgical Anesthesiology, "The main aims of anesthesia for pituitary surgery include maintenance of hemodynamic stability, provision of conditions that facilitate surgical exposure, and a smooth emergence to facilitate a prompt ...
Data on aneurysm detailed by S. Iltar and co-authors.
Mar 03, 2009 ... According to recent research published in the Journal of Foot & Ankle Surgery, "Aneurysmal bone cyst localized to the metatarsus, while not unheard of, is rather uncommon. The differential diagnosis for this lesion can be challenging, particularly in regard to the possibility of the ...
Reports on angiomyolipoma findings from Cleveland Clinic provide new insights.(Report)
Mar 03, 2009 ... "The purpose of this study was to determine whether counts of pixels with subzero attenuation on CT scans can aid in the diagnosis of renal angiomyolipoma with minimal fat. Of 33 angiomyolipomas identified among 719 renal masses resected from 702 patients over 4 years, 15 masses in 15 ...
Data on apoptosis reported by M. Barbera and co-researchers.(Clinical report)
Mar 03, 2009 ... According to a study from Cambridge, the United Kingdom, "In order to proliferate, solid tumours require the development and continuous expansion of an organised host-derived vascular network. The anti-vascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA),emerged as derivative of the ...
Research on apoptosis detailed by M. Tanaka and co-authors.
Mar 03, 2009 ... "During the process of tumor progression and clinical treatments, tumor cells are exposed to oxidative stress. Tumor cells are frequently resistant to such stress by producing antiapoptotic signaling, including activation of Src family kinases (SFKs), although the molecular mechanism is ...
Study data from K. Hormicarver and colleagues update understanding of apoptosis.
Mar 03, 2009 ... "Apoptosis is an important mechanism for maintaining tissue homeostasis and for preventing the proliferation of cells with mutations that could result in malignancy. Barrett's epithelium has been reported to be more resistant to apoptosis than normal esophageal squamous epithelium," ...
Study findings from University of California broaden understanding of apoptosis.
Mar 03, 2009 ... According to a study from the United States, "The intrinsic damage response is activated by DNA damage that arises during the cell division process. The ability of the cell to repair this damage during proliferation is important for normal cell growth and, when disrupted, may lead to ...
Data from University of Pisa provide new insights into astrocytoma.
Mar 03, 2009 ... According to recent research from Pisa, Italy, "Gliomas are the most common brain tumours with a poor prognosis due to their aggressiveness and propensity for recurrence. The 18 kDa translocator protein (TSPO) has been demonstrated to be greatly expressed in glioma cells and its ...
Research from M. Shirahata and colleagues provide new insights into astrocytoma.
Mar 03, 2009 ... According to recent research published in the journal Cancer Science, "Histopathological classification of gliomas is often clinically inadequate due to the diversity of tumors that fall within the same class. The goal of the present study was to identify prognostic molecular features in ...
Reports from Medical University of Graz advance knowledge in basal cell cancer.(Report)
Mar 03, 2009 ... According to recent research from Graz, Austria, "Superficial BCCs (sBCCs) usually appear as multiple lesions in chronic sun-damaged skin of elderly people and may show a destructive growth if left untreated. Non-invasive treatment modalities, such as cryotherapy have been employed for ...
Research from New York University has provided new data on prostate cancer.
Mar 03, 2009 ... In this recently published study, investigators in the United States conducted a study "To summarize the debate regarding use of intermittent androgen suppression therapy in the treatment of prostate cancer originally presented at the 2007 Spring Meeting of the Society of Urologic ...
Research from K.R.M. Leite and colleagues has provided new data on biopsy.
Mar 03, 2009 ... In this recent report, researchers in Sao Paulo, Brazil conducted a study "To determine the incidence of overestimation of Gleason score (GS) in extended prostate biopsy, and consequently circumventing unnecessary aggressive treatment. This is a retrospective study of 464 patients who ...
Research from University of Miami, Medical Department in the area of biopsy published.
Mar 03, 2009 ... According to recent research published in the journal Clinical Orthopaedics and Related Research, "The evaluation and treatment of aggressive bone tumors continue to be diagnostic and therapeutic challenges for orthopaedic surgeons. Despite compelling data regarding the hazards of biopsy, ...
Study findings from St. Helier Hospital provide new insights into biopsy.
Mar 03, 2009 ... According to a study from Carshalton, the United Kingdom, "Since their introduction in 2006, the tyrosine kinase inhibitors (TKI) Sunitinib and Sorafenib have become the standard of care for many patients with renal cancer." "They are generally well tolerated and have not been ...
Findings in bladder cancer reported from C.M. Villanueva and co-researchers.
Mar 03, 2009 ... "We evaluated the bladder cancer risk associated with coffee consumption in a case-control study in Spain and examined the gene-environment interactions for genetic variants of caffeine-metabolizing enzymes. The analyses included 1,136 incident cases with urothelial carcinoma of the ...
New bladder cancer study findings recently were reported by S.C. Larsson and co-researchers.
Mar 03, 2009 ... According to a study from Stockholm, Sweden, "High meat consumption could potentially increase the risk of bladder cancer, but findings from epidemiologic studies are inconsistent. We prospectively examined the association between meat intake and bladder cancer risk in a population-based ...
New bone cancer study results reported from S. Kapoor et al.
Mar 03, 2009 ... According to recent research from New Delhi, India, "Primary tumours and tumorous lesions of the clavicle are very rare, and little literature is available regarding their characteristics and outcome. We studied the clinical, radiological, and histopathological characteristics, and outcome ...
Findings from Harvard University provide new insights into brachytherapy.
Mar 03, 2009 ... In this recently published study, investigators in the United States conducted a study "To assess the radiation dose delivered to the heart and ipsilateral lung during accelerated partial breast brachytherapy using a MammoSite (TM) applicator and compare to those produced by whole breast ...
New brachytherapy data have been reported by T. Bolling and co-authors.
Mar 03, 2009 ... According to recent research from Munster, Germany, "Radiotherapy plays a pivotal role in tumor treatment. Brachytherapy as an additional radiation technique allows local dose increments in areas at high risk of local failure." "Our past 15-year experience with tissue-equivalent ...
New brain cancer study findings recently were published by researchers at University of Michigan.(Report)
Mar 03, 2009 ... "Differentiation between recurrent neoplasm and postradiation change in patients previously treated for primary brain tumors is often difficult based on imaging features alone. The purpose of this study was to develop a method using alterations in the ratios of standard brain ...
Investigators at Louisiana State University target brain metastasis.(Report)
Mar 03, 2009 ... According to a study from the United States, "The aim of this study was to analyze Our experience with stereotactic radiosurgery in the management of patients with brain metastases from radioresistant primary cancers. We retrospectively reviewed the clinical record of those patients for ...
Research from University of California in the area of brain metastasis described.
Mar 03, 2009 ... "In patients who undergo resection of central nervous system metastases, whole brain radiotherapy (WBRT) is added to reduce the rates of recurrence and neurologic death. However, the risk of late neurotoxicity has led many patients to decline WBRT," researchers in the United States report ...
Data on breast cancer described by researchers at University of Cincinnati, Medical Department.
Mar 03, 2009 ... According to recent research published in the journal Breast Cancer Research and Treatment, " Trastuzumab is a highly effective therapy for the treatment of HER-2/neu positive breast cancer. To maximize benefit and minimize unnecessary toxicity, patient selection is essential." ...
Data on breast cancer detailed by researchers at University of Washington.
Mar 03, 2009 ... According to recent research from the United States, "Of Recommendations: The EGAPP Working Group (EWG) found insufficient evidence to make a recommendation for or against the use of tumor gene expression profiles to improve outcomes in defined populations of women with breast cancer. For ...
Data on breast cancer discussed by researchers at Catholic University.(Report)
Mar 03, 2009 ... "Spinal metastatic disease is characterised by the preservation of the intervertebral disc structure, even after severe destruction of the vertebral body by neoplastic tissues. Anatomical features of the discs are thought to be the reason for the disc's resistance to metastatic cancer," ...
Findings from University of California broaden understanding of breast cancer.
Mar 03, 2009 ... "Four ''one-bead one-compound'' (OBOC combinatorial libraries were designed, synthesized, and screened against MDA-MB-231 breast cancer cells. A novel cyclic peptide 1 (LXY1) with high binding specificity C) C to 0 integrin was identified," scientists in the United States report (see also ...
Findings from University of Vermont in breast cancer reported.
Mar 03, 2009 ... "One might speculate that radiologists who enjoy mammography may exhibit better performance than radiologists who do not. AND MET HODS. One hundred thirty-one radiologists at three Breast Cancer Surveillance Consortium (BCSC) registries completed a survey about their characteristics, ...
Findings in breast cancer reported from Radboud University.
Mar 03, 2009 ... According to recent research published in the journal Biochemical and Biophysical Research Communications, "EFbB3 transactivation can make tumor cells resistance to ErbB1/ErbB2 targeting drugs." "This Urges for a reliable method to determine cell surface ErbB3 levels, but ill ...
Investigators at Duke University zero in on breast cancer.
Mar 03, 2009 ... According to recent research published in the journal Breast Cancer Research and Treatment, " To describe long-term results of a multimodality strategy for stage III breast cancer utilizing neoadjuvant doxorubicin followed by mastectomy, CMF, and radiotherapy. Patients and methods Women ...
Investigators at McGill University target breast cancer.
Mar 03, 2009 ... "Cancer cells with stem cell-like properties (cancer stem cells) are believed to drive cancer and are associated with poor prognosis," scientists writing in the Journal of Cell Science report (see also Breast Cancer). "Data from mouse models have demonstrated that integrins, the ...
New breast cancer findings from University of Nottingham published.
Mar 03, 2009 ... " There are trials comparing different neoadjuvant chemotherapy regimens for locally advanced primary breast cancer (LAPC). Few studies have evaluated alternative therapeutic approaches towards LAPC," researchers in Nottingham, the United Kingdom report (see also Breast Cancer). ...
New breast cancer research from M. Jannuzzo et al outlined.
Mar 03, 2009 ... " Luteinizing hormone-releasing hormone (LHRH) agonists (e.g., triptorelin) reduce ovarian estrogen production in premenopausal women with hormone-sensitive breast cancer. Aromatase inhibitors (e.g., exemestane) inhibit extraovarian production of estrogen and may further reduce circulating ...
New breast cancer study findings have been reported by N. Patani and co-researchers.(Report)
Mar 03, 2009 ... According to a study from London, the United Kingdom, "Osteopontin (OPN) overexpression in breast cancer has been associated with adverse pathological and clinical outcomes. In this study, the OPN expression profiles were examined in a cohort of breast cancer patients." "RNA ...
New breast cancer study findings have been reported by researchers at Harvard University.
Mar 03, 2009 ... "Oxidative stress may be involved in breast carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS)," investigators in the United States report (see also Breast Cancer). "A single nucleotide polymorphism (SNP) G-463A in ...
New breast cancer study findings have been reported by researchers at University of California.
Mar 03, 2009 ... "Specific inhibitors of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) have been developed that efficiently inhibit the oncogenic RAF-MEK-ERK pathway. We used a systems-based approach to identify breast cancer subtypes particularly susceptible to ...
New breast cancer study findings reported from T. Shien and co-authors.
Mar 03, 2009 ... "Neoadjuvant chemotherapy (NAC) is increasingly used for operable disease. However there are several pathological response classification systems and the correlation between the pathological response to NAC according to each system and the patient outcome is still under debate," ...
New breast cancer study results from University of Santiago described.
Mar 03, 2009 ... "A polygenic model has been proposed in order to explain the genetic susceptibility to sporadic breast cancer. According to this model, common population variants Would be responsible for low to modest effects on the risk of developing the disease," researchers in La Coruna, Spain report ...
New data from Nagoya University illuminate research in breast cancer.
Mar 03, 2009 ... According to a study from Nagoya, Japan, "We investigated the role of Nek2, a member of the serine-threonine kinase family, in the tumorigenic growth of breast carcinoma. Increased expression of Nek2 was observed in all breast carcinoma cell lines examined (BT20, BT474, Hs578T, MCF7, ...
New data from University of British Columbia illuminate research in breast cancer.
Mar 03, 2009 ... In this recent report, researchers in Victoria, Canada conducted a study "To evaluate locoregional recurrence according to nodal status in women with T1 to T2 breast cancer and zero to three positive nodes (0-3N+) treated with breast-conserving surgery (BCS;). The study subjects comprised ...
New findings from E. Campora and co-authors in the area of breast cancer published.
Mar 03, 2009 ... "Docetaxel is the most active agent for metastatic breast cancer, but the optimal treatment regimen as a single agent has yet to be defined. Two consecutive monocentric phase II trials of docetaxel in metastatic breast cancer were carried out," investigators in Imperia, Italy report (see ...
New findings from J.S. The and co-researchers in the area of breast cancer described.(Report)
Mar 03, 2009 ... According to a study from the United States, "The purpose of this study was to evaluate computer-aided detection (CAD) performance with full-field digital mammography (FFDM). CAD (Second Look, version 7.2) was used to evaluate 123 cases of breast cancer detected with FFDM (Senographe DS)." ...
New findings in breast cancer described by J.S. Kang and co-researchers.
Mar 03, 2009 ... According to recent research from South Korea, "Breast cancer is one of the most frequent female cancers in the Western world. Perturbation of estrogen levels by hormone replacement therapy or pregnancy is associated with a variety of diseases, including breast cancer." ...
Recent findings from Fudan University highlight research in breast cancer.
Mar 03, 2009 ... "Gene expression data has in recent years demonstrated the superior capacity to predict the prognosis of breast cancer patients unreceiving adjuvant chemotherapy comparing to the information available from traditional clinical and pathological sources. Meanwhile, adjuvant chemotherapy can ...
Recent findings in breast cancer described by L. Bucchi and colleagues.
Mar 03, 2009 ... According to recent research from Forli, Italy, " Few studies have compared screen-detected (SD) breast cancer patients with symptomatic patients for the frequency and determinants of receipt of adjuvant systemic therapy according to accepted guidelines. Depending on the date of ...
Recent findings in breast cancer described by researchers from University of Toronto.
Mar 03, 2009 ... "Most of the breast cancer susceptibility genes identified to date are involved in DNA repair, including BRCA1, BRCA2, PALB2, CHEK2 and BRIP1. RAP80 works upstream of BRCA1 and is essential for the localization of BRCA1 to the site of damaged DNA," investigators in Toronto, Canada report ...
Reports from Erasmus University add new data to research in breast cancer.(Report)
Mar 03, 2009 ... " Two genes, TSC22 domain family, member 1 (TSC22D1) and prosaposin (PSAP) were identified in an in vitro functional screen for genes having a causative role in tamoxifen resistance. These genes were also present in our previously established 81-gene signature for resistance to first-line ...
Reports from New York University add new data to research in breast cancer.
Mar 03, 2009 ... According to a study from the United States, "Information is lacking regarding the interaction of established breast cancer risk factors and patient age. We attempted to study this interaction in high-risk women at the extremes of age in our population." "The Women-At-Risk ...
Reports from O. Gentilini and co-researchers add new data to research in breast cancer.
Mar 03, 2009 ... According to a study from Milan, Italy, " Many physicians recommend mastectomy in case of multifocal (MF) or multicentric (MC) breast cancer due to a theoretical risk of poor local control with less extensive surgery. We retrospectively evaluate outcome of patients with MF/MC cancers who ...
Reports on breast cancer findings from University of Washington provide new insights.(Report)
Mar 03, 2009 ... "The human breast cancer resistance protein (BCRP/ABCG2) mediates efflux of drugs and organic anions across the plasma membrane. Hydropathy analysis suggests that BCRP consists of a nucleotide-binding domain (residues similar to 1-395) and a membrane-spanning domain (MSD) (residues similar ...
Reports summarize breast cancer research from Vanderbilt University.
Mar 03, 2009 ... "Green tea is a commonly consumed beverage in China. Epidemiological and animal data suggest tea and tea polyphenols may be preventive against various cancers, including breast cancer," researchers in the United States report (see also Breast Cancer). ...
Research conducted at R.L. Jones and co-authors has provided new information about breast cancer.
Mar 03, 2009 ... "Accelerated (dose-dense) chemotherapy, in which the frequency of administration is increased without changing total dose or duration, may increase the efficacy of cancer chemotherapy. We performed a randomised Phase II study to assess the safety and relative toxicity of AC (doxorubicin; ...
Research conducted at University of Florence has updated our knowledge about breast cancer.
Mar 03, 2009 ... In this recent article published in the International Journal of Radiation Oncology Biology Physics, scientists in Florence, Italy conducted a study "To analyze the relationship between a delay in radiotherapy (RT) after breast-conserving surgery and ipsilateral breast recurrence (BR). We ...