Cancer Weekly back issues from June 2009:
Allos Therapeutics Announces Updated Data from Pivotol Phase 2 PROPEL Study of Pralatrexate to be Presented at ASCO 2009.
Jun 02, 2009 ... Allos Therapeutics, Inc. (Nasdaq: ALTH) announced that updated data from its pivotal Phase 2 PROPEL study of pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma will be presented at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO) to ...
Concordia Pharmaceuticals Reports Encouraging Clinical Data in Patients with K-Ras Mutations Treated with First-in-Class Ras Antagonist, Salirasib.
Jun 02, 2009 ... Concordia Pharmaceuticals reported encouraging new clinical data for salirasib, its novel small-molecule direct Ras antagonist, from two ongoing clinical trials - one in patients with advanced pancreatic cancer, and another in patients with advanced non-small cell lung cancer (NSCLC). The ...
deCODE Study Shows Complex Interplay of the Human Biological Clock With Height, Weight and Disease.
Jun 02, 2009 ... In a paper published in the online edition of Nature Genetics, scientists from deCODE genetics (Nasdaq:DCGN) and academic colleagues from Iceland, Denmark and the Netherlands present the discovery of single letter variations in the sequence of the human genome (SNPs) that influence the age ...
Spectrum Pharmaceuticals to Present at the Eighth Annual JMP Securities Research Conference.(Conference news)
Jun 02, 2009 ... Spectrum Pharmaceuticals, Inc. (NasdaqGM: SPPI), a commercial-stage biotechnology company with a focus in oncology, announced that an overview of the Company's business strategy will be presented at the 8th Annual JMP Securities Research Conference on May 20, 2009 at 1:00 p.m. Pacific. The ...
Data on cancer gene therapy discussed by researchers at University of Alabama, Gene Therapy Center.
Jun 02, 2009 ... A report, 'Armed replicating adenoviruses for cancer virotherapy,' is newly published data in Cancer Gene Therapy. According to a study from the United States, "Conditionally replicating adenoviruses (CRAds) have many advantages as agents for cancer virotherapy and have been safely used in ...
Studies from H. Gerullis et al further understanding of adverse drug reactions.
Jun 02, 2009 ... According to recent research published in the journal Cancer Chemotherapy and Pharmacology, " To detail tolerance of temsirolimus in a routine practice setting within a compassionate use program for patients with renal cell carcinoma. We treated 32 patients with advanced renal cell ...
New Alzheimer disease research has been reported by scientists at University of Leuven.
Jun 02, 2009 ... According to a study from Louvain, Belgium, "The gamma-secretase complex plays a role in Alzheimer's disease and cancer progression. The development of clinically useful inhibitors, however, is complicated by the role of the gamma-secretase complex in regulated intramembrane proteolysis of ...
Researchers from Medical University of Innsbruck report on findings in amyloidosis.
Jun 02, 2009 ... According to recent research from Innsbruck, Austria, "A patient who presented with dyspnea and suspected interstitial pulmonary fibrosis suffered a fatal pulmonary haemorrhage with no feasible cause for bleeding. Autopsy revealed abundant amyloid deposits in both lungs with a diffuse ...
Recent findings from University of Zurich highlight research in anesthesia.
Jun 02, 2009 ... According to recent research from Zurich, Switzerland, "Movements of the liver caused by spontaneous breathing (during sedation or local anaesthesia) or by ventilation during anaesthesia are a source of concern in CT-guided procedures because of the limited spatial and contrast resolution ...
Research results from A.M. Priola and colleagues update understanding of angiomyolipoma.
Jun 02, 2009 ... "Perivascular epithelioid cell (PEC) tumors (or PEComas) are myomelanocytic lesions defined by coexpression of melanocytic and muscle markers, suggesting dual differentiation. They are rare mesenchymal tumors and include subtypes with distinct clinical features: angiomyolipoma, ...
Research reports on aortic stenosis from M. Halleck and colleagues provide new insights.
Jun 02, 2009 ... "Ezetimibe blocks intestinal absorption of sterols via interaction with the Neimann-Pick C1-Like 1 (NPC1L1) transporter and is approved for use in the treatment of primary hyperlipidemia (heterozygous familial and non-familial), homozygous familial hypercholesterolemia, and homozygous ...
Researchers from Medical University of Vienna detail findings in apoptosis.
Jun 02, 2009 ... According to recent research from Vienna, Austria, "Exposure of asynchronously growing human HeLa cervical carcinoma cells to roscovitine (ROSC), a selective cyclin-dependent kinases (CDKs) inhibitor, arrests their progression at the transition between G(2)/M and/or induces apoptosis. The ...
Study results from L. Li and colleagues update understanding of apoptosis.
Jun 02, 2009 ... According to recent research from Kimiidera, Japan, "Although death-associated protein kinase (DAPK) is a Ca2+/calmodulin-regulated serine/threonine kinase that plays important roles in various types of apoptotic cell death, there have been no reports of its tissue distributions and ...
Study results from M. Furuya et al provide new insights into apoptosis.
Jun 02, 2009 ... According to recent research from Sapporo, Japan, "Survivin, a member of the apoptosis inhibitor family, shows increased expression in human cancers of various origins. It has been demonstrated that survivin inhibits apoptosis via caspase inhibition and promotes mitosis via aurora-B kinase ...
Data on autoimmune disease described by H.A. Ferreyra et al.
Jun 02, 2009 ... In this recently published article, scientists in the United States conducted a study "To report the results of treating autoimmune retinopathy (AIR) with immunosuppression therapy. Retrospective review of 30 consecutive patients with AIR followed for 3 to 89 months (median, 17 months) ...
Investigators at Prince of Wales Hospital zero in on basal cell cancer.
Jun 02, 2009 ... "We conducted a 12-year retrospective review of vulvar basal cell carcinoma (BCC) in a Chinese population. Medical records and histopathologic reports were examined from 5 major Hospitals in Hong Kong to list all patients diagnosed with vulvar BCC," scientists in Hong Kong, People's ...
Investigators at University of Copenhagen publish new data on basal cell cancer.
Jun 02, 2009 ... According to a study from Roskilde, Denmark, "Accurate assessment of tumour size is important when planning treatment of nonmelanoma skin cancer (NMSC). Imaging with optical coherence tomography (OCT) has the potential to diagnose and measure depth of NMSC." "To compare ...
Studies conducted at M. Cretnik et al on basal cell cancer recently published.
Jun 02, 2009 ... "The involvement of two tumor suppressors p 16 and Ptch in pathogenesis of cutaneous melanomas and basal cell carcinomas (BCCs) was studied through expression of Ptch and p16 and genetic alterations in 9p21 region (p16) and in 9q22.3 region (PTCH) of chromosome 9. Immunohistochemical ...
Reports from University of Alabama advance knowledge in biopsy.(Report)
Jun 02, 2009 ... According to recent research from the United States, "The best method of tissues ampling for performance of immunohistochemistry on prostate needle biopsy tissue sections has not been established. The aim of this study was to prospectively compare the usefulness of using saved interval ...
Studies from L.Q. Kang and colleagues provide new data on biopsy.
Jun 02, 2009 ... " CT perfusion imaging (CTP) has been proved to be a powerful functional imaging technique. This study aimed to evaluate the value of CTP in guiding biopsy of pulmonary lumps," scientists in Hebei, People's Republic of China report (see also Biopsy). " A total of 147 patients ...
New bladder cancer research from University of Crete discussed.
Jun 02, 2009 ... According to a study from Greece, "Bladder cancer is the fifth most common malignancy in men in Western society. We determined RAS codon 12 and 13 point mutations and evaluated mRNA expression levels in transitional cell carcinoma cases." "Samples from 30 human bladder cancers ...
New bladder cancer research from University of Leicester described.
Jun 02, 2009 ... According to recent research from Leicester, the United Kingdom, "Survival rate of patients diagnosed with the invasive form of bladder cancer is low suggesting an urgent need to implement novel treatments. GTC (gemcitabine, paclitaxel and cisplatin) is a new chemotherapeutic regimen, ...
New findings from M.J.J. Vanhemelrijck and co-researchers in the area of bladder cancer described.
Jun 02, 2009 ... In this recent study, researchers in London, the United Kingdom conducted a study "To quantify the relation between second-hand smoking (SHS) and levels of 4-aminobiphenyl (4-ABP; in urine or blood) and SHS and bladder cancer risk in nonsmokers. PubMed and Embase were searched (search ...
Data on brain cancer detailed by researchers at Tohoku University, Medical Department.(Report)
Jun 02, 2009 ... According to a study from Sendai, Japan, "Convection-enhanced delivery (CED) with various drug carrier systems has recently emerged as a novel chemotherapeutic method to overcome the problems of current chemotherapies against brain tumors. Polymeric micelle systems have exhibited ...
New brain cancer study findings recently were reported by researchers at University of Cincinnati, Brain Tumor Center.
Jun 02, 2009 ... According to recent research from the United States, "In this retrospective study, we evaluate the efficacy of surgical resection and I-125 seeds, without upfront whole brain radiotherapy (WBRT), for newly diagnosed single brain metastasis. About 40 women and 32 men underwent gross total ...
Report summarizes brain cancer study findings from University of Quebec.
Jun 02, 2009 ... "Mesenchymal stromal cell (MSC) markers are expressed on brain tumor-initiating cells involved in the development of hypoxic glioblastoma. Given that MSCs can survive hypoxia and that the glucose-6-phosphate transporter (G6PT) provides metabolic control that contributes to MSC mobilization ...
Data from R. Bori et al provide new insights into breast cancer.
Jun 02, 2009 ... "Breast cancer in the young is considered a special clinical presentation of the disease. Sixty-nine breast cancer cases diagnosed at or before the age of 35 were analyzed for common morphological and immunophenotypical features of basal-like carcinomas," researchers in Kecskemet, Hungary ...
Findings from D. Chambo et al in breast cancer reported.
Jun 02, 2009 ... "Radiologic breast density is one of the predictive factors for breast cancer and the extent of the density is directly related to postmenopause. However, some patients have dense breasts even during postmenopause," researchers in Vitoria, Brazil report (see also Breast Cancer). ...
Findings from J. Xu and co-authors broaden understanding of breast cancer.
Jun 02, 2009 ... "BRCA1 dysfunction is associated with hormone-responsive cancers. We have identified a consensus SUMO modification site in the amino-terminal region of BRCA1/1a/1b proteins and the mutation in this potential SUMO acceptor site (K 109 to R) impaired their ability to bind and repress ...
New breast cancer study findings have been reported by researchers at Malmo University.(Report)
Jun 02, 2009 ... "Single nucleotide polymorphisms (SNP) of the folate-metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR) may modify associations between folate intake and breast cancer. We examined if the association between tertiles of dietary folate equivalents (DFE) and breast cancer was ...
New findings from University of Verona in the area of breast cancer described.
Jun 02, 2009 ... "We evaluated intratumoral heterogeneity of 30 ductal breast carcinomas with HER2/neu amplification, scored by the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) criteria, and 3+ immunoexpression. High-grade (ratio >= 4.0) vs low-grade amplification ...
New findings from Y. Takata and co-authors describe advances in breast cancer.
Jun 02, 2009 ... According to recent research published in the journal Cancer Causes & Control, "To examine the association between breast cancer risk and the fatty acid composition of phospholipids in prediagnostic serum samples. We analyzed the fatty acid composition in 130 incident postmenopausal breast ...
Reports from Fudan University highlight recent research in breast cancer.
Jun 02, 2009 ... "Aims and background. To evaluate the immunohistochemical characterization of CK5/6 and CK17 and whether the expression level of the two markers was correlated with clinical outcome or pathological feature in triple negative (ER-, PR-, HER-2-) patients with breast cancer," investigators in ...
Reports from Harvard University highlight recent research in breast cancer.
Jun 02, 2009 ... "During breast cancer progression, a substantial increase in chromosomal aberrations is observed in the transition from ductal hyperplasia to carcinoma in situ. Telomeres are essential structures to chromosomal integrity," scientists writing in the journal Cancer Epidemiology Biomarkers & ...
Reports outline breast cancer study findings from Semmelweis University.
Jun 02, 2009 ... According to recent research from Budapest, Hungary, "Claudins (CLDN) are tight junction proteins which contribute to the paracellular transport and ionic permeability of various epithelia. In recent years they came into focus for their suggested role in carcinogenesis and possible role in ...
Research from A. Bruzzone and co-authors provides new data about breast cancer.
Jun 02, 2009 ... "Breast cancer is the most frequent cancer in women. However, in vivo hormone receptor positive and metastatic models are scarce," researchers in Buenos Aires, Argentina report (see also Breast Cancer). "The aim of the present manuscript was to assess if the novel steroid ...
Research on breast cancer reported by scientists at University of Messina.
Jun 02, 2009 ... According to a study from Messina, Italy, "Aim and background. In breast cancer, as in almost all neoplastic diseases, the prognosis is strictly related to the invasive capacity, local and distant, that characterizes the growth of all tumors." "Since the mechanisms that regulate ...
Researchers from University of Toronto report on findings in breast cancer.
Jun 02, 2009 ... According to a study from Toronto, Canada, "The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with a decreased risk of colon cancer although it may, increase the risk of breast cancer. This polymorphism is associated with changes in intracellular ...
Scientists at University of Colorado, Medical Department discuss research in breast cancer.
Jun 02, 2009 ... According to recent research published in the journal Cell Cycle, "The anti-diabetic drug metformin reduces human cancer incidence and improves the survival of cancer patients, including those with breast cancer. We studied the activity of metformin against diverse molecular subtypes of ...
Studies from A. Eric and colleagues reveal new findings on breast cancer.
Jun 02, 2009 ... According to recent research from Serbia, "The aim was to investigate whether the humoral immunity and overexpression of calreticulin in tumor tissue determined before surgery, correlate with incidence of metastases in breast cancer patients within two years after operation. Before ...
Studies from J.M. Dolle and colleagues yield new information about breast cancer.(Report)
Jun 02, 2009 ... According to recent research from the United States, "Little is known about the etiologic profile of triple-negative breast cancer (negative for estrogen receptor/progesterone receptor/human epidermal growth factor), a breast cancer subtype associated with high mortality and inadequate ...
Studies from University of Insubria provide new data on breast cancer.
Jun 02, 2009 ... "In the Milan area (Northern Italy), we identified a family characterized by a high prevalence of ovarian and breast cancer cases (5 out of 6 subjects, over 3 generations), and a predominant prevalence of ovarian lesions (4 out of 5 patients). Analysis of BRCA1 and BRCA2 genes allowed the ...
Studies from University of North Carolina further understanding of breast cancer.(Report)
Jun 02, 2009 ... "As new genomic technology expands the number of medical tests available to physicians and patients, identifying gaps in our understanding of how best to communicate risk is increasingly important. We examined how health literacy informs breast cancer survivors' understanding of and ...
Studies from University of Pittsburgh have provided new information about breast cancer.
Jun 02, 2009 ... "We previously showed that silencing profilin-1 (Pfn1) expression increases breast cancer cell motility, but the underlying mechanisms have not been explored. Herein, we demonstrate that loss of Pfn1 expression leads to slower but more stable lamellipodial protrusion thereby enhancing the ...
Studies from Vanderbilt University, Medical Department have provided new data on breast cancer.
Jun 02, 2009 ... "Amplification of the epithelial growth factor receptor gene ERBB2 (HER2, NEU) in breast cancer is associated with a poor clinical prognosis. In mammary gland development, this receptor plays a role in ductal and lobuloalveolar differentiation," scientists writing in the journal Cancer ...
Studies from Y.F. Huang and co-researchers yield new data on breast cancer.(Report)
Jun 02, 2009 ... "CYP1B1 is a key enzyme involved in estrogen metabolism and may Play an important role in the development and progression of breast cancer. In a population-based case-control study, we examined eight CYP1B1 haplotype-tagging single nucleotide polymorphisms in relation to invasive breast ...
Study data from University of Ljubljana update understanding of breast cancer.
Jun 02, 2009 ... According to a study from Ljubljana, Slovenia, "Several animal models of breast cancer have been developed to study various aspects of breast cancer biology. Substantial evidence suggests that the N-methylnitrosourea (MNU) animal model mimics human breast cancer in many respects." ...
Study findings from L.A. Korde et al provide new insights into breast cancer.
Jun 02, 2009 ... According to recent research published in the journal Cancer Epidemiology Biomarkers & Prevention, "Historically, breast cancer incidence has been substantially higher in the United States than in Asia. When Asian women migrate to the United States, their breast cancer risk increases over ...
Study results from C. Charpin and colleagues in the area of breast cancer published.(Report)
Jun 02, 2009 ... According to recent research from Marseille, France, "We aimed in this study at identifying prognostic immunohistochemical molecular signatures indicative of disease outcome, also relevant for development of new specific therapies, in triple-negative (ER, PR, c-erbB2-negative) breast ...
Study results from Johns Hopkins University update understanding of breast cancer.
Jun 02, 2009 ... According to recent research published in the journal Proteomics, "MicroRNA (miRNA) play essential roles in biological processes ranging from cellular proliferation to apoptosis. Recently, miRNA have also been implicated in a number of diseases including cancers." "However, the ...
Study results from L. Mariani et al provide new insights into breast cancer.
Jun 02, 2009 ... According to a study from Milan, Italy, "We studied the diagnostic accuracy of carcinoembryonic antigen (CEA) and cancer antigen 15.3 (CA 15.3) in detecting breast cancer recurrence. Biomarker follow-up determinations, made over 900 patients, were related to local-regional or distant ...
Data on cancer detailed by T. Borovski and co-authors.
Jun 02, 2009 ... "The CSC compartment represents the subpopulation of tumor cells with clonogenic potential and the ability to initiate new tumors. Besides self renewal, one of their main features is their ability to differentiate into the variety of cells within the tumor," scientists writing in the ...
Findings from University of Maryland, Medical Department in cancer reported.
Jun 02, 2009 ... According to recent research from the United States, "The androgen receptor (AR) plays a critical role in prostate cancer. We have identified a ubiquitin E3 ligase, RNF6, as an AR-associated protein in a proteomic screen." "RNF6 induces AR ubiquitination and promotes AR ...
Findings in cancer reported from Wayne State University.(Report)
Jun 02, 2009 ... According to recent research from the United States, "The purpose of this study was to compare the prognostic variables and survival of younger (< 50 years) to that of older (>= 50 years) women with vulvar cancer. Subjects with invasive squamous cell carcinoma of the vulva were identified ...
Investigators at University of Washington publish new data on cancer.
Jun 02, 2009 ... "Given the established links among young age at first intercourse (AFT), number of sex partners, high-risk human papillomavirus infection, and squamous cell cervical cancer (SCC), we hypothesized that women diagnosed with SCC at younger ages would be more likely to report young AFT than ...
Karolinska University publishes research in cancer.
Jun 02, 2009 ... "Although the authors of several studies report elevated numbers of immunosuppressive regulatory T cells (Tregs) in hematologic and solid malignancies, the underlying mechanism is not fully clarified. Cancer is associated with oxidative stress mediated through reactive oxygen species ...
New cancer findings from X.S. Xiong and co-authors described.
Jun 02, 2009 ... "Peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists have shown benefit in treating diabetes mellitus, atherosclerosis and cancer. However, widespread use of thiazolidinediones (TZDs), the clinically used synthetic PPAR gamma agonists, has been limited by adverse ...
New cancer research from National Institutes of Health discussed.
Jun 02, 2009 ... "Designing strategies for anti-cancer therapy have posed a significant challenge. One approach has been to inhibit specific DNA repair proteins and their respective pathways to enhance chemotherapy and radiation therapy used to treat cancer patients," scientists in the United States report ...
New cancer research has been reported by scientists at Third Military Medical University.
Jun 02, 2009 ... According to a study from Chongqing, People's Republic of China, "Previous evidence implicates polymorphisms of GSTM1 and GSTT1, candidates of phase II enzymes, as risk factors for various cancers. A number of studies have conducted on the association of GSTM1 and GSTT1 polymorphism with ...
New cancer study findings have been reported by researchers at Vita-Salute University.(Clinical report)
Jun 02, 2009 ... "According to the 2002 American Joint Committee on Cancer TNM classification, perinephric and renal sinus fat invasion are classified as pT3a renal cell carcinoma. However, only a few studies have assessed the impact of sinus fat invasion on patient survival and with controversial ...
New data from Hong Kong Polytechnic University illuminate research in cancer.(Report)
Jun 02, 2009 ... According to a study from Hong Kong, People's Republic of China, "A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this ...
New findings from C.J. Ye and co-authors in the area of cancer published.(Report)
Jun 02, 2009 ... According to recent research published in the Journal of Cellular Physiology, "Cancer progression represents an evolutionary process where overall genome level changes reflect system instability and serve as a driving force for evolving new systems. To illustrate this principle it must be ...
New findings in cancer described from University of Pittsburgh.(Report)
Jun 02, 2009 ... " STAT3 overexpression has been detected in several cancers including head and neck squamous cell carcinoma (HNSCC). Previous studies using intratumoral administration of a STAT3 decoy oligonucleotide that abrogates STAT3- mediated gene transcription in preclinical cancer models have ...
New findings reported from University of East Anglia describe advances in cancer.(Report)
Jun 02, 2009 ... According to recent research from Norwich, the United Kingdom, "Cyclooxygenase-2 (COX-2) overexpression has been associated with the grade, prognosis and recurrence of transitional cell carcinoma (TCC) of the bladder. In this study, sulforaphane, a dietary isothiocyanate, down-regulated ...
Reports on cancer findings from National Institutes of Health provide new insights.
Jun 02, 2009 ... According to recent research from the United States, "Cancer epidemiology articles often point out that cancer rates tend to be higher among males than females yet rarely is this theme the subject of investigation. We used the Surveillance, Epidemiology and End Results program data to ...