Recently added articles from Critical Reviews in Biochemistry and Molecular Biology:
Role of Type 2C Protein Phosphatases in Growth Regulation and in Cellular Stress Signaling
Nov 01, 2007; ... ABSTRACT A number of interesting features, phenotypes, and potential clinical applications have recently been ascribed to the type 2C family of protein phosphatases. Thus far, 16 different PP2C genes have been identified in the human genome, encoding (by means of alternative splicing) for at ...
Encoding Olfactory Signals via Multiple Chemosensory Systems
Nov 01, 2007; ... ABSTRACT Most animals have evolved multiple olfactory systems to detect general odors as well as social cues. The sophistication and interaction of these systems permit precise detection of food, danger, and mates, all crucial elements for survival. In most mammals, the nose contains two well ...
Glycan Antagonists and Inhibitors: A Fount for Drug Discovery
Nov 01, 2007; ... ABSTRACT Glycans, the carbohydrate chains of glycoproteins, proteoglycans, and glycolipids, represent a relatively unexploited area for drug development compared with other macromolecules. This review describes the major classes of glycans synthesized by animal cells, their mode of assembly, and ...
Genetic Constraints on Protein Evolution
Sep 01, 2007; ... ABSTRACT Evolution requires the generation and optimization of new traits ("adaptation") and involves the selection of mutations that improve cellular function. These mutations were assumed to arise by selection of neutral mutations present at all times in the population. Here we review recent ...
Stationary Phase Mutagenesis in B. subtilis: A Paradigm to Study Genetic Diversity Programs in Cells Under Stress
Sep 01, 2007; ... ABSTRACT One of the experimental platforms to study programs increasing genetic diversity in cells under stressful or nondividing conditions is adaptive mutagenesis, also called stationary phase mutagenesis or stress-induced mutagenesis. In some model systems, there is evidence that mutagenesis ...