Recently added articles from Critical Reviews in Toxicology:
Lipid Vesicles as Membrane Models for Toxicological Assessment of Xenobiotics
Jan 01, 2008; ... Traditionally animals and cell cultures have been used to assess the toxic potential of xenobiotics on cell membranes. In search for more reproducible, quantitative, cost- and time-effective assays, toxicologists have recently become interested in biomimetic lipid vesicle-based test systems ....
Paraquat Poisonings: Mechanisms of Lung Toxicity, Clinical Features, and Treatment
Jan 01, 2008; ... Paraquat dichloride (methyl viologen; PQ) is an effective and widely used herbicide that has a proven safety record when appropriately applied to eliminate weeds. However, over the last decades, there have been numerous fatalities, mainly caused by accidental or voluntary ingestion. PQ poisoning ...
Neurotoxins From Australo-Papuan Elapids: A Biochemical and Pharmacological Perspective
Jan 01, 2008; ... Most of the medically important snakes in Papua New Guinea and Australia belong to the family Elapidae and are referred to as "Australo-Papuan" elapids. Neurotoxicity is often a life-threatening symptom of envenoming by these snakes; therefore, much attention has been paid to the isolation and ...
Issues in the Design and Interpretation of Chronic Toxicity and Carcinogenicity Studies in Rodents: Approaches to Dose Selection
Oct 01, 2007; ... For more than three decades chronic studies in rodents have been the benchmark for assessing the potential long-term toxicity, and particularly the carcinogenicity, of chemicals. With doses typically administered for about 2 years (18 months to lifetime), the rodent bioassay has been an integral ...
In Memorium: Robert M. Kroes
Sep 01, 2007; ... The authors note with sadness the passing of Professor Robert Kroes and wish to dedicate this manuscript to his memory. He provided significant and noteworthy contributions to the development of the manuscript, the critical evaluation of the studies, and the assessment of the overall weight of ...