Dermatology Times back issues from September 2002:
Selective dermal heating lowers lesion counts
Sep 01, 2002; ... Pilot, split-side study of 26 patients shows 1450nm diode laser safe for inflammatory acne Paris - In preliminary studies, selective dermal heating with a 1450nm diode laser (Smoothbeam) has shown promise as a safe and effective new approach to treating inflammatory acne, E. Victor Ross ...
Nonablative lasers improve atrophic scars
Sep 01, 2002; ... Acne Atlanta - Nonablative treatment with a 1320nm Nd:YAG or 1450nm diode laser offers a viable option for achieving moderate improvement in the appearance of atrophic acne scars with no downtime, according to preliminary results from a randomized study conducted at the Washington ...
Topical retinoids successfully stand alone
Sep 01, 2002; ... Paris - Topical retinoids are highly effective as monotherapy in treating inflammatory acne and deserve a greater role in that indication then they often have in clinical practice, James J. Leyden, M.D., said at the World Congress of Dermatology. He presented the results of a ...
Spotlight on adult acne
Sep 01, 2002; ... Acne Compliance, treatment, and results differ vastly in post-teen population than in traditional groups Acne, although often considered the scourge of the teen years, in reality can last well into adulthood. Dermatologist David J. Watts, M.D., Omaha, Neb., thinks ...
Out of plain view
Sep 01, 2002; ... Support group offers community, empathy, forum to disenfranchised patients with severe acne scars Washington - She spent much of her adult life crying herself to sleep and frequently contemplating suicide. A model in her teens, Rose Hayton stopped getting modeling gigs, as well as much ...
TLRs linked to origin of inflammatory acne
Sep 01, 2002; ... Research of pathogenesis offers new target for anti-acne treatment, drug development Los Angeles - The recent identification of human toll-like receptors (TLRs) has led to the description of new pathways for acne pathogenesis and presents a novel therapeutic target for the future, Jenny ...
Less common modalities play role in Tx
Sep 01, 2002; ... Acne Buenos Aires - Conventional treatment regimens based on the use of topical and systemic retinoids and antimicrobial agents are effective in controlling the majority of cases of acne across the entire spectrum of disease severity, but there are a wide range of less commonly used ...
Combination clindamycin/benzoyl peroxide succeeds simply in moderate-to-severe acne
Sep 01, 2002; ... Acne New Orleans - The combination product containing clindamycin 1 percent with benzoyl peroxide 5 percent in an aqueous vehicle base (BenzaClin) is a highly effective and well-tolerated treatment for patients with moderate to moderately severe acne, according to the results of two ...
Combination adapalene/clindamycin hastens, improves clearing of inflammatory acne
Sep 01, 2002; ... Paris - Combination topical-antibioticplus--retinoid treatment of inflammatory acne using adapalene 0.1 percent gel (Differin) with clindamycin 1 percent lotion offers better efficacy and safety compared with clindamycin 1 percent lotion alone, according to the results of a study presented at ...
Antibiotic use linked to colonization rates
Sep 01, 2002; ... Study shows higher rates of streptococcus pyogenes colonization in oro-pharynx Los Angeles - A preliminary, cross-sectional study found an association between antibiotic use among acne patients and higher rates of colonization of Streptococcus pyogenes in the oropharynx, as well as ...
Issues influence antimicrobial treatment decisions
Sep 01, 2002; ... New Orleans - The growing emergence of resistant bacteria and confusion created by an expanding number of antimicrobial agents on the market make selection of effective antimicrobial therapy an increasing challenge for dermatologists, James Q. Del Rosso, D.O., said at the annual meeting of the ...
Call made for anti-inflammatory systemic Tx
Sep 01, 2002; ... Acne Berlin - New therapeutic modalities are needed for treating the substantial population of acne patients with marked inflammatory disease and scarring. Available data indicate compounds with selective antiinflammatory activity may help fill that niche, Christos C. Zouboulis, M.D., ...
Enzyme converting DHEAS to DHEA deemed viable target for anti-acne drug development
Sep 01, 2002; ... Acne "We know that P. acnes can produce LPS-like compounds, and so the finding that bacterial products stimulate STS expression in monocytes makes sense." Andreas Billich, Ph.D. Novartis Research Institute Paris - Selective inhibition of the enzyme steroid ...
LHA serves multiple roles in acne management
Sep 01, 2002; ... Paris - A new cosmetic product incorporating beta-lipohydroxy acid (LHA), a lipophilic derivative of salicylic acid, appears to be useful when used alone for preventing relapses in patients who have responded to acne treatment and as an adjunct to topical tretinoin for improving the tolerability ...
Isotretinoin program relies on compliance
Sep 01, 2002; ... System to Manage Accutane Related Teratogenicity requires patient, physician education and cooperation New York - The System to Manage Accutane Related Teratogenicity (SMART) developed by Roche Laboratories and the FDA requires both physician and patient compliance to prevent a ...
Isotretinoin expensive but cost-effective
Sep 01, 2002; ... New York - Although the price of some treatments for acne vulgaris may seem steep, the simple dollar cost of the medication only tells part of the story, according to Julie Claire Harper, M.D. Just ask any patient, who would gladly forgo a considerable sum of cash in exchange for an ...
Wax works
Sep 01, 2002; ... Epilation treatment before laser use reduces hair growth Los Angeles - Wax epilation prior to laser hair removal improves early cosmetic outcomes, according to a pilot study presented by University of Pennsylvania dermatology department researchers. Noting reports indicating ...
TIMs make impact on infants
Sep 01, 2002; ... Winston-Salem, N.C. - Separate studies involving atopic dermatitis drugs tacrolimus (Protopic) and pimecrolimus (Elidel) show the topical immunomodulators (TIMs) are safe and effective for off-label use on children under age 2. "The topical immunomodulators are absolutely the safest ...
Illegal 'Botox' clinic leaves patients ill
Sep 01, 2002; ... New York - The upstart, unproven Botox alternative Hyacell and its alleged illegal use in a makeshift clinic here in July point to an incident many physicians figured would happen. But just what to do about it is another matter completely-and perhaps a more serious one. A New York ...
WHO rolls out uniform global UV index
Sep 01, 2002; ... Geneva - The global solar ultraviolet radiation index, recently introduced by the World Health Organization, is all about awareness of the damaging effects of ultraviolet radiation. However, while not unlike regional indices in use around the world, the effort is the first to deploy universal ...
'They don't want to treat children'
Sep 01, 2002; ... EDITORIAL COMMENT Many dermatologists enter field bereft of training, motivation to treat pediatric patients It's 10:45 p.m. on a Sunday. You're winding down from an enjoyable weekend when, suddenly, the sound of your pager summons you. There's a call from your local hospital ....
Informed consent: Is evidence of my habit enough?
Sep 01, 2002; ... A written record of education ends all arguments, but a reputation for disclosure holds legal water Dr. A, like every other dermatologist, performs myriad skin biopsies during the course of her workweek. She explains to her patients in detail the purpose of the biopsy; the possible need ...
Neither party animal nor party pooper
Sep 01, 2002; ... ON CALL While most dermatologists agree alcohol and Botox Cosmetic don't mix, some physicians admit en masse participation has its merits Even before botulinum toxin (Botox Cosmetic) received FDA approval in April for use in cosmetic procedures, the demand for the treatment had ...
(Clear) faces in the crowd
Sep 01, 2002;
Letters to the editor
Sep 01, 2002; ... Tanning bed trouble Dear Editor: The June 2002 issue of DERMATOLOGY TIMES (Vol. 23, No. 6) has a front-page article titled "Tanning beds, acitretin equal psoriasis clearing." The lead author and clinician involved in the study is Dr. Christopher Carlin, department of ...
Corrections
Sep 01, 2002; ... The clinical photographs accompanying the story "Excimer laser repigments facial scars," on page 1 of the July 2002 issue should have accompanied the story on page 49 of that issue, "Laser-assisted PDT clears AK lesions." The headline on page 42 of the August 2002 issue should have read ...
Reforms needed in face of rising malpractice costs
Sep 01, 2002; ... WASHINGTON AND YOU The high cost of medical malpractice insurance, both for patients and physicians, is gaining renewed attention in Washington with President Bush calling for reform and a new report by the Department of Health and Human Services urging legislative action. "The ...
Rosacea extra-facial signs common
Sep 01, 2002; ... CLINICAL DERMATOLOGY Study finds erythema on trunk and telangiectasia on neck associated with erythemotelangiectatic subtype of rose-colored outbreak Los Angeles - Researchers conducting a study to determine the frequency of extra-facial lesions of the erythemotelangiectatic or ...
Tobacco isolated as cause of skin aging
Sep 01, 2002; ... Researchers look at what habit does to dermis of men and women Los Angeles - Researchers in The Netherlands who looked at nearly 1,000 patients added to the confirmation that smoking causes wrinkles and enhances skin aging in both sexes. They also found that smoking seems to wreak even ...
Itraconazole use covers various inflammatory diseases
Sep 01, 2002; ... CLINICAL DERMATOLOGY Drug effective against underlying fungal infection New Orleans - Disorders that seemingly have no mycotic component could respond to a course of itraconazole (Sporanox), according to Ruggero Caputo, M.D. In fact, for certain patients, it may have a role in ...
Fluconazole Tx for cutaneous leishmaniasis
Sep 01, 2002; ... CLINICAL DERMATOLOGY Antifungal may be side-effect-sparing alternative to treating sandfly-transmitted protozoan infection Riyadh, Saudi Arabia - For treatment of cutaneous leishmaniasis caused by Leishmania major, a six-week course of oral fluconazole is effective and avoids ...
Azathioprine efficacy is 'gold standard' in trial
Sep 01, 2002; ... Study results show drug an effective treatment for severe AD in adults Los Angeles - Azathioprine is an effective treatment for severe atopic dermatitis in adults, although it can be poorly tolerated by some patients due to gastrointestinal side effects, and careful laboratory ...
Peanut oil rehydrates AD kids
Sep 01, 2002; ... CLINICAL DERMATOLOGY Atopic Dermatitis Briefs Typical allergic reactions in peanut-sensitive patients stemmed by elimination of causal protein in substance used as vehicle Paris - Magadelene A. Dohill, M.D. examined pediatric patients and atopic dermatitis at the World ...
Stress jump-starts HSPs, prompts vitiligo
Sep 01, 2002; ... CLINICAL DERMATOLOGY Research may lead to new therapeutic strategies Los Angeles - Stress leads to an aberrant expression of heat shock proteins (HSP) in the skin of vitiligo patients, Caroline Le Poole, Ph.D., said at the annual meeting of the Society for Investigative ...
Controlled trial finds efficacy of narrowband UVB for vitiligo treatment
Sep 01, 2002; ... New Orleans - Narrowband UVB phototherapy can produce repigmentation of vitiligo, and some patients may achieve an excellent response, but the extent of the treatment benefit appears to depend on the anatomic region of involvement, Iltefat H. Hamzavi, M.D., reported at the annual meeting of the ...
Mast cells play key role in bacterial infection defense
Sep 01, 2002; ... CLINICAL DERMATOLOGY Research shows mammalian mast cells produce and secrete antimicrobial peptide to help cells fight bacterial infections Los Angeles - Mast cells are directly involved in innate defense against bacterial infection through the synthesis of antimicrobial ...
Dermatologic emergencies
Sep 01, 2002; ... Preparing for the worst-case scenario New Orleans - Each dermatologist has the possibility of being confronted by a skin condition that requires emergent diagnosis and treatment for a patient's overall health, Paul Krusinski, M.D., said at the annual meeting of the American Academy of ...
Women First HealthCare acquires Vaniqa, plans relaunch
Sep 01, 2002; ... San Diego - With its acquisition from Bristol-Myers Squibb of worldwide rights and title to Vaniqa (eflornithine hydrochloride) Cream, Women First HealthCare plans to take another pass at providing women with hirsutism a pharmaceutical alternative. Approved for marketing by the FDA in ...
IgM antibodies occur earlier than IgG in EM
Sep 01, 2002; ... Los Angeles -The kinetics of Borrelia burgdorferi antibody titers in 394 patients with erythema migrans and correlations of IgM and IgG antibody profiles with clinical disease were described at the annual meeting of the Society for Investigative Dermatology. Robert Mullegger, M.D., ...
Beyond immunosuppression: Study shows corticosteroids' role in pemphigus
Sep 01, 2002; ... Los Angeles - The role of corticosteroids in treating pemphigus vulgaris goes beyond the conventional wisdom of immunosuppression and anti-inflammatory action, according to Sergei A. Grando, M.D., Ph.D., D.Sc., and colleagues, who presented their findings at the annual meeting of the Society for ...
Gene combinations implicated in psoriasis
Sep 01, 2002; ... New Orleans -- Although multiple abnormal genes probably control psoriasis, only a few people inherit a combination of disease genes that causes psoriasis, according to James T Elder, M.D., Ph.D. "We are close to discovering several of these genes, and we hope this will let us design ...
Imiquimod inhibits NMSC tumor growth
Sep 01, 2002; ... CUTANEOUS ONCOLOGY Paris - Immunotherapy with a topical immune response modifier is a valid therapeutic option for nonmelanoma skin cancers (NMSC). It has the advantage of allowing at-home treatment and the potential to provide long-term protective immunity in addition to a clinical ...
Two antioxidants team up against UV light
Sep 01, 2002; ... CUTANEOUS ONCOLOGY Los Angeles - With the knowledge that users apply only one-fourth to one-fifth of the sunscreen necessary to achieve the full SPF and resultant UV protection, additional protections are needed to deflect skin cancer, according to Sheldon Pinnell, M.D., J. Lamar ...
Planning, proper clothing important to protect against sun
Sep 01, 2002; ... New Orleans - In a perfect world all clothing would be rated for its sun-protective value, and sun-protective clothing would be part of the average wardrobe, according to Raymond Kuwahara, M.D., who described the sun-protective properties of clothing at the annual meeting of the American Academy ...
Standard dogma still holds: Remove nevus sebaceous prior to onset of adolescence
Sep 01, 2002; ... CUTANEOUS ONCOLOGY New Orleans - While the risk of malignant conversion of nevus sebaceous has been a subject of recent controversy, pediatric dermatologist Sheila Fallon Friedlander, M.D., still recommends prophylactic surgical excision of such lesions prior to adolescence ....
Congenital nevi now have broader definition
Sep 01, 2002; ... CUTANEOUS ONCOLOGY Misunderstood markings can include moles that present at birth and within first few years New Orleans -The management of congenital nevi is an extremely challenging and easily misunderstood area for dermatologists. New insights into the disorder were shared ...
Melanoma immunotherapy trial shows some improvement in survival
Sep 01, 2002; ... Still, results fail to reach clinical significance London - Researchers in Australia reporting on an immunotherapy trial with vaccinia viral melanoma cell lysates in patients with stage lIb and III melanoma say that finding an effective adjuvant treatment for melanoma is proving to be a ...
Atypical presentation of scabies among nursing home residents
Sep 01, 2002; ... SPECIAL REPORT: Geriatric Dermatology St. Louis - Scabies epidemics can present in unusual ways among nursing home patients, according to Dr. Margaret-- Mary G. Wilson. This may lead to a delay in diagnosis and changes the treatment modality, she said. An assistant ...
Poll garners patient, prescriber opinions on AK treatments
Sep 01, 2002; ... SPECIAL REPORT: Geriatric Dermatology Cryotherapy most popular form of treatment; satisfaction levels lead to hopes for new modalities New Orleans - Patients and physicians express various levels of satisfaction and dissatisfaction with the most common treatment ...
Varicella vaccine could be effective zoster prophylactic for older patients
Sep 01, 2002; ... SPECIAL REPORT: Geriatric Dermatology Inactivated vaccine may keep immunocompromised patients from developing infection for up to year Stanford, Calif. - Use of an inactivated varicella vaccine may prevent immunocompromised patients from developing varicella-zoster virus ...
Deep excision necessary for merkel cell carcinoma
Sep 01, 2002; ... SPECIAL REPORT:. Geriatric Dermatology Physicians need to be aware of rare cancer and know best ways to excise tumor BY CAROLINE HELWICK STAFF CORRESPONDENT New Orleans - Merkel cell carcinoma is a very rare tumor - U.S. physicians see only about 500 cases a ...
Undiagnosed skin cancers critical problem in institutionalized elderly
Sep 01, 2002; ... Surveillance mechanisms lacking despite known association between increasing age, higher incidence of NMSC Paris -- Geriatricians and nurses responsible for the routine care of older patients dwelling in hospitals and other longterm care facilities need to be more diligent in performing ...
Estrogen's keratinocyte connection
Sep 01, 2002; ... In vitro tests show estradiol induces proliferation of epidermal keratinocytes Los Angeles - In an attempt to prove estrogen's unknown effect on keratinocytes, researchers presented in vitro data at the Society for Investigative Dermatology that suggest a direct link of the hormone to ...
Fibroblasts found to have surprising proliferative potential into old age
Sep 01, 2002; ... San Antonio - One take-home lesson from a study on aging is that even the fibroblasts of very old people have significant proliferative potential, James R. Smith, Ph.D., said. "This suggests that fibroblasts may not be the best cells to use in determining a relationship between in vivo and in ...
Cosmetic conundrums
Sep 01, 2002; ... COSMETIC DERMATOLOGY Q. How should antiperspirants be applied for maximum effectiveness? A. Many patients are concerned about hyperhidrosis, especially involving the armpits. There are a variety of prescription methods of treating increased perspiration - including aluminum ...
Extracted autologous veins fill facial soft-tissue defects
Sep 01, 2002; ... New Orleans -- Autologous veins extracted during ambulatory phlebectomy procedures provide a safe and effective material for facial soft tissue augmentation and correction of atrophic dermal defects, Mitchel P. Goldman, M.D., said at the annual meeting of the American Academy of Dermatology ....
Cosmetic practice poses ethical challenges
Sep 01, 2002; ... Are patients being treated as well as physician's mother or father would be? New Orleans - Cosmetic dermatology presents a number of complex ethical issues for clinicians and researchers alike, but the bottom line for measuring what constitutes ethical practice is to consider whether ...
Spin trap-like compounds may block inflammation, deter aging
Sep 01, 2002; ... Chicago - Several bioactive compounds similar to spin traps have been identified that can cool down and block the process of inflammation and also stop the molecular events involved in the aging of skin, Bryan Fuller, Ph.D., said. A particular compound, called Quadrinone, has now been formulated ...
Diminished inflammation combats skin aging
Sep 01, 2002; ... COSMETIC DERMATOLOGY Three-tiered program may reduce `underlying cause' of various maladies BY CORIENE E. HANNAPEL STAFF CORRESPONDENT Chicago - A three-tiered program to reduce inflammation in the body on a cellular level includes a diet rich in antioxidants, ...
Cosmeceuticals are basically 'hope in a jar'
Sep 01, 2002; ... Separating myth from fact within gray area separating drugs and cosmetics New Orleans - Before solid research establishes their validity, "cosmeceuticals" should be considered "hope in a jar," according to Leslie Baumann, M.D. In discussing the burgeoning field, where cosmetic products ...
Studies demonstrate value of procollagen fragment Pal-KTTKS
Sep 01, 2002; ... Pal-KTTKS improves wrinkle appearance without causing irritation; shows positive changes in elastin Paris - Results from a series of studies presented at the World Congress of Dermatology support the conclusion that palmitoyl-pentapeptide 3 (Pal-KTTKS) is a very safe and effective agent ...
New technology, patient demand spur cosmetic surgery advances
Sep 01, 2002; ... From new uses for excimer laser to rebirth of injectable silicone, march of progress continues New Orleans - Significant technological developments continue to advance laser and cosmetic surgery, according to Jeffrey Dover, M.D., who reviewed progress in the field over the last year at ...
Are derm surgeons properly trained?
Sep 01, 2002; ... Controversy rises with some general surgeons saying training not adequate for accreditation; dermatologists defend specialty's education New Orleans - The training received by dermatologic surgeons is more than adequate for the task; in fact, dermatologists pioneered many of the skin ...
Skin substitutes valuale for hard-to-heal wounds
Sep 01, 2002; ... Paris - Bioengineered skin substitutes can facilitate healing of difficult wounds and even achieve closure of some long-standing chronic wounds refractory to other measures, but the success of these modalities depends on proper wound bed preparation and even then, they may not be the answer for ...
Stem cells may aid in postischemic revascularization
Sep 01, 2002; ... DERMATOLOGIC SURGERY Restoration of blood flow in ischemic limbs in mice accelerated when epidermal stem cells injected Los Angeles - The restoration of the blood flow in ischemic limbs in mice is accelerated when epidermal stem cells are injected into the site, Martine ...