Drug Week back issues from October 2004:
Erythromycin combined with common drugs may increase cardiac death risk.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Patients who took the antibiotic erythromycin with medications that inhibit CYP3A drug enzymes, such as certain calcium-channel blockers, certain antifungal drugs and some antidepressants, had a five-times greater risk of sudden death from cardiac ...
Neramexane did not demonstrate statistical significance in recent AD trial.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Forest Laboratories, Inc., (FRX) announced that in a preliminary analysis, data from the first phase III study of the investigational Alzheimer disease (AD) treatment, neramexane, failed to achieve statistical significance. The 6-month, ...
Results from Thelin and Viagra drug interaction study announced.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Encysive Pharmaceuticals (ENCY) announced results from a 12-subject drug-interaction study of Thelin (sitaxsentan) and Viagra (sildenafil) demonstrated a minor pharmacokinetic drug-drug interaction. In the study, a group of 24 normal ...
Milestone II Registry reaffirms positive safety outcomes stent system.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Angiotech Pharmaceuticals, Inc.'s, (ANPI, ANP) corporate partner, Boston Scientific, announced 6-month clinical findings from the European component of its Milestone II Registry. Boston Scientific said it has enrolled nearly 3700 ...
West Nile Virus clinical study initiated.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Avi BioPharma, Inc., (AVII) announced that it will initiate a clinical trial with its Neugene antisense drug candidate, Avi-4020, for the treatment of patients with acute West Nile virus disease who have serious neurological impairment (WNV ...
Promising results announced for AdVac.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Dutch biotechnology company Crucell, NV, (CRXL) and Harvard Medical School announced results of a joint study supporting novel vaccine vectors developed by Crucell. The results were outlined in a paper presented by Dr. Dan Barouch of ...
SIVmac Gag p27 capsid protein gene expression in potato reported.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Researchers have achieved SIVmac Gag p27 capsid protein gene expression in potatoes. According to published research from the United States, "A cDNA encoding the simian immunodeficiency virus type (SIV[subscript]mac) Gag capsid protein ...
Osteopontin is expressed in the lungs of acute respiratory distress syndrome.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Osteopontin is strongly expressed by alveolar macrophages in the lungs of acute respiratory distress syndrome. According to recent research published in the journal Lung, "Acute respiratory distress syndrome (ARDS) is characterized by an ...
NDA submitted to FDA for acne product.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Atrix Laboratories, Inc., (ATRX) announced that on August 31, 2004, together with co-development partner Fujisawa Healthcare, Inc., they submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for Aczone Gel 5%(dapsone ...
Acne treatments do not increase sunburn risk.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Azelaic acid, benzoyl peroxide, and adapalene do not seem to enhance UVB erythema, researchers say. According to recent research from Turkey, "The enhancing effects on UVB erythema of topical agents applied on sun exposed areas are ...
Serum levels of 20 kilodalton human growth hormone key in acromegaly patients.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- High serum levels of 20K-hGH might elicit a chronic change in the clearance kinetics of 20K-hGH and increase the proportion of 20K-hGH in acromegalic patients. "Circulating human GH (hGH) consists of several molecular isoforms. It was ...
Effects of cannabis on information-processing speed explored.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- The effects of cannabis on information-processing speed were recently studied by Australian researchers. According to the recent research, "Despite extensive research on the effects of cannabis on cognitive and motor performance, studies ...
Federal study shows drug treatment among 12-17 year olds up 65% over decade.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- The number of admissions to substance abuse treatment for adolescents ages 12 to 17 increased again in 2002, continuing a 10-year trend. These data were released in the "Treatment Episode Data Set: National Admissions to Substance Abuse ...
Biopharmaceutical company receives clearance for Remoxy clinical trials.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Pain Therapeutics, Inc., (NASDAQ:PTIE) announced that it has received regulatory clearance to initiate clinical studies with Remoxy in the United States. The company had been conducting clinical studies with Remoxy in England and ...
Prerecorded presentation on HANDS protocol available online.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Hythiam, Inc., (AMEX:HTM) announced that a lecture given by Crescenzo Pisano, MD, and medical director of the Peninsula Recovery Center at Little Company of Mary San Pedro Hospital (LCM), is available on the company's Web site. Hythiam, ...
Study documents benefits of adolescent substance abuse treatment.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- A study published in a leading scientific journal found that adolescents treated at one of Phoenix House's teen treatment centers demonstrated substantial reductions in drug use and unlawful behavior and an improvement in psychological status - and ...
Substance P may play role in hypersensitivity reactions induced by paclitaxel.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Substance P may play a role in hypersensitivity reactions induced by paclitaxel, suggest pharmacologists at Kyushu University, Japan. "The role of substance P in adverse pulmonary reactions induced by an anticancer agent paclitaxel was ...
FDA advisory committee reviews clinical submission for Macugen.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Nektar Therapeutics (NKTR) reported that Eyetech Pharmaceuticals, Inc., (EYET) and Pfizer Inc. (PFE) announced that the U.S. Food and Drug Administration's (FDA) Dermatologic & Ophthalmic Drugs Advisory Committee met to review the clinical ...
FDA advisory committee reviews Macugen data.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Eyetech Pharmaceuticals, Inc., (EYET) and Pfizer, Inc., (PFE) announced that the U.S. Food and Drug Administration's (FDA) Dermatologic & Ophthalmic Drugs Advisory Committee has met to review the clinical submission for the investigational drug ...
Buzz in the air can cause stinging insect allergies, asthma group advises.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- As summer comes to an end, you may have noticed an increase in the number of stinging insects, such as yellow jackets and wasps, flying through the air. For most people, getting stung results in temporary redness, swelling and itching at ...
Wheat gluten causes dendritic cell maturation and chemokine secretion.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Wheat gluten causes dendritic cell maturation and chemokine secretion, according to a new report. According to the research published in the Journal of Immunology, "Wheat gluten causes gut inflammation in genetically predisposed ...
FDA approves Clarinex syrup for allergies and hives in children.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Schering-Plough Corp. (SGP) announced that the U.S. Food and Drug Administration (FDA) has approved the use of Clarinex (desloratadine) Syrup for the relief of symptoms associated with seasonal allergic rhinitis (outdoor allergies) in children 2 ...
Pharmaceutical company changes symbol from "CBSC" to "CLSC".
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Cobalis Corp. (CBSC), a pharmaceutical company specializing in the development of anti-allergy medications, announced that its trading symbol changed to CLSC at the start of trading on August 27, 2004. The symbol change has been made to ...
12-Lipoxygenase blockade protects neurons from peptide-induced degeneration.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- 12-Lipoxygenase blockade protects neurons from peptide-induced degeneration. "The cyclooxygenase (COX) and lipoxygenase (LOX) pathways belong to the eicosanoid synthesis pathway, a major component of the chronic inflammatory process ...
Acetylcholine minor role in prepulse inhibition regulation in Alzheimer disease.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Acetylcholine has only a minor role in prepulse inhibition regulation in Alzheimer disease. According to published research from Denmark, "Prepulse inhibition (PPI) is used as a measure for sensorimotor gating. Studies in animals have ...
Alzheimer researchers eye brain buildup.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- How to prevent a sticky gunk from clogging up, and probably killing, the brain cells of Alzheimer patients is the newest focus in the fight against the disease. Half a dozen companies are developing drugs to target the buildup, and ...
Influence of O-3/O-2-pneumoperitoneum as an oxidative stressor analyzed.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- The influence of O-3/O-2-pneumoperitoneum has been studied as an oxidative stressor on duration of anesthesia, loss of different reflexes and cytokine mRNA expression. "We analyzed the effect of intraperitoneal insufflated ozonized ...
GENASIS phase IIb clinical trial for severe cardiovascular disease begins.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Corautus Genetics, Inc., (CAQ) announced the commencement of its phase IIb clinical trial to evaluate the safety and efficacy of vascular endothelial growth factor-2 (VEGF-2) for the treatment of severe cardiovascular disease. Corautus ...
Angiogenic response is heightened in collagen XVIII/endostatin-null mice.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Angiogenic response is heightened in collagen XVIII/endostatin-null mice. According to a study from the United States, "endostatin, a proteolytic fragment of basement membrane-associated collagen XVIII, has been shown to be a potent ...
Caveolin-1 is critical for vascular remodeling following limb ischemia.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Caveolin-1 is critical for vascular remodeling following limb ischemia. According to recent research published in the journal Circulation Research, "nitric oxide (NO) is a powerful angiogenic mediator acting downstream of vascular ...
Most widely used stress modality for CMR perfusion studies is adenosine.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Cardiovascular magnetic resonance and the role of adenosine pharmacologic stress were the focus of a recent report. "As an advanced imaging modality, cardiovascular magnetic resonance (CMR) offers high spatial resolution and produces ...
Superoxide dismutase gene transfer improves impaired aortic relaxation.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Superoxide dismutase gene transfer improves impaired aortic relaxation. According to a study from the United States, "lipopolysaccharide (LPS) impairs vascular function, in part by generation of reactive oxygen species. One goal of this ...
Inhibition may aid protective effect of IL-10 on postangioplasty restenosis.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- IL-10 inhibits vascular smooth muscle cell activation in vitro and in vivo. According to published research from France, "The anti-inflammatory cytokine IL-10 inhibits intimal hyperplasia after stent implantation via a powerful ...
Captopril works without affecting cardiac sympathetic neurotransmission.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Captopril enhances cardiac vagal but not sympathetic neurotransmission in pithed rats. According to a study from Japan, "The effect of captopril on neurally evoked bradycardia and tachycardia was investigated in pithed rats. Captopril ...
Enalapril and ramipril provide similar clinical benefits in animals.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- The benefits of ACE inhibitors with tissue-active levels were recently examined in the cardiac-compromised animals. According to published research from Australia, "Angiotensin converting enzyme inhibitors (ACEI) have been proven ...
Predictors of leptin in adolescent girls with anorexia identified.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Researchers have identified hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa. "Anorexia nervosa (AN) is associated with very low levels of ...
U.S. FDA approves ciprofloxacin to manage postexposure inhalational anthrax.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- The U.S. Food and Drug Administration (FDA) has approved ciprofloxacin hydrochloride for the management of postexposure inhalational anthrax. According to a study from the United States, "In August 2000, the U.S. FDA approved ...
Dinitroanilines disrupt protozoan microtubules by binding alpha-tubulin.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Dinitroanilines disrupt protozoan microtubules by binding alpha-tubulin. "Protozoan parasites are remarkably sensitive to dinitroanilines such as oryzalin, which disrupt plant but not animal microtubules," scientists in the United States ...
Nisin forms cage-like structure around bacterial cell wall.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Many antibiotics kill bacteria by weakening their cell walls. However, some bacteria are finding ways to prevent the destructive action of the antibiotics, and drug-resistant pathogens have become an increasingly critical public health issue. ...
Pharma company completes hiring of sales team for FACTIVE.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Oscient Pharmaceuticals Corporation (Nasdaq: OSCI) has completed the hiring of its sales force and sales leadership team for its U.S. Food and Drug Administration-approved FACTIVE (gemifloxacin mesylate) tablets. All of the 100-plus ...
Optimal level of anticoagulation remains matter of debate.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- What are the remaining questions regarding monitoring of heparin therapy during extracorporeal bypass? According to published research from France, "Cardiac surgery with extracorporeal circulation induces major alterations of hemostasis ...
Use of antidepressants by children debated after shooting in Houston.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- The case of a 10-year-old boy accused of killing his father is fueling ongoing concerns about the use of antidepressants by pediatric patients. Deborah Geisler, the boy's mother, said a psychiatrist prescribed Prozac for her son in early ...
Bioscience company files patent for silver dihydrogen citrate formulations.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- PURE Bioscience (OTCBB:PURE) announced that it has filed a utility patent application to protect its proprietary silver dihydrogen citrate disinfectant in combination with other antimicrobial compounds, including quaternary ammonia, oxidizers or ...
Double-stranded complexes increase antisense oligonucleotide uptake.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Double-stranded complexes increase antisense oligonucleotide uptake. "Antisense oligonucleotides were potentially very powerful tools to modulate gene expression. Progress in chemical modification of oligonucleotides to enhance the ...
Chronic hepatitis C nonresponders are a challenge to clinical management.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Chronic hepatitis C nonresponders are a challenge to clinical management. "A significant proportion of chronic hepatitis C patients fails to achieve sustained virologic response even after treatment with the current, more potent, ...
Impact of genetic variations on treatment of early rheumatoid arthritis studied.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Characterized by inflammation in the connective tissues of the joints, rheumatoid arthritis (RA) can be a painful, crippling autoimmune disease. Traditionally, patients have been treated with disease-modifying antirheumatic drugs, or DMARDs, such ...
Allergens, endotoxins don't have same effects in tropical environments.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Indoor concentrations of allergens traditionally associated with asthma symptoms and severity may not be applicable in tropical environments and highly ventilated households. According to a study from the United States, "A ...
Antimicrobial-coated vascular grafts provide antimicrobial protection.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Antimicrobial-coated vascular grafts provide antimicrobial protection. "The serious medical consequences and costly management of infections associated with vascular grafts have prompted an expanding interest in examining the preventive ...
Immune system's neuroprotective response to brain injury analyzed.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Autoreactivities to brain tissue in autism patients may represent the immune system's neuroprotective response to a previous brain injury that occurs during neurodevelopment. According to published research from Portugal, "The hypothesis ...
Genetically modified bone marrow cells produce tolerance to self antigens.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Genetically modified bone marrow cells produce tolerance to self antigens. "The challenge of finding a lasting cure for autoimmune disease(s) has not been met. Although the use of systemic anti-inflammatory agents still dominates the ...
Some SCPs are relevant to our understanding of autoimmunity.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Some subcellular particles (SCPs) are relevant to our understanding of autoimmunity, researchers posit. "Firm evidence links the process of apoptosis to the induction of autoimmune disease. However, questions remain regarding the precise ...
IADR, GlaxoSmithKline Consumer Healthcare sponsor Innovation in Oral Care Awards.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- The International Association for Dental Research (IADR) and GlaxoSmithKline (GSK) Consumer Healthcare will sponsor the 2005 Innovation in Oral Care Awards. Competitive awards, up to $75,000, will be provided to recipients to advance ...
Myeloma research group announces 2004 senior Research and Fellows Awards winners.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- The Multiple Myeloma Research Foundation (MMRF), a private funder of myeloma-specific research, announced the awarding of 20 one-year research grants worth nearly $1.6 million to leading myeloma researchers through its Senior Research and Fellows ...
Rapid diagnosis of pharyngitis caused by group A streptococci is vital.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Rapid diagnosis of pharyngitis caused by group A streptococci can reduce the risk of spreading the disease. "Although commercial rapid antigen detection tests (RADTs) are more expensive than blood agar plate (BAP) cultures, the advantage ...
Model system assesses Escherichia coli evolution during stationary phase.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- A model system assesses Escherichia coli evolution during its stationary phase. According to a study from the United States, "The process of evolution by natural selection has been known for a century and a half, yet the mechanics of ...
Association: German biotech industry sees light at the end of the tunnel.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- After two difficult years, there are more signals in 2004 that trends are turning in the economic situation of the German biotechnology industry. Professor Peter Stadler, chairman of the German Association of Biotechnology Industries ...
Newer anticonvulsants for treating bipolar disorder reviewed.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Researchers review newer anticonvulsants for the treatment of bipolar disorder in a recent issue of the Journal of Clinical Psychiatry. According to a study from Canada, "The anticonvulsants valproate and carbamazepine have efficacy in ...
BMI determines evoked growth hormone responsiveness in healthy male subjects.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Body mass index (BMI) determines evoked growth hormone (GH) responsiveness in normal healthy male subjects. "GH secretion is decreased in obese subjects, whereas age-adjusted IGF-I concentrations are normal. This study was undertaken to ...
Diabetic metabolic state affects healing of large bone defects.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Diabetic metabolic state affects healing of large bone defects. According to recent research from Germany, "Insulin-dependent type 1 diabetes mellitus (IDDM) has been shown to after the properties of bone and impair bone repair in both ...
Symptoms predictive of death in patients with food-borne botulism reported.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Researchers outline the signs and symptoms predictive of death in patients with food-borne botulism in a recent issue of Clinical Infectious Diseases. According to published research from the United States and the Republic of Georgia, ...
Urokinase receptor ligands spoil glioma growth via antiangiogenesis.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Urokinase receptor ligands spoil glioma growth via antiangiogenesis. "Species-specific urokinase receptor (uPAR) ligands with improved pharmacokinetics were generated by site-specific mutagenesis and amino-terminal pegylation. These ...
iBAC system-mediated gene delivery stifles glioma cell growth.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- iBAC system-mediated gene delivery stifles glioma cell growth. "The expression of genes from genomic loci can be relatively complex, utilizing exonic, intronic and flanking sequences to regulate tissue and developmental specificity ....
Breast tumor cells may swell in response to tamoxifen methiodide treatment.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Diffusion breast magnetic resonance imaging (MRI) may be applied to the clinical evaluation of breast cancer. "The parameters that characterize the intricate water diffusion in tumors may serve to reveal their distinct pathology. ...
Breast-conserving surgery plus radiation good for older women, too.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Surgery plus radiation therapy is an effective way to treat early breast cancer in women aged 70 and older, according to a new study published in the September 1, 2004, issue of the International Journal of Radiation Oncology Biology Physics, the ...
Prevention study seeks postmenopausal women at high risk for breast cancer.
Oct 01, 2004 ... 2004 OCT 1 - (NewsRx.com & NewsRx.net) -- Healthy, postmenopausal women at high risk for breast cancer may be eligible to participate in a major new international study to determine whether the drug exemestane can prevent the disease. The University of California, Davis, Medical ...