Recently added articles from Folia Histochemica et Cytobiologica:

Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells

Apr 01, 2008; Pajak, Beata; Orzechowski, Arkadiusz; Gajkowska, Barbara ... Abstract: This review outlines the molecular events that accompany the anti-tumor action of parthenolide (PN). Parthenolide (PN) is naturally derived compound, isolated from plant Tanacetum parthenium. PN has been previously shown to withdraw cells from cell cycle or to promote cell ...

Triple immunofluorescence labeling of atherosclerotic plaque components in apoE/LDLR^sup -/-^ mice

Apr 01, 2008; Gajda, Mariusz; Jawien, Jacek; Mateuszuk, Lukasz; Lis, Grzegorz J; Radziszewski, Andrzej; Chlopicki, Stefan; Litwin, Jan A ... Abstract: This paper presents a simple and reliable method of triple immunofluorescence staining that allows simultaneous detection of various cell types present in atherosclerotic plaque of apolipoprotein E and LDL receptor-double knockout (apoE/LDLR ^sup -/-^) mice. We used combined direct and ...

ZAP-70 and CD38 expression are independent prognostic factors in patients with B-cell chronic lymphocytic leukaemia and combined analysis improves their predictive value

Apr 01, 2008; Hus, Iwona; Bojarska-Junak, Agnieszka; Dmoszynska, Anna; Wasik-Szczepanek, Ewa; Sieklucka, Malgorzata; Trzesniewska, Wioletta; Glazer, Magdalena; Rolinski, Jacek ... Abstract: Recently identified biological risk factors in B-cell chronic lymphocytic leukemia (B-CLL) include ZAP-70 and CD38 expression. The present study was conducted to clarify whether a combined analysis could improve predictive impact of these two parameters. We examined the expression of ...

Application of primary cell cultures of laryngeal carcinoma and laser scanning cytometry in the evaluation of tumor reactivity to cisplatinum

Apr 01, 2008; Klatka, Janusz; Paduch, Roman; Pozarowski, Piotr; Pietruszewska, Wioletta; Kupisz, Krzysztof; Trojanowski, Piotr; Rolinski, Jacek ... Abstract: Unsatisfactory effects of treatment of laryngeal carcinoma patients stimulate the clinicians as well as researchers to develop new more effective treatment models and to find new reliable prognostic factors. The aim of the present study was the evaluation of the use of primary cell ...

Dendritic cells based immunotherapy of patient with chondrosarcoma - case report

Apr 01, 2008; Tabarkiewicz, Jacek; Radej, Sebastian; Hus, Iwona; Wasiak, Magdalena; Wdowiak, Paulina; Giannopoulos, Krzysztof; Piechnik, Beata; Klos, Adam; Dmoszynska, Anna; Rolinski, Jacek ... Abstract: We present a case report of patient with intracranial chondrosarcoma and attempt to use vaccination of dendritic cells as the salvage therapy. To our knowledge, this is the first case report of DCs vaccination in the head and neck chondrosarcoma. Immunotherapy with allogeneic DCs ...

Expression of connexin 26 in endometrial adenocarcinoma - analysis of correlations with some anatomoclinical features

Apr 01, 2008; Lesniewicz, Tomasz; Kanczuga-Koda, Luiza; Baltaziak, Marek; Sulkowska, Mariola; Rutkowski, Ryszard; Koda, Mariusz; Sulkowski, Stanislaw ... Abstract: Alterations of gap junctional intercellular communication appear to play a role in the development and progression of cancer. Gap junction channel is composed of two connexons - hexameric units formed of transmembrane proteins called connexins (Cxs). The aim of the study was to ...

The release of soluble forms of TRAIL and DR5 by neutrophils of oral cavity cancer patients

Apr 01, 2008; Jablonska, Ewa; Jablonski, Jakub; Marcinczyk, Magdalena; Grabowska, Zyta; Piotrowski, Leszek ... Abstract: In the present study we examined the release of the soluble form of TRAIL by neutrophils (PMN) derived from patients with oral cavity cancer. Simultaneously, we estimated the ability of PMNs of these patients to release the soluble form of DR5 receptor, a natural regulatory protein of ...

Plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator (uPA) in sputum of allergic asthma patients

Apr 01, 2008; Kowal, Krzysztof; Zukowski, Sebastian; Moniuszko, Marcin; Bodzenta-Lukaszyk, Anna ... Abstract: Urokinase plasminogen activator (uPA) and its inhibitor (PAI-1) have been associated with asthma. The aim of this study was to evaluate concentration of uPA and PAI-1 in induced sputum of house dust mite allergic asthmatics (HDMAAs). The study was performed on 19 HDM-AAs and 8 healthy ...

The effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and SU1498, on autocrine growth of prostate cancer cells (DU145)

Apr 01, 2008; Kisielewska, Joanna; Ligeza, Janusz; Klein, Andrzej ... Abstract: It is well established that autocrine growth of human prostate cancer cell line DU145 is dependent on TGF (EGF)/EGFR loop. However, the participation of several other growth factors in proliferation of DU145 cells has been also proposed. We employed two selective tyrosine kinase ...

The concentration of kynurenine in rat model of asthma

Apr 01, 2008; Kucharewicz, Iwona; Kasacka, Irena; Pawlak, Dariusz; Tankiewicz-Kwedlo, Anna; Mroczko, Barbara; Buczko, Wlodzimierz; Bodzenta-Lukaszyk, Anna ... Abstract: Asthma is a chronic inflammatory disease that involves the immune system activation. Evidence is accumulating about the role of kynurenine pathway in the immune system regulation. The kynurenine pathway includes several metabolites of tryptophan, among others kynurenine (KYN). To study ...

Age-dependent different action of curcumin in thyroid of rat

Apr 01, 2008; Papiez, Monika A; Kaja, Marcin; Gebarowska, Agata ... Abstract: The aging is associated with alterations in the hypothalamic-pituitary-thyroidal axis which can lead to hypothyreosis. Our previous investigations has shown that polyphenol curcumin can enhance the manifestation of hypothyreosis in rats simultanous treated with propylthiouracil. The ...

Inducible nitric oxide synthase immunoreactivity in healthy rat pancreas

Apr 01, 2008; Keklikoglu, Nurullah ... Abstract: Nitric oxide (NO) is produced by NO synthase (NOS) isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (iNOS). It is believed that, while nNOS and eNOS are effective in regulation of normal physiological processes, iNOS is expressed at an increasing rate especially ...

Aminoglycosides resistance in clinical isolates of Staphylococcus aureus from a University Hospital in Bialystok, Poland

Apr 01, 2008; Hauschild, Tomasz; Sacha, Pawel; Wieczorek, Piotr; Zalewska, Marta; Kaczynska, Katarzyna; Tryniszewska, Elzbieta ... Abstract: Staphylococcus aureus obtained from a University Hospital in Poland were characterized in relation to resistance to aminoglycoside antibiotics and the distribution of the genes encoding the most clinically relevant aminoglycoside modifying enzymes (AMEs). Of a total of 118 S. aureus, ...

Cannabinoids enhance gastric X/A - like cells activity

Apr 01, 2008; Zbucki, Robert Lukasz; Sawicki, Boguslaw; Hryniewicz, Anna; Winnicka, Maria Malgorzata ... Abstract: It has been reported that cannabinoids may cause overeating in humans and in laboratory animals. Although, endogenous cannabinoids and their receptors (CB1) have been found in the hypothalamus, and recently also in gastrointestinal tract, the precise mechanism of appetite control by ...

Somatostatin-like immunoreactivity in the amygdala of the pig

Apr 01, 2008; Równiak, Maciej; Robak, Anna; Bogus-Nowakowska, Krystyna; Kolenkiewicz, Malgorzata; Bossowska, Agnieszka; Wojtkiewicz, Joanna; Skobowiat, Cezary; Majewski, Mariusz ... Abstract: The distribution and morphology of neurons containing somatostatin (SOM) was investigated in the amygdala (CA) of the pig. The SOM-immunoreactive (SOM-IR) cell bodies and fibres were present in all subdivisions of the porcine CA, however, their number and density varied depending on ...

Thiocyanate concentration in saliva of cystic fibrosis patients

Apr 01, 2008; Minarowski, Lukasz; Sands, Dorota; Minarowska, Alina; Karwowska, Alicja; Sulewska, Anetta; Gacko, Marek; Chyczewska, Elzbieta ... Abstract: Thiocyanates (SCN-) are ubiquitous in nature. There are indispensable part of host defense system that act as a substrate for lactoperoxidase (LPO). In our study we present initial data on SCN- concentration in saliva of CF patients in comparison to healthy non-smokers and healthy ...

An efficient two-step method to purify very small embryonic-like (VSEL) stem cells from umbilical cord blood (UCB)

Apr 01, 2008; Halasa, Maciej; Baskiewicz-Masiuk, Magdalena; Dabkowska, Elzbieta; Machalinski, Boguslaw ... Abstract: The identification in murine bone marrow (BM) of very small embryonic-like (VSEL) stem cells, possessing several features of pluripotent stem cells, encouraged us to investigate if similar population of cells could be also isolated from the human umbilical cord blood (UCB). Here our ...

Metallo-[beta]-lactamases of Pseudomonas aeruginosa - a novel mechanism resistance to [beta]-lactam antibiotics

Apr 01, 2008; Sacha, Pawel; Wieczorek, Piotr; Hauschild, Tomasz; Zórawski, Marcin; Olszanska, Dorota; Tryniszewska, Elzbieta ... Abstract: Since about twenty years, following the introduction into therapeutic of news β-lactam antibiotics (broad-spectrum cephalosporins, monobactams and carbapenems), a very significant number of new β-lactamases appeared. These enzymes confer to the bacteria which put them, the ...

Naive helper T cells from BCG-vaccinated volunteers produce IFN-[gamma] and IL-5 to mycobacterial antigen-pulsed dendritic cells

Apr 01, 2008; Kowalewicz-Kulbat, Magdalena; Kazmierczak, Dominik; Donevski, Stefan; Biet, Franck; Pestel, Joël; Rudnicka, Wieslawa ... Abstract: Mycobacterium bovis bacillus Calmette-Guerin (BCG) is a live vaccine that has been used in routine vaccination against tuberculosis for nearly 80 years. However, its efficacy is controversial. The failure of BCG vaccination may be at least partially explained by the induction of poor ...