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Genetics articles

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Professional journal providing news and analysis on field of genetics. Features special reports such as policy reviews and awards.

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Nonmetric Multidimensional Scaling Corrects for Population Structure in Association Mapping With Different Sample Types

Jul 01, 2009; ... ABSTRACT Recent research has developed various promising methods to control for population structure in genomewide association mapping of complex traits, but systematic examination of how well these methods perform under different genetic scenarios is still lacking. Appropriate methods ...

Linkage Disequilibrium Between Loci With Unknown Phase

Jul 01, 2009; ... ABSTRACT Linkage disequilibrium is often measured by two statistics, D and r, which can be interpreted as the covariance and the correlation between loci and across gametes. When data consist of diploid genotypes, however, gametes cannot be identified. A variety of iterative statistical ...

The nsdC Gene Encoding a Putative C^sub 2^H^sub 2^-Type Transcription Factor Is a Key Activator of Sexual Development in Aspergillus nidulans

Jul 01, 2009; ... ABSTRACT The formation of the Aspergillus nidulans fruiting body is affected by a number of genetic and environmental factors. Here, the nsdC (never in sexual development) gene-encoding a putative transcription factor carrying a novel type of zinc-finger DNA-binding domain consisting of ...

CORRIGENDUM

Jul 01, 2009; ... In the article by I. Georis, A. Feller, J. Tate, T. Cooper and E. Dubois (Genetics 181: 861-874) entitled ''Nitrogen Catabolite Repression-Sensitive Transcription as a Readout of Tor Pathway Regulation: The Genetic Background, Reporter Gene and GATA Factor Assayed Determine the Outcomes,'' ...

Genomewide Analysis Reveals Novel Pathways Affecting Endoplasmic Reticulum Homeostasis, Protein Modification and Quality Control

Jul 01, 2009; ... ABSTRACT To gain new mechanistic insight into ER homeostasis and the biogenesis of secretory proteins, we screened a genomewide collection of yeast mutants for defective intracellular retention of the ER chaperone, Kar2p. We identified 87 Kar2p-secreting strains, including a number of ...