Health & Medicine Week back issues from November 2003:
Prevalence and risk factors for mild cognitive impairment in elderly described.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The prevalence of mild forms of cognitive impairment among the elderly increases with age and may be associated with cerebrovascular disease, depression, and racial factors, according to two new studies. Mild cognitive impairment (MCI) ...
Scientists discover overweight, obesity jump between adolescence, adulthood.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- More than 2 million U.S. adolescents became obese and another 1.5 million remained obese as they grew into adulthood between 1996 and 2001, a new University of North Carolina at Chapel Hill (UNC) study concludes. During the same period, only ...
Vowel quality improves after cochlear implantation.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Vowel quality improves after cochlear implantation. According to a study from Austria, "Since auditory feedback is partially restored after cochlear implantation, the aim of the present study was to investigate features of vowels, which ...
Standard improves tests of male DNA.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Mother Goose tells us that boys are made of "snips and snails and puppy dog tails." She was clearly misinformed about the snails and tails, but she was on to something with the snips. What you really need to build a boy is a "Y" ...
Adductor pollicis fatigue is comparable in older men and women.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Adductor pollicis fatigue is comparable in older men and women. "Sex differences in fatigue resistance of the adductor pollicis (AP) muscle were studied in 24 older adults who were divided into three groups: 12 older men (69.8[+ or ...
Hormone replacement therapy augments the influence exercise has on bone health.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Hormone replacement therapy augments the influence exercise has on bone health. "Osteoporosis is a major public health concern. The combination of exercise, hormone replacement therapy, and calcium supplementation may have added benefits ...
Stem-cell donation by Crohn colitis patients may put recipients at risk.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Stem-cell donation by Crohn colitis patients may pass the disorder to graft recipients. In the journal Gut, scientists in England described "a case of fulminant Crohn's colitis that occurred following non-myeloablative allogeneic ...
Gates Foundation doubles grant for India.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The Bill and Melinda Gates Foundation says it is doubling, to $200 million, the prevention funds for HIV and AIDS that the Microsoft chairman promised India in a visit last year. The announcement came as a former U.S. diplomat said India ...
VScan test kits are being shipped to People's Republic of China.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Medical Services International (MSITF) has received a letter of intent to supply 250,000 VScan HIV rapid-test kits to a major Chinese pharmaceutical company in the People's Republic of China. Shipping began immediately upon approval. ...
FDA grants anti-CD4 drug fast-track status for the treatment of HIV-1.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Tanox, Inc., (TNOX) announced that the U.S. Food and Drug Administration (FDA) has granted fast-track status to TNX-355 for the treatment of patients with human-immunodeficiency virus 1 (HIV-1) infection who have failed or are failing ...
Operative technique and postoperative care reduce abortion-related problems.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Operative technique and postoperative care reduce abortion-related problems. According to recent research published in the American Journal of Obstetrics and Gynecology, "surgical abortion in the first trimester comprises the majority of ...
New device-based skin treatments reported.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Device-based acne treatments are rapidly finding acceptance from physicians and patients, according to clinical news reports in the most recent issue of the Aesthetic Buyers Guide, published by Medical Insight, Inc. The SkinStation from ...
Cell infusions boost heart function, revive damaged heart muscle.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Infusing a patient's own cells into a heart artery several days after a heart attack speeds the healing process and strengthens the heart's pumping power, researchers report. In a small study of heart attack patients, German researchers ...
Parental education is significant for preventing inhalant abuse.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Parental education is significant for preventing inhalant abuse. According to a study from the United States, "inhalant abuse is a prevalent and often overlooked form of substance abuse in adolescents. Survey results consistently show ...
Treatment for substance abuse during pregnancy improves infant outcomes.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Treatment for substance abuse during pregnancy improves infant outcomes. "The objective of this study was to analyze the effects of residential substance abuse treatment on pregnancy outcome among gravidas in a gender-specific program ....
Adipose tissue and women's health discussed.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The view of adipose tissue and its role in women's health is discussed in a recent issue of the journal Pathologie Biologie. "Nowadays, in industrialized societies, it is fashionable for women to be slim. However, throughout history, ...
Clinical and molecular aspects of adrenocortical tumorigenesis reviewed.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Clinical and molecular aspects of adrenocortical tumorigenesis is reviewed. "Adrenal masses are a common problem affecting 3-7% of the population. The majority turn out to be benign adrenocortical adenomas, which may be functional or ...
5-FU infusion plus CPT-11 is an active and safe regimen in advanced CRC.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- 5-FU infusion plus CPT-11 is an active and safe regimen in advanced colorectal cancer (CRC). "We carried out a single-center series with the combination of irinotecan (CPT-11) plus protracted 5-fluorouracil (5-FU) infusion as ...
Liver transplant tacrolimus neurotoxicity may be preceded by leukoencephalopathy.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Liver transplant neurotoxicity following tacrolimus may be preceded by leukoencephalopathy. According to recent research published in the journal Liver Transplantation, "Neurotoxicity is a well-known side effect of tacrolimus-based ...
Medical Mutual to use RationalMed to prevent drug-induced problems.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Medical Mutual is introducing RationalMed, a health and safety system from Medco Health Solutions, Inc. The system uses integrated medical and pharmaceutical data to prevent unnecessary hospitalizations and drug-induced illnesses. ...
Families with periodontitis have elevated levels of IgG2 that are inherited.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Families with aggressive periodontitis are found to have elevated levels of IgG2 that are inherited. According to a study from the United States, "IgG2 is elevated in localized but not in generalized aggressive periodontitis (AgP). ...
Asthma may occur due to vagal reflex stimulation from gastroesophageal reflux.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Vagal reflex stimulation may be involved in the airway hyperresponsiveness that can accompany gastroesophageal reflux. "Airway hyperresponsiveness is among the defining phenomena in asthma. In this article, 3 mechanisms are reviewed to ...
Tri-Nasal Nasal Spray acquired from Muro Pharmaceutical.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Collegium Pharmaceutical, Inc., a closely held specialty pharmaceutical company, announced that it has acquired from Muro Pharmaceutical, Inc., all rights to Tri-Nasal (triamcinolone acetonide, USP) Nasal Spray, including the product's approved new ...
Avoiding pets may not prevent allergies.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Exposure to high levels of cat allergen as a child may prevent the development of allergies, according to a study published in the Journal of Allergy and Clinical Immunology (JACI). Researchers found that avoiding having cats or dogs as ...
APOE epsilon4 associated with shorter lifespan.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- APOE epsilon4 was associated with a shorter lifespan in elderly adults. "Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE epsilon4 is associated with increased prevalence and severity of CAA in ...
APOE expression increases Alzheimer disease risk.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- APOE expression increases the risk of Alzheimer disease risk and is predictive of a poor outcome after head injury. "The APOE-epsilon4 allele is associated with risk for Alzheimer disease (AD) and poorer outcome after head injury ....
CBP binding transcriptional repressor inhibited by PS1FAD mutations.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1FAD mutations. According to published research from the United States, "Presenilin1 (PS1), a protein implicated in Alzheimer ...
G-protein alpha-subunits decline as Alzheimer disease progresses.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The levels of G-protein alpha-subunits decline as Alzheimer disease progresses. "G-protein alpha-subunits (G-alpha[subscript]o, G-alpha[subscript]i, G-alpha[subscript]s, G-alpha(q)) and adenylyl cyclase (AC) I and II isoforms were ...
Inhibition of NF-kB promotes apoptosis induced by amyloid beta peptides.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Inhibition of NF-kB renders cells more vulnerable to apoptosis induced by amyloid beta peptides. According to recent research from Portugal, "One of the mechanisms leading to neurodegeneration during Alzheimer disease (AD) is amyloid ...
Melatonin inhibition of beta-amyloid peptide attenuated by bicuculline.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The melatonin inhibition of beta-amyloid peptide overexpression could be attenuated by bicuculline treatment. According to recent research from People's Republic of China, "Melatonin deficiency in cerebrospinal fluid has been postulated ...
Biologic marker specific for the diagnosis of Alzheimer disease.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Berlex Pharmaceuticals, a U.S. affiliate of Schering AG Germany (SHR), announced that it has discovered that a receptor protein molecule, CCR1, that is usually found on the surface of white blood cells also is present in the brains of patients with ...
Massachusetts General to battle ALS with RNAi technology.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Massachusetts General Hospital and CytRx Corp. (CYTR) have jointly initiated a broad-based research program for the use of RNAi gene-silencing technology in the development of a drug for the prevention, treatment, or cure for amyotrophic lateral ...
Research program funded for study of RNAi technology in ALS.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- CytRx Corporation (CYTR) announced that it has agreed to fund a sponsored research program at the University of Massachusetts Medical School (UMMS) for the use of RNAi gene silencing technology in the development of a treatment for amyotrophic ...
Erythropoietin treatment could worsen cancer prognosis.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Results of a European study cast doubt over the value of treating anemia with erythropoietin (epoetin beta) among patients who have cancer. Results of the study show that anemic patients fare better in terms of reduced cancer progression and ...
No association found between serum hepcidin and markers of anemia.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- No significant association exists between serum hepcidin and other markers of iron status or anemia. "The hepatic antimicrobial protein, hepcidin, is implicated in duodenal iron absorption and mobilization. Overexpression of the ...
NIH grant funds study of (un)consciousness.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- With a 4-year, $1,200,000 grant to the Medical College of Wisconsin, the U.S. National Institutes of Health (NIH) is funding a scientific study of the enigmatic problem of consciousness. Specifically, the researchers will investigate the neural ...
Update provided on FDA review of PMR System.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- CardioGenesis Corporation (CGCP), a provider of angina-relieving Transmyocardial Revascularization (TMR) and percutaneous myocardial revascularization (PMR), announced that the company and the U.S. Food and Drug Administration (FDA) have made ...
CD226 is on nonresting human endothelial cells, allows adhesion of leukocytes.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The transmembrane glycoprotein CD226 is involved in adhesion of leukocytes to endothelial cells and in endothelial cells it is an inducible molecule. According to recent research published in the journal Life Sciences, "CD226 is a 67 kDa ...
Two-stage procedures create rodent models of severe limb ischemia at rest.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Two-stage procedures create rodent models of severe limb ischemia at rest. "We sought an animal model able to discriminate metabolic and angiogenic processes in limb ischemia. For that we modified and evaluated a rat model of severe ...
Spectrum of components of angiosarcomas accounts for difficulty in tumor typing.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A wide spectrum of cellular components of angiosarcomas accounts for the difficulty in establishing accurate tumor typing. According to recent research from France, "To characterize the cytological features of angiosarcomas, we reviewed ...
P-glycoproteins for multidrug resistance are in Haemonchus contortus, eggs.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Nematode eggshells and adults of Haemonchus contortus contain P-glycoproteins involved in multidrug resistance, although individual parasites have different degrees of it. "The multidrug resistance (MDR) system involves the action of ...
Phase I trial yields positive results for the prevention of serious infections.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Ipsat Therapies presented positive Phase I clinical trial data for its lead product, P1A, at the BioPartnering Europe Conference in London. This product fulfils many of the criteria for fast-track development by the U.S. Food and Drug ...
IL-17 alone may enhance osteosarcoma cell lysis by natural killer cells.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Osteosarcoma cells have receptors to IL-17; IL-17 alone may enhance lysis by NK cells, but with IFNgamma they resist NK more. "We investigated the effect of the proinflammatory cytokine interleukin 17 (IL-17) on the lysis of osteosarcoma ...
Ligand-targeted liposomal anticancer drugs may be developed soon.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Ligand-targeted liposomal anticancer drugs may be developed soon. "Antibody or ligand-mediated targeting of liposomal anticancer drugs to antigens expressed selectively or over-expressed on tumor cells is increasingly being recognized as ...
Luminescent imaging is a useful tool for evaluating anticancer drugs in vivo.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Luminescent imaging is a useful tool for evaluating anticancer drugs in vivo. "Human DU-145 prostate and MCF-7 breast tumor cell lines were stably transfected with plasmid pcDNA3.1-Luc expressing firefly luciferase. Studies were ...
Researchers develop an anticancer agent of marine origin.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Researchers develop an anticancer agent of marine origin. According to recent research from Netherlands, "Yondelis (trabectedin, ET-743) is a novel antitumor agent derived from a marine source, the Caribbean tunicate Ecteinascidia ...
Virus delivered nitroreductase/CB1954 acts synergistically with 5-FU on cancer.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The enzyme-prodrug combination nitroreductase/CB1954 creates cancer cell apoptosis by the caspase pathway, and acts synergistically with 5-fluorouracil. According to published research from England, "Virus-directed enzyme prodrug therapy ...
Passive immunotherapy appears to be an effective way to treat melanoma.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Passive immunotherapy should soon be a recognized way of effectively treating melanoma. According to recent research published in the journal Bulletin du Cancer, "The protocols of tumor immunotherapy have been largely developed in the ...
On-X prosthetic heart valve maker begins aspirin study.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Medical Carbon Research Institute, L.L.C., (MCRI), manufacturer of the On-X prosthetic heart valve, announced the initiation of a clinical study under an aspirin-only anticoagulation protocol. The protocol was approved by the German ...
The asparaginyl endopeptidase inhibitor, acyloxymethylketone, is cell-permeable.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The potent asparaginyl endopeptidase inhibitor, acyloxymethylketone, is cell-permeable; alters antigen presentation. "Mammalian asparaginyl endopeptidase (AEP) or legumain is a recently identified lysosomal cysteine protease belonging to ...
The C-terminal domain of human CAP18 was used to develop more active analogues.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The C-terminal domain of human antibacterial protein CAP18 was used as a base to develop 2 proteins with stronger antibacterial effect. "This paper reports the effect of the synthesized 27-amino acid (aa) sequence in the C-terminal ...
Pacidamycin derivatives active against drug-resistant bacterial pathogens.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A series of pacidamycin derivatives have demonstrated activity against drug-resistant bacterial pathogens, including E. coli and M. tuberculosis. According to a recent study from California, "Dihydropacidamycins having an antibacterial ...
Innate antimicrobials are important, despite some bacterial immune evasion.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Antimicrobial peptides are involved in innate immune defense against bacteria, and bacteria have evolved some ways to evade these molecules. According to recent research published in the journal Current Allergy and Asthma Reports, ...
Aggregated antibiograms useful for monitoring drug-resistant Streptococcus.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Aggregated antibiograms are useful for the monitoring of drug-resistant Streptococcus pneumoniae. "Community-specific antimicrobial susceptibility data may help monitor trends among drug-resistant Streptococcus pneumoniae and guide ...
Mechanism of metronidazole-resistance by Enterococcus proposed.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Researchers propose a mechanism for metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. According to recent research published in the ...
Ganoderma lucidum, a mushroom, may prevent cisplatin-induced nephrotoxicity.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Ganoderma lucidum, a mushroom, may prevent cisplatin-induced nephrotoxicity. According to recent research published in the journal Current Science, "Cisplatin (cisplatinum (II) diamine dichloride) is an anticancer drug extensively used ...
Interferons alpha and beta act on p53; do have antitumor, antiviral activities.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Interferons alpha and beta collaborate with p53, effecting tumor suppression and antiviral effects; new types of interferon or better targeted delivery may be clinically effective. "In the recent paper by Takaoka et al. (2003), the ...
Plasmid-driven siRNAs useful for controlling viral pathogen gene expression.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Plasmid-driven siRNAs offer extensive control over the gene expression of viral pathogens. In a recent study from St. Louis, "Short interfering double-stranded RNAs (siRNAs) expressed under the control of an RNA polymerase I promoter ...
Children with constipation manifest more toileting anxiety than well kids.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Researchers at the Cleveland Clinic Foundation department of pediatric gastroenterology & nutrition report that children with functional constipation have significantly more anxiety specific to toileting behavior than well children, without ...
Parents favor counseling over meds for kids.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- New research suggests that parents would rather send their children to counseling than give them medication for social anxiety disorder, a preference that has also been noted for childhood depression and attention-deficit disorder therapy. ...
Death risk hinges on choice of surgeon, study finds.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- If the largest blood vessel in your body threatens to burst, a new study finds that your best bet is to have it repaired by a surgeon who has operated on many other patients with the same condition. If you do, your risk of dying before you leave ...
Aorta area ratio can be used in noninvasive quantitation of flow turbulence.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Postvalvular aorta to valvular orifice cross-sectional areas ratio can be used in noninvasive quantitation of blood flow turbulence in aortic valve disease. According to a study from France, "Previous experimental studies have ...
Unusual form of memory loss often confused for Alzheimer disease.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- More than 4 million Americans have Alzheimer disease, the single most common cause of dementia. Its high prevalence may lead people to believe that dementia is always due to Alzheimer disease and that memory loss is a feature of all dementias. ...
Catheter insertion site can make a difference for apheresis patients.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The site of insertion and other aspects concerning catheters can make a difference for apheresis patients. According to published research from Germany, "In the intensive care unit, apheresis therapy (including plasma exchange, ...
Cardiac imaging can be "gatekeeper" for implantable heart-shocker.
Nov 03, 2003 ... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- High-tech images of the heart and its surrounding blood flow can help identify patients who will benefit most from implanted electronic devices that treat heart rhythm disturbances, according to a new study. Researchers used single ...