Immunotherapy Weekly back issues from October 1999:
Serotherapy No Help for Scorpion Stings.(antivenom)
Oct 11, 1999; ... (CW HENDERSON PUBLISHER www.newsfile.com) -- A needle prick can't cure a scorpion sting. That's the word from Tunisia, where a clinical trial shows that the established treatment for scorpion stings works no better than placebo. "We found no benefit in routine ...
Inhaled IL-2 Inhibits Pulmonary Metastases.(in renal-cell carcinoma)
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Inhaled interleukin-2 (IL-2) prevented progression of pulmonary metastases in 70 percent of treated patients. E. Huland and colleagues from the University of Hamburg, Germany, reported on six years of case experience with inhaled IL-2 ...
Eosinophilic Infiltrates Result from Type II Immune Response.
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Classifying eosinophilic tumor infiltrates may have implications for immunotherapy of cervical squamous carcinoma. Studies have shown that the presence of an eosinophilic infiltrate in patients with cervical squamous carcinoma is ...
Gliadin Down-Regulates Specific Immune Response in Mice.
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Intranasal or intravenous routes may be useful for immunomodulatory strategies against coeliac disease (CD), a recent study suggests. M. Rossi and colleagues from the Institute of Sciences Alimentaz, Italy, examined the immunological ...
Radioimmunotherapy Trial Results Promising Against Colorectal Cancer.
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Phase I/II clinical trial results suggest that radioimmunotherapy (RIT) may be a viable therapeutic option for colorectal cancer patients. T.M. Behr and colleagues from the University of Gottingen, Germany, compared in a preclinical ...
Sperm CD52 Glycoform Responsible for Anti-Sperm Immune Responses.(carbohydrate moieties)
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Unique carbohydrate moieties of a sperm CD52 glycoform are responsible for the anti-sperm immune response initiated by some infertile women. Building on a benchmark study that established H6-3C4 as the first successful heterohybridoma ...
Antimalarials Augment Viral Replication.
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Widespread use of antimalarials in geographic regions where malaria is endemic may predispose the population to viral infections. Antimalarial drugs are widely used in malaria endemic areas, both for chemoprophylaxis and also ...
Somatostatin Analogues May Be Effective Against Neuroblastoma.
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Somatostatin analogues may be useful against metastatic neuroblastoma, a recent study suggested. P. Borgstrom and colleagues from the Childhood Cancer Research Unit, Sweden, examined somatostatin (SOM) analogues for their anticancer ...
Bone Protein Found To Reduce Bone Loss Significantly.(osteoprotegerin)
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers reported that injections of osteoprotegerin (OPG), one of the body's natural protectors against bone loss, reduced bone loss significantly in a study of postmenopausal women. OPG, a natural bone protein, had been shown ...
High Plasma TNF-Alpha Associated with Dementia.(tumor necrosis factor)
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- A high plasma concentration of TNF-alpha is associated with dementia in centenarians, according to a recent study. Research has suggested that inflammatory mechanisms and immune activation may play a role in the pathogenesis of ...
T-Cell Directed Therapy Improves Immunological Function.(adenosive daminase-severe combined immunodeficiency disease)
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- T-cell directed gene therapy in a boy with adenosine daminase (ADA)-severe combined immunodeficiency disease (SCID) resulted in improved immunological function. N. Kawamura and colleagues from Hokkaido University, Japan, issued a ...
Pure Thymus Defects Reconstituted By Thymic Grafts.
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Allogeneic and xenogeneic thymic grafts may be able to reconstitute pure thymus defects, researchers indicated. T lymphocytes mature in the thymus to become functional T cells. Studies with chimeric mice and T-cell receptor (TCR) ...
Malignant Melanoma Cancer Vaccine Trial Reaches Full Enrollment -.(Progenics Pharmaceutical Inc. and Bristol-Myers Squibb test GMK)
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Progenics Pharmaceuticals, Inc., Tarrytown, New York, announced that Progenics and Bristol-Myers Squibb have reached the targeted full enrollment in the pivotal Phase III clinical trial of GMK, a therapeutic cancer vaccine. GMK is ...
More Young Washington State Children Are Fully Immunized.(Centers for Disease Control and Prevention's National Immunization Survey)
Oct 11, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- In 1998, 81.1 percent of Washington state children age 19 to 35 months were fully immunized against seven important childhood diseases - an increase from 80 percent in 1997 and a continuation of a five-year upward trend. The ...
Immunity to Hepatitis C in Liver Transplant Recipients.
Oct 11, 1999 ... Immunology (HCV) "Immunity to Hepatitis C in Liver Transplant Recipients." Margaret J. Koziel. Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 5R29AI41563-03 ....
The Relationship of Chronic Pain and Immunity.
Oct 11, 1999 ... Chronic Pain "The Relationship of Chronic Pain and Immunity." Susan W. Vines. University of Southern Maine, 96 Falmouth St., Portland, Maine 04103, USA. (CW HENDERSON PUBLISHER www.newsfile.com) -- GRANT NUMBER: 1R15NRO4209-01. GRANT EXPIRES: August 31, 2000 ....
Flt3 Ligand Induces Skin Dendritic Cells and Is Protective Against Disease Progression in Susceptible BALB/C Mice Infected with Leishmania major.
Oct 11, 1999 ... Growth Factors "Flt3 Ligand Induces Skin Dendritic Cells and Is Protective Against Disease Progression in Susceptible BALB/C Mice Infected with Leishmania major." I.B. Kremer, K.D. Cooper and F.P. Heinzel. Department of Dermatology and Division of Geographic Medicine, Case ...
Immunologic Approaches to the Therapy of HIV-1 Infection.
Oct 11, 1999 ... HIV Immunotherapy "Immunologic Approaches to the Therapy of HIV-1 Infection." R. Walker. Affiliation not provided. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 1Z01A100636-08. PRINCIPLE INVESTIGATOR: R. Walker. DESCRIPTION: "The purpose of this ...
Spontaneous and Anti-Fas-Induced Apoptosis in Lymphocytes from HIV Infected Patients Undergoing Anti-Retroviral Therapy.
Oct 11, 1999 ... HIV Immunotherapy "Spontaneous and Anti-Fas-Induced Apoptosis in Lymphocytes from HIV Infected Patients Undergoing Anti-Retroviral Therapy." S. Grelli, E. Balestrieri, S. Vella, M. Lichpner, G. Ricci, F. Montella, B. Macchi and A. Mastino. University of Rome, Tor Vergata; Ist ....
Xenogeneic Thymic Transplantation as an Adjunct to Treatment of AIDS.
Oct 11, 1999 ... Immune Reconstitution (AIDS) "Xenogeneic Thymic Transplantation as an Adjunct to Treatment of AIDS." Michael Rosenzweig. Harvard University, Boston Campuses, Boston, Massachusetts 02115, USA. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: ...
Enhancement of Antibody-Directed Enzyme Prodrug Therapy in Colorectal Xenografts by an Antivascular Agent.
Oct 11, 1999 ... Cancer Immunotherapy Pedley, R.B.; Sharma, S.K.; Boxer, G.M.; Boden, R.; Stribbling, S.M.; Davies, L.; Springer, C.J.; Begent, R.H.J. "Enhancement of Antibody-Directed Enzyme Prodrug Therapy in Colorectal Xenografts by an Antivascular Agent." Cancer Research, August 15, ...
Induction of Antitumor Immunity After Cure of Pulmonary Metastases, Using Staphylococcal Enterotoxin B and Bispecific Antibody.
Oct 11, 1999 ... Cancer Immunotherapy Rice, D.C.; Chapoval, A.I.; Porter, L.; Nelson, H. "Induction of Antitumor Immunity After Cure of Pulmonary Metastases, Using Staphylococcal Enterotoxin B and Bispecific Antibody." Cancer Immunology Immunotherapy, August 1999;48(5):230-238. (CW ...
Pharmacokinetics and Antitumor Activity of a Bivalent Disulfide-Stabilized Fv Immunotoxin With Improved Antigen Binding to erbB2.
Oct 11, 1999 ... Cancer Immunotherapy Bera, T.K.; Viner, J.; Brinkmann, M.; Pastan, I. "Pharmacokinetics and Antitumor Activity of a Bivalent Disulfide-Stabilized Fv Immunotoxin With Improved Antigen Binding to erbB2." Cancer Research, August 15, 1999;59(16):4018-4022. (CW HENDERSON ...
Pretargeting of Renal Cell Carcinoma: Improved Tumor Targeting With a Bivalent Chelate.
Oct 11, 1999 ... Cancer Immunotherapy Boerman, O.C.; Kranenborg, M.H.G.C.; Oosterwijk, E.; Griffiths, G.L.; Mcbride, W.J.; Oyen, W.J.G.; Deweijert, M.; Oosterwijkwakka, J.; Hansen, H.J.; Corstens, F.H.M. "Pretargeting of Renal Cell Carcinoma: Improved Tumor Targeting With a Bivalent Chelate." ...
Selective Transfer of a Lipophilic Prodrug of 5-Fluorodeoxyuridine From Immunoliposomes to Colon Cancer Cells.
Oct 11, 1999 ... Cancer Immunotherapy Koning, G.A.; Morselt, H.W.M.; Velinova, M.J.; Donga, J.; Gorter, A.; Allen, T.M.; Zalipsky, S.; Kamps, J.A.A.M.; Scherphof, G.L. "Selective Transfer of a Lipophilic Prodrug of 5-Fluorodeoxyuridine From Immunoliposomes to Colon Cancer Cells." Biochimica Et ...
Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics.
Oct 11, 1999 ... Diagnostics Jayasena, S.D. "Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics." Clinical Chemistry, September 1999;45(9):1628-1650. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to the author's abstract of an article published in ...
Comparative Cytotoxicity and Pharmacokinetics of Antimelanoma Immunotoxins Containing Either Natural or Recombinant Gelonin.
Oct 11, 1999 ... Melanoma Rosenblum, M.G.; Marks, J.W.; Cheung, L.H. "Comparative Cytotoxicity and Pharmacokinetics of Antimelanoma Immunotoxins Containing Either Natural or Recombinant Gelonin." Cancer Chemotherapy and Pharmacology, October 1999;44(4):343-348. (CW HENDERSON ...
Thin Film Biosensor for Rapid Visual Detection of Nucleic Acid Targets.
Oct 11, 1999 ... Nucleic Acid Detection Ostroff, R.M.; Hopkins, D.; Haeberli, A.B.; Baouchi, W.; Polisky, B. "Thin Film Biosensor for Rapid Visual Detection of Nucleic Acid Targets." Clinical Chemistry, September 1999;45(9):1659-1664. (CW HENDERSON PUBLISHER www.newsfile.com) -- ...
Treatment of Typhoid Fever With Azithromycin Versus Chloramphenicol in a Randomized Multicentre Trial in India.
Oct 11, 1999 ... Typhoid Fever Butler, T.; Sridhar, C.B.; Daga, M.K.; Pathak, K.; Pandit, R.B.; Khakhria, R.; Potkar, C.N.; Zelasky, M.T.; Johnson, R.B. "Treatment of Typhoid Fever With Azithromycin Versus Chloramphenicol in a Randomized Multicentre Trial in India." Journal of Antimicrobial ...
SQ IL-2 + HAART: The Key to HIV Control?
Oct 18, 1999; ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Interleukin 2 (IL-2) may be the push the immune system needs to roll over HIV. When given together with highly active antiretroviral therapy (HAART), daily subcutaneous (SQ) IL-2 boosts T-cell and natural-killer (NK) cell counts, a ...
Hope for HIV Cure Fades.
Oct 18, 1999; ... (CW HENDERSON PUBLISHER www.newsfile.com) -- New data dash high hopes that potent drugs might rid a person of HIV infection. It has been only a few years since two factors came together to raise hopes of an AIDS cure: the availability of potent antiretroviral drugs, and a first ...
Foods May Be Used To Treat Food Allergy.
Oct 18, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- New 'functional foods' may be useful in the treatment of food allergies. E. Isolauri and colleagues from the University Turku, Finland, evaluated alternative methods of treating food allergy. Their results were reported in the Annals ...
Immunoblotting Helps Diagnose Insect Venom Allergy.
Oct 18, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Immunoblotting is a useful tool for diagnosing insect venom allergy and helping pinpoint specific immunotherapy. K. Jung and colleagues from the Klinikum Erfurt GMBH, Germany, evaluated immunoblotting as a diagnostic tool in allergic ...
NIAID Spearheads Collaborative Network for Clinical Research on Immune Tolerance.
Oct 18, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- The U.S. National Institute of Allergy and Infectious Diseases (NIAID) is spearheading a $144 million initiative to develop new ways of inducing immune tolerance - selectively modulating the immune system by inhibiting harmful immune responses ...
Galectin-1 Gene Delivery Suppressed Arthritis in Mice.
Oct 18, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Genetic delivery of galectin-1 (GAL-1) has therapeutic potential in the treatment of T-helper cell type 1-mediated autoimmune diseases. G. Rabinovich and colleagues from the University of London Queen Mary and Westfield College, ...
Local Interferon Engineered by Gene Transfer Safely Halts Malignant Mesothelioma.
Oct 18, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Locally produced interferon, engineered by gene-transfer methods, can prevent tumor growth in a mouse model of human malignant mesothelioma without causing any obvious side effects, according to research published in the September 1999 issue of ...
Local Immunotherapy Reduces Prostate Cancer Growth.
Oct 18, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Local intratumor immunotherapy with interleukin-2 (IL-2) reduces tumor growth in a rat prostate cancer model. S.H. Hautmann and colleagues from the University of Miami, Florida, evaluated the effectiveness and toxicity of local ...
IL-10 Inhibits Tumor Metastasis.
Oct 18, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Interleukin-10 should be researched further as an antimetastatic agent, researchers indicated. Because interleukin-10 (IL-10) has potent immunosuppressive and anti-inflammatory properties and is produced by some cancers, including ...
Acalypha wilkesiana Has Immunomodulating Properties.
Oct 18, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Extracts from the seeds of Acalypha wilkesiana have immunomodulating properties that may work against some tumors. A. Bussing and colleagues from the University Witten Herdecke, Germany, explored the biological properties of A ....
Pegylated Blood Products May Help Treat Immunosuppressed Patients.
Oct 18, 1999; ... (CW HENDERSON PUBLISHER www.newsfile.com) -- The use of blood products modified with methoxy(polyethylene glycol) (mPEG) may be helpful in treating both immunosuppressed and chronically transfused patients. Previously, Kari L Murad, Albany Medical College, Albany, New York, and ...
Second U.S. Patent Received for Use of Zadaxin To Treat Hepatitis C.
Oct 18, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- SciClone Pharmaceuticals, San Mateo, California, announced that the U.S. Patent and Trademark Office has issued a Notice of Allowance for the company's second U.S. patent covering the use of its lead drug, Zadaxin, to treat hepatitis C. ...
Flu Virus Used As Vaccine Delivery System.
Oct 18, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Immunopotentiating reconstituted influenza virosomes provide a suitable delivery system for synthetic peptide vaccines, according to a recent report. F. Poltl-Frank and colleagues, Swiss Tropical Institute, Basel, Switzerland, used ...
NCI Announces SPORE Grants for Ovarian Cancer Research.
Oct 18, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- The U.S. National Cancer Institute (NCI) has announced grants to four institutions for research on ovarian cancer. The research projects will focus on translating basic research findings into improvements in prevention, earlier ...
Cyclosporin A and Glucocorticoids Inhibit Osteoprotegerin Production in Human Osteoblastic and Coronary Artery Smooth Muscle Cells: Potential Mechanism of Post-Transplant Osteoporosis and Vascular Disease.
Oct 18, 1999 ... Transplantation (Side Effects) "Cyclosporin A and Glucocorticoids Inhibit Osteoprotegerin Production in Human Osteoblastic and Coronary Artery Smooth Muscle Cells: Potential Mechanism of Post-Transplant Osteoporosis and Vascular Disease." L.C. Hofbauer, B.L. Riggs, C.R. Dunstan, ...
Prephase I Gene/Immune Therapy of Malignant Brain Tumor.
Oct 18, 1999 ... Cancer Gene Therapy (Cancer Vaccines) "Prephase I Gene/Immune Therapy of Malignant Brain Tumor." Hassan M. Fathallah-Shaykh. University of Texas SW Medical Center, Dallas, Texas 75235, USA. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: ...
Gamma-Interferon (gamma-IFN)-Induced Interactions Between Stat1 Homodimers and the Vitamin D Receptor (VDR) Reduce 1,25-Dihydroxyvitamin D (1,25D) Mediated Transcription in Human Monocyte Macrophages.
Oct 18, 1999 ... Inflammatory Processes (Vitamin D Resistance) "Gamma-Interferon (gamma-IFN)-Induced Interactions Between Stat1 Homodimers and the Vitamin D Receptor (VDR) Reduce 1,25-Dihydroxyvitamin D (1,25D) Mediated Transcription in Human Monocyte Macrophages." Adriana S. Dusso. Renal ...
Immunological Consequences of Transfusion.
Oct 18, 1999 ... Transfusion "Immunological Consequences of Transfusion." Loren D. Fast. Rhode Island Hospital, 593 Eddy St., Providence, Rhode Island 02902, USA. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 1R01BL59241-01A2. GRANT EXPIRES: March 31, 2003. PRINCIPLE ...
The Distinct Role of CD4(+) and CD8(+) T Cells During the Anti-Tumour Effects of Targeted Superantigens.
Oct 18, 1999 ... Cancer Immunotherapy Litton, M.J.; Dohlsten, M.; Rosendahl, A.; Ohlsson, L.; Sogaard, M.; Andersson, J.; Andersson, U. "The Distinct Role of CD4(+) and CD8(+) T Cells During the Anti-Tumour Effects of Targeted Superantigens." British Journal of Cancer, September ...
Pharmacokinetics and Biodistribution of Engineered Single-Chain Antibody Constructs of MAb CC49 in Colon Carcinoma Xenografts.
Oct 18, 1999 ... Colon Cancer Pavlinkova, G.; Beresford, G.W.; Booth, B.J.M.; Batra, S.K.; Colcher, D. "Pharmacokinetics and Biodistribution of Engineered Single-Chain Antibody Constructs of MAb CC49 in Colon Carcinoma Xenografts." Journal of Nuclear Medicine, September 1999;40(9):1536-1546. ...
Cellular and Humoral Immune Responses Against Autoreactive T Cells in Multiple Sclerosis Patients After T-Cell Vaccination.
Oct 18, 1999 ... T-Cell Vaccination Hermans, G.; Denzer, U.; Lohse, A.; Raus, J.; Stinissen, P. "Cellular and Humoral Immune Responses Against Autoreactive T Cells in Multiple Sclerosis Patients After T-Cell Vaccination." Journal of Autoimmunity, September 1999;13(2):233-246. (CW ...
Mutations in rpoB Gene and Rifabutin Susceptibility of Multidrug-Resistant Mycobacterium tuberculosis Strains Isolated in Australia.
Oct 18, 1999 ... Tuberculosis (Drug Resistance) Sintchenko, V.; Chew, W.K.; Jelfs, P.J.; Gilbert, G.L. "Mutations in rpoB Gene and Rifabutin Susceptibility of Multidrug-Resistant Mycobacterium tuberculosis Strains Isolated in Australia." Pathology, August 1999;31(3):257-260. (CW ...
Analysis of Rifapentine for Preventive Therapy in the Cornell Mouse Model of Latent Tuberculosis.
Oct 18, 1999 ... Tuberculosis (Therapy) Miyazaki, E.; Chaisson, R.E.; Bishai, W.R. "Analysis of Rifapentine for Preventive Therapy in the Cornell Mouse Model of Latent Tuberculosis." Antimicrobial Agents and Chemotherapy, September 1999;43(9):2126-2130. (CW HENDERSON PUBLISHER ...
Treatment of Experimental Viral Myocarditis with Interleukin-10.
Oct 18, 1999 ... Viral Myocarditis Nishio, R.; Matsumori, A.; Shioi, T.; Ishida, H.; Sasayama, S. "Treatment of Experimental Viral Myocarditis with Interleukin-10." Circulation, September 7, 1999;100(10):1102-1108. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to the ...
CpG Immunostimulation: More than Mice.
Oct 25, 1999; ... (CW HENDERSON PUBLISHER www.newsfile.com) -- An exciting immunostimulatory peptide has moved out of the mouse. Immunostimulatory oligonucleotides (ISS ODN) containing unmethylated cytidine-guanosine dinucleotides (CpG motifs) have extremely potent adjuvant effects in the mouse ...
Cloned Allergens Facilitate Diagnostics and Treatment.
Oct 25, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Selective cloning of peanut allergens should facilitate diagnostics and treatment of this food allergy. T. Kleberjanke and colleagues from the Research Center, Borstel, Germany, applied the pJuFo cloning system based on the phage ...
New Light on Role of Microbial Pathogens in Atherosclerosis.
Oct 25, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Cardiovascular disease is the leading cause of death in industrialized countries (32 percent of all deaths in France, for example), and atherosclerosis is often the underlying process. Genetic and environmental factors (such as ...
Glowing Mice Help Screen Cancer Therapies.
Oct 25, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Mice that light up when cancer cells are on the rampage and dim when the invaders are poisoned by drugs may help researchers pinpoint effective new anti-cancer drugs and will also spare the lives of many lab mice. A firefly gene makes ...
Antigen-Specific Th1/Th2 Cells Function in Tumor Eradication.
Oct 25, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Antigen-specific Th1 and Th2 cells have distinct roles in eradication of established tumors. T. Nishimura and colleagues from the Hokkaido University, Japan, investigated the role of T helper type 1 (Th1) and Th2 cells in tumor ...
IL-15 Augments Antitumor Effect of IL-12.
Oct 25, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Subtherapeutic doses of interleukin-15 (IL-15) augment the antitumor effect of IL-12 in a murine model. W. Lasek and colleagues from the Medical University of Warsaw, Poland, investigated the ability of IL-15, a cytokine sharing many ...
Adjuvant Interferon Therapy May Be Beneficial in Renal Cell Carcinoma.
Oct 25, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- A retrospective study of renal cell carcinoma (RCC) in pediatric patients suggests that adjuvant interferon therapy is beneficial. H. Asanuma and colleagues from the Tokyo Metropolitan Kiyose Children's Hospital, Japan, analyzed the ...
5,000 Volunteers Inoculated in U.S. Trial of HIV Vaccine.
Oct 25, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- VaxGen, Inc., Brisbane, California, announced that it has inoculated more than 5,000 volunteers, completing enrollment in the United States portion of the North American trial of AIDSVAX, a vaccine designed to prevent infection by HIV. ...
Lactic Acid Bacteria Modulate the Immune System.
Oct 25, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Different lactic acid bacteria modulate the immune system in different manners to protect against diseases. H. Yasui and colleagues from the Yakult Center Institute for Microbiological Research, Japan, evaluated two different strains ...
Insufficient IL-1(beta) in HCV Sinusoidal Cells Linked to Viral Persistence.
Oct 25, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Sinusoidal cells in chronic hepatitis C appear to produce insufficient interleukin-1(beta). The intrahepatic expression of interleukin (IL)-1(beta) and tumor necrosis factor (TNF)-(alpha) was studied in liver specimens from patients ...
Joint Effort Researches HIV Drug Resistant Strains.
Oct 25, 1999 ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Hemispherx Biopharma, Inc., Pittsburgh, Pennsylvania, announced that it was developing clinical programs with Anderson Clinical Research that are designed to address the growing problem of multi-drug resistance found in battling the AIDS ...
Chinese Studies Show Consensus Interferon Efficacious.
Oct 25, 1999; ... (CW HENDERSON PUBLISHER www.newsfile.com) -- Consensus interferon therapy was found to be safe and effective against chronic hepatitis C in a group of Chinese patients. Researcher Shinn-Jang Hwang and colleagues reported an alanine transaminase response in 64 percent of patients ...