Immunotherapy Weekly back issues from October 2004:
DNA vaccine reverses allergic airway inflammation and eosinophilia.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Reversal of established CD4+ type 2 T helper-mediated allergic airway inflammation and eosinophilia by therapeutic treatment with DNA vaccines limits progression towards chronic inflammation and remodeling. According to published ...
Side effects greater with aqueous than depot therapy for bee venom allergy.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Early local side effects occur at higher frequency with aqueous than with depot immunotherapy for Hymenoptera venom allergy. "Venom immunotherapy has proven a very effective method for the treatment of allergy to Hymenoptera venom ....
CV capacity, quadriceps muscle strength play modest role in rapid walking.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- A recent study examined associations between walking time, quadriceps muscle strength and cardiovascular capacity in patients with rheumatoid arthritis and ankylosing spondylitis. According to the study from Norway, "The aim of this ...
GD3-L-KLH vaccine elicits antibody response in melanoma patients.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside elicited an antibody response that did not correlate with patient survival. "GD3 ganglioside is ...
Role of CD8+ T-cell immunity in progression of melanoma reviewed.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers review the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients in a recent issue of Clinical Cancer Research. According to published research from the Netherlands, ...
Gag CTL-positive vaccinees recipients do not have anti-gag p17 response.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele did not exhibit immunodominant anti-gag p17 (SL9) responses. According to recent research published in the Journal of Immunology, "According to a number ...
HIV vaccine combination safe and immunogenic in HIV-negative adults.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- An HIV subtype B and E prime-boost vaccine combination was safe and immunogenic in HIV-negative Thai adults. "ALVAC-HIV (vCP1521) and AIDSVAX B/E were evaluated in a phase 1/2 trial of human immunodeficiency virus (HIV)-negative Thai ...
Heat shock protein mediates cross-presentation of exogenous HIV antigen.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Heat shock protein mediates cross-presentation of exogenous HIV antigen on HLA class I and class II. According to a study from the United States, "Strong CD4+ and CD8+ T cell responses are considered important immune components for ...
Immune responses to hemagglutinin/SHIV-like particle vaccine reported.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists report Th cell-independent immune responses to a chimeric hemagglutinin/simian human immunodeficiency virus-like particle vaccine. "CD4+ Th cells are believed to be essential for the induction of humoral and cellular immune ...
Immunization with Listeria controls virus load after FIV challenge.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Oral immunization with recombinant Listeria monocytogenes controls virus load after vaginal challenge with feline immunodeficiency virus. "Recombinant Listeria monocytogenes has many attractive characteristics as a vaccine vector against ...
Methods to monitor oligomeric state of HIV vaccine antigen evaluated.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers have evaluated on-line high-performance size-exclusion chromatography, differential refractometry, and multi-angle laser light scattering analysis for the monitoring of the oligomeric state of human immunodeficiency virus vaccine ...
Papillomavirus-HIV-1 gp41 virus-like particles induce HIV antibodies.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Oral immunization with bovine papillomavirus-HIV-1 gp41 chimeric virus-like particles induced mucosal and systemic neutralizing antibodies against human immunodeficiency virus type 1 (HIV-1). "Human immunodeficiency virus type 1 (HIV-1) ...
Plasmacytoid dendritic cell activation augments SIV-specific T cells.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques augments the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T cells. "There are two principle ...
Recruiting London gay men into HIV vaccine trial is feasible.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Recruiting London gay men into an HIV vaccine trial is feasible. "This paper describes a study among HIV-negative gay men in London to examine willingness to volunteer for an HIV vaccine trial. HIV-negative gay men (n=506) were surveyed ...
Screening for HIV-specific T-cell responses recommended.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers recommend screening for HIV-specific T-cell responses using overlapping 15-mer peptide pools or optimized epitopes. "The IFN-gamma enzyme-linked immunospot (ELISpot) assay is often used to map HIV-specific CD8 T-cell ...
Paper describes new treatment for prevention of postsurgical adhesions.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- ARC Pharmaceuticals, Inc., announced that Dr. Johanne Cashman, director of preclinical research, published a paper entitled "Camptothecin-loaded Films for the Prevention of Postsurgical Adhesions" in the August 2004 issue of Inflammation Research. ...
Food Allergy Buddy dining card launched.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Philip Lempert, known by both consumers and the food industry as the "Supermarket Guru" and an expert analyst on consumer, marketing and food safety trends, announced the launch of the Food Allergy Buddy (FAB) Dining Card. FAB is a free ...
Drug in phase 2 clinical trial for patients suffering from peanut allergy.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Tanox, Inc. (TNOX) announced that the first patient has been enrolled in a phase 2 clinical trial evaluating the safety and efficacy of Xolair (omalizumab) in patients suffering from allergy (immediate hypersensitivity) to peanuts. ...
S- but not R-enantiomers of flurbiprofen and ibuprofen are neuroprotective.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- S- but not R-enantiomers of flurbiprofen and ibuprofen are neuroprotective. According to recent research from Canada, "The protective effects of non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease have been demonstrated ...
Animal models are guiding development of new immunotherapies for cancer.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Animal models are guiding the development of new immunotherapies for cancer. According to recent research published in the Journal of Leukocyte Biology, "Immunotherapy using adoptive cell transfer is a promising approach that can result ...
In vitro-based potency assay for anthrax vaccine developed.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists have developed an in vitro-based potency assay for anthrax vaccines. According to recent research published in the journal Vaccine, "The potency assay currently used to evaluate consistency of manufacture for the anthrax ...
Streptococcolytic enzyme zoocin A is a penicillin-binding protein.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Streptococcolytic enzyme zoocin A is a penicillin-binding protein. "Zoocin A is a streptococcolytic enzyme produced by Streptococcus equi subsp. zooepidemicus 4881 that has an unknown site of action on the peptidoglycans of susceptible ...
Novel antifungal protein from gold kiwi fruit active against Fusarium oxysporum.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- A novel antifungal protein from the gold kiwi fruit is active against Fusarium oxysporum. "An antifungal protein designated actinchinin, with an N-terminal sequence different from that of the thaumatin-like antifungal protein from green ...
Two-thirds of prescription antihistamine users test negative for allergies.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- A new study in the current issue of Journal of Managed Care Pharmacy concludes that 62% of frequent antihistamine users did not test positive for allergies. The authors recommend that objective diagnosis with an allergen-specific IgE ...
Novel podophyllotoxin derivatives have anti-HIV activity.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Novel podophyllotoxin derivatives have anti-HIV activity. According to recent research from the United States, "A series of novel podophyllotoxin derivatives containing structural modifications at C-4 (7-14), C-4' (16-17), and the ...
Recommendations made for two versus three drugs for postexposure HIV prophylaxis.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Recommendations are made for two versus three drugs for postexposure HIV prophylaxis. "Thousands of health care workers are potentially exposed to human immunodeficiency virus (HIV) each year via occupationally acquired needlesticks," ...
Inhibition of nitric oxide synthase exacerbates GBS sepsis, arthritis in mice.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Inhibition of nitric oxide synthase exacerbates GBS sepsis and arthritis in mice. Researchers from Italy reported, "The role of nitric oxide in group B Streptococcus (GBS) infection was evaluated by inhibiting its production with ...
Hand-held device measures airway inflammation.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Clinical data on a new first-of-a-kind hand-held analyser of inflammation in asthma patients, Niox Mino, were presented for the first time on September 5, 2004, at the European Respiratory Society (ERS) meeting, in Glasgow, Scotland. ...
IFN-gamma induces apoptosis in allergen-activated T cells.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- IFN-gamma induces apoptosis in allergen-activated T cells from atopic asthma patients. "The defect in interferon-gamma (IFN-gamma) production that results in a T helper cell type 2-dominated response may be responsible for a decrease in ...
Injected corticosteroids reduce eosinophilic airway inflammation.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- In a study of patients with severe asthma who had eosinophils in their sputum despite extensive antiasthma medication, investigators showed that a high dose of extra intra-muscular corticosteroids resulted in almost complete disappearance of ...
Potential asthma monoclonal antibody to enter phase I clinical trial.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Cambridge Antibody Technology (CATG) will be starting a phase I clinical trial of CAT-354, a human anti-IL-13 monoclonal antibody, which is a potential treatment for severe asthma, following recent approval from the Medicines and Healthcare ...
Regular sustained combination therapy may reduce asthma exacerbations.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- New data presented at the 14th annual European Respiratory Society (ERS) Congress in Glasgow have revealed the results of the EXCEL (EXacerbation Control Evaluated in a 6 month Long) study, a head to head trial comparing Seretide ...
Scientists discover link between serotonin and airway allergic inflammation.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists at the La Jolla Institute for Molecular Medicine (LJIMM) have discovered that serotonin, a naturally occurring neurotransmitter that is elevated in the blood of asthmatics, can directly cause an influx of eosinophils, which are ...
Understanding biology of AT can lead to greater knowledge of its underlying processes.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Ataxia telangiectasia (AT) causes a variety of problems and results from defects in the response to specific types of DNA damage, researchers say. According to a study from the United States, "Ataxia telangiectasia (AT) has long ...
Anti-atherosclerosis polypeptide vaccine expressed in E. coli.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists have expressed an anti-atherosclerosis polypeptide vaccine in Escherichia coli. According to recent research from China, "A chimeric polypeptide of TTP-CETPC was successfully expressed as inclusion bodies in Escherichia coli ...
Listeria monocytogenes composed of at least three evolutionary lineages.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Listeria monocytogenes is composed of at least three evolutionary lineages. According to published research from the United States, "Listeria monocytogenes is a serious food-borne pathogen that can cause invasive disease in humans and ...
Multidrug-resistant S. enterica serovar Typhimurium found in shellfish in Spain.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Multidrug-resistant Salmonella enterica serovar Typhimurium was found in shellfish off the coast of Spain. "Twenty-three Salmonella enterica serovar Typhimurium isolates from marine environments were characterized by phage typing, ...
L. monocytogenes in biofilms controlled by competitive-exclusion microorganisms.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Listeria monocytogenes in biofilms are controlled by competitive-exclusion microorganisms. "Biofilms from drains in food processing facilities with a recent history of no detectable Listeria monocytogenes in floor drains were cultured ...
Bacterial resistance increased from 1998 to 2002 in hospital in Slovakia.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Bacterial resistance increased from 1998 to 2002 in a hospital in Slovakia. According investigators in Slovakia, "The purpose of this study was to analyze the resistance during the period of 1998-2002 based on results of quantitative ...
Community MSRA isolates in Australia belong to five CHEF electrophoretic patterns.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Community methicillin-resistant Staphylococcus aureus isolates in Australia belong to five contour-clamped homogeneous electric field electrophoretic patterns. According to a study from Australia, "Community methicillin-resistant ...
MRSA strains susceptible to aminoglycosides genotyped.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- MRSA strains susceptible to aminoglycosides were genotyped. According to a study from France, "Methicillin-resistant Staphylococcus aureus (MRSA) susceptible strains to aminoglycosides (AS-MRSA) have been increasingly isolated in the ...
astA gene transposed into prophage of S. enterica serovar abortusovis.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Heat-stabile toxin astA gene was transposed into the prophage of Salmonella enterica serovar abortusovis. "The horizontal transfer and acquisition of virulence genes via mobile genetic elements have been a major driving force in the ...
Heat-shock proteins and host-pathogen interactions reviewed.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists review heat-shock proteins and the host-pathogen interaction during bacterial infection in a recent issue of Current Opinion in Immunology. "Heat-shock proteins (HSPs) are expressed at high levels by bacterial pathogens during ...
Comparative study released on superficial papillary urothelial carcinomas.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Superficial papillary urothelial carcinomas in 'young' patients had a better prognosis than those in the 'elderly' group, according to new research. According to a study from Italy, "To compare the clinicopathological and ...
Profile of continuous antigenic regions of botulinum H-chain reported.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers present the full profile of the continuous antigenic regions of the H-chain of botulinum neurotoxin A in a recent issue of the Protein Journal. According to recent research from the United States, "Previously, we mapped the ...
Biologic therapy for brain cancers reviewed.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- A reseracher reviews biologic therapy for brain cancers in a recent issue of the Yonsei Medical Journal. According to a study from the United States, "The overall goal of our research projects is to develop effective immunotherapeutic ...
Silicone induces strong local T-cell immune response.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Silicone in breast implants induces a strong local response by T lymphocytes, but why this is remains unclear. "During the past 30 years, much debate has centered around side effects of silicone breast implants. Meta-analyses rejected ...
Novel tumor antigen may be useful in osteosarcoma immunotherapy.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- A novel tumor antigen may be useful in osteosarcoma immunotherapy. According to recent research from Japan, the "prognosis for patients with osteosarcoma who do not respond to current chemotherapy protocols still remains poor." ...
Antibodies in tumor immunotherapy reviewed.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers review antibodies in tumor immunotherapy in a recent issue of Expert Opinion on Biological Therapy. "The role of antibodies as therapeutic cancer vaccines includes two distinct approaches, which are summarized in this review, ...
Dendritic cell-based immunotherapy for cancer reviewed.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers review dendritic cell-based immunotherapy for cancer in a recent issue of Transfusion Medicine Reviews. According to recent research from the United States, "The encouraging results from dendritic cell-related cancer ...
Gene-engineered T cells are superior adjuvant therapy for cancer.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Gene-engineered T cells are a superior adjuvant therapy for metastatic cancer. According to a study from Australia, "The major limiting factor in the successful application of adjuvant therapy for metastatic disease is the lack of ...
Heat shock proteins reviewed.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers review heat shock proteins in a recent issue of Immunology Letters. "The contribution of major histocompatibility complex (MHC) I and II to the adaptive immune response has been well documented. In 1996, Peter Doherty and ...
Strategies to improve dendritic cell cancer immunotherapy outlined.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers outline strategies to improve dendritic cell-based immunotherapy against cancer in a recent issue of the Yonsei Medical Journal. "Dendritic cells (DCs) play a pivotal role in T cell-mediated immunity and have been shown to ...
Ubiquitin-fusion degradation pathway plays key role in DNA vaccination.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The ubiquitin-fusion degradation pathway plays an indispensable role in naked DNA vaccination with a chimeric gene encoding a syngeneic cytotoxic T lymphocyte epitope of melanocyte and green fluorescent protein. According to published ...
Yeast-based immunotherapy causes mutation-selective tumor remission.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Ras-targeted, whole yeast-based immunotherapy resulted in mutation-selective tumor remission. "Activating mutations in Ras oncoproteins represent attractive targets for cancer immunotherapy, but few vectors capable of generating immune ...
Alemtuzumab may have a role in inducing important cardiac side effects.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Cardiac toxicity of alemtuzumab in patients with mycosis fungoides/Sezary syndrome "Alemtuzumab is a monoclonal antibody to CD52 that has activity in T-cell leukemia and lymphoma. This study alms to describe the complications and ...
Rashes from Oka vaccine are derived from single clones of virus.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Rashes occurring after immunization with a mixture of viruses in the Oka vaccine are derived from single clones of the virus. According to recent research published in the Journal of Infectious Diseases, "Vaccination against chickenpox ...
Clinical trials of drug for internal genital warts broadened.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Stressgen Biotechnologies (SSB) announced that it has broadened the clinical program for its lead drug candidate, HspE7. The company has expanded the program through the enrollment of patients in a phase 2 clinical trial to investigate ...
Companies to commence second phase III trial for milnacipran in Q4.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Cypress Bioscience, Inc., (CYPB) expects its partner, Forest Laboratories (FRX) to initiate the second phase III trial evaluating milnacipran for the treatment of fibromyalgia syndrome (FMS) during the fourth quarter of this year. ...
Strategic biopharm research, development and commercialization alliance formed.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- ZymoGenetics, Inc. (ZGEN) and Serono (SRA) announced their intent to enter into a broad partnership to research, develop and commercialize protein and antibody therapeutics based on discoveries made by ZymoGenetics. Under the ...
Diagnostics company enters broad diagnostic collaboration with Compugen.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Diagnostic Products Corp. (DP) and Compugen, Ltd., (CGEN) announced a broad collaboration for the development and commercialization of novel diagnostic products, with an anticipated focus in the cancer and cardiovascular fields. Terms of ...
Strong association of ARK5 with tumor invasion and metastasis.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- There is a strong association of ARK5 with tumor invasion and metastasis. According to a study from Japan, "We recently identified a novel human AMPK family member, ARK5, and discovered that is a major factor in Akt-dependent cancer cell ...
Cocaine- and amphetamine-regulated transcript stimulates colonic motility.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Cocaine- and amphetamine-regulated transcript stimulates colonic motility via central CRF receptor activation and peripheral cholinergic pathways in fed, conscious rats. "Many neuropeptides participating in the hypothalamic control of ...
PX3.102 appears to diminish chronic airway allograft rejection.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- PX3.102 appears to diminish chronic airway allograft rejection. According to a study from the United States, "More effective immunosuppressants are needed to improve lung-transplantation survival. PX3.102 is a novel immunosuppressant ...
Efficacy of dendritic cell-induced tolerance dependent on delivery path.
Oct 06, 2004 ... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The efficacy of peripheral tolerance induced by dendritic cells is dependent on the route of delivery. "Previous studies have demonstrated that the route of delivery of dendritic cells (DC) is an important variable in eliciting antitumor ...