Immunotherapy Weekly back issues from September 2008:
Leishmaniasis parasites evade death by exploiting the immune response to sand fly bites.
Sep 03, 2008 ... Cutaneous leishmaniasis, a disease characterized by painful skin ulcers, occurs when the parasite Leishmania major, or a related species, is transmitted to a mammalian host by the bite of an infected sand fly. In a new study from the National Institute of Allergy and Infectious Diseases ...
Long-Term Safety Profile of SYMBICORT[R] Analyzed in Patients With Moderate to Severe Persistent Asthma.
Sep 03, 2008 ... A 52-week study examined the long-term safety of the maintenance combination asthma therapy, SYMBICORT[R] (budesonide/formoterol fumarate dehydrate) Inhalation Aerosol, at up to double the approved dosage.1 More than 700 patients ages 12 years and older with moderate to severe persistent ...
Study results from R. Yagci et al provide new insights into Behcet disease.
Sep 03, 2008 ... According to a study from Ankara, Turkey, "The objective of our study was to elucidate serum levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) in Behcet's disease (BD) patients with active and inactive period. The multicenter ...
Scientists at Massachusetts General Hospital publish research in bioengineering.
Sep 03, 2008 ... "Monoclonal antibodies (mAbs) against the cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule are used as an adjuvant to experimental tumor immunization protocols in the treatment of malignant melanomas and ovarian cancers. Aside from noted early therapeutic successes, a spectrum of adverse ...
Findings from C.B. Nunes et al in breast cancer reported.
Sep 03, 2008 ... In this recent report, researchers in Belo Horizonte, Brazil conducted a study "To compare the sensitivity and specificity of new rabbit monoclonal antibody SP3 with those of mouse monoclonal and rabbit polyclonal antibodies using HER2 amplification defined by chromogenic in situ ...
Enjoy Life Foods Named to Inc. 500 for Second Consecutive Year.
Sep 03, 2008 ... For the second consecutive year, Enjoy Life Foods, which makes great-tasting allergy-friendly and gluten-free foods, has been named to the Inc. 500 list of the fastest growing privately held businesses in the U.S.(1) The 2008 list is the 27th that Inc. magazine has published that in the ...
Study findings on life sciences are outlined in reports from University of Lille.(Report)
Sep 03, 2008 ... According to recent research published in the International Journal of Industrial Ergonomics, "This study aims to realize a kinematic simulation of handcycling propulsion in order to investigate some ergonomic aspects specific to this mode of propulsion. We hypothesize that adjustments ...
Study findings from Cleveland Clinic provide new insights into multiple sclerosis.
Sep 03, 2008 ... According to recent research from the United States, "Recent studies indicate that functional connectivity using low-frequency BOLD fluctuations (LFBFs) is reduced between the bilateral primary sensorimotor regions in multiple sclerosis. In addition, it has been shown that ...
New findings in arthritis described from Ehime University.(Report)
Sep 03, 2008 ... According to a study from Japan, "Based on the hypothesis that the complex pathological and immunological manifestations of rheumatoid arthritis (RA) and the related diseases are under the control of multiple gene loci with allelic polymorphism, a recombinant congenic mouse strain was ...
Data on immunology reported by researchers at University of Oxford.
Sep 03, 2008 ... "Regulatory T cells (Treg) have been shown to play a role in the prevention of autoimmune diseases and transplant rejection. Based on an established protocol known to generate alloantigen reactive Treg in vivo, we have developed a strategy for the in vitro selection of Treg," scientists ...
New immunology research from Oregon Health & Science University discussed.
Sep 03, 2008 ... "The intracytosolic niche for replication of Listeria monocytogenes (Lm) facilitates delivery of bacteria-derived Ags into the MHC class I pathway for subsequent stimulation of CD8 effector T cells. Using Lm strains that are equivalent for in vivo virulence yet express marked differences ...
New research on immunology from University of Rochester summarized.
Sep 03, 2008 ... "Although the ability of gp96 to activate APCs and generate CD8 CTLs against peptides they chaperone through interaction with the endocytic receptors CD91 is supported by solid evidence, its biological relevance in immune surveillance is debated. We have used an evolutionary approach to ...
Reports from Department of Agriculture highlight recent research in animal endocrinology.(Report)
Sep 03, 2008 ... "The overall goal of our research is to characterize and identify gene expression profiles of porcine hepatic cells. In this study, we have prepared two-dimensional electrophoresis maps of cytosol and membrane fractions from freshly prepared hepatocytes which were pooled from three ...
Research reports from K.C. Roy and co-authors provide new insights into immunology.
Sep 03, 2008 ... According to a study from the United States, "Natural Killer T (NKT) cells recognize both self and foreign lipid Ags presented by CD1 molecules. Although presentation of the marine sponge-derived lipid alpha GalCer to type I NKT cells has been well studied, little is known about ...
Studies from J. Trowsdale and co-researchers in the area of immunology published.(Reprint)
Sep 03, 2008 ... According to recent research published in the Journal of Immunology, "Class I molecules of the major histocompatibility complex (MHC) bind and present peptides derived from the degradation of Intracellular, often cytoplasmic, proteins, whereas class II molecules usually present proteins ...
Study results from University of Pittsburgh update understanding of immunology.
Sep 03, 2008 ... According to a study from the United States, "Exosomes are nanovesicles released by different cell types including dendritic cells (DCs). The fact that exosomes express surface MHC-peptide complexes suggests that they could function as Ag-presenting vesicles or as vehicles to spread ...
New lupus data have been reported by researchers at University of Newcastle.(Clinical report)
Sep 03, 2008 ... According to recent research published in the journal Quality of Life Research, " The extent and variability of unmet care needs over time of people with systemic lupus erythematosus (SLE) has not been previously reported. A prospective study was undertaken to determine the variability ...
New oral immunology study findings recently were published by D. Beighton and co-researchers.
Sep 03, 2008 ... According to recent research from London, the United Kingdom, "The predominant Veillonella spp. were isolated from the dorsum surface of the tongues of 11 healthy adults and identified to species level using rpoB sequencing because 16S ribosomal RNA sequence analysis does not reliably ...
Research on oral immunology reported by A. Haukioja et al.(Report)
Sep 03, 2008 ... According to recent research from Turku, Finland, "The use of probiotic bacteria is increasing worldwide and at least some of them can transiently colonize the oral cavity. Several studies have shown that probiotic bacteria, which are often thought of in relation only to intestinal health, ...
Studies from Osaka University have provided new data on oral immunology.
Sep 03, 2008 ... According to a study from Suita, Japan, "Streptococcus mutans has been implicated as a primary causative agent of dental caries in humans, and its cell surface protein antigen c (PAc) is known to be associated with sucrose-independent adhesion to tooth surfaces. PAc is composed of several ...
Studies from University of Rennes update current data on oral immunology.(Report)
Sep 03, 2008 ... According to recent research from Rennes, France, "Porphyromonas gingivalis, a gram-negative anaerobic bacterium, is a major periopathogen whose transmission from host to host involves exposure to atmospheric oxygen. P. gingivalis contains genetic factors that function in an oxidative ...
New rheumatology study findings recently were reported by S. Sastre and co-researchers.
Sep 03, 2008 ... In this recently published article, scientists in Barcelona, Spain conducted a study "To obtain images of the articular surface of osteochondral grafts (fresh, frozen, and cryopreserved in RPMI) using an environmental scanning electron microscope (ESEM). To evaluate and compare the main ...
Studies from New York University describe new findings in rheumatology.
Sep 03, 2008 ... In this recently published article, scientists in the United States conducted a study "To analyze visual analog scales (VAS) for pain and patient global estimate on a Multidimensional Health Assessment Questionnaire (MDHAQ) in formats other than a traditional 10 cm horizontal line, ...
Study findings on life sciences are outlined in reports from Institute of Aviation Medicine.
Sep 03, 2008 ... Researchers detail in 'The performance of Drager Oxylog ventilators at simulated altitude,' new data in life sciences. According to a study from Australia, "Ventilated patients frequently require transport by air in a hypobaric environment. Previous studies have demonstrated significant ...
AHRQ News and Numbers: Children Hospitalized Less Often for Asthma but More Have the Disease.
Sep 03, 2008 ... Hospitalizations of children principally for asthma fell by almost 60,000 between 1997 and 2006, according to the latest News and Numbers from the Agency for Healthcare Research and Quality. However, the number of children who are admitted to hospitals to treat other conditions but who ...
Lung Association: Going Back to School With Asthma Shouldn't Cause Anxiety.
Sep 03, 2008 ... As the school bells get ready to ring, parents and other caregivers of children who have asthma should prepare for a possible peak in asthma episodes (also known as attacks or exacerbations). According to the American Lung Association of the Upper Midwest, the greatest number of asthma ...
Three Utah Non-Profit Organizations Chosen as Finalists for Humana's Utah Benefits Program.
Sep 03, 2008 ... Three Utah charitable organizations have been selected as finalists for consideration of a one-time, $100,000 grant in the inaugural Utah Benefits charity program, created and funded by The Humana Foundation and health benefits company Humana Inc. (NYSE: HUM) (see also Humana Inc.). ...
Experimental Apartment in Beijing Achieves 99% Purity of Indoor Air.
Sep 03, 2008 ... Two indoor air quality (IAQ) experts who are in China to work with athletes during the Beijing 2008 Olympic Games announced that they have achieved up to 99% purity of the indoor air in their Beijing apartment. They installed specialized ultra-high efficiency air cleaning equipment to ...
World-Class MS Information at the Touch of a Button.
Sep 03, 2008 ... People affected by the debilitating neurological condition multiple sclerosis (MS) now have world-class information at their fingertips thanks to a UK first by the MS Society (see also Multiple Sclerosis Society). The charity, which is the largest of its kind supporting people ...
Researchers from Osaka University, Medical Department describe findings in alopecia.
Sep 10, 2008 ... According to a study from Suita, Japan, " Frontal fibrosing alopecia (FFA) is characterized by frontotemporal hair recession and eyebrow loss and by a histopathology identical to lichen planopilaris. Differential diagnosis from other types of alopecia, including alopecia areata (AA), is ...
Investigators at University of Helsinki target angiogenesis.
Sep 10, 2008 ... "Angiogenesis, the growth of new blood vessels from pre- existing vasculature, is a key process in several pathological conditions, including tumour growth and age- related macular degeneration(1). Vascular endothelial growth factors ( VEGFs) stimulate angiogenesis and lymphangiogenesis by ...
Study data from University of Sao Paulo provide new insights into asthma.
Sep 10, 2008 ... According to a study from Sao Paulo, Brazil, "Oral tolerance attenuates changes in in vitro lung tissue mechanics and extracellular matrix remodeling induced by chronic allergic inflammation in guinea pigs. J Appl Physiol 104: 1778-1785, 2008." "First published April 3, 2008; ...
Research from G. Simone et al broadens understanding of cancer.
Sep 10, 2008 ... According to recent research published in the journal Urology, "To retrospectively evaluate the functional and oncologic results of 20 prostatic capsule and seminal vesicle-sparing cystectomies. From June 2002 to January 2006, we performed 360 radical cystectomies, for 20 of which we used ...
Research data from China Agricultural University update understanding of chromatography.
Sep 10, 2008 ... According to recent research from Beijing, People's Republic of China, "A rapid and sensitive colloidal gold immunochromatography test strip based on one monoclonal antibody with broad-specificity, which can detect 12 fluoroquinolones (FQs), was developed. Antigen and goat anti-mouse IgG ...
Research from C. Forn and co-researchers provides new data on life sciences.(Report)
Sep 10, 2008 ... According to recent research from Spain, "The Paced Auditory Serial Addition test (PASAT) is a sensitive task for evaluating cognitive impairment in patients with diffuse brain disorders, such as multiple sclerosis patients. Brain areas involved in this task have been investigated in ...
Recent studies by B. Audoin and co-authors add new data to multiple sclerosis findings.
Sep 10, 2008 ... Researchers detail in 'Efficiency of cognitive control recruitment in the very early stage of multiple sclerosis: a one-year fMRI follow-up study,' new data in multiple sclerosis. "Functional magnetic resonance imaging (FMRI) studies have established that patients with multiple sclerosis ...
Researchers from McGill University, Montreal Neurological Institute publish findings in multiple sclerosis.
Sep 10, 2008 ... Data detailed in 'Atrophy in white matter fiber tracts in multiple sclerosis is not dependent on tract length or local white matter lesions' have been presented. According to recent research from Montreal, Canada, "The pathogenesis of tissue injury outside the white matter (WM) plaques of ...
University of British Columbia, Department of Statistics describes research in multiple sclerosis.(Report)
Sep 10, 2008 ... Research findings, 'Magnetic resonance imaging as a surrogate outcome for multiple sclerosis relapses,' are discussed in a new report. According to recent research from Vancouver, Canada, "Magnetic resonance imaging (MRI) of lesions in the brain may be the best current candidate for a ...
Research from A.R. Santos and co-researchers provides new data on allergic contact dermatitis.
Sep 10, 2008 ... According to a study from Spain, "We report three new cases of allergic contact dermatitis due to vitamins in cosmetic creams." "The first patient was diagnosed with worsening rosacea but had allergic contact dermatitis from alpha-tocopherol in a moisturizing cream. The second ...
New allergies study findings have been reported by researchers at University of Connecticut.(Report)
Sep 10, 2008 ... " Eosinophilic infiltration into the airways is frequently associated with allergic asthma; however, the role of antigen deposition in mediating this phenomenon has not been studied in detail. Using a murine model of ovalbumin (OVA) allergy, we examined how differential deposition of OVA ...
Research from D.E. Cohen and co-authors in the area of allergies published.(Report)
Sep 10, 2008 ... "The ''gold standard'' for diagnosing allergic contact dermatitis is patch testing. Previous studies have not adequately addressed the validity and usefulness of the North American Contact Dermatitis Group (NACDG) Standard 65-allergen series alone as a screening tool in the evaluation of ...
Reports from Mayo Clinic describe recent advances in asthma.
Sep 10, 2008 ... According to recent research published in the journal American Family Physician, "Each month, three presenters review an interesting journal article in a conversational manner." "These articles involve ''hot topics'' that affect family physicians or ''bust'' commonly held ...
Reports from University of Virginia, Medical Department advance knowledge in asthma.
Sep 10, 2008 ... In this recent study, researchers in the United States conducted a study "To investigate short- and long-time-scale He-3 diffusion in asthma. A hybrid MRI sequence was developed to obtain coregistered short- and long-time-scale apparent diffusion coefficient (ADC) maps during a single ...
Data on atopic dermatitis reported by M. Oiwa and co-researchers.
Sep 10, 2008 ... " Airborne contact dermatitis to cedar pollen is a recently identified disease that generally affects individuals with cedar pollinosis of the nasal and/or ocular symptoms, as well as some patients with atopic dermatitis. To elucidate the pathological mechanisms of cedar pollen ...
New research on clinical and experimental allergy research from National Taiwan University summarized.(Clinical report)
Sep 10, 2008 ... " Attempts to identify predictors of atopic dermatitis (AD) have focused on genetic and immunologic factors. However, the role of neuro-mediators remains to be elucidated," investigators in Taipei, Taiwan report (see also Clinical and Experimental Allergy Research). " To ...
Researchers from University of Basel discuss findings in clinical and experimental allergy research.(Report)
Sep 10, 2008 ... According to recent research published in the journal Clinical and Experimental Allergy, " In the healthy lung, airway epithelial cells (AEC) regulate fibroblast proliferation through release of soluble factors, such as prostaglandins and proteins. Fibroproliferative diseases and airway ...
Reports outline clinical immunology study findings from Lund University.(Clinical report)
Sep 10, 2008 ... "Some primary immunodeficiencies (PIDs) express tow serum levels of antibodies. The constant heavy G chain (IGHG) genes, also representing Fc domains of gamma 3, gamma 1 and gamma 2 on chromosome 14q32.3, genotyped by the alternative IgG subclass allotypes, found in four fixed IGHG ...
New experimental immunology study results from University of Birmingham, Medical Department described.
Sep 10, 2008 ... "Stimulation of T lymphocytes results in the calcium-dependent activation and repression of a large number of genes. However, the functional response made by different T cell subsets is heterogeneous, as their differentiation results in alterations in their sensitivity to activation and in ...
Research results from Tokai University update knowledge of experimental immunology.
Sep 10, 2008 ... According to recent research published in the journal Clinical and Experimental Immunology, "When oral tolerance was induced in either specific pathogen-free (SPF) or germ-free (GF) mice, ovalbumin (OVA) feeding before immunization induced oral tolerance successfully in SPF mice. On the ...
New immunology findings from H.N. Zhang and co-researchers published.(Report)
Sep 10, 2008 ... According to recent research from Guangzhou, People's Republic of China, "A growing body of evidence has shown that professional antigen-presenting cells (APC) treated with transforming growth factor-beta (TGF-beta) can induce a systemic antigen (Ag)-specific tolerance, similar to anterior ...
Reports on immunology findings from Chonnam National University provide new insights.(Report)
Sep 10, 2008 ... According to recent research from South Korea, "Platelet-activating factor (PAF) has been demonstrated to augment resistance against Candida albicans infection. In this study, the role of nitric oxide (NO) in PAF-induced resistance in the kidneys was investigated." ...
Research from E. Pace and colleagues has provided new data on immunology.(Report)
Sep 10, 2008 ... "Airway epithelium is emerging as a regulator of innate immune responses to a variety of insults including cigarette smoke. The main goal of this study was to explore the effects of cigarette smoke extracts (CSE) on Toll-like receptor (TLR) expression and activation in a human bronchial ...
Research from Kyorin University, Medical Department in the area of immunology described.
Sep 10, 2008 ... "Toll-like receptors (TLRs) play an important role in innate immunity while, beta(2)-adrenergic receptors (beta(2)AR) provide the key linkages for the sympathetic nervous system to regulate the immune system. However, their role in macrophages remains uncertain," scientists writing in the ...
Scientists at University of Montreal publish research in immunology.
Sep 10, 2008 ... According to a study from Montreal, Canada, "A critical role for leukotriene B-4 (LTB4) and/or platelet-activating factor (PAF) in regulating polymorphonuclear cell (PMN) trafficking to inflammatory sites has been reported in a number of experimental inflammatory models. In vitro, newly ...
New parasite immunology findings from University of Agriculture described.
Sep 10, 2008 ... According to a study from Obihiro, Japan, "We have studied the impact of complement component 3 (C3) deficiency on the progression of lethal Babesia rodhaini infection in immune mice. A B. gibsoni ribosomal phosphoprotein P0 (BgP0) previously reported to be a cross-protective antigen ...
New parasite immunology study results reported from M. Hagberg et al.
Sep 10, 2008 ... "Adult Dictyocaulus viviparus homogenate induced proliferation of lymphocytes from naive cattle. We characterized the responding cells by carboxyfluorescein diacetate succinimidyl ester (CFSE) loading, for detection of proliferation, and antibody labelling for cell surface molecules," ...
Studies from S. Suchitra and colleagues yield new information about parasite immunology.
Sep 10, 2008 ... "Calreticulin (CalR), a Ca2+ binding multifunctional protein, is secreted by the parasitic nematode Haemonchus contortus. We have earlier observed binding of this protein to a 24-kDa polypeptide (p24) present in an enriched preparation of prothrombin," scientists in Izatnagar, India report ...
Studies from University of Wurzburg in the area of parasite immunology described.
Sep 10, 2008 ... "In immunocompetent rats and humans infection with Toxoplasma gondii remains mostly without overt clinical symptoms, but can be fatal, if the T-cell response is impaired. For a better understanding of the lack of control of T. gondii infection under immunosuppressed conditions, ...
New findings from University Hospital describe advances in rheumatology.
Sep 10, 2008 ... "A consensus paper concerning the interaction of anti-rheumatic drugs and reproduction was published in 2006, representing data collected during the year 2004 and 2005. Because of an increasing use of biological agents in women of fertile age, the information was updated for the years 2006 ...
Studies in the area of rheumatology reported from I. Miniati and co-researchers.
Sep 10, 2008 ... According to recent research published in the journal Rheumatology, "While in the past, pregnant SSc patients were thought to be at high risk for poor fetal and maternal outcome, at present, careful planning, close monitoring and appropriate therapy allows these patients to have a ...
Studies from V. Dauriac and co-researchers yield new data on life sciences.
Sep 10, 2008 ... Investigators publish new data in the report 'Isoelectric focusing in an ordered micropillar array.' According to a study from Paris, France, "An original micropillar array dedicated to electrophoretic separations has been developed. It consists of a rectangular zone of PDMS micropillars ...
Americans Elect Poodle as Obama's Top Dog.
Sep 10, 2008 ... Now that Democratic presidential nominee Barack Obama has chosen his running mate, it's time for him to concentrate on another important selection: family dog. The American Kennel Club(R) (AKC) announced that the public has elected a Poodle as their breed of choice for the Obama family ...
New Endust Free Asks - Are You Allergic to Dusting?
Sep 10, 2008 ... Endust(R), the makers of the successful dusting and cleaning spray, is launching a new product that's nothing to sneeze at - literally. New Endust Free Dusting and Cleaning Spray is the first fragrance-free, hypo-allergenic dusting and cleaning product designed to reduce allergens on ...
Reports outline B-cell lymphoma study findings from Korea University.
Sep 17, 2008 ... "B-cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) regulate survival and proliferation of B cells. Thus the association of elevated serum levels of BAFF and APRIL with worse prognosis has been suggested in B-cell lymphoid ...
Researchers at Laval University have published new data on bladder cancer.
Sep 17, 2008 ... "Intravesical bacillus Calmette-Guerin (BCG) immunotherapy is effective in preventing recurrence and progression in nonmuscle-invasive bladder cancer but the dosing schedule and duration of treatment remain empirical. The outcome of BCG therapy was prospectively evaluated on patients ...