Indian Journal of Dermatology, Venereology and Leprology back issues from January 2008:
A clinicoepidemiological study of polymorphic light eruption
Jan 01, 2008; ... Introduction Polymorphic Light Eruption is an abnormal cutaneous response which occurs on exposure to sunlight. The reported prevalence in various cohort studies from England, Sweden and Singapore varies from 10-20% and 26% in a study by Fotiades et al. [1],[2],[3],[4],[5] No such data ...
Comparative study of efficacy and safety of hydroxychloroquine and chloroquine in polymorphic light eruption: A randomized, double-blind, multicentric study
Jan 01, 2008; ... Introduction Polymorphic light eruption (PLE), first described in 1817 by Robert Willan, is the most common of idiopathic photodermatoses. [1] It is an acquired disorder characterized as an intermittent, transient, delayed response after ultraviolet (UV) light exposure that results in an ...
IJDVL gets into the Science Citation Index Expanded!
Jan 01, 2008; ... Dear Members, The year 2007 has been a busy one for the Indian Journal of Dermatology, Venerealogy and Leprology (IJDVL) with the number of submitted articles showing a steady upward trend. We had a record of 89 original articles being submitted during this year, this being a major gain ...
Many faces of cutaneous leishmaniasis
Jan 01, 2008; ... Introduction Cutaneous leishmaniasis (CL) is a major world health problem that is growing epidemically in Pakistan and Afghanistan. [1] It is a parasitic disease caused by Leishmania and transmitted by the bite of some species of sandflies and it affects various age groups. Phlebotomus ...
Forehead plaque: A cutaneous marker of CNS involvement in tuberous sclerosis
Jan 01, 2008; ... Introduction Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous genodermatosis characterized by hamartoma formation in multiple organs - like skin, brain, kidney, lung, heart and eyes. [1],[2],[3] The incidence of TSC is about 1 in 10,000, with half of the TSC ...
Registration and reporting of clinical trials
Jan 01, 2008; ... Clinical trials form an integral part of the drug discovery process worldwide. However, registration of clinical trials is not restricted to drug interventions. A clinical trial is defined as "any research study that prospectively assigns human participants or groups of humans to one or more ...
Ligand-binding prediction for ErbB2, a key molecule in the pathogenesis of leprosy
Jan 01, 2008; ... Introduction Cell adhesion plays a pivotal role in diverse biological processes that occur in the dynamic setting of an infection. [1] Although complex, cell adhesion in the vasculature can be exploited to direct drug carriers to targeted cells and tissues. Ligand-binding is an important ...
SCORTEN: Does it need modification?
Jan 01, 2008; ... Introduction Toxic epidermal necrolysis (TEN) is a drug related, acute life threatening dermatological disease. Apoptosis of cells causes erosion of mucous membranes, extensive detachment of epidermis and severe constitutional symptoms. Stevens-Johnson syndrome (SJS) and TEN are ...
Universal acquired melanosis (Carbon baby)
Jan 01, 2008; ... Introduction Melanin production normally is not maximal in the newborn skin. As a result, all babies, irrespective of race, may look slightly tanned or red in color at birth. Within the first few weeks racial color becomes more evident because melanin production is stimulated by exposure ...
Adult onset, hypopigmented solitary mastocytoma: Report of two cases
Jan 01, 2008; ... Introduction Mastocytosis is a disease characterized by the proliferation of mast cells in the skin, bone marrow, liver, spleen, lymph nodes or gastrointestinal tract. Cutaneous mastocytosis can present as urticaria pigmentosa, solitary mastocytoma (SM), diffuse mastocytosis and ...
Incidental finding of skin deposits of corticosteroids without associated granulomatous inflammation: Report of three cases
Jan 01, 2008; ... Introduction Intralesional steroids (usually triamcinolone acetonide) are commonly used by dermatologists for the treatment of various dermatological conditions including keloids and hypertrophic scars, chronic lichenified eczemas and stubborn patches of alopecia areata etc. Side-effects ...
Erythromelanosis follicularis faciei et colli: Relationship with keratosis pilaris
Jan 01, 2008; ... Introduction Erythromelanosis follicularis faciei et colli (EFF) was originally described by Kitamura et al. [1] This condition is characterized by well-demarcated erythema, pigmentation and follicular papules, involving mainly the pre-auricular areas, with extension to the sides of the ...
Naxos disease: A rare occurrence of cardiomyopathy with woolly hair and palmoplantar keratoderma
Jan 01, 2008; ... Introduction Naxos disease is a rare autosomal recessive inherited association of right ventricular dysplasia/dilated cardiomyopathy with woolly hair and palmoplantar keratoderma. [1] Woolly hair appears from birth, palmoplantar keratoderma develops during the first year of life and ...
Granular parakeratosis presenting with facial keratotic papules
Jan 01, 2008; ... Introduction Axillary granular parakeratosis was first described by Northcutt et al., in four patients who presented with pruritic red patches in the axillae, which on biopsy revealed severe compact parakeratosis, maintenance of the stratum granulosum and remarkable retention of ...
Adult cutaneous myofibroma
Jan 01, 2008; ... Introduction Adult solitary cutaneous myofibroma is a relatively recently described entity. It is considered the adult counterpart of multiple juvenile fibromatosis. The condition is of great interest amongst dermatologists and pathologists because of characteristic histopathology, which ...
Extragenital lichen sclerosus of childhood presenting as erythematous patches
Jan 01, 2008; ... Sir, Lichen sclerosus (LS) originally described by Hallopeau in 1887, is a chronic inflammatory dermatosis of obscure etiology. It is rather a rare mucocutaneous disorder that predominantly affects the genitoanal area with white porcelain-like sclerotic lesions. [1] Its incidence peaks ...
Preventing steroid induced osteoporosis
Jan 01, 2008; ... The most frequently encountered secondary cause of osteoporosis is steroid induced osteoporosis (SIOP). The association between Cushing's syndrome and osteoporosis has been recognized since 1932 when Harvey Cushing first described the clinical features of endogenous ...
Leukocytoclastic vasculitis during pegylated interferon and ribavirin treatment of hepatitis C virus infection
Jan 01, 2008; ... Sir, Chronic hepatitis C virus (HCV) infection is one of the main causes of liver disease in the world. Based on several clinical trials, pegylated interferon (peg-IFN) plus ribavirin (RIB) given for 24 or 48 weeks is now established as the standard therapy in chronic HCV infection. [1] ...
Poland's syndrome
Jan 01, 2008; ... Sir, Poland's syndrome is a rare congenital anomaly characterized by unilateral chest wall hypoplasia and ipsilateral hand anomalies. We are reporting a 10-year-old boy with right-sided Poland's syndrome. A 10-year-old boy presented with complaints of weakness on the right side ...
Hereditary leiomyomatosis with renal cell carcinoma
Jan 01, 2008; ... Sir, Hereditary leiomyomatosis with renal cell carcinoma (HLRCC) is a rare syndrome of cutaneous leiomyoma, uterine leiomyomatosis and renal cell carcinoma. [1] It is an autosomal dominant disorder caused by mutations in the gene encoding the enzyme fumarate hydratase (FH). Launonen et ...
Infantile onset of Cockayne syndrome in two siblings
Jan 01, 2008; ... Sir, Cockayne syndrome is a rare autosomal recessive degenerative disease with cutaneous, ocular, neurologic and somatic abnormalities. The entity was first described in 1936 by Cockayne. Till now around 150 cases have been reported in the literature. [1] Classically, Cockayne syndrome ...
Multiple xanthogranulomas in an adult
Jan 01, 2008; ... Sir, A 21-year-old old unmarried male presented to our Department with a 2 year history of numerous well-demarcated, firm, rubbery brownish yellow papular lesions of different sizes, over the face, neck, trunk and upper extremities, the majority being on the face. The patient was ...
Bullous pyoderma gangrenosum associated with ulcerative colitis
Jan 01, 2008; ... Sir, Pyoderma gangrenosum (PG) is a rare non-infectious neutrophilic dermatosis associated with underlying systemic disease, characterized by distinctive cutaneous ulcers with undermined borders; lesions usually require aggressive therapy and they heal with a characteristic cribriform ...
Sporotrichoid pattern of malignant melanoma
Jan 01, 2008; ... Sir, Malignant melanoma is a highly invasive neoplasm of skin, strongly influenced by environmental factors that develop in a genetically susceptible host. Incidence of melanoma is rising in Caucasians although it is a rare presentation in India. [1] A 28-year-old female ...
Acitretin for Papillon-Lefevre syndrome in a five-year-old girl
Jan 01, 2008; ... Sir, Papillon-Lefevre Syndrome (PLS) is a rare genetic disorder with an autosomal recessive mode of inheritance and is characterized by symmetrical transgradient palmoplantar keratoderma and severe periodontal disease. Other features may include tendency to frequent pyogenic infections ...
Bilateral Becker's nevi
Jan 01, 2008; ... Sir, Becker's nevus is a relatively common condition present in about 0.5% of young men. It is also known as pigmented hairy epidermal nevus. [1] Classically, Becker's nevus often appear as a sharply demarcated, unilateral, hyperpigmented tan colored macule over the shoulder or pectoral ...
Madarosis: A dermatological marker
Jan 01, 2008; ... Introduction Madarosis is derived from the ancient Greek word "madaros" meaning "bald" and is defined as hair loss of the eyebrows (superciliary madarosis) or loss of eyelashes (ciliary madarosis). Loss of eyelashes is also known as milphosis. In addition to the obvious cosmetic blemish ...
Botulinum toxin
Jan 01, 2008; ... Introduction Cosmetic dermatology is fast emerging as the preferred subspeciality of budding dermatologists. Its recent and sudden rise in popularity has much to do with the efficacy of botulinum toxin that has become a part of lay person's vocabulary. History The word " ...
A study of oxidative stress in paucibacillary and multibacillary leprosy
Jan 01, 2008; ... The major defense against microbial infection is the macrophage system. Microbial killing by macrophages is associated with a burst of respiratory activity that leads to the production of a variety of molecules and free radicals called reactive oxygen species (ROS), such as superoxide anion, ...
Clinical study of cutaneous drug eruptions in 200 patients
Jan 01, 2008; ... Introduction Cutaneous drug eruptions have become very common in recent times. The incidence of cutaneous drug eruptions is about 2.2% and is higher amongst inpatients and females. [1] Fatal reactions to drugs occur even though benign reactions are more common. The incidence increases in ...
Porokeratosis confined to the genital area: A report of three cases
Jan 01, 2008; ... Porokeratosis (PK) is a clonal disorder of keratinization showing one or multiple atrophic patches surrounded by a distinct ridge-like border. The common clinical variants include classical plaque-type porokeratosis of Mibelli (PM), disseminated superficial porokeratosis, linear porokeratosis, ...
Camisa disease: A rare variant of Vohwinkel's syndrome
Jan 01, 2008; ... Sir, Vohwinkel's syndrome is a rare, dominantly inherited keratoderma of palms and soles with a characteristic honeycomb appearance, linear and/or starfish keratoses on the extensor surfaces of the elbows, knees, knuckles and hands with flexion contractures and constricting bands ...
Fixed drug eruption due to cross reaction between two azoles used for different indications
Jan 01, 2008; ... Sir, It is well known that an eruption caused by one drug can be reactivated by another chemically related drug. Usually, these chemically related drugs belong to a single class of therapeutic agents, e.g., antibiotics or anticonvulsants. Such patients are usually advised to avoid the ...
Asymptomatic erythematous plaque on eyelid
Jan 01, 2008; ... A 30-year-old Indian woman presented with 1-year history of erythematous, mildly scaly plaque on right eyelid. The lesion started as a small papule, which gradually evolved into a plaque. The lesion was asymptomatic and there were no ocular complaints. Past medical history was insignificant and ...
A bluish nodule on the arm
Jan 01, 2008; ... A 21-year-old male presented with an asymptomatic, slow-growing swelling on the left arm of 4 years duration. He gave history of expression of black-colored fluid and, sometimes, blood when punctured. On examination, solitary, sessile, globular, well-circumscribed bluish nodule, measuring 2 cm ...
Molecular diagnostics in genodermatoses - simplified
Jan 01, 2008; ... Introduction The field of genetics in dermatology has progressed at an astonishing rate. Most of the known single gene disorders have at least been mapped to a particular chromosomal region and the causative genes have been identified and studied in many of them. However, most research ...