Recently added articles from Indian Journal of Medical Research:
Optimizing radiotherapy of brain tumours by a combination of temozolomide & lonidamine
Aug 01, 2008; ... Background & objectives : Temozolomide (TMZ), a second generation alkylating drug, an effective cytotoxic agent as well as radiosensitizer for malignant brain tumours, has side effects like myelosuppression. Lonidamine (LND) increases the effectiveness of several experimental multiple ...
Indian childhood cirrhosis: Several dilemmas resolved
Aug 01, 2008; ... Indian childhood cirrhosis (ICC) is a chronic liver disease in 1 -3 yr old children, unique to the Indian subcontinent. The Indian Council of Medical Research (ICMR) in 1983, set up a Multi-centric National Collaborative Study (MNCS) on ICC in six centres, except in Kolkata, its original home, ...
Putative stem cell markers in limbal epithelial cells cultured on intact & denuded human amniotic membrane
Aug 01, 2008; ... Background & objectives: The ocular surface is an ideal region to study the epithelial stem cell (SC) biology because of the unique spatial arrangement of stem cells and transient amplifying cells. A major challenge in corneal SC biology is the ability to identify SC in vitro and in situ, ...
Mitochondrial ultrastructure & release of proteins during liver regeneration
Aug 01, 2008; ... Background & objectives: It has been reported that some proteins are released from mitochondria during liver regeneration after partial hepatectomy (PH), but the relationship between proteins release and mitochondrial permeability transition (MPT) remains unclear. We undertook this study to ...
Phenol ammonium sulphate basic fuchsin staining of sputum in pot for the detection of acid-fast bacilli
Aug 01, 2008; ... Background & objectives: Improper practices of making direct smears of sputum for detection of acid-fast bacilli (AFB) and of disposing sputum cups are hazardous. The present study was undertaken with the objective to stain sputum samples in their containers by 'phenol (10%) ammonium ...
Protective efficacy of Emblica officinalis against Klebsiella pneumoniae induced pneumonia in mice
Aug 01, 2008; ... Background & objectives: Emblica officinalis (amla), which is a good source of vitamin C, has been shown to be beneficial due to its immune system enhancing property coupled with its tonifying and antiageing effect. The present study was conducted to evaluate the effect of E. officinalis ...
Research issues in HIV/AIDS
Aug 01, 2008; ... Research issues in HIV/AIDS, Raghunath D, Durga Rao C, editors, Sir Dorabji Tata Symposium Series, Vol. 7 (Tata McGraw-Hill Publishing Co. Ltd., New Delhi). 2007. 410 pages. Price: not mentioned. ISBN 978-0-07-065674-1 HIV, a deadly virus, has devastated some of the developed as well as ...
Multiplex PCR for the detection of Clostridium botulinum & C. perfringens toxin genes
Aug 01, 2008; ... Sir, Food-borne diseases constitute a major public health problem. Due to increased morbidity and mortality leading to time loss in the work place and reduced productivity, food-borne diseases across the world cost billions of dollars annually1. The Clostridium group of bacteria is ...
Diagnosis of leptospirosis by recombinant antigen based single serum dilution ELISA
Aug 01, 2008; ... Background & objectives: Leptospirosis, a zoonosis with a worldwide distribution is an acute febrile illness caused by spirochaetes of the pathogenic Leptospira interrogans. Microscopic agglutination test (MAT), the reference method for diagnosis was successively done to evaluate the ...
Antimicrobial prescription patterns for common acute infections in some rural & urban health facilities of India
Aug 01, 2008; ... Background & objectives: Irrational use of antimicrobials is a key factor behind rapidly spreading antimicrobial resistance in microorganisms. This study was undertaken to determine the rate and pattern of antimicrobial prescribing in patients with uncomplicated acute respiratory infections, ...
Comparison of disk diffusion, disk potentiation & double disk synergy methods for detection of extended spectrum beta lactamases in Enterobacteriaceae
Aug 01, 2008; ... Sir, Extended spectrum beta lactamases (ESBLs) are Ambler class A ß-lactamase enzymes that have the ability to hydrolyze ß-lactam antibiotics containing an oxyimino group (third generation cephalosporins and aztreonam) and are inhibited by ß-lactamase inhibitors'. ESBLs are usually ...
A study on nosocomial pathogens in ICU with special reference to multiresistant Acinetobacter baumannii harbouring multiple plasmids
Aug 01, 2008; ... Background & objectives : Antibiotic resistant bacterial nosocomial infections are a leading problem in intensive care units (ICU). Present investigation was undertaken to know antibiotic resistance in Acinetobacter baumannii and some other pathogens obtained from clinical samples from ICU ...
Human development, poverty, health & nutrition situation in India
Aug 01, 2008; ... Background & objectives: Human development index (HDI) is extensively used to measure the standard of living of a country. India made a study progress in the HDI value. Extreme poverty is concentrated in rural areas of northern States while income growth has been dynamic in southern States ...
Concise International Chemical Assessment Document (CICAD) 73, Mono- and disubstituted methyltin, butyltin, and octyltin compounds
Aug 01, 2008; ... emphasized in plenary lecture 4. Microbicide research in the field of HIV has shown great results in the last five years. A published paper included in the book has very lucidly covered the topic, highlighting the advantages of microbicides, their mode of action, types, merits and demerits of ...
Experience of conducting a phase I safety & acceptability clinical trial of a candidate vaginal microbicide & lessons learned
Aug 01, 2008; ... Sir, Topical vaginal microbicides are products designed to prevent the transmission of HIV and other sexually transmitted diseases'. About 60 products, are being evaluated as possible microbicides2. A few clinical trials on vaginal microbicides have been conducted in India so far, which ...
The IJMR hits a new high
Aug 01, 2008; ... Come Spring, like all editors of scientific journals, we look out for our 'performance indicators' for the year gone by in the Journal Citation Reports (JCR), published by Thomson Scientific, Philadelphia1. Equally important to us is to know how sister journals from India and outside our shores ...
Issues in nutrient supplementation of breast-milk fed low birth weight infants
Aug 01, 2008; ... Of the 20.6 million low birth weight (LBW) infants born every year, about 8 million are born in India1. Low birth weight is the most important risk factor for neonatal mortality, contributing to about three quarters of neonatal deaths in India2. In order to survive through infancy, LBW infants ...
Preventing hypertension - An exercise in social engineering
Aug 01, 2008; ... A large number of population surveys from different parts of the globe have consistently demonstrated hypertension to be a ubiquitous disease1-5 encompassing all ethnic groups and geographic regions. The disease affects both sexes and more and more patients are turning up at younger ages ....
Mycoplasma pneumoniae: an emerging pulmonary pathogen
Aug 01, 2008; ... Mycoplasmas are unique forms of life that lack the ability to produce cell walls. Recognition of Mycoplasma as a bacterial pathogen took many years of intense clinical and research work. The first Mycoplasma to be isolated in culture was the bovine pleuropneumonia (now known as Mycoplasma ...
Malaria in the South-East Asia Region: Myth & the reality
Jul 01, 2008; ... Malaria continues to remain a major public health problem worldwide. Much emphasis in the past has been on sub-Saharan Africa due to its heavy burden. However, concerned with the persisting situation of malaria in Africa as well as other regions, the 60th World Health Assembly passed a ...