Indian Journal of Pharmacology back issues from January 2008:
Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan-induced diabetic rats
Jan 01, 2008; ... Diabetes mellitus is heterogeneous primary disorder of carbohydrate metabolism with multiple etiological factors; it generally involves absolute or relative insulin deficiency, or insulin resistance, or both. Whatever the cause, diabetes ultimately leads to hyperglycemia, which is the landmark ...
Antiasthmatic activity of Moringa oleifera Lam: A clinical study
Jan 01, 2008; ... Bronchial asthma is a syndrome, characterized by increased responsiveness of trachea and bronchi to various stimuli and manifested by acute, recurrent, and chronic attacks of widespread narrowing of airways. Clinically, asthma is expressed by airway obstruction that involves inflammation of the ...
Evaluation of hypoglycemic effect of Morus alba in an animal model
Jan 01, 2008; ... Diabetes mellitus is a chronic disease characterized by elevated blood glucose levels and disturbances in carbohydrate, fat, and protein metabolism. These metabolic abnormalities result, in part, from a deficiency of the blood sugar-lowering hormone insulin; this deficiency in insulin results in ...
Antidiabetic activity of aqueous root extract of Ichnocarpus frutescens in streptozotocin-nicotinamide induced type-II diabetes in rats
Jan 01, 2008; ... Diabetes mellitus is a metabolic disorder characterized by disturbances in carbohydrate, protein, and lipid metabolism and by complications like retinopathy, microangiopathy, and nephropathy. [1] Currently available synthetic antidiabetic agents produce serious side effects like hypoglycemic ...
Reviewing the peer review
Jan 01, 2008; ... Peer review or refereeing is a process to subject a scholarly work, research or an idea to the scrutiny of others who are experts in the same field. The development of this process has been interesting. Different editors have employed varying styles of peer review in the past. The Lancet , ...
Adverse Drug Reactions (ADR) in the inPatients of Medicine Department of a Rural Tertiary Care Teaching Hospital and Influence of Pharmacovigilance in Reporting ADR
Jan 01, 2008; ... Adverse drug reactions (ADR) are common occurrences in a hospital setting, attributed to the severity and complexity of the disease process, the use of multiple drugs, drug interactions and possible negligence. [1] ADR could be observed in 10-20% of hospitalised patients and may be responsible ...
Effect of Morus alba L. (mulberry) leaves on anxiety in mice
Jan 01, 2008; ... Anxiety affects one-eighth of the total population worldwide and has become an important area of research in psychopharmacology during this decade. Benzodiazepines (BZDs) are the major class of compounds used in anxiety and they remain the most commonly prescribed treatment for anxiety. However, ...
The potential role of vildagliptin in the management and prevention of type 2 diabetes mellitus
Jan 01, 2008; ... The hallmark of type 1 diabetes mellitus (T1DM) is selective destruction of beta-cells associated with severe or complete insulin deficiency, thereby making administration of exogenous insulin mandatory. On the other hand, type 2 diabetes mellitus (T2DM), distinguished by a deficient insulin ...
Peptides and proteins with antimicrobial activity
Jan 01, 2008; ... A substance to be deemed a useful chemotherapeutic agent must have toxic selectivity for the parasite; this means that, at an effective concentration in the tissues, the substance must have low toxicity to host cells and high toxicity to the infective agent; it also should not alter the natural ...
A case of ciprofloxacin-induced erythema multiforme
Jan 01, 2008; ... Ciprofloxacin is a fluorinated quinolone having broad antimicrobial activity and is effective after oral or parenteral administration. Side effects with the use of ciprofloxacin are relatively few and development of resistance by microbes is not rapid. [1] It is used in urinary tract infection, ...
Antibacterial, antifungal and cytotoxic activities of amblyone isolated from Amorphophallus campanulatus
Jan 01, 2008; ... Introduction The frequency of life-threatening infections caused by pathogenic microorganisms has increased worldwide and is becoming an important cause of morbidity and mortality in immunocompromised patients in developing countries. [1] Although a large number of antimicrobial agents ...
Early phase studies in India: Are we too early to explore?
Jan 01, 2008; ... Early phase studies are exploratory, first-in-man studies that are conducted most often (but not always) in healthy volunteers and are critical to the development of a potential new drug. The objective of these studies is to establish proof of safety of the new molecule, as well as its ...
Partial nicotinic acetylcholine ([alpha]4[beta]2) agonists as promising new medications for smoking cessation
Jan 01, 2008; ... Introduction Smoking is widely recognized as a serious health problem, which is increasing in prevalence across the world. Smoking is a high risk factor for coronary heart disease, chronic obstructive pulmonary disease, cancers and various other health related problems. [1] According to ...
Antiulcer activity of cod liver oil in rats
Jan 01, 2008; ... Introduction Cod liver oil (CLO) is a dietary supplement that consists of polyunsaturated fatty acids (PUFA), which includes C 20 fatty acids (17%), palmitoleic acid (7%) and C 22 fatty acids (11%), vitamin A not less than 850 USP units/g and vitamin D not less than 85 USP units/g ....
Protective effect of aqueous extract of Embelia ribes Burm fruits in middle cerebral artery occlusion-induced focal cerebral ischemia in rats
Jan 01, 2008; ... Introduction Being the second most common cause of death in industrial countries and one of the major causes of death and disability, stroke has a great effect on public health. Among the neurological diseases, stroke accounts for the largest number of hospitalizations. [1] A variety of ...
Anti-dopaminergic effect of the methanolic extract of Morus alba L. leaves
Jan 01, 2008; ... Introduction Morus alba L. (Moraceae) (MA) is a moderately sized tree, three to six metres high, native of India, China and Japan. It is occasionally cultivated elsewhere in Europe, North America, and Africa. Morus alba is commonly known as white mulberry. White mulberry is cultivated ...
Preliminary isolation and in vitro antiyeast activity of active fraction from crude extract of Gracilaria changii
Jan 01, 2008; ... Introduction Today, there is an increasing demand for biodiversity in the screening programs seeking therapeutic drugs from natural products. There is great interest being shown in marine organism, especially algae or seaweed. The ability of seaweed to produce secondary metabolite has ...
Effect of fresh Triticum aestivum grass juice on lipid profile of normal rats
Jan 01, 2008; ... Introduction Fresh juice of grass (GJ) from Triticum aestivum Linn (Poaceae) or common wheat seed is used as a health improving adjuvant in several diseases including coronary artery disease in India as folk medicine. Hyperlipidemia is a major risk factor for coronary artery disease and ...
Olanzapine induced tardive dystonia
Jan 01, 2008; ... Introduction Extra-pyramidal symptoms (EPS) and tardive syndromes are commonly associated with the use of typical antipsychotic drugs. Tardive dystonia (TD), a very rare side effect induced by antipsychotics, is characterized by local or general sustained, involuntary twisting movements, ...
Recent advances in pharmacotherapy of glaucoma
Jan 01, 2008; ... Introduction Glaucoma is characterized by slow progressive degeneration of the retinal ganglion cells (RGCs) and the optic nerve axons, leading to increasing deterioration of the visual field. If untreated, the condition can lead to irreversible blindness. [1] Glaucoma represents ...
Antibiotic susceptibility patterns of Pseudomonas aeruginosa at a tertiary care hospital in Gujarat, India
Jan 01, 2008; ... Introduction Multiple antibiotic resistance in bacterial populations is a pervasive and growing clinical problem, which is recognized as a threat to public health. Hence, there is a need to conduct area-specific monitoring studies to profile different pathogens responsible for specific ...