Recently added articles from Journal of Clinical Investigation:
Th17 cells convert to IFN-[gamma] secretion to cause diabetes.(In this issue)(Brief article)
Mar 01, 2009 ... IL-17-secreting Th17 cells are pathogenic in mouse models of some autoimmune diseases, including MS and RA. However, it is not clear whether they contribute to the development of type 1 diabetes, which is commonly thought to be driven by IFN-[gamma]--secreting Th1 cells. To address this ...
Human resistin contributes to insulin resistance.(In this issue)(Brief article)
Mar 01, 2009 ... The development of insulin resistance in individuals who are obese is linked to many factors, including dysregulated production of adipocyte-derived factors (adipokines). Although the adipokine resistin clearly contributes to the development of insulin resistance in mice, previous studies ...
Antioxidants can prevent photoreceptor degeneration.(In this issue)(Brief article)
Mar 01, 2009 ... Retinal neovascularization can result in impaired vision. In a number of disease states, including macular telangiectasia (MacTel) and retinal angiomatous proliferation (RAP), it is associated with local photoreceptor degeneration. Dorrell and colleagues have now determined that mice ...
Role of CTLs in COPD becomes clearer.(In this issue)(cytotoxic T lymphocytes)(Chronic obstructive pulmonary disease)(Brief article)
Mar 01, 2009 ... Chronic obstructive pulmonary disease (COPD) is a progressive, lethal pulmonary disease often precipitated by emphysema, which is characterized by chronic inflammation. Although recent findings suggest lymphocytes contribute to this chronic inflammation, there is no evidence that they are ...
All data are not created equal.(Editorial)
Mar 01, 2009; ... Shall we start with some basic biochemistry? For the examples in this editorial, let's discuss Western blots in particular (though the rules apply to Northern, Southern, and PCR blots too). We've stated before (1) that bands can be spliced together, but only, and I repeat only, if they ...