Journal of Drugs in Dermatology back issues from September 2007:
Common and alternate oral antibiotic therapies for acne vulgaris: a review.
Sep 01, 2007; ... Abstract Acne vulgaris is an extremely common disorder affecting many adolescents and adults throughout their lifetimes. The pathogenesis of acne is multifactorial and is thought to involve excess sebum, follicular hyperkeratinization, bacterial colonization, and inflammation ....
The efficacy and safety of rituximab in refractory pemphigus: a review of case reports.
Sep 01, 2007; ... Abstract Rituximab is a chimeric murine-human monoclonal antibody that targets the CD20 antigen found on B cells and results in rapid depletion of this cell population. It is indicated for patients with relapsed or refractory, low-grade or follicular, CD20-positive, B cell ...
Bipolar radiofrequency in the treatment of dermatologic imperfections: clinicopathological and immunohistochemical aspects.(Clinical report)
Sep 01, 2007; ... Abstract Background: Rapid progress in the technology for skin rejuvenation has allowed for shorter post-treatment times than ever before. An example of such technology is the radiofrequency (RF) device, which offers nonablative skin rejuvenation, particularly for skin ...
Long-term safety and efficacy of a unique fixed-dose combination gel of adapalene 0.1% and benzoyl peroxide 2.5% for the treatment of acne vulgaris.(Drug overview)(Clinical report)
Sep 01, 2007; ... Abstract Background: A unique, once-daily, fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BP) 2.5% has been developed for the treatment of acne vulgaris. Objective: To evaluate the long-term (up to 12 months) safety and efficacy of the adapalene ...
Pilot study using topical imiquimod 5% cream in the treatment of nodular basal cell carcinoma after initial treatment with curettage.(Clinical report)
Sep 01, 2007; ... Abstract Background: Nodular basal cell carcinoma (nBCC) is the most common cutaneous malignancy and studies assessing the use of topical imiquimod 5% cream as a monotherapy in the treatment of nBCC have resulted in less than optimal clearance rates. Objective: This ...
Efficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study.(Clinical report)
Sep 01, 2007; ... Abstract Serine protease inhibitors (soybean trypsin inhibitor [STI] and Bowman-Birk protease inhibitor [BBI]) found in soybeans have been shown to inhibit melanosome phagocytosis by keratinocytes via protease-activated receptor 2 (PAR-2). Preclinical studies have confirmed the ...
Comparison of pre and/or postphotodynamic therapy and intense pulsed light treatment protocols for the reduction of postprocedure-associated symptoms and enhancement of therapeutic efficacy.
Sep 01, 2007; ... Abstract Photodynamic therapy (PDT) and intense pulsed light therapy (IPL) are commonly used in the setting of photorejuve-nation. Patient expectations for minimal to no downtime associated with these procedures has become an increasingly important issue. In an attempt to define ...
Mohs micrographic surgery for an unusual case of keratoacanthoma arising from a longstanding tattoo.(CASE REPORTS)(Case study)
Sep 01, 2007; ... Abstract This case report seeks to alert the reader to the possibility that the keratoacanthoma (KA) may develop in tattoo sites, specifically in red tattoo sites. We further wish to describe the senior author's treatment of such a lesion using Mohs micrographic surgery and a ...
Red scrotal syndrome: a localized phenotypical expression of erythromelalgia.(CASE REPORTS)(Case study)
Sep 01, 2007; ... Abstract We report a case of red scrotal syndrome responding to oral gabapentin, a neuropathic mediator that is commonly used in the treatment of primary erythromelalgia. The positive response to oral gabapentin and the resemblance of these 2 conditions supports that red ...
Acquired kinking of the hair caused by acitretin.(CASE REPORTS)(Case study)
Sep 01, 2007; ... Abstract Alopecia, hypertrichosis, and hirsutism may be caused by a variety of medications. Drug-induced alterations in the texture or structure of the hair shaft, however, are much less common. We report a female patient who presented with acquired generalized kinking of the ...
Rebound of psoriasis after efalizumab discontinuation, despite being on high-dose cyclosporine.(CASE REPORTS)(Case study)
Sep 01, 2007; ... Abstract Psoriasis rebound after efalizumab discontinuation is well-documented in the literature. We report the case of a patient who experienced psoriasis rebound 2 months after efalizumab discontinuation, despite being on more than 5 mg/kg/day of cyclosporine. This case ...
Alopecia universalis: hair growth following initiation of simvastatin and ezetimibe therapy.(CASE REPORTS)(Case study)
Sep 01, 2007; ... Abstract Alopecia areata is an organ specific autoimmune disease in which hair is lost in various patterns. Its most extreme form, alopecia universalis, is the total loss of all scalp and body hair. This form of the condition is very resistant to treatment and spontaneous ...
No nonsense dermoscopy: self-assessment.
Sep 01, 2007; ... Introduction Dermoscopy is the standard of care in many countries around the world and has been steadily gaining popularity in the US. As a proponent and teacher of the technique for many years, it has been my hope that it becomes the standard of care in the US as well. From my ...
Updates & perspectives on management of common dermatologic disorders.(LIT REVIEW)
Sep 01, 2007; ... Acne Vulgaris Tretinoin 0.025%/Clindamycin Phosphate 1.2% Gel: Summary of Available Data A novel aqueous gel formulation, which contains crystalline tretinoin 0.025% and solubilized clindamycin phosphate 1.2%, has been evaluated in 3 pivotal phase III studies and ...
Upcoming dermatology meetings.(Brief article)(Calendar)
Sep 01, 2007 ... Domestic 9/27-30 Women's and Pediatric Dermatology Seminar Grand Hyatt San Francisco, San Francisco, CA www.sdefderm.com 10/11-14 American Society for Dermatologic Surgery Sheraton Hotel & Towers, Chicago, IL ...
Topical devices for atopic dermatitis: what is the data behind these new products?(NEWS, VIEWS, AND REVIEWS)
Sep 01, 2007; ... The last 5 years have brought a host of new treatments for dermatitis marketed as devices, rather than drugs, to work as stabilizers of the epidermal barrier. Their active ingredients have been tested independently and they are approved through a medical device approval process as 510(k) ...
Extina[R] receives FDA approval.(PIPELINE PREVIEWS)(Brief article)
Sep 01, 2007; ... Stiefel Laboratories, Inc recently announced that the FDA has granted approval for Extina (ketoconazole) Foam, 2%, for the treatment of seborrheic dermatitis. Extina Foam is formulated with VersaFoam[R] technology and is the first foam formulation of ketoconazole on the market. Extina Foam ...
FDA approval for generic terbinafine tablets and cream.(PIPELINE PREVIEWS)(Brief article)
Sep 01, 2007; ... The FDA has granted the first approval for generic versions of the prescription medication Lamisil[R] (terbinafine hydrochloride) manufactured by Novartis Pharmaceuticals. The medication is indicated for the treatment of onychomycosis. The medication will be marketed as terbinafine ...
New Drug Application for Taclonex Scalp[R] gel.(PIPELINE PREVIEWS)(Brief article)
Sep 01, 2007; ... Warner Chilcott and LEO Pharma recently announced that a New Drug Application has been submitted to the FDA for Taclonex Scalp gel. Taclonex Scalp gel contains calcipotriene ...
Phase III study for PurTox[R] botulinum toxin type A.(PIPELINE PREVIEWS)(Brief article)
Sep 01, 2007; ... Mentor Corporation recently announced that it has begun initial patient enrollment and treatment in its phase III clinical trial of PurTox. PurTox is a purified botulinum ...
Oral Rambazole[TM] for moderate to severe psoriasis.(PIPELINE PREVIEWS)(Brief article)
Sep 01, 2007; ... Barrier Therapeutics recently announced positive results in its phase II, dose-finding trial for the treatment of moderate to severe psoriasis with Oral Rambazole. Rambazole is a novel retinoic ...
Patch-non-Patch[TM] transdermal drug delivery system.(PIPELINE PREVIEWS)(Brief article)
Sep 01, 2007; ... A recent report in the European Journal of Dermatology (Volume 17, Number 4, pages 309-312) describes a new transdermal drug delivery system called Patch-non-Patch. Patch-non-Patch is a monolaminated bioadhesive film that incorporates all the components of transdermal patches (backing, ...
VivaGel[TM] trial begins.(PIPELINE PREVIEWS)(Brief article)
Sep 01, 2007; ... Starpharma Holdings, Ltd recently has begun a trial in the US to assess the safety and efficacy of its SPL7013 (VivaGel). VivaGel is a vaginal microbicide that has been developed for the prevention ...
Cyclosporine for vulvar lichen sclerosus.(PIPELINE PREVIEWS)(Brief article)
Sep 01, 2007; ... A recent report in the Journal of the American Academy of Dermatology (Volume 57, Number 2, pages 276-278) evaluated the efficacy of oral cyclosporine in refractory vulvar lichen sclerosus. The study enrolled 5 patients with refractory lichen sclerosus and initiated treatment with oral ...
A multicenter, randomized, double-blind, parallel-group study to demonstrate the efficacy and safety of adapalene/benzoyl peroxide topical gel in subjects with acne vulgaris.(ACNE)(Brief article)
Sep 01, 2007 ... Sponsored by Galderma. The primary objective is to demonstrate the superiority in efficacy and assess the safety of adapalene/benzoyl peroxide topical gel versus 0.1% adapalene topical gel, 2.5% benzoyl peroxide topical gel, and topical gel vehicle in the treatment of acne vulgaris for up ...
A study of continuous oral contraceptives and doxycycline.(ACNE)(Brief article)
Sep 01, 2007 ... Sponsored by Oregon Health and Science University. The purpose of this study is to learn if the study drug, doxycycline, can decrease the amount of unplanned vaginal bleeding that women commonly experience when taking combined oral contraception (pills with estrogen and progestin) in a ...
Gefitinib and PEG-interferon alfa-2a in treating patients with unresectable or metastatic skin cancer.(SKIN CANCER)(Brief article)
Sep 01, 2007 ... Sponsors and Collaborators: University of California, San Diego and National Cancer Institute (NCI). This phase I/II trial is studying the side effects and best dose of PEG-interferon alfa-2a when given together with gefitinib and to see how well they work in treating patients with ...
Topical tazarotene in treating patients with basal cell skin cancer and basal cell nevus syndrome.(SKIN CANCER)(Brief article)
Sep 01, 2007 ... Sponsors and Collaborators: University of California, San Francisco and National Cancer Institute (NCI). This phase II trial is studying topical tazarotene to see how well it works in treating patients with basal cell skin cancer and basal cell nevus syndrome. <Pre> Condition...
Gefitinib in treating patients who are undergoing surgery and/or radiation therapy for locally advanced or recurrent squamous cell skin cancer.(SKIN CANCER)(Brief article)
Sep 01, 2007 ... Sponsors and Collaborators: MD Anderson Cancer Center and National Cancer Institute (NCI). This phase II trial is studying how well gefitinib works in treating patients who are undergoing surgery and/or radiation therapy for locally advanced or recurrent squamous cell skin cancer. ...
Study evaluating sirolimus in nonmelanoma skin cancer in kidney transplant recipients.(SKIN CANCER)(Brief article)
Sep 01, 2007 ... Sponsored by Wyeth. The purpose of this study is to determine the effect of sirolimus on the prevention of new nonmelanoma skin cancer in kidney transplant recipients. <Pre> Condition ...
ZD1839 (Iressa) for recurrent or metastatic squamous cell carcinoma of the skin.(SKIN CANCER)(Brief article)
Sep 01, 2007 ... Sponsors and Collaborators: MD Anderson Cancer Center and AstraZeneca. The purpose of this study is to explore the activity of ZD1839 administered to patients with squamous sell carcinoma of the skin who have locoregional recurrence and/or metastatic ...
Spectral diagnosis of cutaneous malignancy.(SKIN CANCER)(Brief article)
Sep 01, 2007 ... Sponsors and Collaborators: MD Anderson Cancer Center and University of Texas. The purpose of this study is to determine the spectroscopic features of skin lesions in vivo. This study also aims to develop the spectral diagnosis system to ...
Complete lymph node dissection or observation in treating patients with localized melanoma and sentinel node metastasis who have undergone sentinel lymphadenectomy.(SKIN CANCER)(Brief article)
Sep 01, 2007 ... Sponsors and Collaborators: John Wayne Cancer Institute at Saint John's Health Center and National Cancer Institute (NCI). This randomized phase III trial is studying complete lymph node dissection to see how well it works compared to observation in treating patients with localized ...
Multicenter selective lymphadenectomy Trial II (MSLT-II).(SKIN CANCER)(Brief article)
Sep 01, 2007 ... Sponsors and Collaborators: John Wayne Cancer Institute and National Institutes of Health (NIH). Subjects must be diagnosed with melanoma. All subjects receive sentinel lymphadenectomy. If the subject is sentinel node positive and meets study requirements, the subject is randomized to ...
Enhanced safety aesthetic laser system.(PHOTOAGING)(Brief article)
Sep 01, 2007 ... Sponsored by Scilex Ltd. The purpose of this study is to determine whether a new laser system provides better safety and efficacy than existing lasers in popular cosmetic procedures such as hair removal, treatment of cosmetically disturbing ...
The effect of a controlled daily skin care regimen on retinoic acid tolerance.(PHOTOAGING)(Brief article)
Sep 01, 2007 ... Sponsors and Collaborators: University of Michigan and Unilever. In this study, we examine whether a daily skin care regimen comprised of an ultra mild cleanser and an effective moisturizer can help improve tolerance to retinoic acid treatment. <Pre> ...
Study to evaluate psoriasis outcomes and safety events in patients with chronic moderate to severe plaque psoriasis (response).(PSORIASIS)(Brief article)
Sep 01, 2007 ... Sponsored by Genentech. This is a multicenter, prospective, 5-year surveillance study of approximately 5,000 Raptiva[R]-treated patients and approximately 500 non-Raptiva treated patients (formerly 2,500 comparison patients who were treated with a biologic ...
A study of the safety and effectiveness of CNTO 1275 compared to etanercept for the treatment of moderate to severe plaque psoriasis.(PSORIASIS)(Brief article)
Sep 01, 2007 ... Sponsored by Centocor, Inc. The purpose of this research study is to compare the effects (good and/or bad) of CNTO 1275 or etanercept on moderate to severe plaque psoriasis. <Pre> ...
Efficacy and safety of cyclosporine a microemulsion in maintenance patients with chronic plaque psoriasis.(PSORIASIS)(Brief article)
Sep 01, 2007 ... Sponsored by Novartis. The study will evaluate the efficacy of cyclosporine when administered twice a week compared to continuous administration, in patients with chronic plaque psoriasis. <Pre> Condition ...
UVA1 light for scleroderma and similar conditions.(FIBROSING DISORDERS)(ultraviolet-A1 )(Brief article)
Sep 01, 2007 ... Sponsored by University of Michigan. The purpose of this investigation is to evaluate the effectiveness of high-dose ultraviolet-A1 (UVA1) irradiation in the treatment of fibrosing conditions of the skin such as keloids (thick scars from growth of fibrous tissue), scleroderma (deposits of ...
Ultraviolet B light therapy in the treatment of skin conditions with altered dermal matrix.(FIBROSING DISORDERS)(Brief article)
Sep 01, 2007 ... Sponsored by University of Michigan. This research study will evaluate the effectiveness of high dose ultraviolet B light therapy in the treatment of keloid (or hypertrophic scar), scleroderma, acne keloidalis nuchae, old burn scars, granuloma annulare, or related conditions. <Pre> ...
Bioelectric field imaging near human skin wounds.(SKIN INFECTION)(Brief article)
Sep 01, 2007 ... Sponsored by National Institute of General Medical Sciences (NIGMS). The investigators have developed a new noninvasive medical device called the Bioelectric Field Imager. They plan to use this device to measure the electric field near small lancet wounds in 60 volunteers. Their hypothesis ...
Efficacy study of antiseptic preoperative scrubs in prevention of postoperative wound infections.(SKIN INFECTION)(Brief article)
Sep 01, 2007 ... Sponsored by Baylor College of Medicine. This trial is to compare the impact of disinfecting the skin with ChloraPrep[R] (2% chlorhexidine and 70% isopropyl alcohol) versus Betadine[R] on the rates of infection of clean-contaminated surgical wounds. The study will also assess the ...
Comparison of cephalexin versus clindamycin for empiric treatment of suspected CA-MRSA skin infections.(SKIN INFECTION)(Brief article)
Sep 01, 2007 ... Sponsored by Johns Hopkins University. The purpose of this study is to help define the role of antibiotics in the treatment of pediatric skin infections caused by CA-MRSA. <Pre> Condition Intervention Phase ...