Journal of Drugs in Dermatology back issues from February 2008:
Upcoming dermatology meetings.(Calendar)
Feb 01, 2008 ... Domestic 2/14- 2/17 6th Annual South Beach Symposium: Advances in Medical Dermatology Miami Beach. FL * www.southbeachsymposium.com 2/25-3/1 Advances in Cosmetic and Medical Dermatology Maui Derm 2008 ...
Clarification: 510k is Premarket Notification; it provides no patent or FDA approval.(LETTER TO THE EDITOR-IN-CHIEF)
Feb 01, 2008; ... Dear Editor-in-Chief, There is much confusion about the 510k and its meaning. The topic has come to light as many dermatologists have heard that 3 new products, namely MimyX[R], Atopiclair[R], and Epicream[R], have been "approved" by the FDA. Physicians understand that these ...
Letter from the guest editors.
Feb 01, 2008; ... Throughout history, humans have had a desire to retain a youthful appearance and therapeutic modalities to this end have been available for thousands of years. Of these, rejuvenation of facial skin maintains a center-stage position with patients and physicians. In this issue, we ...
Early improvement in rhytides and skin laxity following treatment with a combination fractional laser emitting two wavelengths sequentially.(Report)
Feb 01, 2008; ... Abstract Background: Carbon dioxide laser resurfacing remains the gold standard for the treatment of photoaged skin. Today, however, fewer patients will tolerate the postoperative downtime associated with the use of this device. Fractional photothermolysis was designed to ...
Reductions in thigh and infraumbilical circumference following treatment with a novel device combining ultrasound, suction, and massage.(Report)
Feb 01, 2008; ... Abstract Liposuction is the gold standard of body contouring procedures. Many patients, however, will not tolerate the invasiveness and subsequent recovery time associated with this procedure, despite the likelihood of superior results. Consequently, patients opt for minimally ...
Fractional photothermolysis.(Report)
Feb 01, 2008; ... Introduction Photoaging involves the loss and remodeling of collagen in the dermis, increase in vascular ectasia, and a fragmentation of elastin fibers in the dermis known as solar elastosis. (1) Clinical correlates of what is observed histologically are rhytides (both static ...
Dermabrasion in our practice.(Report)
Feb 01, 2008; ... Abstract Dermabrasion is a technique of facial resurfacing that allows the physician to sculpt the skin surface by surgically abrading, or planing the contours of the skin. User technique, device settings, and the combination of dermabrasion with other skin resurfacing ...
A clinical study of topical Pyratine 6 for improving the appearance of photodamaged skin.(Clinical report)
Feb 01, 2008; ... Abstract Objective: Pyratine 6[TM] has been shown to have antiaging effects in human skin cells. The purpose of this study is to determine the cosmetic efficacy and tolerance of topical Pyratine 6 (0.10%) over 12 weeks for improving the baseline clinical signs and symptoms of ...
Photopneumatic technology for the treatment of acne vulgaris.(Report)
Feb 01, 2008; ... Abstract Objective: Treatment of acne vulgaris with light sources necessitates multiple targets including Propionibacterium acnes and sebaceous glands. Traditional light sources such as blue light capitalize on P acnes bacteria as targets while infrared lasers and ...
Visible light photopatch testing of common photocontactants in female Filipino adults with and without melasma: a cross-sectional study.(Report)
Feb 01, 2008; ... Abstract Background: Although consistently associated with sun exposure, melasma is common among sun-shy Filipino women who generally prefer to have lighter skin, use skin lighteners, regularly practice sun avoidance, and are more exposed to indoor lights. Objective: ...
Treatment of hyperkeratosis with Kerafoam emollient foam (30% urea) to assess effectiveness and safety within a clinical setting: a case study report.(CASE REPORTS)(Report)
Feb 01, 2008; ... Abstract Ten patients enrolled in a single center, observational, prospective, open-label case study to assess the effectiveness and safety of a 28 day regimen with Kerafoam[R] 30% urea emollient foam for treatment of hyperkeratosis. Clinician assessments of skin condition were ...
Lisinopril-induced erythroderma in an 85-year-old male.(CASE REPORTS)(Report)
Feb 01, 2008; ... Abstract An 85-year-old male presented with a case of erythroderma secondary to lisinopril ingestion without a previous history of skin disease. While ACE inhibitors have been shown to elicit psoriatic erythroderma in previous cases, to our knowledge this is the first case ...
Folliculotropic mycosis fungoides responding to bexarotene gel.(CASE REPORTS)(Report)
Feb 01, 2008; ... Abstract Folliculotropic mycosis fungoides (FMF) is an uncommon and potentially aggressive form of cutaneous T cell lymphoma (CTCL). Phototherapy, radiotherapy, and systemic chemotherapy are the most commonly employed treatment options, but may have limited success and common ...
Treatment approaches for advanced cutaneous melanoma.(NEWS, VIEWS, AND REVIEWS)(Disease/Disorder overview)
Feb 01, 2008; ... Introduction The prognosis of advanced melanoma remains poor despite decades of research. According to the National Comprehensive Cancer Network (NCCN) guidelines, enrollment in a clinical trial is the preferred treatment for patients with advanced disease. This recommendation ...
Diclofenac sodium topical gel for osteoarthritis.(PIPELINE PREVIEWS)(Drug overview)(Brief article)
Feb 01, 2008; ... The FDA recently granted approval to Novartis to manufacture and market Voltaren[R] gel. Voltaren gel (diclofenac sodium 1% gel) is approved for the use of pain relief due to osteoarthritis of the knees and hands. The product was initially evaluated in a 12-week, randomized, double-blind ...
FDA warning for carbamazepine and skin reactions.(PIPELINE PREVIEWS)(Drug overview)(Brief article)
Feb 01, 2008; ... The FDA recently issued a revised boxed warning for carbamazepine. The warning states that patients with Asian ancestry should be screened for the human leukocyte antigen (HLA) allele HLA-B*1502 prior to being treated with carbamazepine. Patients who have this allele are at increased risk ...
Generic norethindrone acetate and ethinyl estradiol for acne vulgaris.(PIPELINE PREVIEWS)(Drug overview)(Brief article)
Feb 01, 2008; ... The FDA has recently granted approval for the first generic formulations of norethindrone acetate and ethinyl estradiol tablets (28 day and 21 day) in 1 mg/0.02 mg, 1 mg/0.03 mg, and 1 mg/0.035 mg strengths. This oral contraceptive pill is also used for the ...
Bosentan in metastatic melanoma.(PIPELINE PREVIEWS)(Drug overview)(Brief article)
Feb 01, 2008; ... Actelion Ltd recently revealed preliminary data from a study of bosentan for the treatment of metastatic melanoma. Bosentan (Tracleer[R]) is an endothelin receptor antagonist that is currently approved for use in the treatment of pulmonary arterial hypertension. The ...
Gentamicin topical for diabetic foot ulcers.(PIPELINE PREVIEWS)(Drug overview)(Brief article)
Feb 01, 2008; ... Innocoll, Inc recently announced the start of the first phase II clinical study to evaluate CollaRx[R] gentamicin topical for the treatment of diabetic foot ulcer infections. In this multicenter trial, CollaRx gentamicin topical will be compared to an oral antibiotic in the ...
European union approves Humira[R].(PIPELINE PREVIEWS)(Drug overview)(Brief article)
Feb 01, 2008; ... Abbott recently announced that the European Commission has granted marketing authorization for the use of Humira[R] (adalimumab) for the treatment of moderate to severe plaque psoriasis. The drug is currently under review with the FDA for the same indication. Humira is a fully human, ...
Study to compare the acne relapse rate of oral minocycline to oral minocycline in combination with topical tretinoin, followed by topical tretinoin alone.(ACNE)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsors and Collaborators: Derm Research @ 888 Inc. The purpose of this study is to compare the relapse rates of acne with the use of oral antibiotics and topical treatments. <Pre> Condition Intervention Phase Acne Drug: Minocycline ...
Efficacy and safety of azithromycin SR compared with minocycline in acne.(ACNE)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsored by: Pfizer. The primary objective is to evaluate the clinical efficacy of azithromycin microspheres treatment in outpatients with moderate to severe inflammatory acne compared with first line treatment minocycline after 8 weeks ...
Epicream versus Elidel for treatment of mild to moderate atopic dermatitis.(ATOPIC DERMATITIS)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsored by: Ceragenix Pharmaceuticals. The objective of this study is to determine whether Epicream (ceramide based barrier repair cream is a safe and effective therapy for mild to moderate atopic dermatitis and whether it may serve as an alternative to Elidel therapy ....
Efficacy study of montelukast in atopic dermatitis induced by food allergens.(ATOPIC DERMATITIS)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsors and Collaborators: 1st Allergy and Clinical Research Center, Merck. The study will be a randomized, double-blind, placebo-controlled, parallel group trial with a focus on the mechanisms associated in children with atopic dermatitis (AD) induced ...
The effects of probiotics in atopic dermatitis.(ATOPIC DERMATITIS)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsors and Collaborators: University of California, Los Angeles, Thrasher Research Fund. The purpose of this study is to study the clinical effects of taking probiotics in patients who have moderate to ...
Alefacept in patients with severe scalp alopecia areata.(ALOPECIA)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsors and Collaborators: Maria K. Hordinsky MD, National Alopecia Areata Foundation. The purpose of this study is to examine prospectively the safety and efficacy of alefacept in the treatment of subjects with ...
Treatment of alopecia areata of the scalp with intradermal injections of Botulinum Toxin A.(ALOPECIA)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsored by: University of British Columbia. The purpose of this study is to examine prospectively the safety and efficacy of Botulinum Toxin A (Botox) injections in the treatment of patients with alopecia areata of the scalp. <Pre> Condition...
Imiquimod in children with plaque morphea.(CONNECTIVE TISSUE DISORDERS)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsored by: The Hospital for Sick Children. The purpose of this study is to assess the potential efficacy and relative safety of Imiquimod in children with plaque morphea. Study ID ...
UVA1 light for scleroderma and similar conditions.(CONNECTIVE TISSUE DISORDERS)(Product/service evaluation)(Brief article)
Feb 01, 2008 ... Sponsored by: University of Michigan. The purpose of this investigation is to evaluate the effectiveness of high-dose UVA1 irradiation in the treatment of fibrosing conditions of the skin. Study ID Numbers: Derm 364 <Pre> ...
A pilot study of etanercept in dermatomyositis.(CONNECTIVE TISSUE DISORDERS)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsored by: National Institute of Neurological Disorders and Stroke (NINDS). The purpose of this study is to determine the safety and tolerability of etanercept in people with dermatomyositis. ...
Treatment of Cutaneous Lupus Erythematosus (CLE) with the 595 nm flashlamp pulsed-dye laser.(CONNECTIVE TISSUE DISORDERS)(Product/service evaluation)(Brief article)
Feb 01, 2008 ... Sponsored by: University of Pennsylvania. The purpose of using the 595 nm Vbeam Perfecta flashlamp-excited, pulsed dye laser in this study is to help improve study patients' skin disease. <Pre> Condition...
A clinical study of curcuminoids in the treatment of oral lichen planus.(LICHEN PLANUS)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsored by: University of California, San Francisco. A trial of a 2-week course of curcuminoids in oral lichen planus will be conducted for the purpose of studying signs, symptoms, periodontal status and blood tests including complete blood count, liver enzymes, serum c reactive ...
A study to evaluate the safety and effectiveness of etanercept in treating lichen planus on the oral mucosa or skin.(LICHEN PLANUS)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsors and Collaborators: Stanford University. The purpose of this study is to determine the safety and efficacy of etanercept (also known as Enbrel[R]) in the treatment of moderate to severe lichen planus. ...
Safety and effectiveness of efalizumab to treat oral lichen planus.(LICHEN PLANUS)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsors and Collaborators: Washington University School of Medicine, Genentech. This study is to determine whether efalizumab 1.0 mg/kg given by subcutaneous injection for 12 weeks is effective in treating ...
Pimecrolimus cream for oral lichen planus.(LICHEN PLANUS)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsors and Collaborators: University of Utah, Novartis. The purpose of this study is to investigate the use of pimecrolimus 1% cream for oral lichen planus. <Pre> Condition ...
Single-blind study determining the efficacy of Polypodium leucotomos extract supplement in decreasing UVA premutagenic and photoaging markers (heliocare).(PHOTOAGING)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsored by: University of Miami. The purpose of this study is to determine if taking a dose of the study medication, Polypodium leucotomos (PL), prevents some of the changes in the skin caused by the adverse effects of UVA, a type of ultraviolet ...
Erlotinib in women with squamous cell carcinoma of the vulva.(SKIN CANCER)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsors and Collaborators: Dana-Farber Cancer Institute, Genentech, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Women and Infants Hospital of Rhode Island. The purpose of this study is to see how vulvar cancer responds to a short course (4-6 weeks) of erlotinib and ...
Topical tazarotene in treating patients with basal cell skin cancer and basal cell nevus syndrome.(SKIN CANCER)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsors and Collaborators: Children's Hospital & Research Center Oakland, National Cancer Institute (NCI). The purpose of this phase II trial is to study topical tazarotene to see how well it works in treating patients with basal cell skin cancer and basal cell nevus syndrome. ...
Intron-A/Aldara combination therapy for BCC.(Basal cell carcinoma)(SKIN CANCER)(Drug overview)(Brief article)
Feb 01, 2008 ... Sponsored by: The University of Texas Health Science Center, Houston. The purpose of this study is to see if BCC excluding the scalp and face can be treated successfully with a combination therapy of Intron[R]-A and Aldara[R]. <Pre> Condition ...
Complete lymph node dissection or observation in treating patients with localized melanoma and sentinel node metastasis who have undergone sentinel lymphadenectomy.(SKIN CANCER)(Disease/Disorder overview)(Brief article)
Feb 01, 2008 ... Sponsors and Collaborators: John Wayne Cancer Institute at Saint John's Health Center National Cancer Institute (NCI). The purpose of this randomized phase III trial is to study complete lymph node dissection to see how well it works compared to observation in treating patients with ...
Emerging topical antimicrobial options for mild-to-moderate acne: a review of the clinical evidence.(Drug overview)
Feb 01, 2008; ... Abstract Topical antimicrobial agents are commonly used as first-line agents for the management of mild to moderate acne vulgaris. Agents with antibacterial activity (eg, benzoyl peroxide and clindamycin), reduce counts of Propionibacterium acnes, while also decreasing the ...
New developments in topical antimicrobial therapy for acne.(Drug overview)
Feb 01, 2008; ... Abstract Benzoyl peroxide (BPO) has been an important component of the acne treatment armamentarium for decades. A number of characteristics contribute to its success in acne, including its lipophilicity, potent antibacterial activity, and ability to suppress ...
The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure.(Disease/Disorder overview)
Feb 01, 2008; ... Abstract Cutaneous aging occurs through 2 biologically distinct processes: intrinsic and extrinsic aging. The first is a naturally occurring process that results from slow tissue degeneration. In human dermis, intrinsic aging is characterized by 3 features: atrophy of the dermis ...
Cosmeceuticals for the attenuation of extrinsic and intrinsic dermal aging.(Drug overview)
Feb 01, 2008; ... Abstract Since the term "cosmeceutical" was coined over 2 decades ago, the number of products in this category that claim to combat dermal aging has grown dramatically. Topical retinoids remain the mainstay for treating photoaging given their proven efficacy in both clinical and ...
Complementary effects of topical antiaging treatments in conjunction with aesthetic procedures.(Disease/Disorder overview)
Feb 01, 2008; ... Abstract The dermatologist has a variety of tools for improving the appearance of aging skin. These include injectable botulinum toxins and dermal fillers, laser treatments, chemical peels, and various topical agents, including cosmeceuticals. A combined approach using more than ...
Skin through the ages: state-of-the-art options for the topical treatment of acne, photodamage, and aging.
Feb 01, 2008 ... This activity has been certified for physicians. It was planned and produced in accordance with the ACCME Essentials and Standards for enduring materials (release date: February 2008; expiration date: January 2009). To obtain CME credit, please complete this form, remove from the booklet, ...