Life Extension back issues from August 2008:
Novel drug therapy immediately reverses Alzheimer's cognitive deficits.(AS WE SEE IT)(Clinical report)
Aug 01, 2008; ... Twenty million Americans alive today are destined to contract Alzheimer's disease, an affliction that robs us of memory, intelligence, and eventually our most rudimentary cognitive abilities. Newly diagnosed Alzheimer's victims are told they will suffer a relentless decline in ...
Green tea compound reduces breast cancer growth in animals.(IN THE NEWS)(Report)(Brief article)
Aug 01, 2008; ... The green tea antioxidant epigallocatechin-3-gallate (EGCG) slows breast cancer growth in female mice, a new study reveals. * [ILLUSTRATION OMITTED] University of Mississippi researchers added EGCG to the drinking water of seven-week-old female mice for five weeks, ...
Daily aspirin reduces hormone-sensitive breast cancer risk.(IN THE NEWS)(Brief article)(Clinical report)
Aug 01, 2008; ... New research backs the idea that aspirin protects against estrogen receptor-positive breast cancer, (1) a hormone-sensitive malignancy that makes up 75% of all cases of the disease. In this large-scale, long-term study, researchers from the National Cancer Institute evaluated ...
Coenzyme Q10 relieves muscle damage in athletes.(IN THE NEWS)(Brief article)(Clinical report)
Aug 01, 2008; ... Coenzyme Q10 (CoQ10) supplementation significantly reduces muscle injury and oxidative stress due to intensive exercise, a new study reveals. (1) In this double-blind study, 18 elite athletes took 300 mg/day of CoQ10 or placebo for 20 days, during which time they exercised ...
Anthocyanins show promise for obesity.(IN THE NEWS)(Brief article)(Clinical report)
Aug 01, 2008; ... Anthocyanins, the colorful antioxidant pigments contained in many fruits and vegetables, help regulate adipocyte function and obesity in mice, according to a recent study. * Adipocyte (fat cell) dysfunction promotes obesity, which in turn is a major risk factor for metabolic syndrome and ...
Whey protein supplement effective for weight loss.(IN THE NEWS)(Brief article)(Clinical report)
Aug 01, 2008; ... A purified whey protein supplement achieves substantial weight loss while sparing lean muscle, a recent study reports. * The supplement contains high levels of leucine from whey protein, bioactive peptides, and calcium. [ILLUSTRATION OMITTED] More than 100 overweight ...
Fathers-to-be need folate too.(IN THE NEWS)(Report)(Brief article)
Aug 01, 2008; ... Ensuring optimal folate intake during the reproductive years is just as important for men as it is for women, according to a new report. * Men who have reduced levels of this B vitamin have a higher rate of chromosomal abnormalities in their sperm, which puts their children at greater risk ...
Vitamin D may protect against peripheral artery disease.(IN THE NEWS)(Brief article)(Clinical report)
Aug 01, 2008; ... Low serum vitamin D levels are associated with an increased risk of peripheral artery disease, according to a recent report from the National Health and Nutrition Examination Survey (NHANES). (1) Peripheral artery disease occurs when arteries in the legs are damaged by atherosclerotic ...
Green tea combats exercise-induced oxidative damage.(IN THE NEWS)(Brief article)(Clinical report)
Aug 01, 2008; ... Consuming green tea protects against exercise-induced oxidative damage, according to a new study. * Oxidative damage, which results from metabolic activity and is increased following exercise, is linked to degenerative changes associated with aging and chronic disease. Fourteen ...
Low vitamin D levels linked with depression.(IN THE NEWS)(Brief article)(Clinical report)
Aug 01, 2008; ... A new study shows for the first time that older people with low levels of vitamin D and elevated levels of parathyroid hormone (PTH, a hormone that regulates blood calcium levels) are more likely to be depressed than those with normal levels. * In this study, Dutch researchers ...
Common class of drugs accelerates mental, physical decline in elderly.(IN THE NEWS)(Brief article)
Aug 01, 2008; ... Anticholinergic medications, which are commonly used for conditions like overactive bladder, motion sickness, and asthma, may hasten functional and cognitive decline in older adults, according to new research. (1-3) Anticholinergics selectively block receptors for acetylcholine, a ...
Olive oil substance is excellent fish oil preservative, antioxidant.(IN THE NEWS)(Report)(Brief article)
Aug 01, 2008; ... Adding the olive oil polyphenol hydroxytyrosol to fish oil and fish oil-rich food products preserves freshness and dramatically improves their shelf life, according to a new study published in the Journal of Agricultural and Food Chemistry. (1) While fish oil has long been ...
Weight loss critical in diabetes management.(IN THE NEWS)(Brief article)(Clinical report)
Aug 01, 2008; ... Overweight patients with type 2 diabetes should lose weight, rather than take ever-increasing doses of insulin, according to diabetes researcher, Roger H. Unger, MD. In a commentary that appeared recently in the Journal of the American Medical Association, (1) Dr. Unger noted ...
Fish oil improves infants' cognitive and motor function.(IN THE NEWS)(Brief article)(Clinical report)
Aug 01, 2008; ... Infants exposed to a high level of docosahexaenoic acid (DHA) prenatally have improved mental and motor development, according to a study of native Inuit in Arctic Quebec. * DHA is an omega-3 polyunsaturated fatty acid found abundantly in fatty fish that is a staple of the Inuit diet. ...
Nuts reduce cholesterol via monounsaturated fatty acids.(IN THE NEWS)(Brief article)(Clinical report)
Aug 01, 2008; ... Adults who consume a short-term macadamia nut-enriched diet have significantly lower cholesterol levels than those who consume a control diet. * Macadamia nuts contain low levels of saturated fats and high levels of monounsaturated fatty acids. [ILLUSTRATION OMITTED] ...
DHEA inhibits endothelial inflammation.(IN THE NEWS)(dehydroepiandrosterone-sulfate)(Brief article)(Clinical report)
Aug 01, 2008; ... Scientists have shown that dehydroepiandrosterone-sulfate (DHEA-S) inhibits inflammation in human endothelial cells. * Inflammation and endothelial dysfunction are intimately connected with atherosclerosis, the root cause of cardiovascular disease. [ILLUSTRATION OMITTED] ...
Vitamin K2 may protect against prostate cancer.(IN THE NEWS)(Brief article)
Aug 01, 2008; ... A new European study published in the American Journal of Clinical Nutrition suggests that men with the highest intakes of vitamin K2 have the lowest risk of prostate cancer. * Intakes of vitamins K1 and K2 were statistically compared with the incidence of total and advanced ...
US Congress seeks to reverse FDA's blockade on estriol.(IN THE NEWS)(United States. Food and Drug Administration)
Aug 01, 2008; ... The US Congress is taking a key step in attempting to overturn the FDA's action to halt the sale of estriol. The FDA recently sent out a series of warning letters to compounding pharmacies across the country demanding they stop using estriol and the term bioidentical in their ...
A scientific solution to unsightly cellulite.(ON THE COVER)(Disease/Disorder overview)
Aug 01, 2008; ... Cellulite affects nearly every woman as she gets older. The skin dimpling and bumps typically seen on the thighs, hips, and buttocks is a condition that women have endured for centuries. [ILLUSTRATION OMITTED] While purported "cures" for cellulite abound, the ...
Estriol: its weakness is its strength.(REPORT)
Aug 01, 2008; ... Estriol, an estrogen that has virtually been ignored by the mainstream medical community, is one of the three principal estrogens produced by the body. Estriol was originally thought to have little significance due to its weak estrogenic activity when compared with estrone and estradiol ....
Beyond sleep: new medical applications for melatonin.(REPORT)
Aug 01, 2008; ... To the surprise of doctors around the world, melatonin is demonstrating life-saving benefits that far exceed its common use as a sleep aid. (1) Increasingly, researchers have shown that melatonin's impressive ability to control oxidative damage in systems throughout the body can reduce the ...
Insulin resistance--a lethal link between metabolic disease and heart attack.
Aug 01, 2008; ... Due to multimillion dollar advertising and marketing campaigns by the pharmaceutical industry, patients and physicians alike seem to associate heart attack and stroke risk only with cholesterol. Drugs that lower cholesterol (statins), have created a windfall of profit for pharmaceutical ...
Preventing migraine pain with butterbur.(REPORT)(Clinical report)
Aug 01, 2008; ... Every year, nearly a million people in the United States end up in the emergency room seeking relief from debilitating migraine pain. (1) Severe migraine headaches remain an unresolved medical issue for millions of people despite the availability of powerful drugs and specialty migraine ...
Anatomy and physiology of subcutaneous adipose tissue by in vivo magnetic resonance imaging and spectroscopy: relationships with sex and presence of cellulite.(Cellulite)(Brief article)
Aug 01, 2008 ... BACKGROUND: Little is still known concerning subcutaneous adipose tissue and cellulite, and controversial questions are still under discussion. AIMS: Magnetic resonance imaging and spectroscopy were used to address two unresolved questions relating to the anatomy and physiology of ...
Cellulite: a review of its physiology and treatment.(Cellulite)(Brief article)
Aug 01, 2008 ... Cellulite affects 85-98% of post-pubertal females of all races. While not a pathologic condition, it remains an issue of cosmetic concern to a great number of individuals. Despite its high prevalence, there have been few scientific investigations into the physiology of cellulite. There ...
Cellulite--the greatest skin problem in healthy people? An approach.(Cellulite)(Brief article)
Aug 01, 2008 ... Cellulite or so called orange peel skin affects 80-90% of all females. It is not considered as a pathological condition but as aesthetically disturbing dimpling of the skin seen most commonly on the thighs and buttocks. Despite its high prevalence, there have been only a few scientific ...
Cellulite and skin ageing: is there any interaction?(Cellulite)(Brief article)
Aug 01, 2008 ... Objective: This study aimed to identify the characteristics of cellulite in women of different age and to appreciate whether cellulite could interfere with skin ageing or not. Methods: 94 healthy females, divided into three age groups (21-30yrs; 31-40yrs; 51-60yrs) and two grade groups of ...
Licorice reduces serum testosterone in healthy women.(Cellulite)(Brief article)(Clinical report)
Aug 01, 2008 ... Licorice has been considered a medicinal plant for thousands of years. The most common side effect is hypokalemic hypertension, which is secondary to a block of 11beta-hydroxysteroid dehydrogenase type 2 at the level of the kidney, leading to an enhanced mineralocorticoid effect of ...
Clinical implications of glucocorticoid metabolism by 11beta-hydroxysteroid dehydrogenases in target tissues.(Cellulite)(Brief article)
Aug 01, 2008 ... 11beta-Hydroxysteroid dehydrogenases (11beta-HSD) are microsomal enzymes that catalyze the conversion of active glucocorticoids (GC) to their inactive 11-dehydro products and vice versa. Two isoenzymes of 11beta-HSD have been characterized and cloned in human tissues. The tissue-specific ...
A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis.(Cellulite)(Brief article)(Clinical report)
Aug 01, 2008 ... OBJECTIVE: Only a few clinical trials have been published on the topical treatment of atopic dermatitis with herbal ointments. An ointment containing extracts from Mahonia aquifolium, Viola tricolor and Centella asiatica has previously been studied in open uncontrolled trials with ...
Effects of horse-chestnut seed extract on transcapillary filtration in chronic venous insufficiency.(Cellulite)(Brief article)(Clinical report)
Aug 01, 2008 ... The effect of horse-chestnut seed extract (standardized on aescin; Venostasin retard) was assessed in a randomized placebo-controlled crossover double-blind trial of 22 patients with proven chronic venous insufficiency by measuring the capillary filtration coefficient and the intravascular ...
Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency.(Cellulite)(Report)(Brief article)
Aug 01, 2008 ... BACKGROUND: Diseases of the venous system are widespread disorders sometimes associated with modern civilisation and are among the major concerns of social and occupational medicine. This study was carried out to compare the efficacy (oedema reduction) and safety of compression stockings ...
Antioxidative and antigenotoxic effects of Japanese horse chestnut (aesculus turbinata) seeds.(Cellulite)(Report)(Brief article)
Aug 01, 2008 ... Japanese horse chestnut seed extract (HCSE) dose-dependently inhibited the autooxidation of linoleic acid (IC(50): 0.2 mg/ml), and the inhibition was almost complete at a concentration of 1 mg/ml. The HCSE scavenged DPPH (1,1-diphenyl-2- picrylhydrazyl) radicals and superoxide anions with ...
Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk.(Estriol)(Clinical report)
Aug 01, 2008 ... INTRODUCTION: Vitamin D receptor (VDR) genotypes may influence breast cancer risk by altering potential anticarcinogenic effects of vitamin D, but epidemiological studies have been inconsistent. Effect modification by serum 25- hydroxyvitamin D (25 [OH]D), the biomarker for vitamin D ...
Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial.(Estriol)(Report)(Brief article)
Aug 01, 2008 ... BACKGROUND: Numerous observational studies have found supplemental calcium and vitamin D to be associated with reduced risk of common cancers. However, interventional studies to test this effect are lacking. OBJECTIVE: The purpose of this analysis was to determine the efficacy of calcium ...
Glycemic load, glycemic index, and the risk of breast cancer among Mexican women.(Estriol)(Brief article)(Clinical report)
Aug 01, 2008 ... OBJECTIVE: The amount and composition of dietary carbohydrates is a major determinant of postprandial blood glucose and insulin, and risk of breast cancer has been positively associated with plasma levels of insulin and insulin-like growth factor 1. We sought to evaluate dietary glycemic ...
Consumption of dairy products and the risk of breast cancer: a review of the literature.(Estriol)(Report)(Brief article)
Aug 01, 2008 ... Differences in eating patterns and breast cancer rates across countries suggest that several dietary components, including dairy products, could affect breast cancer risk. However, dairy products are a diverse food group in terms of the factors that could potentially influence risk. Some ...
Consumption of sweet foods and breast cancer risk in Italy.(Estriol)(Brief article)(Clinical report)
Aug 01, 2008 ... BACKGROUND: The relation between the intake of sugar and sweets and the risk of breast cancer has been considered in ecological, prospective and case-control studies, but the results are unclear. We analyzed such a relation in a case-control study conducted between 1991 and 1994 in Italy ....
Serum enterolactone levels and the risk of breast cancer in women with palpable cysts.(Estriol)(Brief article)(Clinical report)
Aug 01, 2008 ... Low levels of lignans, namely enterolactone, have been reported to be associated with an increased risk of breast cancer in the general female population. We assessed, retrospectively, the relationship between serum enterolactone concentrations and the occurrence of breast cancer in women ...
Dietary lignan intakes and risk of pre- and postmenopausal breast cancer.(Estriol)(Brief article)(Clinical report)
Aug 01, 2008 ... Lignans are plant compounds metabolized in the mammalian gut to produce the phytoestrogens enterolactone and enterodiol. Because estrogens have been linked to breast cancer etiology, lignans could affect breast cancer risk through modulation of endogenous estrogen metabolism or competitive ...
Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer.(Estriol)(Brief article)(Clinical report)
Aug 01, 2008 ... Dietary indoles, present in Brassica plants such as cabbage, broccoli, and Brussels sprouts, have been shown to provide potential protection against hormone-dependent cancers. 3,3'-Diindolylmethane (DIM) is under study as one of the main protective indole metabolites. Postmenopausal women ...
A phase I study of indole-3-carbinol in women: tolerability and effects.(Estriol)(Brief article)(Clinical report)
Aug 01, 2008 ... We completed a phase I trial of indole-3-carbinol (I3C) in 17 women (1 postmenopausal and 16 premenopausal) from a high-risk breast cancer cohort. After a 4-week placebo run-in period, subjects ingested 400 mg I3C daily for 4 weeks followed by a 4-week period of 800 mg I3C daily. These ...
Plasma 25-hydroxyvitamin d and 1,25-dihydroxyvitamin D and risk of breast cancer.(Estriol)(Brief article)(Clinical report)
Aug 01, 2008 ... Several lines of evidence suggest that vitamin D may reduce incidence of breast cancer, but few epidemiologic studies have addressed the relation of plasma vitamin D metabolites to the risk of this disease. We prospectively examined the relationship between plasma levels of ...
25(OH)D3 and 1,25(OH)2D3 serum concentration and breast tissue expression of 1alphahydroxylase, 24-hydroxylase and vitamin D receptor in women with and without breast cancer.(Estriol)(Brief article)(Clinical report)
Aug 01, 2008 ... 1,25(OH)2D3 is an antiproliferative agent that may inhibit proliferation of breast cancer (BC) cells in vitro and BC development in animals. Epidemiological studies have shown a high incidence of BC in people less exposed to solar rays. To unravel the role of Vitamin D3 in BC patients, we ...
Prevention and anti-aging in endocrinology.(Estriol)(Report)(Brief article)
Aug 01, 2008 ... The aging process is associated with a characteristic decline in the levels of certain hormones. In both sexes, growth hormones, melatonin, dehydroepiandrosterone (DHEA) and its sulfate compound DHEAS reach their maximum levels in the third decade of life, and then decline progressively ....
Symptoms associated with menopausal transition and reproductive hormones in midlife women.(Estriol)(Brief article)(Clinical report)
Aug 01, 2008 ... OBJECTIVE: To test the hypothesis that prevalence of women with menopausal symptoms of hot flushes; aches, joint pain, and stiffness; depressed mood; poor sleep; decreased libido; or vaginal dryness increases with progression through the menopausal transition. METHODS: Women in the Penn ...
The effects of oral and transdermal hormone replacement therapy on C-reactive protein levels and other inflammatory markers in women with high risk of thrombosis.(Estriol)(Brief article)(Clinical report)
Aug 01, 2008 ... INTRODUCTION: In the estrogen in venous thromboembolism (EVTET) study of 140 women with a history of venous thromboembolism (VTE), oral hormone replacement therapy (HRT) was associated with strong activation of coagulation markers and increased risk of recurrent VTE. No such associations ...
Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women.(Estriol)(Brief article)(Clinical report)
Aug 01, 2008 ... OBJECTIVES: We investigated whether the route of estrogen replacement therapy (ET) is the major determinant of C-reactive protein (CRP) in postmenopausal women. BACKGROUND: Recent studies demonstrated that oral ET causes a sustained increase in CRP, implicating a proinflammatory effect ....
Melatonin prevents learning disorders in brain-lesioned newborn mice.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... Perinatal brain injuries often result in irreversible learning disabilities, which manifest in early childhood. These injuries are chiefly ascribable to marked susceptibility of the immature brain to glutamate-induced excitotoxicity. No treatments are available. One well-characterized ...
Protective effect of melatonin against head trauma-induced hippocampal damage and spatial memory deficits in immature rats.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... It is well known that head trauma induces the cognitive dysfunction resulted from hippocampal damage. In the present study, we aimed to demonstrate the effect of melatonin on hippocampal damage and spatial memory deficits in 7-day-old rat pups subjected to contusion injury. Melatonin was ...
Does melatonin protect or treat brain damage from traumatic oxidative stress?(Melatonin)(Clinical report)
Aug 01, 2008 ... A variety of experimental studies have demonstrated the neuroprotective effects of melatonin, based on its antioxidant activity. In a prospective randomized study, the effects of melatonin were investigated in experimental head trauma-induced oxidative stress in rabbits. The experimental ...
Melatonin secretion after head injury: a pilot study.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... PRIMARY OBJECTIVE: To investigate the circadian rhythm of serum melatonin in patients with traumatic brain injury (TBI) during Intensive Care Unit (ICU) stay and its relationship with core body temperature fluctuations and measures of severity of their condition. METHODS AND PROCEDURES: ...
Melatonin protects against ischemia/reperfusion-inducedoxidative damage to mitochondria in fetal rat brain.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... We investigated the effects of melatonin on ischemia/reperfusion-induced oxidative damage to mitochondria in fetal rat brain. The utero-ovarian arteries were occluded bilaterally for 20 min in female Wistar rats on day 19 of pregnancy to induce fetal ischemia. Reperfusion was achieved by ...
Effect of melatonin on brain oxidative damage induced by traumatic brain injury in immature rats.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... Progressive compromise of antioxidant defenses and free radical-mediated lipid peroxidation, which is one of the major mechanisms of secondary traumatic brain injury (TBI), has also been reported in pediatric head trauma. In the present study, we aimed to demonstrate the effect of ...
Melatonin accelerates the process of wound repair in full-thickness incisional wounds.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... The pineal gland hormone melatonin is known to have both anti-inflammatory and immunomodulatory effects. Given this, we propose that melatonin is an ideal candidate to enhance the process of wound healing. The present study assessed the effects of exogenously administered melatonin (1.2 ...
Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... Inflammation is a complex phenomenon involving multiple cellular and molecular interactions which must be tightly regulated. Cyclooxygenase-2 (COX) is the key enzyme that catalyzes the two sequential steps in the biosynthesis of PGs from arachidonic acid. The inducible isoform of COX, ...
Melatonin: potential functions in the oral cavity.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... BACKGROUND: Melatonin is synthesized and secreted by the pineal gland and other organs. The pattern of melatonin secretion is controlled by an endogenous circadian timing system and conveys information about the light-dark cycle to the organism, thereby organizing its seasonal and ...
Comparative study of the effects of melatonin and epitalon on the protracted memory under the shuttle labyrinth test conditions in rats in the course of aging.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... The influence of the chronic administration of melatonin (epiphyseal hormone) and epitalon (a synthetic tetrapeptide increasing melatonin production) on the learning process and the protracted memory has been studied in LIO rats in the course of aging for 2 years under standard ...
Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... It is known since many years that the pineal hormone melatonin (MLT) may play anticancer activity through several mechanisms, including antiproliferative and immunostimulating effects. Moreover, it exerts an important antioxidant action. Therefore, MLT could be useful in the treatment of ...
Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... Melatonin is a potent antioxidant with neuroprotective activity in animal models of ischemic stroke, which based on its lack of serious toxicity has raised hopes that it might be used for human stroke treatment in the future. This study investigated how subacute delivery of melatonin, ...
Effect of pinealectomy and melatonin replacement on morphological and biochemical recovery after traumatic brain injury.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... Numerous studies showed that melatonin, a free radical scavenger, is neuroprotective. In this study, we investigated the effect of pinealectomy and administration of exogenous melatonin on oxidative stress and morphological changes after experimental brain injury. The animals were divided ...
Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... The production of the pineal hormone melatonin is synchronized with day-night cycle via multisynaptic pathway including suprachiasmatic nucleus linking several physiological functions to diurnal cycle. The recent data indicate that impaired melatonin production is involved in several ...
Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector.(Melatonin)(Brief article)(Clinical report)
Aug 01, 2008 ... Melatonin, the main product of the pineal gland, is also released from the gastrointestinal endocrine-neurocrine (EE) cells. The concentrations of melatonin produced in the gut exceeds that originating from central nervous system. In spite of the presence of melatonin receptors in the ...
Role of insulin resistance and hyperglycemia in the development of atherosclerosis.(Diabetes)(Brief article)(Clinical report)
Aug 01, 2008 ... Insulin resistance (IR) is the underlying defect in >90% of patients with type 2 diabetes mellitus and the major pathologic mechanism for the associated susceptibility to premature cardiovascular disease (CVD). The progression of IR to diabetes parallels the progression of endothelial ...
Inflammatory biomarkers and risks of myocardial infarction, stroke, diabetes, and total mortality: implications for longevity.(Diabetes)(Brief article)(Clinical report)
Aug 01, 2008 ... Inflammation is recognized as a major etiologic determinant of multiple disease states including myocardial infarction, stroke, diabetes, and metabolic syndrome, and individuals with elevated levels of the inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) are at increased ...