Obesity & Diabetes Week back issues from August 2008:
No justification for denying obese patients knee replacements.
Aug 04, 2008 ... There is no justification for denying obese patients knee replacement surgery: They benefit almost as much as anyone else from the procedure, concludes a small study published ahead of print in the Annals of the Rheumatic Diseases (see also BMJ-British Medical Journal). Around ...
Data on apoptosis discussed by researchers at McMaster University.(Report)
Aug 04, 2008 ... "In Canada, nicotine replacement therapy is recommended as a safe smoking cessation aid for pregnant women. However, we have shown in an animal model that fetal and neonatal nicotine exposure causes increased beta-cell apoptosis and loss of beta-cell mass, which leads to the development of ...
New findings from F. Giada and co-authors in the area of cardiovascular disease published.(Report)
Aug 04, 2008 ... According to recent research from Venice, Italy, "Epidemiological, clinical and laboratory studies have provided definitive evidence that physical activity is able to improve fitness and reduce cardiovascular morbidity and mortality. Moreover, physical exercise also seems to significantly ...
Research from Medical University of Vienna in the area of diabetes described.
Aug 04, 2008 ... According to a study from Vienna, Austria, "The extract of the white-skinned sweet potato Ipomoea batatas (Caiapo) has been shown to ameliorate glucose control by improving insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). The present study was designed to further ...
Research results from Seoul National University, Medical Department update understanding of diabetes.(Report)
Aug 04, 2008 ... "Many studies show poor agreement between fasting plasma glucose (FPG)-based and 2-h postchallenge glucose (2-h PG)-based criteria to assess glucose metabolism. We examined the rate of agreement between FPG- and 2-h PG-based criteria in the diagnosis of intermediate hyperglycemia in four ...
Findings from University of Chile in hypertension reported.(Report)
Aug 04, 2008 ... "Oxidative stress has been associated with mechanisms of EH (essential hypertension). The aim of the present study was to test the hypothesis that the antioxidant properties of vitamins C and E are associated with a decrease in BP (blood pressure) in patients with EH," researchers in ...
Studies from United Arab Emirates University further understanding of insulin resistance.
Aug 04, 2008 ... "The prevalence of type 2 diabetes mellitus (DM) among Emirati subjects is one of the highest in the world. This has been attributed to rising prevalence of obesity acting on genetically susceptible individuals," scientists in Al Ain, United Arab Emirates report (see also Insulin ...
Data from Texas A&M University provide new insights into obesity and diabetes.(Report)
Aug 04, 2008 ... According to a study from the United States, "In this study we evaluated a 7-month community-based nonpharmacological lifestyle intervention to prevent/reduce the risk of developing diabetes and its complications in a resource-poor village in Tamilnadu, India. A total of 703 village ...
Investigators at Leiden University publish new data on obesity and diabetes.
Aug 04, 2008 ... "An immunogenic peptide (p277) from the 60-kDa heat shock protein (hsp60) arrested beta-cell destruction in non-obese diabetic mice. A randomized, double-blind, phase Ib/II clinical trial of DiaPep277 peptide treatment was performed in recent-onset type 1 diabetes patients with remaining ...
Reports from H.L. Trivedi and colleagues advance knowledge in obesity and diabetes.
Aug 04, 2008 ... "Type 1 diabetes mellitus (DM) is an autoimmune disorder with disturbed glucose/insulin metabolism, which has no medical treatment other than life-long insulin therapy, despite which 30% of subjects develop organ failure. Herein we have reported the use of human adipose-tissue-derived, ...
Reports outline obesity and diabetes study findings from Aarhus University.
Aug 04, 2008 ... In this recent article published in the journal Diabetes Obesity & Metabolism, scientists in Aarhus, Denmark conducted a study "To evaluate the potential advantages of a constant overnight subcutaneous delivery of insulin in type 2 diabetic patients who fail to achieve glycaemic control on ...
Reports outline obesity and diabetes study results from Brigham and Women's Hospital.
Aug 04, 2008 ... "Intestinal transport exhibits distinct diurnal rhythmicity. Understanding the mechanisms behind this may reveal new therapeutic strategies to modulate intestinal function in disease states such as diabetes and obesity, as well as short bowel syndrome," investigators in the United States ...
Research from St. Vincent's Hospital reveals new findings on obesity and diabetes.(Clinical report)
Aug 04, 2008 ... According to recent research from Australia, "Gut-derived hormone peptide YY (PYY) is low in subjects with obesity and type 2 diabetes (T2D). However, it is unknown whether this is a primary defect or a consequence of metabolic disturbances." "In this study, we aimed to assess ...
Research on obesity and diabetes described by J.V. Nielsen and colleagues.
Aug 04, 2008 ... "Low-carbohydrate diets, due to their potent antihyperglycemic effect, are an intuitively attractive approach to the management of obese patients with type 2 diabetes. We previously reported that a 20% carbohydrate diet was significantly superior to a 55 -60% carbohydrate diet with regard ...
Research on obesity and diabetes described by scientists at Campinas State University.
Aug 04, 2008 ... According to a study from Campinas, Brazil, "NOD (non-obese diabetic) mice develop type 1 diabetes mellitus spontaneously and with a strong similarity to the human disease. Differentiation and function of pancreas 0 cells are regulated by a variety of hormones and growth factors, including ...
Research reports from S.S. Lund and co-authors provide new insights into obesity and diabetes.
Aug 04, 2008 ... "In patients with type 2 diabetes mellitus (T2DM), biomarkers reflecting inflammation and endothelial dysfunction have been linked to cardiovascular disease (CVD biomarkers) and metabolic regulation. In T2DM patients, metformin and insulin secretagogues have demonstrated equal ...
Research results from J.J.M. Bouwman and colleagues update understanding of obesity and diabetes.(Report)
Aug 04, 2008 ... According to recent research published in the International Journal of Obesity, "Abdominal obesity plays an important role in the development of insulin resistance, diabetes mellitus and atherosclerosis. The exact pathophysiological mechanisms are unclear but adipocyte dysfunction is ...
Researchers at Miyazaki University publish new data on obesity and diabetes.(Report)
Aug 04, 2008 ... "Thiazolidinediones (TZDs), ligands for peroxisome proliferator-activated receptor gamma, are antidiabetic agents that improve hyperglycemia by decreasing insulin resistance in obese diabetic animal models and patients with type 2 diabetes. We have studied whether pioglitazone, a TZD, can ...
Researchers from Catholic University detail findings in obesity and diabetes.
Aug 04, 2008 ... "Being overweight and obesity are associated with improved survival in hemodialysis (HD) patients, based on mechanisms that are presently uncertain. We compared traditional and uremia-related cardiovascular risk factors in HD patients stratified according to their body mass index (BMI)," ...
Researchers from University of Cincinnati publish findings in obesity and diabetes.
Aug 04, 2008 ... "Excess levels of circulating amino acids (AAs) play a causal role in specific human pathologies, including obesity and type 2 diabetes. Moreover, obesity and diabetes are contributing factors in the development of cancer, with recent studies suggesting that this link is mediated in part ...
Researchers from University of Copenhagen describe findings in obesity and diabetes.(Report)
Aug 04, 2008 ... "It is well established that gluten-free diet reduces the incidence of type 1 diabetes mellitus (T1D) in non-obese diabetic (NOD) mice, though the mechanism is not known. However, regulatory T cells (Treg) are likely to play an important role," researchers in Frederiksberg, Denmark report ...
Scientists at Marshall University publish new data on developmental biology.
Aug 04, 2008 ... According to a study from the United States, "The Drosophila wing is a primary model system for studying the genetic control of epithelial Planar Cell Polarity (PCP). Each wing epithelial cell produces a distally pointing hair under the control of the Frizzled (Fz) PCP signaling pathway." ...
Studies from M. Yamanaka and co-researchers in the area of obesity and diabetes published.(Report)
Aug 04, 2008 ... "We previously demonstrated that repetitive administration of brain-derived neurotrophic factor (BDNF) ameliorates glucose metabolism and energy expenditure in obese diabetic db/db mice. However, we have not evaluated in detail the effect of single or intermittent BDNF administration on ...
Study data from University of Sydney update knowledge of obesity and diabetes.
Aug 04, 2008 ... According to a study from Sydney, Australia, "We investigated the effect of the water extract of Salacia oblonga (SOE), an ayurvedic antidiabetic and antiobesity medicine, on obesity and diabetes-associated cardiac hypertrophy and discuss the role of modulation of cardiac angiotensin II ...
Research conducted at University of Alabama has updated our knowledge about pancreatic cancer.
Aug 04, 2008 ... "Early diagnosis and curative resection are significant predictors of survival in patients with pancreatic cancer. We hypothesize that cholecystectomy within 12 months of pancreatic cancer affects 1-year survival," scientists in the United States report (see also Pancreatic Cancer). ...
Research from Leiden University in the area of spectroscopy described.
Aug 04, 2008 ... According to a study from Netherlands, " In animal models of obesity and diabetes mellitus, myocardial TG accumulation is associated with decreased myocardial function. In the physiologically ageing heart, myocardial triglyceride (TG) accumulation may also occur due to reduced myocardial ...
Studies from T.T. Tran and colleagues yield new information about transplantation.
Aug 04, 2008 ... "Subcutaneous (SC) and visceral (VIS) obesity are associated with different risks of diabetes and the metabolic syndrome. To elucidate whether these differences are due to anatomic location or intrinsic differences in adipose depots, we characterized mice after transplantation of SC or VIS ...
New type 2 diabetes findings from University of Ulm described.(Clinical report)
Aug 04, 2008 ... "Regulated on activation, normal T-cell expressed and secreted (RANTES)/chemokine(C-C motif) ligand (CCL5) is expressed by adipocytes, and serum levels of RANTE'S arc increased in obesity and type 2 diabetes. The aim of this study was to test the hypothesis that RANTES is involved in the ...
New type 2 diabetes study results from Ehime University, Medical Department described.(Report)
Aug 04, 2008 ... " Resistin, secreted from adipocytes, causes insulin resistance in rodents. We reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at -420 increases type 2 diabetes (T2DM) susceptibility by enhancing promoter activity," scientists in Japan report ...
Reports from J.C.N. Chan and co-researchers add new data to research in type 2 diabetes.(Clinical report)
Aug 04, 2008 ... In this recently published study, investigators in the United States conducted a study "To assess the safety of sitagliptin in patients with type 2 diabetes and moderate [creatinine clearance (CrCl) >= 30 to <50 ml/min] or severe renal insufficiency [CrCl <30 ml/min including patients ...
Scientists at Stanford University, Division of Cardiovascular Medicine describe research in cardiovascular disease risk factors.(Report)
Aug 04, 2008 ... New investigation results, 'Comparison of waist circumference versus body mass index in diagnosing metabolic syndrome and identifying apparently healthy subjects at increased risk of cardiovascular disease,' are detailed in a study published in American Journal of Cardiology. "The goal of ...
Study data from H. Takase and co-authors update knowledge of obesity.
Aug 04, 2008 ... A report, 'Metabolic disorders predict development of hypertension in normotensive Japanese subjects,' is newly published data in Hypertension Research. "Each component of the metabolic syndrome is not necessarily clustered coincidentally. Thus, subjects who have obesity, dyslipidemia or ...
Investigators at Takeda Pharmaceutical Company Ltd., Pharmaceutical Research Division have published new data on obesity and diabetes.
Aug 04, 2008 ... New investigation results, 'Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice,' are detailed in a study published in European Journal of Pharmacology ....
Studies from Institute of Physiology in the area of obesity and diabetes described.(Report)
Aug 04, 2008 ... A new study, 'Insulin resistance and glucose tolerance in obese women: the effects of a recreational training program,' is now available. According to a study from Poznan, Poland, "This study was designed to investigate whether recreational physical activity based on aquatic training may ...
New obesity and diabetes animal studies study findings recently were reported by researchers at University of Tokyo, Department of Urology.(Report)
Aug 04, 2008 ... Research findings, 'Blockade of endogenous proinflammatory cytokines ameliorates endothelial dysfunction in obese Zucker rats,' are discussed in a new report. According to a study from Tokyo, Japan, "To study the role of endogenous proinflammatory cytokines in endothelial dysfunction in ...
Studies from Stanford University yield new information about obesity and diabetes risk factors.
Aug 04, 2008 ... A new study, 'Comparison of three treatment approaches to decreasing cardiovascular disease risk in nondiabetic insulin-resistant dyslipidemic subjects,' is now available. According to recent research from the United States, "The efficacy of fenofibrate (FEN), rosiglitazone (RSG), or a ...
Reports on anxiety disorders findings from University of Connecticut provide new insights.(Report)
Aug 04, 2008 ... "The purpose of this study is to examine gender differences in associations between body mass index (BMI) and affective disorders. We used logistic regression to examine the effects of BMI and gender on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) mood and ...
Study findings from Harvard University broaden understanding of asthma.
Aug 04, 2008 ... According to recent research from the United States, "Smoking during pregnancy has been associated with asthma, obesity, and decreased cognitive functioning in the offspring. To study the role of in utero smoking exposure in offsprings' adult health outcomes, it may be necessary to rely ...
Data from G. Welch et al provide new insights into bariatrics.(Clinical report)
Aug 04, 2008 ... According to recent research from the United States, "Morbid obesity (MO) is a major public health issue with high associated morbidity and healthcare costs. Bariatric surgery provides effective treatment for MO although early recognition of emergent perioperative complications is ...
Findings from K.L. Applegate and co-authors broaden understanding of bariatrics.
Aug 04, 2008 ... "Weight loss surgery (WLS) patients can encounter diverse relationship issues as they consider, undergo, and live with bariatric surgery. This article explores ways in which WLS affects romantic relationships before and after surgery, as well as provides suggestions for clinicians to ...
New findings from M. Muir and co-authors in the area of bariatrics published.
Aug 04, 2008 ... According to recent research published in the journal Bariatric Nursing and Surgical Patient Care, "A large percentage of bariatric patients admitted into healthcare facilities will need assistance with patient handling activities such as bathing, hygiene care of skin and wounds, ...
Studies from Umea University have provided new information about bone research.
Aug 04, 2008 ... "The association between retinol and bone mineral density (BMD) in males after puberty has not been fully investigated previously. To investigate the association between retinol, retinol-binding protein-4 (RBP-4), BMD (g/cm(2)), abdominal fat mass, and markers of bone metabolism in young ...
New research on hormones from M. Caprio and co-authors summarized.
Aug 04, 2008 ... According to a study from Rome, Italy, "Beside their role in the control of water and electrolyte homeostasis, recent data clearly indicate that aldosterone and the mineralocorticoid receptor (MR) are involved in adipocyte biology. It has been recently shown that aldosterone promotes white ...
Investigators at Mayo Clinic release new data on life sciences.
Aug 04, 2008 ... "A new medical device uses high-frequency electrical algorithms to create intermittent vagal blocking (VBLOC therapy). The aim is to assess the effects of vagal blocking on excess weight loss (EWL), safety, dietary intake, and vagal function," investigators in the United States report (see ...
New research on life sciences from E.A. Vanbeek and co-authors summarized.
Aug 04, 2008 ... In this recently published article, scientists in Netherlands conducted a study "To obtain insight in the extent to which the human cell lines LiSa-2 and PAZ6 resemble isolated primary human adipocytes. A combination of cDNA subtraction (representative difference analysis; RDA) and cDNA ...
Research data from Massey University update understanding of life sciences.(Report)
Aug 04, 2008 ... "This study assessed the logic of arguments advanced when the New Zealand advertising self-regulation complaints board adjudicated a complaint about a food product; in addition, it compared these arguments and the complainant's experience of the process to international best practice ...
Researchers from Duke University, Medical Department describe findings in life sciences.
Aug 04, 2008 ... According to recent research from the United States, "Detailed knowledge of the pathways by which ghrelin and leptin signal to AMPK in hypothalamic neurons and lead to regulation of appetite and glucose homeostasis is central to the development of effective means to combat obesity. Here we ...
Study findings from Genentech broaden understanding of life sciences.
Aug 04, 2008 ... In this recent report published in the International Journal of Obesity, researchers in the United States conducted a study "To investigate the impact of beta-adrenoceptor deficiency on the metabolic effects of leptin. Leptin was infused subcutaneously through an osmotic minipump in ...
Research on menopause described by scientists at Louisiana State University.(Clinical report)
Aug 04, 2008 ... According to recent research published in the International Journal of Obesity, "This study assessed longitudinal changes in body composition, fat distribution and energy balance in perimenopausal women. We hypothesized that total fat and abdominal body fat would increase at menopause due ...
Research from University of Western Australia has provided new information about metabolism.(Report)
Aug 04, 2008 ... According to recent research from Perth, Australia, " Niemann-Pick C1-like 1 protein (NPC1L1) plays a key role in lipoprotein metabolism. We examined the association of common genetic polymorphisms in NPC1L1 on apolipoprotein (apo) B-100 metabolism and the response to statin treatment in ...
Researchers from University of Washington, Medical Department provide details of new studies and findings in the area of morbid obesity.
Aug 04, 2008 ... " A 29-year-old man presented to a clinic with infertility and hypogonadism in the setting of morbid obesity. On presentation, he had notable gynecomastia and a low testicular volume," researchers in the United States report (see also Morbid Obesity). "The patient's weight was ...
Study data from Chiba University, Medical Department update knowledge of necrosis.(Report)
Aug 04, 2008 ... "Adipocytes accumulated in the visceral area change their function to induce tumor necrosis factor-alpha (TNF-alpha) secretion with concomitant matrix metalloproteinase (MMP)-3 induction in mice. This study was performed to clarify the role of macrophages (M phi)-secreted MMP on the ...
Data from East Carolina University provide new insights into obesity.
Aug 04, 2008 ... "Morbidly obese patients are found not only in the hospital undergoing bypass surgery, but also in almost every area of the healthcare system. Nurses in practice in a variety of settings encounter these patients and must be attuned to their special needs and characteristics," scientists in ...
Findings in obesity reported from M.A. Kueper and co-researchers.(Report)
Aug 04, 2008 ... " The aim of this study was to define a standardized technique for laparoscopic sleeve gastrectomy in the morbidly obese patient. There are several surgical options for the morbidy obese patient," scientists writing in the World Journal of Surgery report (see also Obesity). "In ...
Findings in obesity reported from S. Loves and co-researchers.(Report)
Aug 04, 2008 ... According to recent research from Netherlands, "Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E-2) production and E-2-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can ...
Investigators at Tottori University have published new data on obesity.
Aug 04, 2008 ... "Recently, we have identified novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata BLUME) after processing the natural seeds with wood ashes to remove bitterness. We attempted to determine anti-obesity effects of those saponins from edible seeds as well as ...
New findings reported from University of Minnesota describe advances in obesity.
Aug 04, 2008 ... In this recent report, researchers in the United States conducted a study "To examine whether health status and obesity prevalence differ by race or ethnicity and health care workforce category. Data representing US health care workers aged 20 to 64 between 1982 and 2004 were retrieved ...
New obesity data have been reported by scientists at Mayo Clinic.
Aug 04, 2008 ... According to recent research from the United States, "Body mass index (BMI) is the most widely used measure to diagnose obesity. However, the accuracy of BMI in detecting excess body adiposity in the adult general population is largely unknown." "A cross-sectional design of 13 ...
New obesity findings from H.M. Salihu and co-researchers published.(Report)
Aug 04, 2008 ... "Using data from the Missouri maternally linked files (1989-1997), the authors examined the association among maternal obesity, obesity subtypes, and spontaneous and medically indicated preterm (< 37 weeks) and very preterm (< 33 weeks) births in singletons and twins. Adjusted odds ratios ...
New obesity study findings recently were reported by S.V. Lakhani and co-researchers.
Aug 04, 2008 ... According to a study from the United States, "It has been proposed that thiamine deficiency after gastric bypass surgery in obese patients results from prolonged nausea and emesis. We hypothesized that thiamine deficiency is induced by altered gut ecology." "This report includes ...
Recent findings in obesity described by researchers from University of Cologne.(Report)
Aug 04, 2008 ... According to a study from Cologne, Germany, " Cardiovascular risk factors are associated with decreased levels of circulating progenitor cells (CPC). The aim of this study was to determine whether the number of CPC is an independent correlate of body mass index (BMI) and whether weight ...
Reports outline obesity study results from A.F.M. Vanabeelen et al.
Aug 04, 2008 ... According to a study from Netherlands, "Uncoupling protein 3 (UCP-3) uncouples oxidative metabolism from ATP synthesis, resulting in the production of heat instead of energy storage. Single nucleotide polymorphisms (SNPs) in UCP-3 might result in a reduced function or expression of UCP-3 ...
Research data from Boston University, Medical Department update understanding of obesity.
Aug 04, 2008 ... "The NHLBI Family Heart Study (FHS) genome-wide linkage scan identified a region of chromosome 7q with a logarithm of odds score of 4.9 for body mass index (BMI). We report the results of fine mapping the linkage peak using 1020 single nucleotide polymorphisms ( SNPs) to test for ...
Research findings from Cornell University update understanding of obesity.(Clinical report)
Aug 04, 2008 ... According to recent research from the United States, "We reviewed our experience of performing laparoscopic sleeve gastrectomy (LSG) in super-super-obese (body mass index > 60 kg/m(2)) patients and compared our results with those of laparoscopic adjustable gastric banding (LAGB) performed ...
Research from A. Schwarznau and co-authors yields new data on obesity.
Aug 04, 2008 ... According to recent research from the United States, "The increasing prevalence of obesity among patients with end-stage renal disease accompanies more common renal transplantation from living donors. Since several studies have shown a negative impact of recipient obesity on renal ...