Recently added articles from Physiological Research:
Mechanisms of Neurogenic Pulmonary Edema Development
Jul 01, 2008; Sedý, J; Zicha, J; Kunes, J; Jendelová, P; Syková, E ... Summary Neurogenic pulmonary edema is a life-threatening complication, known for almost 100 years, but its etiopathogenesis is still not completely understood. This review summarizes current knowledge about the etiology and pathophysiology of neurogenic pulmonary edema. The roles of ...
Depressed Cardiac Contractility and Its Postnatal Development in Rats after Chemical Sympathectomy
Jul 01, 2008; Svíglerová, J; Kuncová, J; Nalos, L; Slavíková, J; Stengl, M ... Summary The contribution of the sympathetic innervation to the postnatal development of cardiac contractility remains unclear. In this study, the postnatal maturation of cardiac contractility was compared in control rats and rats after chemical sympathectomy. The chemical sympathectomy ...
Oral Administration of Polyphenolic Compounds from Cognac Decreases ADP-Induced Platelet Aggregation and Reduces Chronotropic Effect of Isoprenaline in Rats
Jul 01, 2008; Carusio, N; Wangensteen, R; Filippelli, A; Andriantsitohaina, R ... Summary This study sought to evaluate whether consumption of polyphenol extract from Cognac (CPC) modulates platelet activation and cardiovascular reactivity in rats. Male Wistar rats were treated daily for 4 weeks by intra-gastric gavage receiving CPC at 80 mg/kg/day or vehicle (5 % ...
Even Mild Changes in Free Thyroxine Could Influence the Degree of Heart Failure Measured by Its Biological Surrogates
Jul 01, 2008; Mayer, O Jr; Simon, J; Cech, J; Rosolová, H; Hrbková, J; Pikner, R; Trefil, L ... Summary Both, severe hypo- or hyperthyroidism may alter hemodynamic parameters. The aim of our study was to ascertain, whether also distinct changes within normal range of free thyroxine (fT4) would be associated with an impairment of left ventricle function in patients with chronic ...
The Relationship between Glycemia, Insulin and Oxidative Stress in Hereditary Hypertriglyceridemic Rat
Jul 01, 2008; Zourek, M; Kyselová, P; Mudra, J; Krcma, M; Jankovec, Z; Lacigová, S; Vísek, J; Rusavý, Z ... Summary The aim of this study was to determine the effects of insulin infusion on oxidative stress induced by acute changes in glycemia in non-stressed hereditary hypertriglyceridemic rats (hHTG) and Wistar (control) rats. Rats were treated with glucose and either insulin or normal ...
Adiponectin and Resistin Gene Polymorphisms in Patients with Anorexia Nervosa and Obesity and Its Influence on Metabolic Phenotype
Jul 01, 2008; Krízová, J; Dolinková, M; Lacinová, Z; Sulek, S; Dolezalová, R; Housová, J; Krajícková, J; Haluzíková, D; Bosanská, L; Papezová, H; Haluzík, M ... Summary Genes for adiponectin and resistin are candidate genes of insulin resistance and type 2 diabetes mellitus. The aim of our study was to determine the frequency of single nucleotide polymorphisms (SNP) 45T>G and 276G>T of the adiponectin gene and 62G>A and -180C>G of ...
Lipoprotein Lipase Activity Determined in vivo Is Lower in Carriers of Apolipoprotein A-V Gene Variants 19W and -1131C
Jul 01, 2008; Kovár, J; Adámková, V ... Summary The apolipoprotein A-V (apo A-V) plays an important role in regulation of triglyceride (TG) concentration in serum. To better understand how apo A-V affects triglyceridemia and glucoregulation, the lipoprotein lipase (LPL) activity was determined using intravenous fat tolerance ...
Role of Ghrelin in the Regulation of Gastric Acid Secretion Involving Nitrergic Mechanisms in Rats
Jul 01, 2008; Bilgin, H M; Tumer, C; Diken, H; Kelle, M; Sermet, A ... Summary Ghrelin, an endogenous ligand for growth hormone secretagogue receptor (GHS-R), has been identified in the rat and human gastrointestinal tract. Ghrelin has been proposed to play a role in gastric acid secretion. Nitric oxide (NO) was shown as a mediator in the mechanism of ...
Glucose Release as a Response to Glucagon in Rat Hepatocyte Culture: Involvement of NO Signaling
Jul 01, 2008; Farghali, H; Hodis, J; Kutinová-Canová, N; Potmesil, P; Kmonícková, E; Zídek, Z ... Summary Glucagon and α-adrenergic-induced glycogenolysis is realized via the agonist/adenylyl cyclase/cAMP/protein kinase signaling pathway or via the activation of phosphorylase kinase by the mobilized calcium that supports the inhibition of glycogen synthase, respectively. The ...
Inhibitory Effect of Curcuminoids and Tetrahydrocurcuminoids on Equine Activated Neutrophils and Myeloperoxidase Activity
Jul 01, 2008; Franck, T; Kohnen, S; Grulke, S; Neven, P; Goutman, Y; Peters, F; Pirotte, B; Deby-Dupont, G; Serteyn, D ... Summary In the horse, the inflammation response to various pathologies (intestinal strangulations, laminitis, etc.) involves an excessive stimulation of the polymorphonuclear neutrophils releasing reactive oxygen species (ROS) and myeloperoxidase (MPO). The aim of the present work was to ...
CD27^sup +^ Peripheral Blood B-Cells Are a Useful Biodosimetric Marker in vitro
Jul 01, 2008; Reháková, Z; Sinkora, J; Vlková, M; Vokurková, D; Österreicher, J; Vávrová, J; Driák, D ... Summary The CD8^sup +^ natural killer (NK) subpopulation has recently been identified as a fast and reliable biodosimetric indicator within human peripheral blood mononuclear cells (PBMC) in vitro. In irradiated and subsequently cultivated PBMC, a decrease of the relative number of ...
Evidences of Apoptosis during the Early Phases of Soleus Muscle Atrophy in Hindlimb Suspended Mice
Jul 01, 2008; Ferreira, R; Neuparth, M J; Vitorino, R; Appell, H J; Amado, F; Duarte, J A ... Summary The purpose of this study was to investigate the occurrence and time-course of apoptosis in soleus skeletal muscle during the first 48 hours of unloading. Fifty Charles River mice were randomly divided into five groups (n=10 each) according to the time of hindlimb suspension ...
Influence of Gemfibrozil on Sulfate Transport in Human Erythrocytes during the Oxygenation-Deoxygenation Cycle
Jul 01, 2008; Tellone, E; Ficarra, S; Scatena, R; Giardina, B; Kotyk, A; Russo, A; Colucci, D; Bellocco, E; Lagana, G; Galtieri, A ... Summary The effects of gemfibrozil (GFZ), an antihyperlipidemic agent, on the anionic transport of the human red blood cells (RBC) during the oxygenation-deoxygenation cycle were examined. Gemfibrozil clearly plays a role in the modulation of the anionic flux in erythrocytes; in fact it ...
Effects of SERCA and PMCA Inhibitors on the Survival of Rat Cochlear Hair Cells during Ischemia in vitro
Jul 01, 2008; Amarjargal, N; Mazurek, B; Haupt, H; Andreeva, N; Fuchs, J; Gross, J ... Summary An important mechanism underlying cochlear hair cell (HC) susceptibility to hypoxia/ischemia is the influx of Ca^sup 2+^. Two main ATP-dependent mechanisms contribute to maintaining low Ca^sup 2+^ levels: uptake of Ca^sup 2+^ into intracellular stores via smooth endoplasmic ...
Lidocaine Suppresses Subthreshold Oscillations by Inhibiting Persistent Na+ Current in Injured Dorsal Root Ganglion Neurons
Jul 01, 2008; Dong, H; Fan, Y-H; Wang, Y-Y; Wang, W-T; Hu, S-J ... Summary The aim of this study was to determine the effect and mechanism of low concentration of lidocaine on subthreshold membrane potential oscillations (SMPO) and burst discharges in chronically compressed dorsal root ganglion (DRG) neurons. DRG neurons were isolated by enzymatic ...
Effects of Diet and Age on Oxidative Damage Products in Healthy Subjects
Jul 01, 2008; Krajcovicová-Kudlácková, M; Valachovicová, M; Pauková, V; Dusinská, M ... Summary Damage of molecules as a consequence of oxidative stress has been implicated in the pathogenesis of chronic diseases related to aging. Diet is a key environmental factor affecting the incidence of many chronic diseases. Antioxidant substances in diet enhance the DNA, lipid and ...
Acute but Not Chronic Tempol Treatment Increases Ischemic and Reperfusion Ventricular Arrhythmias in Open-Chest Rats
Jul 01, 2008; Neckár, J; Ostádal, B; Kolár, F ... Summary The effect of the chronic and acute antioxidant tempol (Superoxide dismutase mimetic) treatment on cardiac ischemic tolerance was investigated in adult male Wistar rats. The first experimental group was given tempol (1 mM) in drinking water for three weeks, the second group ...
Effect of Hindlimb Unweighting on Expression of Hypoxia-Inducible Factor-1[alpha], Vascular Endothelial Growth Factor, Angiopoietin, and Their Receptors in Mouse Skeletal Muscle
Jul 01, 2008; Wagatsuma, A ... Summary Hindlimb unweighting (HU) leads to capillary regression in skeletal muscle. However, the molecular mechanism(s) remains to be elucidated. To gain insight into the regulation of this process, we investigated gene expression of hypoxia-inducible factor-1α (HIF-1α), ...
Family History of Diabetes Mellitus Determines Insulin Sensitivity and [beta] Cell Function in Polycystic Ovary Syndrome
Jul 01, 2008; Vrbíková, J; Grimmichová, T; Dvoráková, K; Hill, M; Stanická, S; Vondra, K ... Summary Objective: To examine the impact of family history of diabetes mellitus 2 (DM 2) on insulin sensitivity and secretion in lean women with polycystic ovary syndrome (PCOS). Thirteen healthy women (C), 14 PCOS without family history of DM 2 (FH-) and 8 PCOS with family history of DM ...