Recently added articles from Physiological Research:
Participation of Nitric Oxide in Different Models of Experimental Hypertension
Nov 01, 2008; ... Summary This review concerns the role of nitric oxide (NO) in the pathogenesis of different models of experimental hypertension (NO-deficient, genetic, salt-dependent), which are characterized by a wide range of etiology. Although the contribution of NO may vary between different models ...
Chronic Atropine Administration Diminishes the Contribution of Vasoactive Intestinal Polypeptide to Heart Rate Regulation
Nov 01, 2008; ... Summary Vasoactive intestinal polypeptide (VIP) is implicated in the modulation of vagal effects on the heart rate. In this study, the impact of acute and chronic atropine administration on VIP levels in rat heart atria was investigated in relation to heart rate in the course of vagus ...
Effect of Exercise on Augmented Aortic Vasoconstriction in the db/db Mouse Model of Type-II Diabetes
Nov 01, 2008; ... Summary We evaluated the effects of exercise on the vascular constrictor responses to α-adrenergic stimulation in the db/db mice. Twenty male db/db and their age-matched wild-type (WT) mice were exercised (1 hour/day, five days a week). Mice were anesthetized 7 weeks later, ...
Mutation Analysis of Candidate Genes SCN1B, KCND3 and ANK2 in Patients with Clinical Diagnosis of Long QT Syndrome
Nov 01, 2008; ... Summary The long QT syndrome (LQTS) is a monogenic disorder characterized by prolongation of the QT interval on electrocardiogram and syncope or sudden death caused by polymorphic ventricular tachycardia (torsades de pointes). In general, mutations in cardiac ion channel genes (KCNQ1, ...
The Effects of Head Cooling on Endurance and Neuroendocrine Responses to Exercise in Warm Conditions
Nov 01, 2008; ... Summary The present study investigated the effects of head cooling during endurance cycling on performance and the serotonergic neuroendocrine response to exercise in the heat. Subjects exercised at 75 % VO^sub 2max^ to volitional fatigue on a cycle ergometer at an ambient temperature of ...
Effect of Pedaling Rates and Myosin Heavy Chain Composition in the Vastus Lateralis Muscle on the Power Generating Capability during Incremental Cycling in Humans
Nov 01, 2008; ... Summary In this study, we have determined power output reached at maximal oxygen uptake during incremental cycling exercise (P^sub I, max^) performed at low and at high pedaling rates in nineteen untrained men with various myosin heavy chain composition (MyHC) in the vastus lateralis ...
Cognac Polyphenolic Compounds Increase Bradykinin-Induced Nitric Oxide Production in Endothelial Cells
Nov 01, 2008; ... Summary We recently reported that in vitro Cognac polyphenolic compounds (CPC) induce NO-dependent vasorelaxant effects and stimulate cardiac function. In the present study, we aim to investigate the effect of CPC on both nitric oxide (NO) and superoxide anions (O^sub 2^^sup -^) ...
The Effect of Lipoic Acid on Antioxidant Status and Lipid Peroxidation in Rats Exposed to Chronic Restraint Stress
Nov 01, 2008; ... Summary This study was designed to investigate effect of alpha-lipoic acid (LA) on lipid peroxidation, nitric oxide production and antioxidant systems in rats exposed to chronic restraint stress. Twenty four male Wistar rats, aged three months, were divided into four groups: control (C), ...
In Vitro Hypoxia Increases Production of Matrix Metalloproteinases and Tryptase in Isolated Rat Lung Mast Cells
Nov 01, 2008; ... Summary Chronic hypoxia results in hypoxic pulmonary hypertension characterized by fibrotization and muscularization of the walls of peripheral pulmonary arteries. This vessel remodeling is accompanied by an increase in the amount of lung mast cells (LMC) and the presence of small ...
Increased Angiotensinogen Production in Epicardial Adipose Tissue during Cardiac Surgery: Possible Role in a Postoperative Insulin Resistance
Nov 01, 2008; ... Summary Critical illness induces among other events production of proinflammatory cytokines that in turn interfere with insulin signaling cascade and induce insulin resistance on a postreceptor level. Recently, local renin-angiotensin system of adipose tissue has been suggested as a ...
Hyperlipidemia is Associated with Altered Levels of Insulin-Like Growth Factor-I
Nov 01, 2008; ... Summary Previous studies revealed altered levels of the circulating insulin-like growth factor-I (IGF-I) and of its binding protein-3 (IGFBP-3) in subjects with coronary atherosclerosis, metabolic syndrome and premature atherosclerosis. Hyperlipidemia is a powerful risk factor of ...
The Developmental Changes in Mitochondrial DNA Content per Cell in Human Cord Blood Leukocytes during Gestation
Nov 01, 2008; ... Summary The mitochondrial DNA (mtDNA) amount in cells as the basis for mitochondrial energy generating system, which produces ATP, plays an important role in the fetal development and postnatal morbidity. Isolated human cord blood leukocytes (HCBL) contribute very little to the overall ...
Different Secretory Response of Pancreatic Islets and Insulin Secreting Cell Lines INS-1 and INS-1E to Osmotic Stimuli
Nov 01, 2008; ... Summary Objective of this study was to characterize osmotically-induced insulin secretion in two tumor cell lines. We compared response of freshly isolated rat pancreatic islets and INS-1 and INS-1E tumor cell lines to high glucose, 30 % hypotonic medium and 20 % hypertonic medium. In ...
Apolipoprotein E/Intrauterine Undernutrition Interaction and Hypercholesterolemia in Children
Nov 01, 2008; ... Summary The inconsistency of data regarding intrauterine programming of cardiovascular risk factors may be largely caused by genetic predisposition and later lifestyle. We analyzed whether low birth weight and apolipoprotein E (Apo E) polymorphism participate in the onset of ...
Age-Related Changes of Human Balance during Quiet Stance
Nov 01, 2008; ... Summary Certain aspects of balance control change with age, resulting in a slight postural instability. We examined healthy subjects between 20-82 years of age during the quiet stance under static conditions: at stance on a firm surface and/or on a compliant surface with eyes either open ...
AMN 082, an Agonist of mGluR7, Exhibits Mixed Anti- and Proconvulsant Effects in Developing Rats
Nov 01, 2008; ... Summary Metabotropic glutamate receptors (mGluRs) represent a potential therapeutic target. Possible anticonvulsant action of AMN 082, an agonist of mGluR7 subtype, was studied in immature rats using pentylenetetrazol (PTZ)-induced seizures as a model. Five age groups of rats (7-, 12-, ...
ERRATUM
Nov 01, 2008; ... Physiol Res. 57 (Suppl. 2): Sl-Sl, 2008 Regulatory Role of Nitric Oxide on the Cardiac Na, K- ATPase in Hypertension J. VLKOVICOVÁ1, V. JAVORKOVÁ1, L. MÉZESOVÁ1, O. PECHÁÑOVÁ2, N. VRBJAR1 1 Institute for Heart Research, Department of Biochemistry, Slovak Academy of ...
Importance of Timing of Magnesium Administration in the Isolated Ischemic-Reperfused Rat Heart: Role of K^sub ATP^ Channels
Nov 01, 2008; ... Summary There is a growing interest for the beneficial effect of magnesium (Mg) in cardiovascular disorders. A number of cardiovascular disorders including myocardial infarction, arrhythmias and congestive heart failure have been associated with low extracellular or intracellular ...
Real Time RT-PCR with a Newly Designed Set of Primers Confirmed the Presence of 2b and 2x/d Myosin Heavy Chain mRNAs in the Rat Slow Soleus Muscle
Nov 01, 2008; ... Summary In order to re-evaluate the presence and relative quantity of 2b and 2x/d myosin heavy chain (MyHC) transcripts in rat slow soleus muscle by using real time RT-PCR we have compared the available relevant cDNA sequences and designed a new set of primers having similar melting ...
Retinol-Binding Protein 4 Expression in Visceral and Subcutaneous Fat in Human Obesity
Nov 01, 2008; ... Summary Retinol binding protein 4 (RBP4) is a novel adipokine which might be involved in the development of insulin resistance. The aim of the study was to investigate the expression of RBP4 mRNA in subcutaneous and visceral fat depots and the relationship between RBP4 plasma and mRNA ...