Recently added articles from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology:
A comparative study of the therapeutic effects of the Zataria multiflora vaginal cream and metronidazole vaginal gel on bacterial vaginosis.(Clinical report)
Dec 01, 2008; ... Abstract Bacterial vaginosis (BV) is one of most prevalent complications among reproductive-aged women. Metromidazole prescription, which is considered as the first-line treatment of BV, is usually followed by a few side effects. Besides, there is a growing tendency toward ...
Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers.(Report)
Dec 01, 2008; ... Abstract Saffron (Crocus sativus) stigma tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. The study was a double-blind, placebo-controlled design consisting of a 1 week treatment of saffron tablets. Volunteers were divided into 3 groups ...
Stimulatory effect of Crocus sativus (saffron) on [[beta].sub.2]-adrenoceptors of guinea pig tracheal chains.(Clinical report)
Dec 01, 2008; ... Abstract To study the mechanism(s) of the relaxant effects of Crocus sativus (Iridaceae), the stimulatory effect of aqueous-ethanolic extracts of this plant and one of its constituent, safranal was examined on [beta]-adrenoceptors in tracheal chains of guinea pigs. ...
Danggui-Shaoyao-San, a traditional Chinese prescription, suppresses [PGF.sub.2.[alpha]] production in endometrial epithelial cells by inhibiting COX-2 expression and activity.(Cyclooxygenase-2)(Clinical report)
Dec 01, 2008; ... Abstract Danggui-Shaoyao-San, a famous traditional Chinese prescription, has been widely used in China for treating various gynecological inflammatory diseases including dysmenorrhea, but it is still poorly understood how it works on those inflammatory disorders. Prostaglandin ...
Synergistic effect of silymarin and standardized extract of Phyllanthus amarus against [CCl.sub.4]-induced hepatotoxicity in Rattus norvegicus.(silymarin)(Clinical report)
Dec 01, 2008; ... Abstract In search of the effective and standardized hepatoprotective combination therapy, silymarin and standardized extract of Phyllanthus amarus has been evaluated against [CCl.sub.4]-induced hepatotoxicity in rats. Eight groups of rats were used. The animals of group A ...
Enhancement of apoptosis of human hepatocellular carcinoma SMMC-7721 cells through synergy of berberine and evodiamine.( alkaloids)(Clinical report)
Dec 01, 2008; ... Abstract Berberine and evodiamine, two kinds of alkaloids, have been reported to show many activities. In the present paper, inhibitory activities of the two compounds and their mixtures on human hepatocellular carcinoma SMMC-7721 cells were investigated, and the inhibitory ...
The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcumin.(Clinical report)
Dec 01, 2008; ... Abstract Identification of natural health products that might benefit skeletal health could reduce the negative impact of osteoporotic bone fractures upon society. The objectives of his study were to evaluate an animal model of postmenopausal osteoporosis and to search for ...
Novel leads from Heliotropium ovalifolium, 4, 7, 8-trimethoxy-naphthalene-2-carboxylic acid and 6-hydroxy-5, 7-dimethoxy-naphthalene-2-carbaldehyde show specific IL-6 inhibitory activity in THP-1 cells and primary human monocytes.(interleukin-6)(Report)
Dec 01, 2008; ... Abstract From our screening program, we identified the anti-inflammatory effects of the extracts of Heliotropium ovalifolium in its ability to inhibit specific cytokines. The H. ovalifolium extract was found to be moderately active with an [IC.sub.50] equaling 10[mu]g/ml for ...
Endothelium-dependent induction of vasorelaxation by Melissa officinalis L. ssp. officinalis in rat isolated thoracic aorta.(Clinical report)
Dec 01, 2008; ... Abstract In the current study, vasorelaxant effect produced by the aqueous extract of Melissa officinalis L. ssp. officinalis (MOO) (Lamiaceae) and its possible mechanism in isolated rat aortic rings precontracted with phenylephrine were examined. In the first series of ...
Serotomide and safflomide modulate forskolin-stimulated cAMP formation via 5-HT1 receptor.(Cyclic adenosine monophosphate)(5-hydroxytryptamine 1 receptor)(Report)
Dec 01, 2008; ... Abstract Serotomide (trans-N-caffeoylserotonin) and safflomide (trans-N-caffeoyltryptamine) belong to serotonin-derived phenylpropenoid amides found in plants. In this paper, serotomide and safflomide were investigated to determine their effects on serotonin receptor 5-HT1 in ...
Suppressive effects of bee venom on the immune responses in collagen-induced arthritis in rats.(Clinical report)
Dec 01, 2008; ... Abstract The effect of bee venom (BVA) on the development of type II collagen (CII)-induced arthritis (CIA) in rats has been studied. Male rats were immunized with an emulsion of 200 [mu]g of CII and complete Freund's adjuvant (CFA). The rats were then given intraperitoneally ...
Efficacy of an aqueous pelargonium sidoides extract against herpesvirus.(Clinical report)
Dec 01, 2008; ... Abstract The compounds of an aqueous root extract of the African medicinal plant Pelargonium sidoides were analysed by LC MS spectroscopy and the antiviral effect of this extract against herpes simplex virus was examined in cell culture. Besides predominant coumarins, simple ...
Effects of extracts and neferine from the embryo of Nelumbo nucifera seeds on the central nervous system.(Clinical report)
Dec 01, 2008; ... Abstract The effects of embryos of the seeds of Nelumbo nucifera on the central nervous system were studied in mice. MeOH extracts of embryos of Nelumbo nucifera seeds significantly inhibited locomotor activity in mice. The MeOH extract was successively partitioned ...
Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata.(SHORT COMMUNICATION)(acyl-carrier-protein)(Clinical report)
Dec 01, 2008; ... Abstract Enoyl-ACP reductase (FabI) is a key enzyme of the type II fatty acid biosynthesis (FAS-II) pathway and validated antimicrobial target. In the current study, three linear sesquiterpene lactones obtained from Anthemis auriculata. namely antheocotulide (1), ...
Antimalarial, antimycobacterial and cytotoxic limonoids from Chisocheton siamensis.(SHORT COMMUNICATION)(Report)
Dec 01, 2008; ... Abstract Five limonoids isolated from the seeds of Chisocheton siamensis were tested for their antimalarial activity against Plasmodium falciparum, antimycobacterial activity against Mycobacterium tuberculosis and cytotoxic activity against NCI-H187 (human small cell lung ...
Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety.(SHORT COMMUNICATION)(Clinical report)
Dec 01, 2008; ... Abstract Crocus sativus L. is a plant cultivated in various parts of the world. Crocins are among the active components of Crocus sativus L. The present study was designed to investigate in the rat whether or not crocins possess anxiolytic properties. For this aim, the ...
Saponins (ginsenosides) from stems and leaves of Panax quinquefolium prevented high-fat diet-induced obesity in mice.(SHORT COMMUNICATION)(Clinical report)
Dec 01, 2008; ... Abstract The present study was performed to clarify whether the crude saponins from stems and leaves of Panax quinquefolium inhibited lipase activity in vitro, and prevented obesity induced in mice by feeding a high-fat diet for 8 weeks. For in vitro experiments, assay for the ...
Willow bark extract (Salicis cortex) for gonarthrosis and coxarthrosis-results of a cohort study with a control group.(Report)
Nov 01, 2008; ... Abstract Study objective: The examination of the effectiveness and tolerance of willow bark extract in patients with gonarthrosis and coxarthrosis compared to conventional therapies. Methods: In an open, multicentric observational study with reference treatment, 90 ...
The effect of Camphor--Crataegus berry extract combination on blood pressure and mental functions in chronic hypotension--a randomized placebo controlled double blind design.(Report)
Nov 01, 2008; ... Abstract A number of studies have provided evidence for reduced cognitive performance due to chronically low blood pressure. The present studies explored whether these deficits can be reduced by pharmacological blood pressure elevation. Effects of the Camphor--Crataegus berry ...
Protective effect of a standardized Ginkgo extract (ginaton) on renal ischemia/reperfusion injury via suppressing the activation of JNK signal pathway.(Jun N-terminal kinase)(Report)
Nov 01, 2008; ... Abstract A new standardized Ginkgo extract (ginaton) destined of i.v. injection was investing in rats for its protective effect on renal ischemia/reperfusion injury. We report on the elucidation of the downstream mechanism of action of JNK on the renal ischemia/reperfusion ...