Progress in Transplantation back issues from June 2004:
Chronic allograft nephropathy: pathogenesis and management of an important posttransplant complication
Jun 01, 2004; ... Chronic allograft nephropathy is a devastating complication of kidney transplantation that is responsible for a significant proportion of graft loss. This complication is characterized by a progressive decline in kidney function, which is not attributable to a specific cause. Many risk factors ...
Use of antidepressant drugs in transplant recipients
Jun 01, 2004; ... Depression is the most prevalent psychiatric disorder in transplant recipients and may lead to noncompliance and negative outcomes without psychosocial and pharmacologic interventions. The pharmacologic treatment of depression in this patient population is complicated by complex ...
Management of opportunistic infections in solid-organ transplantation
Jun 01, 2004; ... Solid-organ transplantation is often the last alternative in many patients with end-stage organ disease. Although advances in immunosuppressive regimens, surgical techniques, organ preservation, and overall management of transplant recipients have improved graft and patient survival, infectious ...
Treating gout in kidney transplant recipients
Jun 01, 2004; ... Objective-To review the etiology, treatment, and preventive strategies of hyperuricemia and gout in kidney transplant recipients. Data Sources-Primary literature was obtained via Medline (1966-June 2003). Study Selection and Data Extraction-Studies evaluating treatment and ...
Strategies to prevent chronic allograft nephropathy in kidney transplantation: focus on calcineurin inhibitors
Jun 01, 2004; ... Chronic allograft nephropathy is one of the leading causes of long-term graft failure in kidney transplant recipients. The etiology of this condition is multifactorial, but administration of calcineurin inhibitors is often implicated. With the introduction of newer immunosuppressive agents, ...
Transplant pharmacists: key to a successful transplant program
Jun 01, 2004; ... Twenty years ago, the primary focus of immunosuppressant regimens was prevention of acute rejection using either 2 or 3 drug combinations that, in retrospect, seem simplistic. Recent advances in immunosuppressant regimens have dramatically reduced acute rejection rates, but concurrently ...
Hepatotoxicity of herbal remedies: an emerging dilemma
Jun 01, 2004; ... The surge in consumption of herbal remedies has been stimulated by several factors, including the notion that all herbal products are safe and effective, consumers becoming more proactive in self-treating, and lack of regulation by the Food and Drug Administration. Although herbal remedies are ...
Critical care pharmacy in donor management
Jun 01, 2004; ... Significant systemic changes occur following neurologic insult and subsequent brain death. If left untreated, the hemodynamic instability and neuroendocrine alterations that ensue may significantly affect the quality of the donor organs, and contribute to posttransplant allograft dysfunction. A ...
Polyomavirus nephropathy in kidney transplantation
Jun 01, 2004; ... Polyomavirus nephropathy has become an important complication in kidney transplantation, with a prevalence of 1% to 8%. Unfortunately, the risk factors for polyomavirus nephropathy and renal allograft loss are not well defined. The definitive diagnosis is made through assessment of a kidney ...
Future immunosuppressive agents in solid-organ transplantation
Jun 01, 2004; ... Objective-To review the pharmacology, pharmacokinetics, efficacy, and safety of mycophenolate sodium, everolimus, and FTY720. Study Selection and Data Extraction-Clinical trials and abstracts evaluating mycophenolate sodium, everolimus, and FTY720 in solid-organ transplantation were ...
Coping ABCs for caregivers
Jun 01, 2004; ... Transplantation is a process, not an event. This process starts when you first learn that your loved one needs a transplant procedure and continues for the rest of your loved one's life. Yes, transplantation will change the color of your life, but you alone have the power to determine what that ...