Respiratory Therapeutics Week back issues from March 2003:
Mitochondrial injury key in eosinophil apoptosis, enhanced by GCs.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a study in the United States, "The mainstay of asthma therapy, glucocorticosteroids (GCs) have among their therapeutic effects the inhibition of inflammatory cytokine production and induction of eosinophil apoptosis. In the absence of ...
Mature T lymphocytes, bronchial and salivary cells produce limitin glycoprotein.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "Several reports have described multifunctional eukaryotic mRNAs producing more than one protein through alternative translational initiation at multiple AUG codons. There are 2 such codons in the 5' region ...
Only low level LPS inhalation induces a TLR4 dependent Th2 response.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Allergic asthma is an inflammatory lung disease initiated and directed by T helper cells type 2 (Th2). The mechanism involved in generation of Th2 responses to inert inhaled antigens, however, is ...
Potential role of apoptotic macrophages in pulmonary inflammation and fibrosis.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Induction of apoptosis has been associated with a variety of exposures which result in inflammatory and fibrotic lung disorders. Macrophages are key regulatory cells in the lung; however, the ...
Pathogenesis is reduced following combined antiviral/immunomodulatory treatment.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- Recent research from the United States reports "the responses of mice with symptomatic pneumovirus infection to combined antiviral and specific immunomodulatory agents. Mice infected with pneumonia virus of mice, a natural mouse pathogen that ...
Vital role of the classical pathway for innate immunity to bacterial pathogens.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- "The complement system is an important component of the innate immune response to bacterial pathogens, including Streptococcus pneumoniae. The classical complement pathway is activated by antibody-antigen complexes on the bacterial surface and has ...
E3 promoter responds to activation signals in human T cells.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a study in the United States, "The group C adenoviruses typically cause acute respiratory disease in young children. In addition, a persistent phase of infection has been observed in which virus may be shed for years without producing ...
Genetic marker identified at Oxford.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- Researchers at Oxford University's Wellcome Trust Centre for Human Genetics have located a variant form of a polynucleotide sequence in the MHC region of chromosome 6p and identified its association with an increased secretion of tumor necrosis ...
Antiinflammatory therapy effects additive, alter decline of pulmonary function.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a study in the United States, "Some of the most important pathobiology in cystic fibrosis occurs not as a direct result of impaired chloride transport, but the downstream consequences of defective CFTR function, particularly the lung ...
Calpain may be a novel therapeutic target for regulation of mast cell activity.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research in Canada, "Nitric oxide is an important messenger that regulates mast cell activity by modifications to gene expression and intracellular pathways associated with exocytosis and adhesion. Integrin interactions with ...
Company responds to FluMist complete response letter.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- MedImmune, Inc., (MEDI) announced that it has completed the submission of information requested by the U.S. Food and Drug Administration (FDA) for FluMist (Influenza virus vaccine live, intranasal), an influenza vaccine delivered as a nasal mist. ...
Oncostatin M regulates eotaxin expression eosinophilic inflammation.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a study from Canada, "Oncostatin M (OSM) is a member of the IL-6/LIF (or gp130) cytokine family, and its potential role in inflammation is supported by a number of activities identified in vitro. "In this study, we ...
Thrombin has role in BAL fluid mitogenicity in lung disease of premature infants.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research from Netherlands, "Chronic lung disease of prematurity (CLD) is a common consequence of neonatal respiratory distress syndrome (RDS) and is characterized by pulmonary fibrosis. Increased thrombin activity in the ...
TNF treatment represses pneumopathy by killing the inflammatory cells.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- "Idiopathic pulmonary fibrosis is a chronic inflammatory lung disease with interstitial fibrosis. As a potent proinflammatory cytokine, TNF has been suggested to play critical roles in the pathogenesis of the human disease and its animal model, ...
Researchers review immunotherapy for allergic bronchopulmonary aspergillosis.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent review from researchers in Russia and the United States, "Allergic bronchopulmonary aspergillosis (ABPA) is a severe allergic pulmonary complication caused by the saprophytic fungus Aspergillus fumigatus. The present review ...
Causation between white blood cells and lung disorders confirmed.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- There is no cure for asthma and other deadly pulmonary disorders. But a new study offers revealing clues on why such disorders may develop - and the roles of key cells in the formation of the disease. For more than a century, ...
IL-6 blockade reduces C5a receptor expression, improving survival.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "IL-6 is known to be an important proinflammatory and anti-inflammatory cytokine, which is upregulated during sepsis. Our previous work has suggested a role for IL-6 in the upregulation of C5aR ...
Phase II/III clinical study of iseganan HCl for VAP launch announced.
Mar 03, 2003 ... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- IntraBiotics Pharmaceuticals, Inc. (NASDAQ:IBPI) announced plans to launch a 500-patient Phase II/III clinical study to investigate iseganan HCl in the prevention of ventilator-associated pneumonia (VAP). The company recently concluded a ...
Glu(263) of the TAP1 protein is critical for proper TAP function.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research in Germany, "The heterodimeric peptide transporter TAP belongs to the ABC transporter family. Sequence comparisons with the P-glycoprotein and cystic fibrosis transmembrane conductance regulator and the functional ...
Lymphocytes and mast cells accumulate during symptomatic natural colds.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- "Knowledge of the virus-induced immune response is important in understanding the pathophysiology of respiratory virus infections. Data on the cellular immune response is still limited and based mainly on experimental studies. Natural colds may ...
At least 22 allergens were found which could be used in diagnostics.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Allergic bronchopulmonary aspergillosis (ABPA) is a severe respiratory disease caused by the fungus Aspergillus fumigatus (Af). It occurs as a secondary complication mostly in patients with atopy and ...
HCMV lung infection downregulates EGF-R and may retard lung maturation.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research in Germany, "Epidermal growth factor plays a key role in late fetal lung development and differentiation as well as in regulating surfactant protein A synthesis, which is involved in innate immunity of the lung. ...
Invasiveness is caused by low antibody titer to capsular polysaccaride.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Germany, "The immune response to pneumococcal capsular polysaccharides (CPSs) and to the pneumococcal surface protein's cell wall associated serine proteinase A (PrtA), pneumococcal surface protein A (PspA), and ...
Smoke extract decreases inducible nitric oxide synthase transcription.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Cigarette smoking has been associated with decreased exhaled nitric oxide (NO). To investigate the mechanism of this decrease, the effects of a cigarette smoke extract were evaluated on a murine lung ...
Virus DNA can be found in sera of children with respiratory infection.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- "Serum samples from 68 immunocompetent infants (mean age, 12.6 mo) with an acute adenovirus infection of the respiratory tract (39 experiencing their first adenovirus infection) were tested for the presence of adenovirus DNA, to investigate ...
Individuals with conspicuous nevi appear to be more pollinosis resistant.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Researchers from Japan "investigated 115 individuals in Tokyo from 2 groups: Persons with conspicuous nevi on the head, neck, and arms, etc., the nevus positive group; and persons who do not exhibit such nevi (nevi negative group), interviewing ...
Paragon Integrated Marketing to sell NasalGuard.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Paragon Integrated Marketing Corp. reached an agreement to become the marketing and sales force for Trutek Corp.'s NasalGuard. NasalGuard, a topical gel, uses an electrostatic concept to restrict inhalation of allergens. NasalGuard is ...
SHP-1 may have role as negative regulator in developing allergic responses.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study in Japan, "Th2 cells are generated from naive CD4 T cells upon T cell receptor (TCR) recognition of antigen and IL-4 stimulation and play crucial roles in humoral immunity against infectious microorganisms and the pathogenesis ...
Model shows how capillary-elastic instabilities can lead to airway closure.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Researchers have developed a way to model the "competition between capillary and elastic forces in controlling the shape of a small lung airway and its interior liquid lining." J. Rosenzweig and colleagues, University London Queen Mary ...
Antibody tests, skin reactivity, and some symptoms presently allow diagnosis.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Allergic bronchopulmonary aspergillosis (ABPA) is characterized by recurrent pulmonary infiltrates that can result in central bronchiectasis and bronchiolitis obliterans, especially if there is a lack ...
Fungal infection has changing pathology from eosinophilia to fibrosis.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Allergic bronchopulmonary aspergillosis (ABPA) occurs in patients with asthma and cystic fibrosis when Aspergillus fumigatus spores are inhaled and grow in bronchial mucus as hyphae. Chronic ...
Th2-type cytokines release factors resulting in bronchiectatic lesions, fibrosis.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study in The Netherlands, "Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease clinically characterized by manifestation of wheezing, pulmonary infiltrates and bronchiectasis and fibrosis which afflicts ...
Researcher outlines treatment options for chronic obstructive pulmonary disease.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Researcher outlines the treatment options for chronic obstructive pulmonary disease in a recent review. According to research from England, "Chronic obstructive pulmonary disease is one of the commonest causes of morbidity and ...
Burkholderia species differ regarding epidemiology and pathology in CF.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- "Although most species in the genus Burkholderia are not pathogenic for healthy persons, a few are capable of causing severe, life threatening infection," researchers in the United States report. "B. mallei and B. pseudomallei are the ...
The lectins DC-SIGN and DC-SIGNR bind virus glycoproteins avidly.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Ebola virus exhibits a broad cellular tropism in vitro. In humans and animal models, virus is found in most tissues and organs during the latter stages of infection. In contrast, a more restricted ...
Tropoelastin based design of peptides are created to inhibit metalloproteinases.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Australia, "Abnormal production of matrix metalloproteinases (MMPs) has been observed in a variety of diseases such as emphysema, atherosclerosis, and cancer metastasis. Destruction of connective tissue ensues ...
Lincare announces fourth-quarter and year-end results.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Lincare Holdings, Inc., (LNCR), a provider of oxygen and other respiratory therapy services delivered to patients in the home, announced financial results for the quarter and year ended December 31, 2002. For the quarter ended December ...
Maternal illness causes behavioral and drug-related changes in offspring.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Maternal viral infection is known to increase the risk for schizophrenia and autism in the offspring. Using this observation in an animal model, we find that respiratory infection of pregnant mice ...
Recognizing influenza may be difficult in older patients with COPD.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Recognizing influenza in older patients with chronic obstructive pulmonary disease (COPD) can be difficult. According to a study from the United States, "A substudy analysis was conducted to determine the clinical characteristics ...
Condoms hold no risk for sensitization of other allergy-prone patients.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- A study from Germany assessed "the prevalence of sensitization to latex in a group of women with a high risk for atopy and determined whether the use of condoms is a relevant risk factor. In the prospective study, 100 atopic women (defined as ...
EBV serology has limited value in posttransplant lymphoproliferative disease.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research in The Netherlands, "The Epstein-Barr virus (EBV)-specific antibody response was studied in lung transplant patients to assess their value in the diagnosis and prognosis of posttransplant lymphoproliferative disease. ...
Lung disease is caused by asbestos and non-asbestos mineral deposit use.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- "Asbestos deposits have been used locally by the rural inhabitants of Central and Southeastern Anatolia for domestic purposes for many years. Mineralogical analysis revealed that tremolite is the most prominent asbestos type found in the region. ...
Pathogen gives GI or respiratory symptoms in immunocompetent children.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from Greece, "Ochrobactrum anthropi is an emerging pathogen in immunocompromised patients, but infections with the bacterium have very rarely been documented in normal hosts. We report the characteristics of O. anthropi ...
Krumdieck technique allows study of mechanisms of bacterial and viral infections.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- "The Krumdieck technique allows the investigation of the so-called precision cut lung slices (PCLS) with a special microtome. It is thus possible to evaluate morphologic changes over a longer period of time using only a small group of animals. ...
Molecular is more accurate than phenotypic typing, especially in cystic fibrosis.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Canada, "Pseudomonas aeruginosa is a serious opportunistic pathogen in certain immunocompromised hosts such as those with cystic fibrosis, thermal burns, and cancer. It also causes less severe noninvasive ...
Replication is inhibited inversely to NO production of target cells.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Nitric oxide (NO) is generated by recruited inflammatory cells and by pulmonary epithelial cells in response to respiratory virus infection, although the relative antiviral efficacy of NO from each of ...
Rapid detection kits for Group A are less sensitive than conventional culture.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from Sweden, "A new, 1 step, enzyme linked immunoassay (ELISA) kit for detection of Group A Streptococci (GAS) in throat samples (QuickVue In-Line One-Step Strep A Test; Quidel Corporation, San Diego, CA) was evaluated for use ...
Rapid Akt activation by tobacco components modulates many signaling pathways.
Mar 10, 2003 ... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Tobacco related diseases such as lung cancer cause over 4.2 million deaths annually, with approximately 400000 deaths per year occurring in the US. Genotoxic effects of tobacco components have been ...
Cyanobacteria, especially Microcystis, produce activity against influenza.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Cyanobacteria, especially Microcystis, produce activity against influenza. According to recent research from Germany, "Aqueous and methanolic extracts of cultured cyanobacteria of several genera; Microcystis, Nodularia, Oscillatoria, ...
SAR 943, a rapamycin analogue, could benefit patients with severe asthma.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- SAR 943, a rapamycin analogue, could benefit patients with severe asthma. "No current therapy is considered to be satisfactory for severe asthma, and alternative approaches are still required for what is a major unmet medical need. In ...
Shriners and MUHC investigate effects of oral steroids on children.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Parents concerned about use of oral steroids to treat their asthmatic children will be reassured by a new study conducted by a team of clinicians at the Research Institute of the McGill University Health Centre (MUHC) and the Shriners Hospital ...
Traditional twin studies can't establish a genetic link to respiratory disorder.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Traditional twin studies can't establish a genetic link to respiratory distress syndrome. According to recent research from Finland, "Recent evidence suggests that the susceptibility to respiratory distress syndrome (RDS) is partly ...
Asthma patients have an increased prevalence of irritable bowel syndrome.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Asthma patients have an increased prevalence of irritable bowel syndrome. According to a study from Greece, "Irritable bowel syndrome (IBS) is one of the most common diseases of the gastrointestinal tract. IBS may represent a primary ...
RSV and virus-induced inflammation are modified by contaminants of indoor air.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- RSV and virus-induced inflammation are modified by contaminants of indoor air. According to recent research from England, "The airway epithelium is the first cellular component of the lung to be encountered by the particles and ...
Granulomatous pneumonitis occurs after exposure to World Trade Center dust.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Granulomatous pneumonitis occurs after exposure to dust generated by the collapse of the World Trade Center in New York. "We describe a 37 year old male engineer who presented with cough and dyspnea 3 weeks after exposure to dust ...
Skin wheal due to allergens may be increased by phone microwave radiation.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Skin wheal due to allergens may be increased by phone microwave radiation. According to recent research from Japan, "Microwave radiation from mobile phones enhanced skin wheal responses induced by house dust mite and Japanese cedar ...
Immunochromatographic binax NOW assay could screen affected community faster.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Immunochromatographic binax NOW assay could screen patients with community-acquired pneumonia faster. Recent research from Spain "evaluated the Binax NOW rapid immunochromatographic membrane test (ICT) for detection of Streptococcus ...
Alveolar cell culture may be good model to study epithelial transport.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- According to a study from Germany, "Human alveolar type II cells were isolated from lung tissue and cultured for several days. The morphology of cells was investigated at different time points postseeding and the synthesis of alveolar cell-type ...
Der p1-pulsed M-DC and P-DC from allergic patients dysregulate T cell response.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Der p1-pulsed M-DC and P-DC from allergic patients dysregulate the T cell response. According to recent research from France, "Although reports suggest that dendritic cells (DC) are involved in the allergic reaction characterized by a T ...
Clinicians should critically appraise the value of diagnostic tests.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Clinicians should critically appraise the value of diagnostic tests. "The case for endobronchial biopsy in the diagnosis of sarcoidosis, faced with the continuous development of new diagnostic tests, the clinician needs to be able to ...
Net loss reported at $0.81 per share for drug maker; clinical update provided.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- InterMune, Inc., (ITMN) announced results from operations for the fourth quarter and year ended December 31, 2002. For the fourth quarter of 2002, InterMune recorded total product sales of $39.3 million, compared to $15.1 million for ...
Cytomegalovirus UL16 glycoprotein retains virally induced NKG2D ligands.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Cytomegalovirus UL16 glycoprotein retains virally induced NKG2D ligands. According to a study from Germany, "Human cytomegalovirus (HCMV) has evolved a multitude of molecular mechanisms to evade the antiviral immune defense of the host ....
Neuraminidase inhibitors work as well in outpatient practice as in trials.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Neuraminidase inhibitors work as well in outpatient practice as in trials. According to a study from Germany, "The neuraminidase inhibitor signifies a breakthrough in the treatment of influenza. We compared the outcomes of influenza in ...
Patient education and proper technique are necessary for inhalation therapy.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Patient education and proper technique are necessary for inhalation therapy. According to a study from Germany, "Inhalation therapy is the main route of drug administration in patients with obstructive pulmonary diseases. ...
Endoscopic debridement effectively manages airway obstruction from carcinoma.
Mar 17, 2003 ... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Endoscopic debridement effectively manages airway obstruction from carcinoma. According to a study from the United States, "Endoscopic debridement of obstructing laryngotracheal carcinoma with the microdebrider is an alternative to CO2 ...