The Journal of Nuclear Medicine back issues from December 2004:
Erratum
Dec 01, 2004; ... November 2004 Newsline A portion of the information in the article about Roger W. Howell, PhD, recipient of the Loevinger-Berman Award for Excellence in Medical Internal Radiation Dosimetry, was erroneous. A corrected version of ...
SNM's Reach Should Exceed Its Grasp
Dec 01, 2004; ... SNM LEADERSHIP UPDATE An essential element of SNM's strategic plan is to communicate the value of nuclear medicine/molecular imaging in patient care, the value of achieving significant growth in science and utilization, and the value of its own role as a premier professional society. To ...
PET in Detection of Salmonella Vectors in Tumors
Dec 01, 2004; ... Several live attenuated recombinant Salmonella vaccines are now in human clinical trials, and, if such treatments are to enter the mainstream, a reliable method is needed for assessing both appropriate individuals for treatment and ongoing efficacy. On October 22 Soghomonyan et al. from the ...
Apoptosis Imaging with ^sup 99m^Tc-Annexin V and Treatment Response
Dec 01, 2004; ... In the September issue of Radiotherapy and Oncology (2004;72:333-339), Kartachova et al. from The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital (Amsterdam) reported on an investigation correlating visual patterns from tumor uptake on ^sup 99m^Tc-Hynicrh-Annexin V scintigraphy ...
SNM to Establish Center of Molecular Imaging as New Field Emerges, Grows Rapidly
Dec 01, 2004; ... FROM THE SNM PRESIDENT Following through on an integral part of its strategic plan, SNM's leadership appointed a task force to explore the possibility of forming a Center of Molecular Imaging. As a member of this task force, I believe that the center's goals should be to disseminate ...
Human Anti-CEA mAbs for RIT in Colorectal Cancer
Dec 01, 2004; ... Garambois et al. from INSERM (Grenoble and Montpellier, France) reported ahead of print in the October 15 issue of BMC Cancer (2004;4:75) on the development of human anticarcinoembryonic antigen (anti-CEA) monoclonal antibodies (mAbs) for colon cancer radioimmunotherapy (RIT). The study was ...
Alzheimer's Neuroimaging Initiative Launched
Dec 01, 2004; ... NEWSBRIEFS A consortium of federal agencies, private companies, and professional organizations announced on October 13 the launch of the Alzheimer's Disease (AD) Neuroimaging Initiative, a $60 million, 5-year public-private partnership to test whether serial MR imaging, PET, other ...
Thyroid Cancer After Chernobyl
Dec 01, 2004; ... Diagnosis Cherenko et al. from the Transplantation of Endocrine Organs and Tissues Public Health Ministry (Kiev, Ukraine) reported ahead of print in the October 21 issue of The World Journal of Surgery on a large-scale clinical analysis of thyroid cancer in individuals who were adults ...
^sup 123^I-loflupane SPECT in Clinically Uncertain Parkinsonian Syndromes
Dec 01, 2004; ... In the October issue of Movement Disorders (2004;October 19), which is devoted to nuclear imaging of Parkinson disease and parkinsonian syndrome, Catalan and Tolosa, from the Hospital de Sant Pau (Barcelona, Spain), reported on pages 1175-1182 on the use of ^sup 123^I-ioflupane SPECT as a marker ...
Potential Agents for Alzheimer's Imaging
Dec 01, 2004; ... In the October 29 issue of Brain Research (2004;1025;98-105), Kung et al. from the University Pennsylvania (Philadelphia) reported on the amyloid plaque binding potential of 2 radiolabeled ligands in postmortem brain tissues from patients with Alzheimer's disease (AD), as an assessment of in ...
NCI Launches New Integrative Cancer Biology Program
Dec 01, 2004; ... The National Cancer Institute (NCI), part of the National Institutes of Health (NIH), announced on October 26 $14.9 million in funding for a new Integrative Cancer Biology Program (ICBP), a unique initiative designed to gain insights into the development and progression of cancer through a ...
PET Radiopharmaceuticals Drive Market in Europe
Dec 01, 2004; ... Significant changes in the European radiopharmaceuticals market were reported in October by health care analysts Frost & Sullivan. Researchers found production and sales of PET agents growing at much faster rates than other segments. The European radiopharmaceuticals market generated revenue ...
PET + SLN Biopsy in Oral and Oropharyngeal Cancer
Dec 01, 2004; ... Kovacs et al. from the Johann Wolfgang Goethe-University Medical School (Frankfurt am Main, German) reported in the October issue of the Journal of Clinical Oncology (2004;22:3973-3980) on a study to assess the impact of the diagnostic combination of 18F-FDG PET and lymphoscintigraphy-guided ...
Early ^sup 18^F-FDG PET after Radical Radiotherapy in NSCLC
Dec 01, 2004; ... Hicks et al. from the Peter MacCallum Cancer Centre (Melbourne, Australia) reported in the October 1 issue of the International Journal of Radiation Oncology, Biology, Physics (2004;60:412-418) on the relationship and predictive significance of inflammatory changes detected by 18F-FDG PET in ...
NIH Neuroscience Blueprint to Shape Intra-Agency Research Cooperation
Dec 01, 2004; ... On October 24 National Institutes of Health Director (NIH) Elias A. Zerhouni, MD, announced a new intra-agency partnership to accelerate neuroscience research. Dubbed the NIH Blueprint tor Neuroscience Research, the agreement reinforces ongoing NIH efforts to increase collaborative research and ...
NIDA, NIA, and JHU Partner in Research
Dec 01, 2004; ... The National Institutes of Health (NIH) and The Johns Hopkins University (JHU) celebrated on October 12 the beginning of construction of the new Biomedical Research Center (BRC) on the Johns Hopkins Bayview campus in Baltimore, MD. The BRC, which is slated for occupancy in the fall of 2006, will ...
Quantification of Serial Changes in Myocardial Perfusion
Dec 01, 2004; ... Myocardial perfusion SPECT (MPS) studies are frequently performed serially to monitor progression of coronary artery disease. MPS also plays an important role in evaluating therapies for coronary artery disease (I). Sensitive methods for detection and estimation of changes in myocardial ...
SCAR Workshop on Crisis in Medical Imaging
Dec 01, 2004; ... The Society for Computer Applications in Radiology (SCAR) will be sponsoring a conference and workshop, "Transforming Medical Imaging," on January 31 and February 1, 2005, in Bethesda, MD. Partially financed with support from the National Institute of Biomedical Imaging and Bioengineering, the ...
Cornell to Mediate NRC Disputes
Dec 01, 2004; ... The Nuclear Regulatory Commission (NRC) announced on October 28 that it has contracted with Cornell University's Institute on Conflict Resolution to act as a neutral administrator in the agency's alternative dispute resolution program (ADR) for addressing discrimination complaints and other ...
NRC Tightens Controls on Web Documents
Dec 01, 2004; ... On October 25, agency experts at the Nuclear Regulatory Commission (NRC) initiated a security review of publicly available documents to remove potentially sensitive information from the NRC Web site. During this review, ADAMS, the NRC's online document library, will not be available to the ...
A Whale of a PET/CT Image
Dec 01, 2004; ... On October 20 the Providence Imaging Center in Anchorage, AK, put its new PET/CT unit to novel use in imaging the head of a rare Stejneger's beaked whale. The mammal was 1 of 2 whales that died near Whittier, AK, within 3 days of one another in mid October. "We've never done an animal before," ...
Quantitative Comparison of Analytic and Iterative Reconstruction Methods in 2- and 3-Dimensional Dynamic Cardiac ^sup 18^F-FDG PET
Dec 01, 2004; ... The aim of this work was to compare the quantitative accuracy of iteratively reconstructed cardiac ^sup 18^F-FDG PET with that of filtered backprojection for both 2-dimensional (2D) and 3-dimensional (3D) acquisitions and to establish an optimal procedure for imaging myocardial viability with ...
Usefulness of Fasting ^sup 18^F-FDG PET in Identification of Cardiac Sarcoidosis
Dec 01, 2004; ... Cardiac PET using ^sup 18^F-FDG under fasting conditions (fasting ^sup 18^F-FDG PET) is a promising technique for identification of cardiac sarcoidosis and assessment of disease activity. The aim of this study was to investigate the usefulness of fasting ^sup 18^F-FDG PET in detecting ...
CERN Celebrates Fiftieth Birthday
Dec 01, 2004; ... Scientists and European leaders gathered in Geneva, Switzerland, on October 19 to celebrate 50 years of groundbreaking science. French President Jacques Chirac, King Juan Carlos of Spain, and Swiss President Joseph Diess were among those who attended ceremonies marking the founding of the ...
Radiolabeled mAb Targeting of Dead Cells in Melanoma
Dec 01, 2004; ... Therapy In a study published in the October 12 issue of the Proceedings of the National Academy of Sciences USA (2004; 101:14865-14870), Dadachova and colleagues from the Albert Einstein College of Medicine (Bronx, NY) reported on a study assessing the feasibility of targeting melanin to ...
The Relative Localizing Value of Interictal and Immediate Postictal SPECT in Seizures of Temporal Lobe Origin
Dec 01, 2004; ... Although interictal hypoperfusion and ictal hyperperfusion are established localizing findings in partial epilepsy, their relative value is disputed. After a meta analysis of several published articles on SPECT brain imaging in patients with epilepsy (with extractable data on at least 6 patients ...
^sup 18^F-Ciprofloxacin as PET Tracer
Dec 01, 2004; ... Widespread international attention has been focused on ciprofloxacin administration, both for its possible use as a remedy in criminal biological attacks and for its more routine use as a potent antibiotic. Brunner et al. from the Medical University of Vienna (Austria) reported in the October ...
Biodistribution and Blood Metabolism of 1-^sup 11^C-Methyl-4-Piperidinyl n-Butyrate in Humans: An Imaging Agent for In Vivo Assessment of Butyrylcholinesterase Activity with PET
Dec 01, 2004; ... 1-^sup 11^C-Methyl-4-piperidinyl n-butyrate (^sup 11^C-MP4B) is a new radiopharmaceutical for the in vivo assessment of butyrylcholinesterase (BuChE) activity using PET. To quantify in vivo activity of BuChE with a kinetic model, investigators must determine the time course of radioactivity ...
Recombinant Human Thyrotropin in ^sup 131^I Therapy
Dec 01, 2004; ... Results of a study on the effects of recombinant human thyrotropin (rhTSH) on ^sup 131^I therapy in patients with nodular goiter were reported on October 19 ahead of print in the Journal of Clinical Endocrinology and Metabolism by Nielsen et al. from the Odense University Hospital (Denmark). The ...
Radiometals as RIT Payloads in Lymphoma
Dec 01, 2004; ... An October supplement to Clinical Lymphoma was devoted to the topic of ^sup 90^Y-ibritumomab tiuxetan (Zevalin; Biogen IDEC, Inc.) therapy for non-Hodgkin's lymphoma (NHL), with an introduction provided by Gerald L. DeNardo (University of California Davis Medical Center; Sacramento). The table ...
Is ^sup 18^F-FDG PET/CT Useful for Imaging and Management of Patients with Suspected Occult Recurrence of Cancer?
Dec 01, 2004; ... Rising serum tumor markers may be associated with negative imaging in the presence of cancer. CT and ^sup 18^F-FDG PET may yield incongruent results in the assessment of tumor recurrence. The present study evaluates the incremental role of ^sup 18^F-FDG PET/CT for the diagnosis and management of ...
Tracer for Folate-Receptor Positive Tumors
Dec 01, 2004; ... Reporting on October 2 ahead of print in Cancer Biology and Therapy, Panwar et al. from the Institute of Nuclear Medicine and Allied Sciences and the University of Delhi (India) reported on the synthesis and evaluation of a new ^sup 99m^Tc-labeled folate derivative for the detection of ...
^sup 18^F-FDG PET in Evaluation of Adrenal Lesions in Patients with Lung Cancer
Dec 01, 2004; ... The purpose of this study was to assess the role of PET with ^sup 18^F-FDG in differentiating benign from metastatic adrenal masses detected on CT or MRI scans of patients with lung cancer. Methods: This retrospective study analyzed ^sup 18^F-FDG PET scans of patients with lung cancer who were ...
PET Brain Imaging and the Mechanisms of Depression
Dec 01, 2004; ... Reivich et al. from the University of Pennsylvania School of Medicine (Philadelphia) reported in the October 15 issue of the Journal of Affective Disorders (2004;82:321-327) on a study using the selective brain serotonin (5-HT) transporter site ligand ^sup 11^C-(+)McN5652 and PET to investigate ...
PET and Effect on Routine Clinical Decision Making
Dec 01, 2004; ... In the October 15 issue of the Journal of Clinical Oncology (2004;22: 4147-4156), Hillner et al. from Virginia Commonwealth University (Richmond) reported on a study evaluating the effect of ^sup 18^F-FDG PET imaging on patient management in routine practice. The authors provided questionnaires ...
^sup 18^F-FDG PET and Therapy Response in Head and Neck Cancer
Dec 01, 2004; ... In the October issue of Head and Neck (2004;26:890-896), McCollum et al. reported on a study of the accuracy and efficacy of ^sup 18^F-FDG PET in restaging disease in 40 patients with small cell cancer of the head and neck alter induction chemotherapy followed by definitive chemoradiotherapy ...
Synthesis and Comparison of ^sup 99m^Tc-Enrofloxacin and ^sup 99m^Tc-Ciprofloxacin
Dec 01, 2004; ... The use of ^sup 99m^Tc-ciprofloxacin as a tracer for infection and inflammation has been examined and discussed in the literature extensively. Its alleged ability to discriminate between sterile inflammation and bacterial versus nonbacterial infections has led to an intense debate. Other labeled ...
COMMENTS AND PERSPECTIVES
Dec 01, 2004; ... Health technology assessment (HTA) groups have been instrumental in restricting patient access to PET worldwide, overpowering spirited patient advocacy by clinical experts who argue that this technology is a seminal advance in diagnostic imaging. Ironically, HTA groups are achieving their ...
External Imaging of CCND1 Cancer Gene Activity in Experimental Human Breast Cancer Xenografts with ^sup 99m^Tc-Peptide-Peptide Nucleic Acid-Peptide Chimeras
Dec 01, 2004; ... Detection of a new or recurrent breast cancer lesion relies on physical examination and imaging studies, primarily mammography, followed by histopathologic evaluation of biopsy tissue for morphologic confirmation. Approximately 66%-85% of detected lesions are not malignant. Therefore, biopsies ...
3-O-Methyl-6-^sup 18^F-Fluoro-L-Dopa, a New Tumor Imaging Agent: Investigation of Transport Mechanism In Vitro
Dec 01, 2004; ... ^sup 18^F-Labeled amino acids represent a promising class of imaging agents in tumors, particularly brain tumors. However, the determination of their potential to image peripheral tumors, possibly depending on individual transport characteristics, still remains an area of investigation. The ...
Enhancement of Radioiodine Treatment of Small-Pool Hyperthyroidism with Antithyroid Drugs: Kinetics and Dosimetry
Dec 01, 2004; ... ^sup 131^I-Iodide is the treatment of choice in most cases of hyperthyroidism, with a standard 7,000-cGy (rad) thyroid absorbed dose generally resulting in an incidental blood absorbed dose of less than 10 cGy (rad). However, in ~15% of patients there is a small, rapidly secreted thyroid iodine ...
Assessment of Myocardial Reperfusion After Myocardial Infarction Using Automatic 3-Dimensional Quantification and Template Matching
Dec 01, 2004; ... Assessment of perfusion defect extent is essential for determining prognosis after a myocardial infarction (MI), but quantification methods usually rely on segmental analysis, which may lack accuracy. We present an automated voxel-based and templatebased approach for precise quantification of ...
History of Nuclear Medicine in Europe
Dec 01, 2004; ... History of Nuclear Medicine in Europe M. Feld and M. De Roo; H. Sehieha, K. Bergdolt, and PJ. Ell, eds.; D.D. Patton, Irans. New York, NY: Schattciiier, 2003, 166 pages, euro49.95 (~$62) This book is a new translated edition of a collaborative effort begun in 1995. The impetus for the ...
Integration of Automatically Measured Transient Ischemic Dilation Ratio into Interpretation of Adenosine Stress Myocardial Perfusion SPECT for Detection of Severe and Extensive CAD
Dec 01, 2004; ... The aim of our study was to derive and to validate the normal threshold for an automatically measured left ventricular transient ischemic dilation (TID) ratio in patients referred for adenosine stress myocardial perfusion SPECT (MPS) and to assess the value of integrating TID in detecting severe ...
Re: Tetraphenylphosphonium as a Novel Molecular Probe for Imaging Tumors/REPLY
Dec 01, 2004; ... TO THE EDITOR: The recent paper by Min et al. (1), extending earlier work by Delmon-Moingeon et al. (2) and Madar et al. (3,4), is an elegant presentation of the potential use of tetraphenylphosphonkim (TPP) as a tumor probe lor PET (1). Min et al. eontend that the specificity of TPP for tumor ...
Prone Versus Supine Patient Positioning During Gated ^sup 99m^Tc-Sestamibi SPECT: Effect on Left Ventricular Volumes, Ejection Fraction, and Heart Rate
Dec 01, 2004; ... Gated myocardial perfusion SPECT allows assessment of left ventricular end-diastolic volume (EDV), left ventricular end-systolic volume (ESV), left ventricular stroke volume (SV), and left ventricular ejection fraction (LVEF). Acquiring images with the patient both prone and supine is an ...
Quantitative SPECT Leads to Improved Performance in Discrimination Tasks Related to Prodromal Alzheimer's Disease
Dec 01, 2004; ... We investigated the impact of the quantitation and reconstruction protocol on clinical tasks. The performance of standard clinical reconstruction procedures in discrimination tasks related to the diagnosis of prodromal Alzheimer's disease (AD) was compared with the performance of a quantitative ...
^sup 99m^Tc-Exametazime as a Breast Tumor-Seeking Agent: Comparison with ^sup 99m^Tc-Sestamibi
Dec 01, 2004; ... ^sup 99m^Tc-Sestamibi is commonly used for mammoscintigraphy. Occasional uptake of ^sup 99m^Tc-exametazime in various tumors has been described. In this study, an intraindividual comparison of these 2 radiopharmaceuticals for mammoscintigraphy was made. Methods: A kinetic study (30 min) in the ...
Prediction of Survival and Therapy Outcome with ^sup 11^C-Tyrosine PET in Patients with Laryngeal Carcinoma
Dec 01, 2004; ... Choosing the optimal treatment for an individual with squamous cell carcinoma of the head and neck is a difficult challenge because of the unpredictable clinical behavior of this malignancy. A reliable method for assessing the clinical behavior and predicting the radiocurability of tumors would ...
Time Course of Apoptotic Tumor Response After a Single Dose of Chemotherapy: Comparison with ^sup 99m^Tc-Annexin V Uptake and Histologic Findings in an Experimental Model
Dec 01, 2004; ... In tumors the process of apoptosis occurs over an interval of time after chemotherapy. To determine the best timing for detecting apoptosis in vivo with ^sup 99m^Tc-annexin V after chemotherapy, we examined the changes in ^sup 99m^Tc-annexin V accumulation over time in comparison with those of ...
^sup 99m^Tc-N-DBODC5, a New Myocardial Perfusion Imaging Agent with Rapid Liver Clearance: Comparison with ^sup 99m^Tc-Sestamibi and ^sup 99m^Tc-Tetrofosmin in Rats
Dec 01, 2004; ... ^sup 99m^Tc-[bis (dimethoxypropylphosphinoethyl)-ethoxyethylamine (PNP5)]-[bis (N-ethoxyethyl)-dithiocarbamato (DBODC)] nitride (N-PNP5-DBODC or N-DBODC5) is a new monocationic myocardial perfusion tracer. We sought to compare the myocardial uptake and clearance kinetics and organ ...
PET: Molecular Imaging and Its Biological Applications/Positron Emission Tomography: Basic Science and Clinical Practice
Dec 01, 2004; ... PET: Molecular Imaging and Its Biological Applications M.E. Phelps, ed. New York, NY: Springer-Verlag, 2004, 621 pages, $169 Positron Emission Tomography: Basic Science and Clinical Practice P.E. Valk, D.L. Bailey, D.W. Townsend, and M.N. Maisey, eds. New York, NY: Springer-Verlag, 2003, ...
Noninvasive Imaging for Monitoring of Viable Cancer Cells Using a Dual-Imaging Reporter Gene
Dec 01, 2004; ... Molecular imaging methods have been used recently to investigate biologic events. To develop a molecular imaging method suitable for monitoring viable cancer cells, we made a dualimaging reporter gene system and examined the correlation between cancer cell number and signals from 2 reporter ...
Number of Iterations When Comparing MLEM/OSEM with FBP/REPLY
Dec 01, 2004; ... TO THE EDITOR: The work that van der Weerdt et al. (1) reported in the article "Postinjection transmission scanning in myocardial 18F-FDG PET studies using both filtered backprojection and iterative reconstruction" has afforded useful and needed results on this topic. It is indeed surprising ...
Dosimetry and Radioimmunotherapy of Non-Hodgkin's Lymphoma/REPLY
Dec 01, 2004; ... TO THE EDITOR: With interest I read the letter of Brition concerning raclioimmunotherapy (RlT) of non-Hodgkin's lymphoma (NHL) (1). In brief, he compares RIT of NHL with other therapies using radionuclides, in which a tracer dose of a radio-pharmaceutical is given and imaging is performed before ...
Eighth Asia and Oceania Congress of Nuclear Medicine and Biology, October 9-13, 2004, Beijing, China
Dec 01, 2004; ... INTERNATIONAL HIGHLIGHTS The Eighth Asia and Oceania Congress of Nuclear Medicine and Biology (AOCNMB) was held October 9-13 in Beijing, China. Of the 456 participants, 230 were from China, and the remaining 226 represented more than 30 other countries. Twenty-three exhibitors ...
AOCNMB Satellite Conference in Hong Kong
Dec 01, 2004; ... The largest nuclear medicine conference in Hong Kong's history was held on October 16 and 17, with about 200 local participants and overseas delegates. The conference was organized as a satellite meeting of the Eighth Asia and Oceania Congress of Nuclear Medicine and Biology (AOCNMB), which took ...
Synthesis and Evaluation of 2'-Deoxy-2'-^sup 18^F-Fluoro-5-Fluoro-1-[beta]-D-Arabinofuranosyluracil as a Potential PET Imaging Agent for Suicide Gene Expression
Dec 01, 2004; ... 2'-Deoxy-2'-18F-fluoro-5-fluoro-1-β-D-arabinofuranosyluracil (^sup 18^F-FFAU) has been synthesized and evaluated in HT-29 cells as a potential PET agent for herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression. Methods: 2-Deoxy-2-^sup ...