The Journal of Nuclear Medicine back issues from April 2005:
Revision Status of USP Chapter <797> Pharmaceutical Compounding-Sterile Preparations
Apr 01, 2005; ... The U.S. Pharmacopeia (USP) 28 is the official source of Chapter <797> Pharmaceutical Compounding-Sterile Preparations. It is currently enforceable by the U.S. Food and Drug Administration (FDA). State boards of pharmacy have either adopted it into statute and regulations or are ...
ICANL Accreditation: A Sign of the Times . . . and the Future
Apr 01, 2005; ... Eight years ago, SNM and SNMTS recognized the importance of having an independent accrediting body tor nuclear medicine, PET, and nuclear cardiology laboratories. Joining with the Academy of Molecular Imaging, the American College of Cardiology, the American College of Nuclear Physicians, and ...
Erratum
Apr 01, 2005; ... March 2005 Newsline The subhead, "Goal: Membership in SNM Will Be Viewed as Essential by All With an Interest in the Field of Nuclear Medicine and Molecular Imaging," was ...
Media Cover DOE Nuclear Medicine Cuts
Apr 01, 2005; ... Under the banner headline "Nuclear Medicine Funds to Disappear Under Plan," Newsday writer Jamie Talan reported on March 2 on proposed budget cuts to nuclear medicine research by the U.S. Department of Energy (DOE). The author detailed the cuts, which would eliminate DOE funding of nuclear ...
Former DOE Worker Screening Program Expanded
Apr 01, 2005; ... U.S. secretary of Energy Samuel W. Bodman announced on February 9 the addition of 9 medical screening centers as part of the Department of Energy (DOE) Former Worker Medical Screening Program. Under this expansion, the program will offer all former DOE employees, contractors, and subcontractors ...
New NCI Gene Expression Database
Apr 01, 2005; ... Researchers at the National Cancer Institute (NCI) described in a press release on March 1 the creation of the largest open-source gene expression database for normal tissue from human organs. "Genes identified by the database as abnormally active in a particular disease could become potential ...
Bone Quality Assessment Meeting Scheduled
Apr 01, 2005; ... The National Institute of Arthritis and Musculoskeletal and Skin Dis eases and the American Society for Bone and Mineral Research, with cosponsors from the National Institute of Biomedical Imaging and Bioengineering and the French Institute of Health and Medical Research, will be offering a ...
Stokes, Lithium Pioneer, Dies
Apr 01, 2005; ... Peter E. Stokes, MD, a Cornell Medical College endocrinologist and psychiatrist and a pioneer in the use of lithium to treat manic depression, died January 22 at St. Luke'sRoosevelt Hospital Center in New York City. In addition to his work in psychiatry, Stokes also trained in neuroendocrinology ...
Initial Treatment with ^sup 131^I-Tositumomab
Apr 01, 2005; ... Evidence of the effectiveness of ^sup 131^I-tositumomab therapy continues to accrue, as the results of clinical trials are assessed and as elapsed time provides perspective on survival and quality of life. Results of a multiinstutional study were published in 2 journals in February. In the ...
PET in Follow-Up of Hepatic Tumor Ablation
Apr 01, 2005; ... Blokhuis et al. from the VU Medical Center (Amsterdam, The Netherlands) reported in a late-year supplement to the Scandinavian Journal of Gastroenterology (2004; 241[suppl]:93-97) on the use of ^sup 18^F-FDG PET and CT in long-term follow-up of patients who had undergone radiofrequency ablation ...
PET/CT in RT Planning for Non-Small Cell Lung Cancer
Apr 01, 2005; ... ^sup 18^F-FDG PET/CT and CT alone were compared in modeling of radiotherapy planning for patients with CT-staged N2-N3MO non-small cell lung cancer (NSCLC) in a study by van der WeI et al. from the Maastro Clinic (Maastricht, The Netherlands) published in the March 1 issue of the International ...
PET Assesses Function in Vegetative States
Apr 01, 2005; ... In an article published in the March issue of the Journal of Neurology, Neurosurgery, and Psychiatry (2005;76:432-434), Coleman et al. from Addenbrooke's Hospital (Cambridge, UK) reported on continued research with PET to identify and differentiate the neurologic characteristics of patients in ...
PET and Cardiac Hemodynamics in Adenosine Infusion
Apr 01, 2005; ... In an article published in the February 15 issue of the Journal of the American College of Cardiology (2005;45:553-558), Mishra et al. from the Harvard Medical School (Boston, MA) reported on the use of ^sup 13^N-ammonia PET to elucidate the relationship between myocardial blood flow and ...
SNMTS Names Scholarship Recipients; Announces New Awards
Apr 01, 2005; ... The Society of Nuclear Medicine Technologist section (SNMTS) announced the names of the first recipients of 2 newly created scholarships and also announced 2 additional scholarships that will be awarded at the SNM 2005 Annual Meeting in Toronto. On February 25, SNMTS officers reported ...
PET Identifies Spinal Cord Compression in Melanoma
Apr 01, 2005; ... In the March issue of the European Journal of Surgical Oncology (2005; 31:197-204), Francken et al. from the Royal Prince Alfred Hospital (Camperdown, Australia) described a study designed to evaluate the utility of 18FFDG PET in identifying spinal cord compression in patients with metastatic ...
^sup 99m^Tc-MDP and Bone Mineral Density Measurements
Apr 01, 2005; ... Campbell et al. from the Royal Perth Hospital (Australia) reported in the spring issue of the Journal of Clinical Densitometry (2005;8:14-17) on the effect of ^sup 99m^Tc-methylene diphosphonate ^sup 99m^1Tc-MDP) on bone mineral density (BMD) measurements in the lumbar spine and neck of the ...
CMS Activates CPT Codes, Discontinues G Codes for PET
Apr 01, 2005; ... The Centers for Medicare & Medicaid Services (CMS) announced in February activation of the adoption of Current Procedural Terminology (CPT) codes for PET procedures, essentially discontinuing previously used G series Healthcare Common Procedure Coding System (HCPCS) codes. This change will ...
^sup 11^C-WAY PET and Chronic Fatigue Syndrome
Apr 01, 2005; ... Cleare et al. from the Institute of Psychiatry and Guy's, King's and St. Thomas' School of Medicine (London, UK) reported in the February issue of Biological Psychiatry (2005; 57:239-246) on a study assessing brain 5-HT1A receptor binding potential using PET ^sup 11^C-WAY-100635 in patients with ...
Meeting Our Patients' Current, Future Needs for Radionuclides
Apr 01, 2005; ... SNM wants to promote a unified voice for this plan, which, when implemented, will assure our nation of a stable and secure supply of radionuclides for future generations. The future of radionuclide therapies and innovative research in molecular imaging/nuclear medicine depends on a ...
Characterization of Hyperinsulinism in Infancy Assessed with PET and ^sup 18^F-Fluoro-L-DOPA
Apr 01, 2005; ... Hyperinsulinism (HI) of infancy is a neuroendocrine disease secondary to either focal adenomatous hyperplasia or a diffuse abnormality of insulin secretion of the pancreas. HI with focal lesions can revert by selective surgical resection in contrast to the diffuse form, which requires subtotal ...
Timing of Examination Affects Reliability of ^sup 99m^Tc-Methoxyisobutylisonitrile SPECT in Distinguishing Neoplastic from Nonneoplastic Brain Hematomas
Apr 01, 2005; ... ^sup 99m^Tc-Methoxyisobutylisonitrile (MIBI) SPECT has been reported to be 100% sensitive and specific in the early differential diagnosis between neoplastic and nonneoplastic intraparenchymal cerebral hemorrhage (ICH), because nonneoplastic ICH does not show ^sup 99m^Tc-MIBI accumulation on ...
NRC to Amend Fees
Apr 01, 2005; ... The Nuclear Regulatory Commission (NRC) announced on February 22 a proposal to amend its regulations for the licensing, inspection, and annual fees it charges applicants and licensees for fiscal year (FY) 2005. The agency is required by Congress to recover for the Department of the Treasury 90% ...
Research Protection Assurances Simplified
Apr 01, 2005; ... The U.S. Department of Health and Human Services (HHS) on February 9 released a new and simplified mechanism tor all research institutions that receive HHS funding or support to obtain an assurance of compliance with HHS regulations for the protection of human subjects. A single Web-based ...
Comparison Between ^sup 18^F-FDG PET, In-Line PET/CT, and Software Fusion for Restaging of Recurrent Colorectal Cancer
Apr 01, 2005; ... The aim of this study was to compare PET with ^sup 18^F-FDG PET, in-line PET/CT, and software fusion of independently acquired CT and PET scans for staging of recurrent colorectal cancer (CRC). Methods: Fifty-one patients with suspected recurrent CRC were studied with in-line PET/CT. Thirty-four ...
Optimizing Imaging Protocols for Overweight and Obese Patients: A Lutetium Orthosilicate PET/CT Study
Apr 01, 2005; ... High photon attenuation and scatter in obese patients affect image quality. The purpose of the current study was to optimize lutetium orthosilicate (LSO) PET image acquisition protocols in patients weighing ≥91 kg (200 lb). Methods: Twenty-five consecutive patients (16 male and 9 female) ...
Bangladesh Nuclear Medicine Conference
Apr 01, 2005; ... The opening ceremony of the 10th National Conference and International Symposium of the Bangladesh Society of Nuclear Medicine highlighted the ways in which previously out-of-reach medical technologies are being made accessible here and in other developing nations. "Poor people are getting free ...
Joint NCI-FDA Fellowship Program Announced
Apr 01, 2005; ... In preparation for the new generation of molecular-based oncology medical products, the National Cancer Institute (NCI), part of the National Institutes of Health, and the Food and Drug Administration (FDA) announced on February 16 the creation of an NCI-FDA Research and Regulatory Review ...
Biodistribution and Radiation Dosimetry of ^sup 11^C-WAY100,635 in Humans
Apr 01, 2005; ... Serotonin 1A receptors have been implicated in a variety of conditions including depression, suicidal behavior, and aggression. Dose estimates for current human studies are based on data from rat dosimetry studies. We report the biodistribution and dosimetry of the PET serotonin 1A antagonist ...
Pharmacokinetics and Biodistribution of ^sup 111^In- and ^sup 177^Lu-Labeled J591 Antibody Specific for Prostate-Specific Membrane Antigen: Prediction of ^sup 90^Y-J591 Radiation Dosimetry Based on ^sup 111^In or ^sup 177^Lu?
Apr 01, 2005; ... ^sup 111^In-Labeled antibodies and peptides have been routinely used as chemical and biologic surrogates for ^sup 90^Y-labeled therapeutic agents. However, recent studies have shown that there are significant differences in biodistribution between ^sup 111^In- and ^sup 90^Y-labeled agents ....
Long-Circulating Liposomes as Delivery Agents
Apr 01, 2005; ... Oku and Namba from the University of Shizuoka (Japan) reported in the February issue of Methods in Enzymology (2005;391:145-162) on the use of glucuronate-modified, longcirculating liposomes as effective antitumor drug carriers in therapy. The survey article included data previously reported by ...
"Positherapy": ^sup 18^F-FDG in Breast Cancer
Apr 01, 2005; ... Therapy Moadel et al. from the Albert Einstein College of Medicine (Bronx, NY) reported in the February 1 issue of Cancer Research (2005:65:698-702) on continued research into targeted breast cancer therapy with ^sup 18^F-FDG, a technique the group has termed "positherapy." In previous ...
Accuracy of Myocardial Sodium/Iodide Symporter Gene Expression Imaging with Radioiodide: Evaluation with a Dual-Gene Adenovirus Vector
Apr 01, 2005; ... The sodium/iodide symporter (NIS) gene allows convenient reporter imaging with γ-cameras and free radioiodide. In this study, we investigated the accuracy of this technique for assessing myocardial gene expression in living rats by using a dual-gene adenovirus that expresses both NIS ...
PET and Aspects of Cerebral Blood Volume
Apr 01, 2005; ... Diagnosis Ito et al. from the Akita Research Institute of Brain and Blood Vessels (Japan) and Tohoku University (Sendai, Japan) recently published 2 reports in the Journal of Cerebral Blood Flow and Metabolism on the use of PET to measure aspects of cerebral blood volume (CBV). In the ...
Novel Analogs for PET-and SPECT-Aided RT
Apr 01, 2005; ... Ginj et al. from the University Hospital Basel (Switzerland) reported in the February 1 issue of Clinical Cancer Research (2005;! 1: 1136-1145) on preclinical evaluation of novel octreotide analogs with broad human somatostatin receptor (sstr) profiles for PET and SPECT imaging to refine targets ...
Noninvasive Monitoring of Target Gene Expression by Imaging Reporter Gene Expression in Living Animals Using Improved Bicistronic Vectors
Apr 01, 2005; ... Indirect, noninvasive imaging of therapeutic gene expression based on levels of reporter gene expression is a powerful tool to devise improved therapeutic strategies in cancer gene therapy. The use of bicistronic vectors carrying internal ribosome entry sites (IRESs) allows the coexpression of ...
PET in Parkinson's Response to Apomorphine
Apr 01, 2005; ... Hosey et al. from the National Institutes of Health (Bethesda, MD) and scientists from Rush University Medical Center (Chicago, IL) and the University of Amsterdam (The Netherlands) reported in the January/ February issue of Clinical Neuropharmacology (2005;28:18-27) on the use of H^sup 15^^sub ...
Preparation, Biodistribution, and Small Animal PET of ^sup 45^Ti-Transferrin
Apr 01, 2005; ... Investigation of ^sup 45^Ti-transferrin was pursued to provide insight into the mechanism of action of titanocene dichloride, a chemotherapeutic agent currently in clinical trials. Methods: Plasma protein-binding studies of processed ^sup 45^Ti were performed by solubilizing the ^sup 45^Ti ...
^sup 18^F-FDG PET and Depression in Early Alzheimer's
Apr 01, 2005; ... Holthoff et al. from the Dresden University of Technology (Germany) reported in the February 15 issue of Biological Psychology (2005;57:412421 ) on PET measures of altered cerebral glucose metabolism in patients with early Alzheimer's disease (AD). The study included 53 patients with early AD ...
Medical Image Analysis
Apr 01, 2005; ... Medical Image Analysis Atam P. Dhawan Hoboken. NJ: Wiley, 2003, 315 pages, $94.95 Medical linage Analysis covers the fundamentals of medical imaging, as well as image reconstruction, processing, and analysis, and briefly describes recent developments in these areas. The book is organized ...
PET, PET/CT, and MR Imaging in Charcot Neuroarthropathy
Apr 01, 2005; ... PET, hybrid PET/CT, and MR imaging were compared in the preoperative evaluation of diabetics with Charcot foot deformities in a study published in the December issue of Foot and Ankle International (2004; 25:890-895) by Hopfner et al. from the Justus-liebig University of Giessen (Germany). The ...
^sup 99m^Tc-Sestamibi in Radioguided Parathyroidectomy
Apr 01, 2005; ... In the March issue of the European Journal of Surgical Oncology (2005;31:191-196), Rubello et al. from the Istituto Oncologico Veneto (Rovigo, Italy) evaluated the efficacy of low-dose ^sup 99m^Tc-sestamibi administration for radioguided parathyroid surgery in patients with primary ...
Antimicrobial Peptide ^sup 99m^Tc-Ubiquicidin 29-41 as Human Infection-Imaging Agent: Clinical Trial
Apr 01, 2005; ... Ubiquicidin (UBI) 29-41 is a cationic, synthetic antimicrobial peptide fragment that binds preferentially with the anionic microbial cell membrane at the site of infection. The current study was conducted to evaluate its potential as an infection-imaging agent in humans. Methods: Eighteen ...
Myocardial ^sup 11^C-Diacylglycerol Accumulation and Left Ventricular Remodeling in Patients After Myocardial Infarction
Apr 01, 2005; ... Left ventricular (LV) remodeling after myocardial infarction (MI) is a maladaptive process that increases the risk of heart failure and death. The myocardial phosphoinositide cycle, which is located downstream from several neurohumoral factors, plays a crucial role in LV remodeling. Our animal ...
Imaging Glioma Extent with ^sup 131^I-TM-601
Apr 01, 2005; ... TM-601, a 36-amino-acid peptide, selectively binds to glioma cells but not normal brain parenchyma. A phase I/II clinical trial of intracavitary ^sup 131^I-TM-601 in adult patients with recurrent high-grade glioma was performed to determine the biodistribution and toxicity of this potential ...
On the Use of Positioning Aids to Reduce Misregistration in the Head and Neck in Whole-Body PET/CT Studies
Apr 01, 2005; ... Involuntary patient motion from insufficient patient preparation may lead to local misregistration of PET/CT images and, thus, can invalidate the attempt to fuse the resulting images. We estimate the efficacy of selected patient support structures in reducing the likelihood of patient motion in ...
Radiation Exposure of Patients Undergoing Whole-Body Dual-Modality ^sup 18^F-FDG PET/CT Examinations
Apr 01, 2005; ... We investigated radiation exposure of patients undergoing whole-body ^sup 18^F-FDG PET/CT examinations at 4 hospitals equipped with different tomographs. Methods: Patient doses were estimated by using established dose coefficients for ^sup 18^F-FDG and from thermoluminescent measurements ...
A Phase I Trial Combining High-Dose ^sup 90^Y-Labeled Humanized Anti-CEA Monoclonal Antibody with Doxorubicin and Peripheral Blood Stem Cell Rescue in Advanced Medullary Thyroid Cancer
Apr 01, 2005; ... This trial determined the pharmacokinetics, dosimetry, and dose-limiting toxicity of ^sup 90^Y-hMN-14 IgG (humanized anticarcinoembryonic antigen [CEA, or CEACAM5] monoclonal antibody; labetuzumab), combined with doxorubicin and peripheral blood stem cell (PBSC) support in advanced medullary ...
Patient-Specific Dosimetry of Pretargeted Radioimmunotherapy Using CC49 Fusion Protein in Patients with Gastrointestinal Malignancies
Apr 01, 2005; ... Pretargeted radioimmunotherapy (RIT) using CC49 fusion protein, comprised of CC49-(scFv)^sub 4^ and streptavidin, in conjunction with ^sup 90^Y/^sup 111^In-DOTA-biotin (DOTA = dodecanetetraacetic acid) provides a new opportunity to improve efficacy by increasing the tumor-to-normal tissue dose ...
Evaluation of ^sup 18^F-Annexin V as a PET Imaging Agent in an Animal Model of Apoptosis
Apr 01, 2005; ... Annexin V is a 36-kDa protein that binds with high affinity to phosphatidylserine lipids in the cell membrane. Because one of the earliest measurable events in apoptosis is the eversion of phosphatidylserine from the inner membrane leaflet to the outer cell surface, annexin V has proven useful ...
Biologic Correlates of Intratumoral Heterogeneity in ^sup 18^F-FDG Distribution with Regional Expression of Glucose Transporters and Hexokinase-II in Experimental Tumor
Apr 01, 2005; ... The biologic mechanisms involved in the intratumoral heterogeneous distribution of ^sup 18^F-FDG have not been fully investigated. To clarify factors inducing heterogeneous ^sup 18^F-FDG distribution, we determined the intratumoral distribution of ^sup 18^F-FDG by autoradiography (ARG) and ...
GRP Receptor-Targeted PET of a Rat Pancreas Carcinoma Xenograft in Nude Mice with a ^sup 68^Ga-Labeled Bombesin(6-14) Analog
Apr 01, 2005; ... Bombesin (BN), a 14-amino-acid peptide, shows high affinity for the human gastrin-releasing peptide receptor (GRP-r), which is overexpressed on several types of cancer, including prostate, breast, gastrointestinal, and small cell lung cancer. Thus, radio-labeled BN or BN analogs may prove to be ...
Diseases of the Brain, Head and Neck, Spine: Diagnostic Imaging and Interventional Techniques
Apr 01, 2005; ... Diseases of the Brain, Head and Neck, Spine: Diagnostic Imaging and Interventional Techniques G.K. Von Schulthess and Ch.L. Zollikofer, eds. New York, NY: Springer-Verlag, 2004, 200 pages, $99 This collection of 32 seminars presented during the 36th International Diagnostic Course in ...
Evaluation of Methods to Detect Interhemispheric Asymmetry on Cerebral Perfusion SPECT: Application to Epilepsy
Apr 01, 2005; ... Detecting perfusion interhemispheric asymmetry in neurologic nuclear medicine imaging is an interesting approach to epilepsy. Methods: This study compared 4 methods that detect interhemispheric asymmetries of brain perfusion in SPECT. The first (M1) was conventional side-by-side expert-based ...
Radiopharmaceutical Chemistry of Targeted Radiotherapeutics, Part 1: Effects of Solvent on the Degradation of Radiohalogenation Precursors by ^sup 211^At [alpha]-Particles
Apr 01, 2005; ... The high energy and short range of α-particles make them attractive for targeted radiotherapy. However, these properties can be problematic when the production of high activity levels of α-particle-emitting radiotherapeutics is required. For example, difficulties were encountered in ...