The Journal of Nuclear Medicine back issues from February 2006:
Enriching Professional Lives
Feb 01, 2006; ... The Society of Nuclear Medicine actively inaugurates and participates in programs and events to enrich its members' professional lives. SNM advances the highest standards in the practice of nuclear medicine and molecular imaging, addresses socioeconomic and governmental issues that significantly ...
The State of Nuclear Medicine 2006
Feb 01, 2006; ... From the Newsline Editor The year 2006 is off to a promising start for the nuclear medicine community. As I look at 2006 and rellect on 2005, I remain thankful that I am practicing nuclear medicine today and am able to experience the advances in medical technology, molecular medicine, ...
Preparing for the Future
Feb 01, 2006; ... The Society of Nuclear Medicine Technologist section is meeting the future head on: its officers have deliberated-and support-baccalaureate degree entry-level requirements for nuclear medicine technologists (NMTs) and the development of a master's degree-level nuclear medicine practitioner ...
SNM Government Relations Report
Feb 01, 2006; ... Department of Energy The administration's FY 2006 budget request for the Department of Energy (DOE) Office of Science cut approximately $23 million from the Medical Applications and Measurement Science program within the Office of Biological and Environmental Research (OBER)-a program ...
Education and Research Foundation for the SNM
Feb 01, 2006; ... The Education and Research Foundation (ERF) for the Society of Nuclear Medicine had a successful year in 2005 due to the generosity of the many members of SNM as well as industry. Its relationship with the SNM through the Strategic Alliance has continued and evolved to truly become a ...
Delivering Quality
Feb 01, 2006; ... The quality of the Society of Nuclear Medicine's programs, courses, meetings, products, and services is the result of high intention, sincere effort, intelligent direction, and skillful execution. Guided by SNM leaders, it is the society's habit to provide the best for our members-and this ...
Physics Applications in Nuclear Medicine: Organization and Progress
Feb 01, 2006; ... The year 2005 was again a year of significant progress in the area of physics applications in nuclear medicine. Significant developments were seen in detector development and reconstruction technology, and new tools became available. The dosimetry community organized several important compendia ...
SNM Brain Imaging Council
Feb 01, 2006; ... The SNM Brain Imaging Council (BIC) has been active in the initial part of its 2005-2006 term. One of the goals for the council has been to draft procedure guidelines for ^sup 18^F-FDG PET brain imaging for SNM. Alan Waxman, MD, is heading a task force charged with drafting the guidelines. Work ...
The SNM Strategic Plan for Education
Feb 01, 2006; ... The SNM Committee on Education held a meeting on September 16, 2005, to review the society's educational program to ensure that it meets our strategic goals and the needs of SNM members and other health care professionals with an interest in nuclear medicine and molecular imaging. The committee ...
The Young Professionals Committee
Feb 01, 2006; ... The SNM Young Professionals Committee (YPC) has gained great momentum over the past year and a half, and I am delighted to provide this brief summary to update the nuclear medicine community on our ongoing and upcoming endeavors. During the first half of the 2005-2006 year, the YPC's ...
From the Computer and Instrumentation Council
Feb 01, 2006; ... The year 2005 was busy for the SNM Computer and Instrumentation Council (CaIC). with much of the activity revolving around the Annual Meeting of the SNM, held last June in Toronto. Canada. Through the efforts of Tim Turkington, PhD, and David Cooke, MSEE, the council organized a categorical ...
International Atomic Energy Agency Highlights
Feb 01, 2006; ... It was a very good year for the International Atomic Energy Agency (IAEA). Any year in which you win the Nobel Peace Prize can be counted as good, but this hardworking group saw a number of long-term plans come to fruition in 2005 and achieved significant milestones in other projects, some with ...
From the Correlative Imaging Council
Feb 01, 2006; ... The SNM Correlative Imaging Council (CIC) had a very productive year, with educational activities continuing to be our main function. At the 2005 SNM Mid-Winter Meeting, the CIC organized an educational track in PET/CT. Topics included PET/CT instrumentation, CT protocols and techniques, ...
Committee on Pharmacopeia: Most Recent Proposed Revisions to USP <797>
Feb 01, 2006; ... Throughout the year, the Committee on Pharmacopeia (COP) of the SNM Radiopharmaceutical Sciences Council keeps members of the nuclear medicine community apprised of important news through the SNM Web site, periodic announcements, educational offerings at professional meetings, and articles in ...
Council on Radionuclides and Radiopharmaceuticals
Feb 01, 2006; ... The Energy Policy Act of 2005 Congress passed the Energy Policy Act of 2005. and President Bush signed it into law on August 8, 2005. The bill contained 2 important sections for nuclear medicine. First, the bill assured a continued supply of high-enriched uranium (HEU) that is used to ...
NRC and States Issue Controls Requirements
Feb 01, 2006; ... The Nuclear Regulatory Commission (NRC) and state regulators announced on December 5 the issuance of legally binding requirements to licensees to implement increased controls over radioactive materials in certain "quantities of concern." The requirements are the first part of a cooperative ...
Nuclear Medicine an Imaging Utilization Driver
Feb 01, 2006; ... In an article appearing in the January issue of the American Journal of Roentgenology (2006; 186:7-11), Matin and colleagues from the Brigham and Women's Hospital of the Harvard Medical School (Boston, MA) assessed the use of imaging services at their institution from 1993 to 2002 to determine ...
DOE Off-Site Source Recovery Project
Feb 01, 2006; ... On December 12 the U.S. Department of Energy (DOE) issued a special announcement about its program to recover excess and unwanted radioactive sealed sources presenting disposal difficulties. The DOE conducts the program with reduced or no costs to licensees. When initiated in the 1970s, the ...
NIH Launches Cancer Genomics Project
Feb 01, 2006; ... The National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) announced on December 13 the launch of a comprehensive effort to accelerate understanding of the molecular basis of cancer through the application of genome analysis technologies, especially large-scale ...
U.S. Progress Slow in Improving Patient Safety
Feb 01, 2006; ... A study published in the December 14 issue of the Journal of the American Medical Association (2005:294:2858-2865) and authored by Longo et al. from the University of Missouri-Columbia reported slow progress in improving patient safety in U.S. hospitals. In response to concerns originally raised ...
Fire Sale on NM Equipment?
Feb 01, 2006; ... A story in the December 9 issue of the Nashville Business Journal suggested that an "impending glut" in the PET imaging market will make used nuclear medicine equipment "a real bargain" during 2006. Attorney William Wright, Jr., wrote that the effects of the November 2 Centers for Medicare & ...
NIBIB Workshop on Point-of-Care Tech
Feb 01, 2006; ... The National Institute of Biomedical Imaging and Bioengineering (NIBIB), in partnership with the National Science Foundation (NSF), has announced a workshop to address the topic of "Improving Health Care Accessibility through Point-of-Care Technologies." The meeting, which will be held April 11 ...
^sup 90^Y Microsphere Treatment Response Measured by PET and CT
Feb 01, 2006; ... Lewandowski et al. from Northwestern Memorial Hospital (Chicago, IL), DataMedix Corp. (Newtown Square, PA), and the Johns Hopkins Hospital (Baltimore, MD) reported in the December issue of the Journal of Vascular and Interventional Radiology (2005;16:1641-1651) on a phase II study to determine ...
^sup 99m^Tc-Labeled mAb Detection of Ganglioside Expression in Breast Cancer
Feb 01, 2006; ... In an article e-published on December 2 ahead of print in Breast Cancer Research and Treatment, Oliva et al. from the National Institute of Oncology and Radiobiology (Havana. Cuba) described the use of ^sup 99m^Tc-labeled monoclonal antibody scintigraphy for in vivo detection of GM3(NeuGc) ...
Tolerance of Therapy After ^sup 131^I-Tositumomab RIT
Feb 01, 2006; ... Therapy and Adjunct Imaging In an article e-published on December 16 ahead of print in Cancer, Dosik et al. from the Weill Medical College of Cornell University and New York Presbyterian Hospital (New York, NY) reported on a study designed to determine whether patients with progressive ...
^sup 131^I Therapy and Juvenile Differentiated Thyroid Carcinoma
Feb 01, 2006; ... In an article published in the December issue of Endocrine-Related Cancer (2005; 12:773-803), Jarzab et al. from the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (Glidice, Poland) reviewed the current status and management of juvenile differentiated thyroid carcinoma ...
Radionuclide Therapy as Palliation
Feb 01, 2006; ... Liepe et al. from University Hospital Dresden (Radeberg. Germany) reported in the November/December issue of the American Journal of Hospice and Palliative Care (2005; 22:457-464) on a study investigating the efficacy and toxicity of several radiopharmaceuticals in the palliation of painful hone ...
PET Targeting of HSV Oncolytic Gene Therapy in Prostate Cancer
Feb 01, 2006; ... In an article e-published on December 16 ahead of print in the Journal of Molecular Imaging and Biology, Mullerad et al. from the Memorial Sloan-Kettering Cancer Center (New York, NY) reported on a proof of concept study of the ability of 18F-FDG PET to predict tumor response to oncolytic herpes ...
^sup 18^F-FDG PET Radioguided Surgery in Thyroid Cancer
Feb 01, 2006; ... Kraeber-Bodere et al. from the Hôtel Dieu Hospital and the René Gauducheau Cancer Center (Nantes. France) and the Claude Huriez Hospital (Lille. France) reported in the December issue of Suiycry (2005:138: 1176-1182) on the feasibility of ^sup 18^F-FDG PET radioguided surgery in patients with ...
SLN Biopsy and Oral Cancer Staging
Feb 01, 2006; ... In the December issue of Laryngoscope (2005;115:2217-2220), Rigual et al. from the Roswell Park Cancer Institute (Buffalo, NY) and St. Paul's Hospital (Vancouver, Canada) reported on a study to determine the feasibility and accuracy of sentinel lymph node (SLN) biopsy in the staging of patients ...
Early ^sup 18^F-FLT PET and Response to Breast Cancer Therapy
Feb 01, 2006; ... In an article e-published on December 14 ahead of print in the Journal of Molecular Imaging and Biology, Pio et al. from the David Geffen School of Medicine at the University of California Los Angeles compared the utility of ^sup 18^F-FDG and 3'-^sup 18^F-fluoro-3'-deoxythymidine (^sup 18^FFLT) ...
PET/CT and Thyroid Nodules Before Surgery
Feb 01, 2006; ... Mitchell et al. from Harvard Medical School (Boston, MA) reported in the December issue of Surgery (2005;138:1166-1175) on a study assessing the utility of ^sup 18^F-FDG PET/CT in the preoperative evaluation of thyroid nodules. The study included 31 patients with a total of 48 lesions who ...
^sup 131^I-MIBG Imaging and Pheochromocytoma
Feb 01, 2006; ... Diagnosis Guller et al. from University Hospital Basel (Basel, Switzerland), Durham Veterans Affairs Medical Center and Duke University (Durham, NC), and the University of Missouri (Columbia) reported in the January issue of Annals of Surgery (2006;243: 102-107) on a study designed to ...
PET and Brain Ammonia in Cirrhosis
Feb 01, 2006; ... In an article e-published in the December issue of Hepatology (2005; 43:42-50), Keiding et al. from the Aarhus University Hospital (Denmark) reported on the methodology and implications of PET imaging of brain metabolism of ^sup 13^N-ammonia during acute hepatic encephalopathy (HE) in patients ...
PET, CT, and Size of Lymph Nodes in NSCLC
Feb 01, 2006; ... In an article e-puhlished on December 5 ahead of print in the European Journal of Cardiothoracic Surgen; de Langen et al. reported on the results of a meta-analysis of published studies on metastatic involvement for different size categories of enlarged lymph nodes in patients with non-small ...
PET/CT vs CT in Adrenocortical Carcinoma
Feb 01, 2006; ... In an article e-published on December 20 ahead of print in the Journal of Clinical Endocrinology and Metabolism, Leboulleux et al. from the Institut Gustave Roussy (Villejuif, France) reported on a study comparing PET/CT and CT in diagnosis and prognosis of adrenocortical carcinoma. The study ...
Sentinel Lymph Node Biopsy in Melanoma
Feb 01, 2006; ... Sentinel lymph node (SLN) biopsy was first described by Morton et al. (1) in 1992 in patients with malignant melanoma. Many others over almost 100 y had made significant scientific contributions that ultimately led to the development of the technique (2-4): however, it was Morion's group from ...
^sup 99m^Tc-Sestamibi Scans and ^sup 18^F-FDG PET in Multiple Myeloma
Feb 01, 2006; ... Hung et al. from the Changhua Christian Hospital (Taiwan) reported in the November/December issue of Anticancer Research (2005:25:4737-4741) on a comparison of ^sup 99m^Tc-sestamibi scans and ^sup 18^F-FDG PET imaging in the assessment of multiple myeloma. The study included 12 patients with ...
PET Assessment Before Radical Hysterectomy
Feb 01, 2006; ... Unger et al. from lhc Louisiana State University Health Sciences Center (Shreveport) reported in the November/December issue of the Inli'riKitiomtl Journal of Gynecological Cancer (2005:15:1060-1064) on a retrospective study to evaluate the ability of whole-body ^sup 18^F-FDG PET imaging to ...
^sup 18^F-CPFPX PET: On the Generation of Parametric Images and the Effect of Scan Duration
Feb 01, 2006; ... 8-cyclopentyl-3-(3-^sup 18^F-fluoropropyl)-1-propylxanthine (^sup 18^F-CPFPX) is a novel PET ligand for in vivo quantification of cerebral A^sub 1^ adenosine receptors. The present study investigated the applicability of voxelwise graphical analysis to the generation of parametric images of the ...
PET and Surgical Management in Melanoma
Feb 01, 2006; ... In an article e-published on December 1 ahead of print in the British Journal of Surgery, Bastiaannet et al. from the University Medical Centre Groningen (The Netherlands) reported on a retrospective, multicenter study of the effect of ^sup 18^F-FDG PET imaging on surgical management in patients ...
Brain White-Matter Volume Loss and Glucose Hypometabolism Precede the Clinical Symptoms of Huntington's Disease
Feb 01, 2006; ... We studied the anatomic and functional changes in various brain areas during the course of Huntington's disease (HD) in a large cohort of mutation-positive individuals (n = 71) encompassing the complete range of disability (presymptomatic through stage V), and in healthy controls, for the ...
Radioimmunotherapy of Solid Tumors: The Promise of Pretargeting Strategies Using Bispecific Antibodies and Radiolabeled Haptens
Feb 01, 2006; ... Radioimmunotherapy (RIT) of malignancies has been studied for more than 2 decades (1). The basic premise of RIT-that monoclonal antibodies (mAbs) directed against a tumor-associated antigen can be used to target radionuclides to cancer cells for in situ radiation therapy-has been proven in ...
The Impact of Lymphoscintigraphy Technique on the Outcome of Sentinel Node Biopsy in 1,313 Patients with Cutaneous Melanoma: An Italian Multicentric Study (SOLISM-IMI)
Feb 01, 2006; ... An observational multicentric Italian trial on sentinel node biopsy (SNB) in melanoma patients was performed to diffuse a common SNB protocol nationwide (Italy). We report herein the results of this trial. The influence of some technical aspects on the outcome of SNB was also investigated, ...
Targeting, Toxicity, and Efficacy of 2-Step, Pretargeted Radioimmunotherapy Using a Chimeric Bispecific Antibody and ^sup 131^I-Labeled Bivalent Hapten in a Phase I Optimization Clinical Trial
Feb 01, 2006; ... Safety, targeting, and antitumor efficacy of pretargeted radioimmunotherapy using anti-carcinoembryonic antigen (CEA) hMN-14 × m734 bispecific antibody (BsmAb) and ^sup 131^I-di-diethylenetriamine pentaacetic acid (DTPA)-indium hapten were evaluated in a phase I study performed on patients with ...
PET Imaging of Serotonin Transporters with [^sup 11^C]DASB: Test-Retest Reproducibility Using a Multilinear Reference Tissue Parametric Imaging Method
Feb 01, 2006; ... Parametric imaging of serotonin transporters (SERT) with ^sup 11^C-labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile ([^sup 11^C]DASB) PET is a useful data analysis tool. The purpose of this study was to evaluate the reproducibility of measurements of SERT binding potential ...
Localization of Primary Prostate Cancer with Dual-Phase ^sup 18^F-Fluorocholine PET
Feb 01, 2006; ... This study compared ^sup 18^F-fluorocholine uptake in malignant and benign areas of the prostate at 2 time points to determine the suitability of delayed or dual-phase ^sup 18^F-fluorocholine PET for localizing malignancy in the prostate gland. Methods: Twenty-six men (15 newly diagnosed with ...
Factors Predicting Tracer Uptake in Somatostatin Receptor and MIBG Scintigraphy of Metastatic Gastroenteropancreatic Neuroendocrine Tumors
Feb 01, 2006; ... Radiolabeled octreotide analogs (Oct) and metaiodobenzylguanidine (MIBG) offer 2 different approaches for imaging and targeting metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NET). Despite successful establishment of the revised World Health Organization (WHO) classification, which ...
Bone Marrow Transplantation Nephropathy after an Intensified Conditioning Regimen with Radioimmunotherapy and Allogeneic Stem Cell Transplantation
Feb 01, 2006; ... Intensification of the conditioning regimen with a radioactively labeled anti-CD66 antibody is feasible before allogeneic stem cell transplantation. The use of radioimmunotherapy may deliver a significant dose of radiation to the kidneys. We therefore studied the incidence and clinical picture ...
^sup 18^F-FET PET Compared with ^sup 18^F-FDG PET and CT in Patients with Head and Neck Cancer
Feb 01, 2006; ... Recent studies suggest a somewhat selective uptake of O-(2-[^sup 18^F]fluoroethyl)-L-tyrosine (FET) in cerebral gliomas and in squamous cell carcinoma (SCC) and a good distinction between tumor and inflammation. The aim of this study was to investigate the diagnostic potential of ^sup 18^F-FET ...
Standard PET/CT of the Chest During Shallow Breathing Is Inadequate for Comprehensive Staging of Lung Cancer
Feb 01, 2006; ... The incidence of malignancy associated with subcentimeter pulmonary nodules (micronodules) in patients with malignant disease has been reported to be as high as 58%. Thus, detection of small lung nodules is important for appropriate staging of lung cancer. Because of respiratory motion, small ...
Biodistribution and Radiation Dosimetry of the Dopamine D^sub 2^ Ligand ^sup 11^C-Raclopride Determined from Human Whole-Body PET
Feb 01, 2006; ... Whole-body radiation dosimetry of ^sup 11^C-raclopride was performed in healthy human volunteers. Methods: Subjects (n = 6) were scanned with PET. Subjects received single-bolus injections of ^sup 11^C-raclopride ...
Visualization of Telomerase Reverse Transcriptase (hTERT) Promoter Activity Using a Trimodality Fusion Reporter Construct
Feb 01, 2006; ... Our goal was to noninvasively measure chemotherapy-induced changes in the expression of critical tumor growth genes. To achieve this goal, we used radionuclide and optical methods to measure changes in human telomerase reverse transcriptase (hTERT) gene expression in tumor cells before and after ...
Minimally Invasive Method of Determining Blood Input Function from PET Images in Rodents
Feb 01, 2006; ... For cardiovascular research on rodents, small-animal PET has limitations because of the inherent spatial resolution of the system and because of cardiac motion. A factor analysis (FA) technique for extracting the blood input function and myocardial time-activity curve from dynamic small-animal ...
PET Imaging of Brain 5-HT^sub 1A^ Receptors in Rat In Vivo with ^sup 18^F-FCWAY and Improvement by Successful Inhibition of Radioligand Defluorination with Miconazole
Feb 01, 2006; ... ^sup 18^F-FCWAY (^sup 18^F-trans-4-fluoro-N-(2-[4-(2-methoxyphenyl) piperazin-1-yl)ethyl]-N-(2-pyridyl)cyclohexanecarboxamide) is useful in clinical research with PET for measuring serotonin 1A (5-HT^sub 1A^) receptor densities in brain regions of human subjects but has significant bone uptake ...
The Detection of Bone Metastases in Patients with High-Risk Prostate Cancer: ^sup 99m^Tc-MDP Planar Bone Scintigraphy, Single- and Multi-Field-of-View SPECT, ^sup 18^F-Fluoride PET, and ^sup 18^F-Fluoride PET/CT
Feb 01, 2006; ... The aim of this study was to compare the detection of bone metastases by ^sup 99m^Tc-methylene diphosphonate (^sup 99m^Tc-MDP) planar bone scintigraphy (BS), SPECT, ^sup 18^F-Fluoride PET, and ^sup 18^F-Fluoride PET/CT in patients with high-risk prostate cancer. Methods: In a prospective study, ...
Brain Receptor Imaging*
Feb 01, 2006; ... Receptors have a prominent role in brain function, as they are the effector sites of neurotransmission at the postsynaptic membrane, have a regulatory role on presynaptic sites for transmitter reuptake and feedback, and are modulating various functions on the cell membrane. Distribution, ...
Annals of the ICRP: ICRP Publication 94-Release of Patients After Therapy with Unsealed Radionuclides
Feb 01, 2006; ... Annals of the TCRP: ICRP Publication 94-Release of Patients After Therapy with Unsealed Radionuclides J. Valentin, ed. New York, NY: Elsevier, 2004, 79 pages, $95 This interesting booklet documents the recommendations of the International Commission on Radiologie Protection (ICRP) on the ...
Initial Mechanistic Studies of Antisense Targeting in Cells
Feb 01, 2006; ... The continued development of antisense targeting will require a better understanding of the mechanism. Methods: We performed initial studies of the mechanism of intracellular antisense targeting through measurements of in situ transcription, immunofluorescence, reverse transcription polymerase ...
Initial Infarct Size Predicts Subsequent Cardiac Remodeling in the Rat Infarct Model: An In Vivo Serial Pinhole Gated SPECT Study
Feb 01, 2006; ... The rat infarct model is widely used to study left ventricular (LV) remodeling, a main cause of heart failure characterized by progressive LV dilatation. Using pinhole collimators and advances in data processing, gated SPECT was recently adapted to image the rat heart. The aim of this study was ...
RENEX: An Expert System for the Interpretation of ^sup 99m^Tc-MAG3 Scans to Detect Renal Obstruction
Feb 01, 2006; ... A renal expert system (RENEX) has been developed to assist physicians detect renal obstruction in patients undergoing pre- and postfurosemide ^sup 99m^Tc-mercaptoacetyltriglycine (^sup 99m^Tc-MAG3) scans. RENEX uses quantitative parameters extracted from the dynamic renal scan data and heuristic ...
Radiation and Modern Life: Fulfilling Marie Curie's Dream
Feb 01, 2006; ... Radiation and Modern Life: Fulfilling Marie Curie's Dream A.E. Waltar, ed. Amherst, NY: Prometheus Books, 2004, 336 pages, $28 Several aspects of this book are initially off-putting, including the author's style of writing. However, having read the book, set it aside, and let its message ...
In Vitro Modeling of the Clinical Interactions Between Octreotide and ^sup 111^In-Pentetreotide: Is There Evidence of Somatostatin Receptor Downregulation?
Feb 01, 2006; ... Some authors have suggested that chronic octreotide use enhances the efficiency of radiolabeled somatostatin receptor (sst) imaging. Conversely, desensitization of sst on tumor tissue (tachyphylaxis) may occur occasionally in patients on chronic octreotide therapy. Assuming that chronic exposure ...
Breast MRI: Diagnosis and Intervention
Feb 01, 2006; ... Breast MRI: Diagnosis and Intervention E.A. Morris and L. Liberman, eds. New York, NY: Springer, 2005, 513 pages, $149 MRI is gaining wider acceptance as a breast-imaging procedure, and its role in a variety of clinical indications is being examined. Despite its high sensitivity in ...
Serum Concentrations of IL-2 and TNF-[alpha] in Patients with Painful Bone Metastases: Correlation with Responses to ^sup 89^SrCl^sub 2^ Therapy
Feb 01, 2006; ... We have used ^sup 89^SrCl^sub 2^ for the palliative treatment of painful bone metastases from various malignant diseases. We studied the correlation between serum interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) levels and the response to ^sup 89^SrCl^sub 2^ therapy. Methods: ...