The Journal of Nuclear Medicine back issues from April 2006:
Q&A: Perspective on Pediatric Nuclear Medicine
Apr 01, 2006; ... Michael J. Gelfand, MD, is chief of the section of Nuclear Medicine at Cincinnati Children's Hospital Medical Center (OH) and a past president of SNM. He co-edited the 1994 text Pediatric Nuclear Imaging and has published more than 100 articles and 30 book chapters. Newsline spoke with Gelfand ...
Multiagency Effort to Focus on PET as Biomarker
Apr 01, 2006; ... On February 14, the National Cancer Institute (NCI), the Food and Drug Administration (FDA), and the Centers for Medicare and Medicaid Services (CMS) announced the formation of the Oncology Biomarker Qualification Initiative (OBQI), an agreement among the 3 agencies to collaborate on improving ...
SNM 2006 Awards Include New Initiatives and Innovative Support for Research and Education
Apr 01, 2006; ... A series of research awards and competitive grant recipients were announced by the SNM at its MidWinter Educational Symposium in Tempe, AZ, on February 11. Several of these funding mechanisms are new in 2006 and represent a renewed effort by the SNM and the Education and Research Foundation ...
A Memoir of Pediatric Nuclear Medicine: Part 1. Pioneers and Early Advances
Apr 01, 2006; ... Dr. Conrad Nagle, Newsline editor, has requested that I provide an essay on the history of pediatrie nuclear medicine. I recognize that the development of a complex medical discipline results from a series of introductory innovations and contributions by many individual practitioners and by ...
SNMTS Announces 2006 Scholarship and Grant Recipients
Apr 01, 2006; ... Al the SNM Mid-Winter Educational Symposium in Tempe, AZ, on February 11, the SNMTS released the names of 37 molecular and nuclear medicine technologist students and researchers who will be awarded a total of $58,000 in scholarships and grants in 2006. "Through its scholarship and grants ...
Our Preferred Future
Apr 01, 2006; ... As physicians, technologists, and scientists, we strive to be wise and enlightened guides to the young women and men who are our profession's future. We discuss-and often passionately express-our feelings about the necessary level of education needed for entry into the molecular and nuclear ...
SNM Works with USP, Congress, NRC on Diverse Issues
Apr 01, 2006; ... USP: MEDMARX Data On January 18 the United States Pharmacopeia (USP) released a MEDMARX database report on medication errors occurring in radiology services, cardiology cath labs, ICUs, and nuclear medicine departments during the period of 2000-2004. The data implied that very low ...
NIH Launches Large-Scale Alzheimer's Neuroimaging Study
Apr 01, 2006; ... The National Institute on Aging (NIA) of the National Institutes of Health (NIH) announced on February 10 an initiative to recruit 800 older adults to participate in a study aimed to identify biological markers of memory decline and Alzheimer's disease (AD), as part of the Alzheimer's Disease ...
2007 DOE Budget Requests Presented
Apr 01, 2006; ... On February 2, U.S. secretary of Energy Samuel W. Boclman announced President Bush's fiscal year (FY) 2007 budget for the Department of Energy (DOE), requesting $23.6 billion, a $ 124 million increase over the FY 2006 request. "This budget signifies an investment in our future." Bodman said ....
DOE/NIH Study to Evaluate Nuclear Medicine Effectiveness
Apr 01, 2006; ... Details of a $700,000 Department of Energy (DOE)/National Institutes of Health (NlH) study to determine the importance of nuclear medicine research came to light during a press briefing on "The Future of Medical Imaging: Transforming Health Care." held in Washington. DC. on January 31. In the ...
^sup 111^In-Labeled Carbon Nanotubes in Drug Delivery
Apr 01, 2006; ... Therapy Researchers from England and France reported on February 21 ahead of print in the Proceedings of !lie National Academy of Sciences USA on the pharmocokinetics and apparent safety of intravenously administered radiolabeled carbon nanotubes. a step that brings this innovative drug ...
Reluctant Radiologists?
Apr 01, 2006; ... According to the results of a survey released in January, 29% of radiologists practicing in the United States in 2005 would not choose medicine if given the opportunity to go back in time and choose another career, an increase of 24% since the question was last asked in 1997. The survey results ...
BioShield Contract for Radiation Countermeasures
Apr 01, 2006; ... The Department of Health and Human Services (HHS) announced on February 13 the award of a $21.9 million BioShield program contract to Akorn. Inc. of Buffalo Grove, IL, for the manufacture and delivery of 2 medical countermeasures for radiological or nuclear incidents. Akorn. Inc. will deliver ...
DOE Awards Supercomputing Time
Apr 01, 2006; ... On February 1. secretary of Energy Samuel W. Bodman announced that the DOE Office of Science had awarded a total of 18.2 million hours of computing time on some of the world's most powerful supercomputers to help researchers in government labs, universities, and industry who are working on ...
The Cost of Developing Imaging Agents
Apr 01, 2006; ... AD Nunn, from Bracco Research USA (Princeton, NJ) reported in the March issue of Investigative Radiology (2006;41:206-212) on the financial cost of developing imaging agents for routine clinical use and on the potential effects of these costs on the future clinical imaging agent environment ....
Nuclear Medicine in Germany
Apr 01, 2006; ... In an article in the January issue of Niikleannedicine (2006:45:1-9). Stamm-Meyer et al. reported on the frequency and collective effective doses of diagnostic nuclear medicine procedures in Germany between 1996 and 2002. The authors estimated the application frequencies for 10 groups of common ...
^sup 131^I-Metuximab in Hepatocellular Carcinoma
Apr 01, 2006; ... In a study e-published on March 20 ahead of print in Cancer Biology and Therapy, Zhang et al. from the Fourth Military Medical University (Xi'an, China) reported on research on the biodistribution, localization, and imaging characteristics of ^sup 131^I-labeled metuximab radioimmunotherapy (RIT) ...
HAMA Titers and Survival in RIT
Apr 01, 2006; ... Azinovic et al. from the Hospital San Jaime (Torrevieja. Spain) and the University of California, Davis (Sacramento), reported on February 22 ahead of print in Cancer Immunology, lmnnmofherapy on the relationship between human antimouse antibody (HAMA) and survival in patients with B-cell ...
^sup 18^F-FLT and ^sup 18^F-FDG PET in Thoracic Tumors
Apr 01, 2006; ... In a study published in the February issue of Chest (2006; 129:393-401), Yap et al. from the University of California at Los Angeles School of Medicine compared the use of ^sup 18^F-FTDG and ^sup 18^F-FLT in PET tumor staging and other characteristics in individuals with solitary pulmonary ...
^sup 18^F-FDG PET in RT Planning
Apr 01, 2006; ... Dietl et al. from the University of Regensburg (Germany) reported on February 21 ahead of print in Auris, Nasus, Larynx on the results of a prospective clinical analysis of the diagnostic and therapeutic effect of ^sup 18^F-FDG PET on planning radiotherapy in patients with advanced head and neck ...
Embryonic Stem Cell Therapy Visualization
Apr 01, 2006; ... In the February 21 issue of Circulation (2006;113:1005-114), a team of researchers from the Stanford University School of Medicine (CA) reported on work with embryonic stem cells that stably express fluorescence, bioluminescence, and PET reporter genes with a resulting imaging platform that can ...
^sup 18^F-Labeled Insulin for PET
Apr 01, 2006; ... Diagnosis Guenther et al. from McMaster University (Hamilton, ON) and Hamilton Health Sciences (ON) reported in the February 23 issue of the Journal of Medical Chemistry (2006;49:1466-1474) on a novel method for the preparation of ^sup 18^F-labeled insulin for use as a PET tracer and ...
PET/CT in Low Rectal Cancer
Apr 01, 2006; ... Gearhart et al. from the Johns Hopkins Medical Institution (Baltimore. MD) reported in the March issue of the Annals of Surgical Oncology (2006;13:397-404) on a study of the staging utility of pretreatment PET/CT in patients with low rectal cancer. The study included 37 previously untreated ...
Fused PET, MR, and CT Volume Targeting in RT
Apr 01, 2006; ... In a study e-published ahead of print on February 17 in the International Journal of Radiation Oncology, Biology, Physics, Milker-Zabel et al. from the University of Heidelberg (Germany) reported on the use of ^sup 68^GA-DOTATOC PET as a complementary modality to CT and MR imaging for target ...
PET vs Scintigraphy in Staging of Nasopharyngeal Cancer
Apr 01, 2006; ... Liu et al. from the Chang Gung Memorial Hospital (Taipei, Taiwan) reported in the February 1 issue of the Journal of Clinical Oncology (2006;24:599-604) on a study comparing ^sup 18^F-FDG PET and skeletal scintigraphy in the detection of bone metastasis in endemic nasopharyngeal carcinoma (NPC) ...
PET SUVs Predict Survival After Esophageal Surgery
Apr 01, 2006; ... In a study published in the March issue of the Annals of Thoracic Surgery (2006;81:1076-1081), Rizk et al. from the Memorial Sloan-Kettering Cancer Center (New York, NY) reported on a retrospective review of patients undergoing ^sup 18^F-FDG PET imaging before surgical resection for esophageal ...
PET/CT in Carcinoma of the Larynx
Apr 01, 2006; ... Gordin et al. from the Rambam Medical Center and the Carmel Medical Center (Haifa, Israel) reported in the February issue of Laryngoscope (2006,116:273-278) on a study designed to compare the efficacies of ^sup 18^F-FDG PET/CT with PET or CT alone in patients with carcinoma of the larynx. The ...
Preoperative PET in High-Risk Melanoma
Apr 01, 2006; ... In an article e-published ahead of print on February 15 in the Annals of Surgical Oncology, Brady et al. from the Memorial Sloan-Kettering Cancer Center (New York, NY) reported on the use of preoperative whole-body ^sup 18^F-FDG PET in addition to routine CT (chest, abdomen, and pelvis) in ...
Using Radiolabeled DNA as an Imaging Agent to Recognize Protein Targets
Apr 01, 2006; ... An the article by Hicke et al. (1) in this issue of The Journal of Nuclear Medicine, a method to target tumors by a novel class of imaging probes (aptamers) is developed and validated in a small-animal model. Aptamers are synthetic, singlestranded DNA or RNA molecules that have a unique ...
Hurthle Cell Thyroid Cancer Therapy
Apr 01, 2006; ... Besic et al. from the Institute of Oncology (Ljubljana, Slovenia) reported in the January issue of Thyroid (2006; 16:67-72) on a study designed to determine the factors associated with survival in patients with Hurthle cell papillary thyroid carcinoma (HCPTC) in Slovenia, an iodinedeficient ...
SPECT/CT and Functional Mapping of Brain Tumors
Apr 01, 2006; ... In a study published in the February issue of Cancer Biotherapy and Radiopharmaceuticals (2006;21:41-48), Filippi et al. from the University Tor Vergata (Rome, Italy) reported on research to assess the clinical usefulness and incremental value of fused ^sup 99m^Tc-tetrofosmin SPECT/CT for the ...
Effect of Intramyocardial Injection of Autologous Bone Marrow-Derived Mononuclear Cells on Perfusion, Function, and Viability in Patients with Drug-Refractory Chronic Ischemia
Apr 01, 2006; ... Intramyocardial injection of bone marrow cells has been proposed as a new therapeutic option for patients with chronic ischemic heart disease. We investigated whether autologous bone marrow-derived mononuclear cell injection into the myocardium of patients with drug-refractory ischemia reduces ...
Gluc-Lys([^sup 18^F]FP)-TOCA PET in Patients with SSTR-Positive Tumors: Biodistribution and Diagnostic Evaluation Compared with [^sup 111^In]DTPA-Octreotide
Apr 01, 2006; ... A recently developed ^sup 18^F-labeled PET tracer for somatostatin receptor (sstr) imaging, N^sup α^-(1-deoxy-D-fructosyl)-N^sup ε^-(2-[^sup 18^F]fluoropropionyl)-Lys^sup 0^-Tyr^sup 3^-octreotate (Gluc-Lys([^sup 18^F]FP)-TOCA), was evaluated in patients with sstr-positive tumors by ...
A Novel Approach to Multipinhole SPECT for Myocardial Perfusion Imaging
Apr 01, 2006; ... Myocardial perfusion imaging with SPECT remains critically important for diagnosing, assessing, and evaluating treatment of coronary artery disease. However, conventional rotational SPECT suffers from prolonged study times because of relatively low detection efficiency. We therefore have ...
SPECT/CT Using ^sup 67^Ga and ^sup 111^In-Labeled Leukocyte Scintigraphy for Diagnosis of Infection
Apr 01, 2006; ... The present study evaluated the role of SPECT/CT as an adjunct to ^sup 67^Ga (GS) or ^sup 111^In-labeled white blood cell (WBC) scintigraphy for diagnosis or localization of infection. Methods: Eighty-two patients (56 male and 26 female; mean age, 62 y) assessed for known or suspected infectious ...
Bone Marrow Hypermetabolism on ^sup 18^F-FDG PET as a Survival Prognostic Factor in Non-Small Cell Lung Cancer
Apr 01, 2006; ... PET is now widely used in the diagnosis and staging of lung cancer with ^sup 18^F-FDG. The purpose of the study was to evaluate the prognostic value of diffuse bone marrow hypermetabolism along with other PET prognostic factors with respect to survival and compare them with other established ...
Focal Thyroid Lesions Incidentally Identified by Integrated ^sup 18^F-FDG PET/CT: Clinical Significance and Improved Characterization
Apr 01, 2006; ... In this retrospective study, we investigated whether the ^sup 18^F-FDG uptake pattern and CT findings improved the accuracy over the standardized uptake value (SUV) for differentiating benign from malignant focal thyroid lesions incidentally found on ^sup 18^F-FDG PET/CT. We also defined the ...
Integrated PET/CT in Differentiated Thyroid Cancer: Diagnostic Accuracy and Impact on Patient Management
Apr 01, 2006; ... The aim of this study was to investigate the diagnostic accuracy and impact on patient management of the new integrated PET/ CT modality in patients with suspected iodine-negative, differentiated thyroid carcinoma (DTC). Methods: Forty patients with DTC and a suggestion of iodine-negative tumor ...
Validation of a Blood-Sampling Method for the Measurement of ^sup 99m^Tc-Methylene Diphosphonate Skeletal Plasma Clearance
Apr 01, 2006; ... Quantitative studies of bone using ^sup 99m^Tc-methylene diphosphonate (MDP) reflect bone remodeling. The simplest method of evaluating ^sup 99m^Tc-MDP kinetics involves taking multiple blood samples and measuring total clearance (K^sub total^) from the area under the plasma curve (AUC) and ...
Dual-Time-Point ^sup 18^F-FDG PET for the Evaluation of Gallbladder Carcinoma
Apr 01, 2006; ... Conventional imaging techniques such as ultrasonography, CT, and MRI are able to detect gallbladder abnormalities but are not always able to differentiate a malignancy from other disease processes such as cholecystitis. The purpose of the present study was to evaluate the efficacy of ...
Stunning and Its Effect on ^sup 3^H-FDG Uptake and Key Gene Expression in Breast Cancer Cells Undergoing Chemotherapy
Apr 01, 2006; ... Shortly after chemotherapy, relatively little is known about the expression of key genes and proteins involved in glycolysis. Doxorubicin (DOX) and 5-fluorouracil (5FU) are two commonly used chemotherapy agents that work through differing pathways. Glucose transporter-1 (Glut-1) and hexokinase ...
Performance Test of an LSO-APD Detector in a 7-T MRI Scanner for Simultaneous PET/MRI
Apr 01, 2006; ... PET combined with CT has proven to be a valuable multimodality imaging device revealing both functional and anatomic information. Although PET/CT has become completely integrated into routine clinical application and also has been used in small-animal imaging, CT provides only limited ...
Voxel-Based Mouse and Rat Models for Internal Dose Calculations
Apr 01, 2006; ... The ability to estimate absorbed doses in experimental animals to which radiolabeled material has been administered may be important in explaining and controlling potential radiation toxicity observed during preclinical trials. Most previously reported models for establishing doses to small ...
Potential Increased Tumor-Dose Delivery with Combined ^sup 131^I-MIBG and ^sup 90^Y-DOTATOC Treatment in Neuroendocrine Tumors: A Theoretic Model
Apr 01, 2006; ... ^sup 131^I-Metaiodobenzylguanidine (MIBG) and ^sup 90^Y-DOTA-D-Phe1-Tyr3-octreotide (DOTATOC) have been used as radiotherapeutic agents for treating neuroendocrine tumors. The tumor dose delivered by these agents is often insufficient to control or cure the disease. However, these 2 agents used ...
Imaging Infection with ^sup 18^F-FDG-Labeled Leukocyte PET/CT: Initial Experience in 21 Patients
Apr 01, 2006; ... The aim of this study was to assess the feasibility and the potential role of PET/CT with ^sup 18^F-FDG-labeled autologous leukocytes in the diagnosis and localization of infectious lesions. Methods: Twenty-one consecutive patients with suspected or documented infection were prospectively ...
Assessment of Myocardial Metabolism in Diabetic Rats Using Small-Animal PET: A Feasibility Study
Apr 01, 2006; ... This feasibility study was undertaken to determine whether kinetic modeling in conjunction with small-animal PET could noninvasively quantify alterations in myocardial perfusion and substrate metabolism in rats. Methods: All small-animal PET was performed on either of 2 tomographs. Myocardial ...
Iodine Biokinetics and Dosimetry in Radioiodine Therapy of Thyroid Cancer: Procedures and Results of a Prospective International Controlled Study of Ablation After rhTSH or Hormone Withdrawal
Apr 01, 2006; ... Technical aspects and results of the dosimetric assessments of postoperative radioiodine ablation in the framework of an international, prospective, controlled, randomized, comparative study of the effectiveness of ablation therapy with 3.7 GBq ^sup 131^I in differentiated thyroid cancer after ...
Evaluation of D-Isomers of O-^sup 11^C-Methyl Tyrosine and O-^sup 18^F-Fluoromethyl Tyrosine as Tumor-Imaging Agents in Tumor-Bearing Mice: Comparison with L- and D-^sup 11^C-Methionine
Apr 01, 2006; ... The aim of this study was to investigate whether D-amino acid isomers of O-^sup 11^C-methyl tyrosine (^sup 11^C-CMT) and O-^sup 18^F-fluoromethyl tyrosine (^sup 18^F-FMT) were better than the corresponding L-isomers as tumor- detecting agents with PET in comparison with the difference between L- ...
Preclinical Safety Evaluation of ^sup 18^F-FHBG: A PET Reporter Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase (HSV1-tk) or Mutant HSV1-sr39tk's Expression
Apr 01, 2006; ... 9-(4-^sup 18^F-Fluoro-3-[hydroxymethyl]butyl)guanine (^sup 18^F-FHBG) is a sensitive and specific PET reporter probe for imaging the PET reporter genes, herpes himplex 1 thymidine kinase (HSV1-tk) and its mutant HSV1-sr39tk. ^sup 18^F-FHBG has suitable pharmacokinetics and dosimetry for clinical ...
Enhanced Efficacy of ^sup 90^Y-Radiolabeled Anti-Lewis Y Humanized Monoclonal Antibody hu3S193 and Paclitaxel Combined-Modality Radioimmunotherapy in a Breast Cancer Model
Apr 01, 2006; ... Radioimmunotherapy (RIT) of solid tumor is often limited in efficacy because of restrictions in achieved tumor dose. In an effort to overcome this, the combination of RIT with other therapeutic modalities was investigated in an animal model of breast carcinoma. The rationale for this ...
Contrast Agents III: Radiopharmaceuticals-From Diagnostics to Therapeutics
Apr 01, 2006; ... Contrast Agents III: Radiopharmaceuticals-From Diagnostics to Therapeutics W. Krause, ed. New York, NY: Springer-Verlag, 2005, 222 pages, $189 The main goal of this book is to provide the reader with the chemical, radiochemical, and biologic knowledge necessary for the development of ...
Basics of PET Imaging: Physics, Chemistry, and Regulations
Apr 01, 2006; ... Basics of PET Imaging: Physics, Chemistry, and Regulations G.B. Saha, ed. New York, NY: Springer, 2005, 206 pages, $59.95 Molecular biologic discoveries have great implications for disease prevention, detection, and targeted therapy. Molecular diagnostics (i.e., prostate-specific ...
Radiosynthesis and Preclinical Evaluation of ^sup 11^C-ABP688 as a Probe for Imaging the Metabotropic Glutamate Receptor Subtype 5
Apr 01, 2006; ... ^sup 11^C-ABP688 (3-(6-methyl-pyridin-2-ylethynyl)-cyclohex-2-enoneO-^sup 11^C-methyl-oxime), a noncompetitive and highly selective antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5), was evaluated for its potential as a PET agent. Methods: ABP688 was radiolabeled with ^sup ...
Tumor Targeting by an Aptamer
Apr 01, 2006; ... Aptamers are small oligonucleotides that are selected to bind tightly and specifically to a target molecule. We sought to determine whether aptamers have potential for in vivo delivery of radioisotopes or cytotoxic agents. Methods: TTA1, an aptamer to the extracellular matrix protein tenascin-C, ...
Clinical PET and PET/CT
Apr 01, 2006; ... Clinical PET and PET/CT H. Jadvar and J. A. Parker New York, NY: Springer, 2005, 279 pages, $69.95 This is a small book consisting of 279 pages that are divided into 18 chapters. The first chapter covers in reasonable detail the basic physics of and instrumentation used in PET and PET/ ...
Advantage of Late Scanning in Brain ^sup 18^F-FDG PET/REPLY
Apr 01, 2006; ... TO THE EDITOR: I have read with great interest and enthusiasm the recent article by Chen et al. on the rapid scanning protocol for brain ^sup 18^F-FDG PET (1). They found that rapid scanning for brain ^sup 18^F-FDG PET is nearly equivalent to conventional scanning in the diagnosis of Alzheimer's ...