The Journal of Nuclear Medicine back issues from August 2007:
Early Results from Alzheimer's Neuroimaging Biomarker Project
Aug 01, 2007; ... Alzheimer's disease (AD) researchers soon may be able to reduce the time and expense associated with clinical trials, according to early results from the AD Neuroimaging Initiative ( ADNI), a public-private research partnership organized by the National Institutes of Health (NIH). Preliminary ...
Erratum
Aug 01, 2007; ... In the article "SNMTS Honors Member Contributions, Achievements" (J Nucl. Med. 2007;48[7]:22N), the photo caption incorrectly ...
Alazraki Named as AFIP Distinguished Scientist
Aug 01, 2007; ... Naomi Alazraki, MD, professor of radiology at the Emory University School of Medicine and chief of nuclear medicine at the Atlanta (GA) Veterans Affairs (VA) Medical Center, is this year's recipient of the Distinguished Scientist Award from the Armed Forces Institute of Pathology (AFIP) ...
Through Grants and Awards, SNM Advances Molecular Imaging
Aug 01, 2007; ... Molecular imaging promises to extend current knowledge about the pathogenesis of many diseases to new meaningful dimensions that can play a pivotal role in prolonging patient lives with quality and dignity. History suggests that advancing medicine is a science as well as an art and relies ...
Molecular Imaging: Thriving All Over the World
Aug 01, 2007; ... The Highlights Lecture is presented at the closing session of each SNM Annual Meeting by Henry N. Wagner, Jr., MD. This year's lecture was presented on June 6 in Washington, DC. To mark the 30th year in which Wagner has presented this summary of presentations, innovations, and personal ...
U.S./European Pharmaceutical Cooperation
Aug 01, 2007; ... The U.S. Food and Drug Administration (FDA), the European Commission (EC), and the European Medicines Agency (EMEA) announced on June 18 their agreement to expand current cooperative activities in several areas. At a meeting held June 14-15, the FDA and the EU reviewed the past year's activities ...
Mobile PET/CT Staff More Exposed To Radiation, Study Shows
Aug 01, 2007; ... On June 13 Researchers from Surrey University (Guildford, UK) reported on a study suggesting additional precautions and rathation dose awareness for those staffing mobile PET/CT units. The results of the study were presented at the United Kingdom Radiological Congress (Manchester) by Khalid ...
Pennsylvania Requests Agreement State Status
Aug 01, 2007; ... The Nuclear Regulatory Commission (NRC) announced on June 15 that it is considering a request from Governor Edward G. Rendell of Pennsylvania to assume part of the NRCs regulatory authority over certain nuclear materials in the state. If the request is accepted, Pennsylvania will become the 35th ...
HHS Advisory Board to be Appointed
Aug 01, 2007; ... U.S. Department of Health and Human Services (HHS) Secretary Mike Leavitt announced on June 19 the establishment of a public health advisory panel on chemical, biological, nuclear, and radiological agents. To be called the National Biodefense Science Board, the group will advise the secretary on ...
NIH Funds Knockout Mouse Repository
Aug 01, 2007; ... The National Institutes of Health (NIH) announced on June 26 $4.8 million in funding to establish and support a repository for its Knockout Mouse Project (KOMP). This award is the final component of a more than $50-million trans-NIH initiative to increase the availability of genetically altered ...
Imaging and NIH High-End Instrumentation Grants
Aug 01, 2007; ... The National Center for Research Resources (NCRR), a part of the National Institutes of Health (NIH), announced announced on June 1 2 that it will provide $20.65 million for 14 high-end instrumentation (HEI) grants to fund cutting-edge equipment required in biomedical research. Of these ...
Radiation Summer School
Aug 01, 2007; ... Students and scientists from around the world gathered at the U.S. Department of Energy Brookhaven National Laboratory (BNL; Upton, NY) to participate in the 4th annual National Aeronautics and Space Administration (NASA) Space Rathation Summer School. The group worked in BNL's Medical ...
Monitoring Stem Cell Migration and Metabolism
Aug 01, 2007; ... MOLECULAR IMAGING In an article e-published on June 22 ahead of print in Contrast Media and Molecular imaging. Cicchetti et al. from the Centre Hospitalier Université Laval (Quebec City, Canada) reported on dual-modality in vivo monitoring of subventricular zone (SVZ) stem celi migration ...
NIH to Examine Peer Review
Aug 01, 2007; ... National Institutes of Health (NlH) Director Elias A. Zerhouni, MD, announced on June 8 the formation of 2 working groups to examine the NIH peer review process for funding scientific research. "Peer review is such a fundamental and critical part of the research process, that it requires our ...
Suicide Gene Therapy and Radiation in Pancreatic Cancer
Aug 01, 2007; ... In an article e-published on June 5 ahead of print in Molecular Therapy, Freytag et al. from the Henry Ford Health System (Detroit, MI) reported on the efficacy and toxicity of a combination of replication-competent, adenovirus-methated suicide gene therapy and rathation in a preclinical model ...
Long-Term Monitoring of Stem Cells
Aug 01, 2007; ... Guzman et al. from the Stanford University School of Medicine (CA) reported on June 12 in the Proceedings of the National Academy of Sciences USA (2007;104:10211-10216) on an investigation of the utility of MR imaging in long-term monitoring of transplanted human neurai stems cells. The group ...
Molecular Markers in Esophageal Cancer Treatment
Aug 01, 2007; ... Banki et al. from the University of Southern California (Los Angeles) reported in the June issue of the Archives of Surgery (2007;142:533-539) on a study designed to identify a molecular marker for completeness of resection and recurrent disease in patients with esophageal cancer. The study ...
NCI Launches Community Cancer Centers Program
Aug 01, 2007; ... The National Cancer Institute (NCI), part of the National Institutes of Health (NIH), announced on June 14 the launch of a 3-year pilot phase of a new program designed to bring stateof-the-art cancer care to patients in community hospitals across the United States. The NCI Community Cancer ...
Single Cell Detection with MR
Aug 01, 2007; ... In an article e-published on May 31 ahead of print in Contrast Media and Molecular Imaging, Shapiro et al. from Yale University School of Medicine (New Haven, CT) reported on a novel iron oxide labeling technique that facilitates single-cell detection by MR imaging. The researchers labeled rat ...
rhTSH-Stimulated ^sup 131^I Therapy in Large Goiters
Aug 01, 2007; ... THERAPY Bonnema et al. from the Odense University Hospital (Denmark) reported on June 12 ahead of print in the Journal of Clinical Endocrinology and Metabolism on a double-blinded randomized trial of the effect of 131I therapy amplification by recombinant human thyrotropin (rhTSH) ...
Low-Dose-Rate ^sup 227^Th RIT
Aug 01, 2007; ... In an article e-published on May 29 ahead of print in Blood, Dahl e et al. from the Norwegian Radium Hospital (Oslo) reported on stuthes of targeted cancer therapy with a novel low-doserate a-emitting radioimmunoconjugate. The authors labeled rituximab with ^sup 227^Th, a combination that ...
SPECT/CT and Bioluminescence in Breast Cancer Metastasis
Aug 01, 2007; ... Cowey et al. from the University of Alabama at Birmingham reported on May 31 ahead of print in Clinical and Experimental Metastasis on an evaluation of bioluminescent imaging and microSPECT/CT for detecting bone metastasis in mice. The study included young (5-weeks old) mice that received an ...
Microbubble US, PET, and MR in Tumor Perfusion
Aug 01, 2007; ... Niermann et al. from Vanderbilt University Medical Center (Nashville, TN) reported in the June issue of the Journal of Ultrasound in Medicine (2007;26:749-756) on a study correlating microbubble contrast-enhanced sonography with dynamic contrastenhanced MR imaging and ^sup 18^F-FDG PET in the ...
^sup 90^Y-Labeled mAb in Ovarian Cancer
Aug 01, 2007; ... In a study published in the June 15 issue of the International Journal of Cancer (2007;120:2710-2714), Oei et al. from the Radboud University Nijmegen Medical Centre (The Netherlands) reported on a study analyzing the sites and patterns of disease recurrence in patients with epithelial ovarian ...
^sup 213^Bi RIT in Early-Stage Gastric Cancer
Aug 01, 2007; ... Beck et al. from the Technische Universität München (Germany) reported on June 11 ahead of print in Cancer Science on a study designed to optimize the efficacy and evaluate the long-term toxicity of ^sup 213^Bi-labeled immunoconjugate radioimmunotherapy (RIT) in a mouse model of early and ...
Laparoscopic SLN Mapping in Cervical Cancer
Aug 01, 2007; ... DIAGNOSIS Kushner et al. from the University of Wisconsin School of Medicine and Public Health (Madison) reported on June 8 ahead of print in GynecologicOncology on a detailed time analysis of experience with a laparoscopic approach to sentinel lymph node (SLN) detection in cervical ...
PET and Posttherapy Assessment in Head and Neck Cancer
Aug 01, 2007; ... Yao et al. from University of Iowa Health Care (Iowa City) reported in the June issue of the American Journal of Clinical Oncology (2007;30:264-270) on a study designed to determine whether 18F-FDG PET can predict the pathology status of residual cervical lymph nodes in patients undergoing ...
PET as a Predictor in B-Cell Lymphoma
Aug 01, 2007; ... In an article published in the June issue of Haematologica (2007;92: 778-783), Dupuis et al. from the Paris XII University (Créteil, France) reported on the respective prognostic values of germinal center phenotype classification and early PET imaging in selecting optimal treatment strategies in ...
PET and Scintigraphy in Lymphoma: Pathologic Comparison
Aug 01, 2007; ... In an article e-published on June 20 ahead of print in Cancer, Tsukamoto et al. from the Gunma University Graduate School of Medicine (Japan) correlated the comparative efficacies of ^sup 18^F-FDG PET and ^sup 67^Ga scintigraphy in lymphoma with the World Health Organization (WHO) histologic ...
PET in Colorectal Cancer Diagnosis
Aug 01, 2007; ... In an article e-published on June 7 ahead of print in the World Journal of Surgical Oncology, Sarikaya et al. from the Ohio State University (Columbus) reported on the utility of ^sup 18^F-FDG PET imaging in patients with clinically and/or radiologically suspicious colorectal cancer but whose ...
PET/CT and IMRT in Pharyngeal Carcinoma
Aug 01, 2007; ... Rothschild et al. from the University of Zurich (Switzerland) reported on June 9 ahead of print in Rathation Oncology on a study of the value added by hybrid ^sup 18^F-FDG PET/CT in intensity-modulated radiotherapy (IMRT) for locally advanced pharyngeal carcinoma. The retrospective study ...
Role of ^sup 18^F-FDG PET/CT in Management of High-Grade Salivary Gland Malignancies
Aug 01, 2007; ... The role of ^sup 18^F-FDG PET/CT for planning the treatment of highgrade salivary gland malignancies was investigated and was compared with that with using contrast-enhanced CT. Methods: The subjects chosen for the study had high-grade cancer of the salivary gland, as confirmed by surgical ...
^sup 68^Ga-Labeled Bombesin Studies in Patients with Gastrointestinal Stromal Tumors: Comparison with ^sup 18^F-FDG
Aug 01, 2007; ... Dynamic PET stuthes with a ^sup 68^Ga-bombesin analog, DOTA-PEG^sub 2^-[D-Tyr^sup 6^, β-Ala^sup 11^,Thi^sup 13^,Nle^sup 14^] BN(6-14) amide (^sup 68^Ga-BZH^sub 3^; DOTA is 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid, and PEG is ethylene glycol [2-aminoethyl-carboxymethyl ...
^sup 99m^Tc-HMPAO SPECT Study of Cerebral Perfusion After Treatment with Medication and Electroconvulsive Therapy in Major Depression
Aug 01, 2007; ... Compromised regional cerebral blood flow (rCBF) in major depressive disorder may be partly reversed by successful antidepressant treatment. However, it is not known if the reversal of rCBF compromise is dependant on the mode of antidepressant treatment. The current study aimed to address this ...
Prosthetic Vascular Graft Infection: The Role of ^sup 18^F-FDG PET/CT
Aug 01, 2007; ... Graft infection after prosthetic vascular reconstruction is an uncommon but severe complication. The clinical presentation is often subtle and nonspecific and may occur long after surgery. Although defining a prosthetic vascular graft infection can be difficult, early diagnosis and treatment are ...
Diagnosis of Vascular Prosthesis Infection: PET or SPECT?
Aug 01, 2007; ... The well-established gold standard for imaging infection is scintigraphy with radiolabeled autologous white blood cells (WBCs). Indeed, 2 years ago, in a metaanalysis of all papers published in the previous 20 years on imaging techniques for the diagnosis of infection (1-4), the importance of ...
Effect of Reconstruction Algorithms on Myocardial Blood Flow Measurement with ^sup 13^N-Ammonia PET
Aug 01, 2007; ... Filtered backprojection (FBP) is the traditional method for ^sup 13^NNH^sub 3^ PET studies. Ordered-subsets expectation maximization (OSEM) is popular for PET studies because of better noise properties. Scant data exist on the effect of reconstruction algorithms on quantitative myocardial blood ...
Test-Retest Reproducibility of ^sup 18^F-MPPF PET in Healthy Humans: A Reliability Study
Aug 01, 2007; ... The aim of this study was to assess the reliability of 2'-methoxyphenyl-(N-2'-pyridinyl)-p-^sup 18^F-fluoro-benzamidoethylpiperazine (^sup 18^F-MPPF) PET binding parameter's quantification via a test-retest study over a long-term period. Methods: Ten healthy volunteers underwent 2 dynamic ^sup ...
Effect of Postconditioning on Myocardial ^sup 99m^Tc-Annexin-V Uptake: Comparison with Ischemic Preconditioning and Caspase Inhibitor Treatment
Aug 01, 2007; ... ^sup 99m^Tc-Annexin-V imaging has been proved to be feasible to detect phosphatidylserine, which externalizes on the outer cell membrane early in the process of apoptosis. To determine whether postconditioning suppresses myocardial cell damage or apoptosis, we evaluated the intensity and ...
Diagnostic and Prognostic Value of ^sup 18^F-FDG PET/CT for Patients with Suspected Recurrence from Squamous Cell Carcinoma of the Esophagus
Aug 01, 2007; ... Patients with esophageal squamous cell carcinoma (ESCC) are commonly at high risk of recurrence within 2 y after initial treatment. The aim of this study was to evaluate the role of ^sup 18^F-FDG PET/CT in patients with possibly recurrent ESCC who underwent definitive treatment. Methods: ...
Treatment of Breast Tumor Cells In Vitro with the Mitochondrial Membrane Potential Dissipater Valinomycin Increases ^sup 18^F-FDG Incorporation
Aug 01, 2007; ... Mitochondrial membrane potential is essential for adenosine triphosphate (ATP) synthesis by oxidative phosphorylation, and its abolition is an early event during apoptosis, a type of cell death commonly exhibited by tumor cells responding to treatment. Dissipation of mitochondrial membrane ...
Role of Neuroimaging in Alzheimer's Disease, with Emphasis on Brain Perfusion SPECT*
Aug 01, 2007; ... Structural MRI and functional imaging by SPECT as well as ^sup 18^F-FDG PET are widely used in the diagnosis of Alzheimer's disease (AD). Metabolic and perfusion reductions in the parietotemporal association cortex are recognized as a diagnostic pattern for AD. Outstanding progress in the ...
The Effects of Estrogen, Progesterone, and C-erbB-2 Receptor States on ^sup 18^F-FDG Uptake of Primary Breast Cancer Lesions
Aug 01, 2007; ... The purpose of this prospective study was to investigate whether correlations exist between 18F-FDG uptake of primary breast cancer lesions and predictive and prognostic factors such as estrogen receptor (ER), progesterone receptor (PR), and C-erbB-2 receptor (C-erbB-2R) states. Methods: Before ...
Rapid Reduction of ¿^sub 1^-Receptor Binding and ^sup 18^F-FDG Uptake in Rat Gliomas After In Vivo Treatment with Doxorubicin
Aug 01, 2007; ... σ-Receptors are strongly overexpressed in most rodent and human tumors and are proliferation markers. To evaluate the potential of a radiolabeled σ^sub 1^-ligand for therapy monitoring, we compared early changes of ^sup 11^C-1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine (^sup ...
In Vivo VEGF Imaging with Radiolabeled Bevacizumab in a Human Ovarian Tumor Xenograft
Aug 01, 2007; ... Vascular endothelial growth factor (VEGF), released by tumor cells, is an important growth factor in tumor angiogenesis. The humanized monoclonal antibody bevacizumab blocks VEGF-induced tumor angiogenesis by binding, thereby neutralizing VEGF. Our aim was to develop radiolabeled bevacizumab for ...
In Vivo Evaluation and Small-Animal PET/CT of a Prostate Cancer Mouse Model Using ^sup 64^Cu Bombesin Analogs: Side-by-Side Comparison of the CB-TE2A and DOTA Chelation Systems
Aug 01, 2007; ... The BB2 receptor subtype, of the bombesin family of receptors, has been shown to be highly overexpressed in a variety of human tumors, including prostate cancer. Bombesin (BBN), a 14-amino acid peptide, has been shown to target the BB2 receptor with high affinity. ^sup 64^Cu (half-life = 12.7 h, ...
Preparation and Biologic Evaluation of a Novel Radioiodinated Benzylpiperazine, ^sup 123^I-MEL037, for Malignant Melanoma
Aug 01, 2007; ... Radiopharmaceuticals that can target the random metastatic dissemination of melanoma tumors may present opportunities for imaging and staging the disease as well as potential radiotherapeutic applications. A novel molecule, 2-(2-(4-(4-^sup ...
Pharmacokinetic Characterization in Xenografted Mice of a Series of First-Generation Mimics for HLA-DR Antibody, Lym-1, as Carrier Molecules to Image and Treat Lymphoma
Aug 01, 2007; ... Despite their large size, antibodies (Abs) are suitable carriers to deliver systemic radiotherapy, often molecular image-based, for lymphoma and leukemia. Lym-1 Ab has proven to be an effective radioisotope carrier, even in small amounts, for targeting human leukocyte antigen DR (HLA-DR), a ...
Parametric Images of Antibody Pharmacokinetics Based on Serial Quantitative Whole-Body Imaging and Blood Sampling
Aug 01, 2007; ... We present a method for pharmacokinetic modeling of distributions of ^sup 111^In-labeled monoclonal antibodies (mAbs) on individual pixels of planar scintillation-camera images. Methods: The method is applied to 2 sets of clinical whole-body images, each consisting of 6 consecutive images ...
^sup 111^In-Labeled Trastuzumab (Herceptin) Modified with Nuclear Localization Sequences (NLS): An Auger Electron-Emitting Radiotherapeutic Agent for HER2/neu-Amplified Breast Cancer
Aug 01, 2007; ... The cytotoxicity and tumor-targeting properties of the anti-HER2/neu monoclonal antibody trastuzumab modified with peptides (CGYGPKKKRKVGG) harboring the nuclear localization sequence ([NLS] italicized) of simian virus 40 large T-antigen and radiolabeled with ^sup 111^In were evaluated. Methods: ...
Nuclear Uptake and Dosimetry of ^sup 64^Cu-Labeled Chelator-Somatostatin Conjugates in an SSTr2-Transfected Human Tumor Cell Line
Aug 01, 2007; ... ^sup 64^Cu radiopharmaceuticals have shown tumor growth inhibition in tumor-bearing animal models with a relatively low radiation dose that may be related to nuclear localization of the ^sup 64^Cu in tumor cells. Here we address whether the nuclear localization of ^sup 64^Cu from a ^sup ...
Impact Factors in Nuclear Medicine Journals
Aug 01, 2007; ... The annual Journal Citation Reports includes several statistics and figures, the key figure being journal impact factor. Journal impact factor, despite being widely used, is not well understood. This article aims to provide a broader understanding of impact factors and the implications ...
Production of Multimeric Prostate-Specific Membrane Antigen Small-Molecule Radiotracers Using a Solid-Phase ^sup 99m^Tc Preloading Strategy
Aug 01, 2007; ... Small-molecule ligands specific for prostate-specific membrane antigen (PSMA) have the potential to improve prostate cancer imaging. However, highly charged ligands are difficult to label with ^sup 99m^Tc and to purify. In this study, we present an adamantane-trimerized small molecule that has ...
Quantitative Analysis in Nuclear Medicine Imaging
Aug 01, 2007; ... Quantitative Analysis in Nuclear Medicine Imaging H. Zaidi, ed. New York, NY: Springer, 2006, 538 pages, $125 Quantitative Analysis in Nuclear Medicine Imaging is an in-depth review of single-photon and PET nuclear medicine image reconstruction, correction, modeling, and analysis ...
Antithyroid Drugs and Radioiodine and the Absence of Evidence/REPLY
Aug 01, 2007; ... TO THE EDITOR: With interest we read the instructive review on the treatment of thyrotoxicosis by lagaru and McDougall (/). Therein, the authors stated that the outcome of radioiodine tiierapy with adjunctive metiiimazole or Carbimazole would be equal to or better than that achieved when no ...
^sup 18^F-FDG PET in Planning Radiation Treatment of Non-Small Cell Lung Cancer: Where Exactly Is the Tumor?/REPLY
Aug 01, 2007; ... TO THE EDITOR: We read with interest the article by Biehl et al. illustrating the current uncertainty surrounding the use of ^sup 18^F-FDG PET to delineate the gross tumor volume (GTV) of nonsmall cell lung cancer (NSCLC) (1). The importance of this delineation is emphasized by the finding of ...
Maintenance of Certification for ABNM Diplomates
Aug 01, 2007; ... Maintenance of certification (MOC) is the generic term describing the process designed to promote and document continued physician competency and familiarity with changing science and techniques in individual specialties. In nuclear medicine, MOC is conducted under the guidance of the American ...
A Capital Success
Aug 01, 2007; ... The tremendous success of SNM's 54th Annual Meeting was in the sum of all its details. From the big-the stylized society banner hanging outside the Washington Convention Center announcing our determination to advance molecular imaging and therapy-to the small-the red buttons proclaiming ...