The Journal of Nuclear Medicine back issues from October 2007:
Part IV of MOC: How Will It Evolve?
Oct 01, 2007; ... As indicated in last month's Newsline, Part IV of Maintenance of Certification (MOC), as defined by the American Board of Medical Specialties, is poorly understood but likely to be MOC's most critical component. The periodical testing of cognitive knowledge (Part HI of MOC) only measures "Do I ...
Advocacy Now and for the Future
Oct 01, 2007; ... During our Annual Meeting, SNM sent more than 150 members to Capitol Hill to talk to their representatives about issues affecting molecular imaging and nuclear medicine. The topics listed below were points of discussion for that activity; I call diem our 3 "Rs": reimbursement, regulations, and ...
New Biomedical Imaging Meeting
Oct 01, 2007; ... The inaugural "Frontiers of Biomedical Imaging Science" meeting, held June 27-29 on the campus of Vanderbilt University (Nashville, TN), was a different type of conference, bringing together a broad range of topics in a novel forum. The Frontiers meeting was sponsored by the Vanderbilt ...
Potential Effects of Proposed Children's Health and Medicare Protection Act
Oct 01, 2007; ... On August 1, the U.S. House of Representative passed HR 3162, the Children's Health and Medicare Protection (CHAMP) Act of 2007. The CHAMP Act reauthorizes the State Children's Health Insurance Program and provides health insurance coverage to millions of uninsured children; however, the bill ...
Alavi Receives University of Bologna Honorary Degree
Oct 01, 2007; ... On March 23, the Alma Mater Studiorum, University of Bologna, Italy, founded in 1088, bestowed a laurea honoris causa (honorary doctorate) in medicine and surgery on Abass Alavi, MD, professor of radiology at the University of Pennsylvania (Philadelphia). The laurea honoris causa is a ...
IN MEMORIAM: C. Craig Harris
Oct 01, 2007; ... C. Craig Harris passed away on Monday, August 6, 2007, leaving behind a wonderful life as a husband, father, educator, and scientist. He was born on February 20, 1925, in Raymond, MS, and was proud of that heritage. After receiving his BS and MS degrees from the University of Tennessee in ...
SNM 2008 Annual Meeting in New Orleans
Oct 01, 2007; ... Greetings from New Orleans, LA! In August, members of SNM's Scientific Program Committeealong with staff from the society's education and meetings departments-visited the historically rich and welcoming Big Easy, the site of our upcoming 55th Annual Meeting, June 14-18, 2008. A number of ...
NYT Covers Challenges to RIT Use
Oct 01, 2007; ... In an article published in the July 31 issue of the New York Times, reporter Alex Berenson described the remarkable responses of several patients with non-Hodgkin's lymphoma (NHL) to radioimmunotherapy (RIT) regimens with Bexxar (tositumomab and ^sup 131^I-tositumomab; GlaxoSmithKline, ...
Rapid Growth in Small Animal Imaging
Oct 01, 2007; ... A markets analysis report released on August 13 by the global consulting firm Frost & Sullivan (Palo Alto, CA) indicates that a combination of federal initiatives and the established reliability of studies published through the peer-review process have led to greater adoption rates for ...
New Initiative to Study Glycobiology of Cancer
Oct 01, 2007; ... The National Cancer Institute (NCI) announced on August 21 the funding of a new $15.5 million, 5-year initiative to discover, develop, and clinically validate cancer biomarkers by targeting the carbohydrate (glycan) part of molecules. Seven NCI-funded Tumor Glycome Laboratories are now searching ...
3D Images of Cells
Oct 01, 2007; ... Employing a reconstruction method similar to that used in 3D CT, researchers at the Massachusetts Institute of Technology (MIT; Cambridge, MA) reported in the September issue of Nature Methods (2007;4:717-719) on the development of a new imaging technique that can create 3D images of a living ...
SINAPSE Network Launched in Scotland
Oct 01, 2007; ... The Scottish Funding Council and 6 Scottish universities announced in early August the launch of a new £40 million initiative to improve the infrastructure for neuroimaging research in Scotland. Called SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence), the project includes ...
Biomarkers Consortium Grows
Oct 01, 2007; ... Contributing membership in The Biomarkers Consortium now totals 30 companies, nonprofit trade associations, and advocacy groups, including SNM. This large-scale initiative was formally launched in late 2006 to identify and qualify new, quantitative biomarkers for use by biomedical researchers, ...
Americans and Cancer Information
Oct 01, 2007; ... According to Cancer Communication: Health Information National Trends Survey 2003 and 2005, released by the National Cancer Institute (NCI) on August 29, the Internet remains a frequent first source for Americans about general health and cancer information. Confidence in the quality of such ...
Imaging Early-Stage Diabetes Changes
Oct 01, 2007; ... MOLECULAR IMAGING Medarova et al. from the Athinoula A. Martinos Center for Biomedical Imaging and the Massachusetts General Hospital (Boston, MA) reported on August 6 ahead of print in Diabetes on a study of MR imaging of microvascular changes in type 1 diabetes in a mouse model. The ...
Dual-Modality MR and Fluorescence Tracer
Oct 01, 2007; ... Xu and a cooperative research group from the National Cancer Institute (Bethesda, MD), and the Howard Hughes Medical Institute (Chevy Chase, MD) reported on August 21 ahead of print in Bioconjugate Chemistry on the preparation and preliminary evaluation of a biotin- and lectintargeted ...
Noninvasive Optical Evaluation of Bone Mineral
Oct 01, 2007; ... Kozloff et al. from the Massachusetts General Hospital and Harvard Medical School (Boston) reported in the August issue of the Journal of Bone and Mineral Research (2007;22:1208-1216) on a study assessing the ability of a far-red fluorescently labeled pamidronate (FRFP) probe to bind to regions ...
BRET in Single Cells In Vivo
Oct 01, 2007; ... Continuing their groundbreaking work in molecular imaging, researchers from Stanford University (CA) reported in the August 1 issue of Cancer Research (2007;67:7175-7183) on an improved bioluminescence resonance energy transfer (BRET) strategy for imaging intracellular events in single cells and ...
Radioguided Neurosurgery
Oct 01, 2007; ... Bhanot et al. from the Manipal Institute for Neurological Disorders (Bangalore, India) reported in the August issue of the British Journal of Neurosurgery (2007;21:382-388) on initial experiences with radioguided neurosurgery in patients with brain tumors. The study included 19 patients ...
PET and Aggressive Thyroid Cancer
Oct 01, 2007; ... DIAGNOSIS- In a study e-published on August 23 ahead of print in the Annals of Surgical Oncology, Are et al. from the University of Nebraska Medical Center (Omaha) reported on research designed to determine whether thyroid malignancies incidentally detected by ,8F-FDG PET represent a ...
Novel PET Radioligand for Neuroimaging
Oct 01, 2007; ... Boutin et al. from the Laboratoire d'Imagerie Moleculaire Experimentale (Orsay, France) reported in the August 6 issue of Glia (2007;55:14591468) on a new peripheral benzodiazepine receptor (PBR) as an alternative to PK11195 for PET imaging of neuroinflammation. The researchers studied the in ...
PET/CT in IBD
Oct 01, 2007; ... Meisner et al. from the University of Wisconsin Hospital and Clinics (Madison) reported in the August issue of Inflammatory Bowel Disease (2007;13:993-1000) on a pilot study designed to explore the ability of PET/ CT to identify regions of active inflammation in both ulcerative colitis and ...
SPECT/CT in Advanced Pancreatic Cancer
Oct 01, 2007; ... In a study e-published on August 21 ahead of print in Cardiovascular and Interventional Radiology, Ikeda et al. from the Kumamoto University Graduate School of Medical and Pharmaceutical Sciences (Japan) reported on a study comparing images of intrahepatic and pancreatic perfusion acquired with ...
Coregistered PET and CT in RT Planning
Oct 01, 2007; ... THERAPY Macmanus et al. reported in the August issue of Australasian Radiology (2007;51:386-393) on a method for obtaining CT and PET images at separate acquisitions for radiotherapy (RT) planning in non-small cell lung cancer (NSCLC) and compared the results with those obtained using CT ...
PET and Cerebral Amyloid Burden
Oct 01, 2007; ... Johnson et al. from the Massachusetts General Hospital (Boston, MA) reported on August 7 ahead of print in the Annals of Neurology on a study investigating the potential of PET imaging with Pittsburgh Compound B in the detection of cerebrovascular deposition of β-amyloid (cerebral amyloid ...
Gated SPECT in Progressive Coronary Occlusion
Oct 01, 2007; ... In an article e-published on August 17 ahead of print in the International Journal of Cardiovascular Imaging, Christian et al. from the Mayo Clinic and Foundation (Rochester, MN) reported on a study designed to determine whether gated "Tc-sestamibi SPECT imaging can track small changes in ...
RIT Complications and At-Risk Patients
Oct 01, 2007; ... In a study e-published on August 20 ahead of print in the Journal of Clinical Oncology, Czuczman et al. from the Roswell Park Cancer Institute (Buffalo, NY), University of California at Los Angeles, Biogen Idee (San Diego, CA), Mayo Clinic (Rochester, MN), and Northwestern University (Chicago, ...
PET and Adult ADHD
Oct 01, 2007; ... Volkow et al. from the National Institute on Drug Abuse (Bethesda, MD) and the Brookhaven National Laboratory (Upton, NY) reported in the August issue of the Archives of General Psychiatry (2007;64:932940) on a study using PET imaging to test the hypothesis that striatal dopamine activity is ...
PET and PTSD
Oct 01, 2007; ... In an article e-published on July 31 ahead of print in Molecular Psychiatry, Geuze et al. from The Netherlands Ministry of Defense (Utrecht) and the Utrecht University Medical Centre reported on an 11C-flumazenil PET study assessing benzodiazepine 7-aminobutyric acid (GABA[A]) receptors in the ...
Thalidomide and Thyroid Cancer
Oct 01, 2007; ... Ain et al. from the Veterans Affairs Medical Center (Lexington, KY) and the University of Kentucky (Lexington) reported in the August issue of Thyroid (2007;17:663-670) on the results of a phase II trial of thalidomide for therapy of radioiodine-unresponsive and rapidly progressive thyroid ...
Viral-Derived Peptide for Cancer Imaging
Oct 01, 2007; ... Hausner et al. from the University of California, Davis and the Queen Mary's School of Medicine and Dentistry (London, UK) reported in the August 15 issue of Cancer Research (2007;67:7833-7840) on the use of a peptide derived from die foot-andmouth disease virus for PET imaging of α^sub ...
NIDA's Rice Receives Smissman Award
Oct 01, 2007; ... Kenner C. Rice, PhD, whose research led to the development of compounds or medications that have the potential to treat, prevent, or image drug addiction, was presented on August 20 with the 2007 Smissman Award at the American Chemical Society (ACS) national meeting in Boston, MA. Rice is chief ...
FDA Approves NDA for ^sup 13^N-Ammonia Injection
Oct 01, 2007; ... On August 23, the U.S. Food and Drug Administration (FDA) approved a new drug application (NDA) for a ^sup 13^N-ammonia injection product, under the title "Ammonia N 13 Injection." The approved NDA reference number is NDA 22-119. Thomas Chaly, PhD, submitted the NDA on behalf of the Feinstein ...
^sup 18^F-DOPA PET and PET/CT
Oct 01, 2007; ... In the study of Timmers et al. (1) published in this issue of The Journal of Nuclear Medicine, 11 patients with pheochromocytoma and extraadrenal abdominal paraganglioma were evaluated with ^sup 18^F-dihydroxyphenylalanine (DOPA) PET at baseline and after carbidopa administration. This inhibitor ...
^sup 18^F-FDG PET in Non-Hodgkin's Lymphoma: Qualitative or Quantitative?
Oct 01, 2007; ... Several studies have documented that ^sup 18^F-FDG PET is more accurate than CT for assessment of tumor response to chemotherapy in patients with Hodgkin's lymphoma (HL) and high-grade (aggressive) non-Hodgkin's lymphoma (NHL) (7,2). On the basis of these data, the International Workshop ...
Limitations of CT During PET/CT
Oct 01, 2007; ... Our aim was to determine the diagnostic limitations of low-dose, unenhanced CT scans performed for anatomic reference and attenuation correction during PET/CT. Methods: The Radiology Information System at our oncologic hospital was queried during the 9-mo period from July 2002 to April 2003 for ...
Chemotherapy Response Evaluation with ^sup 18^F-FDG PET in Patients with Non-Small Cell Lung Cancer
Oct 01, 2007; ... The aim of this prospective study was to evaluate the value of ^sup 18^F-FDG PET for the assessment of chemotherapy response in patients with non-small cell lung cancer. Furthermore, part of the objective of this study was to compare 2 methods to quantify changes in glucose metabolism. Methods: ...
The Effects of Carbidopa on Uptake of 6-^sup 18^F-Fluoro-L-DOPA in PET of Pheochromocytoma and Extraadrenal Abdominal Paraganglioma
Oct 01, 2007; ... 6-^sup 18^F-fluoro-L-3,4-dihydroxyphenylalanine (^sup 18^F-DOPA) PET is a useful tool for the detection of certain neuroendocrine tumors, especially with the preadministration of carbidopa, an inhibitor of DOPA decarboxylase. Whether carbidopa also improves ^sup 18^F-DOPA PET of adrenal ...
The Role of Interval Nodes in Sentinel Lymph Node Mapping and Dissection for Melanoma Patients
Oct 01, 2007; ... In sentinel node (SN) biopsy, an interval SN is defined as a lymph node or group of lymph nodes located between the primary melanoma and an anatomically well-defined lymph node group directly draining the skin. As shown in previous reports, these interval SNs seem to be at the same metastatic ...
^sup 18^F-FDG PET Can Replace Conventional Work-up in Primary M Staging of Nonkeratinizing Nasopharyngeal Carcinoma
Oct 01, 2007; ... Conventional work-up (CWU) with chest radiography, abdominal ultrasonography, and skeletal scintigraphy has limited value in M staging of nonkeratinizing nasopharyngeal carcinoma (NPC). Our aim was to evaluate whether ^sup 18^F-FDG PET could replace CWU by comparing their diagnostic efficacies ....
The Dental Safety Profile of High-Dose Radioiodine Therapy for Thyroid Cancer: Long-Term Results of a Longitudinal Cohort Study
Oct 01, 2007; ... The long-term dental safety profile of high-dose radioiodine therapy remained elusive despite more than 6 decades of clinical use. Methods: In a cohort study, we investigated the incidence of sialadenitis, xerostomia, caries, and tooth extractions after high-dose radioiodine therapy for ...
Early ^sup 18^F-FDG PET for Prediction of Prognosis in Patients with Diffuse Large B-Cell Lymphoma: SUV-Based Assessment Versus Visual Analysis
Oct 01, 2007; ... The purpose of this study was to assess the prognostic value of early ^sup 18^F-FDG PET using standardized uptake value (SUV) compared with visual analysis in patients with diffuse large B-cell lymphoma (DLBCL). Methods: Ninety-two patients with newly diagnosed DLBCL underwent ^sup 18^F-FDG PET ...
^sup 123^I-5-IA-85380 SPECT Imaging of Nicotinic Acetylcholine Receptor Availability in Nonsmokers: Effects of Sex and Menstrual Phase
Oct 01, 2007; ... The study of the effects of sex and hormones on brain chemistry and neurotransmission is of increasing importance as evidence emerges of sex differences in behavioral symptoms and treatment response in neuropsychiatry disorders. The nicotinic acetylcholine receptor (nAChR) system has been ...
^sup 18^F-FDOPA Kinetics in Brain Tumors
Oct 01, 2007; ... L-3,4-Dihydroxy-6-^sup 18^F-fluoro-phenyl-alanine (^sup 18^F-FDOPA) is an amino acid analog used to evaluate presynaptic dopaminergic neuronal function. Evaluation of tumor recurrence in neurooncology is another application. Here, the kinetics of ^sup 18^F-FDOPA in brain tumors were ...
Evaluation of Probable or Possible Dementia with Lewy Bodies Using ^sup 123^I-IMP Brain Perfusion SPECT, ^sup 123^I-MIBG, and ^sup 99m^Tc-MIBI Myocardial SPECT
Oct 01, 2007; ... We evaluated the diagnostic usefulness of combination studies with a statistical mapping method in N-isopropyl-p-^sup 123^I-iodoamphetamine (^sup 123^I-IMP) brain perfusion SPECT, cardiac sympathetic nerve function by ^sup 123^I-metaiodobenzylguanidine (^sup 123^I-MIBG), and myocardial function ...
Spatial and Temporal Heterogeneity of Regional Myocardial Uptake in Patients Without Heart Disease Under Fasting Conditions on Repeated Whole-Body ^sup 18^F-FDG PET/CT
Oct 01, 2007; ... Imaging of cardiac ^sup 18^F-FDG uptake is used in the diagnostic evaluation of residual viable myocardium. Although, originally, hibernating myocardium was identified by a mismatch between perfusion defect and relatively preserved ^sup 18^F-FDG uptake, at present several studies propose that ...
Feasibility and Diagnostic Accuracy of a Gated SPECT Early-Imaging Protocol: A Multicenter Study of the Myoview Imaging Optimization Group
Oct 01, 2007; ... The aim of this study was to investigate whether early (time 1, or T1) myocardial tetrofosmin imaging is feasible and as accurate in detecting coronary artery disease as is standard delayed (time 2, or T2) imaging. Methods: One hundred twenty patients (100 men and 20 women; mean age ± SD, 61 ± ...
Long-Term Nicorandil Therapy Improves Cardiac Sympathetic Nerve Activity After Reperfusion Therapy in Patients with First Acute Myocardial Infarction
Oct 01, 2007; ... Nicorandil, an adenosine triphosphate-sensitive potassium channel opener, reduces plasma norepinephrine concentration in patients with ischemic heart disease. However, long-term effects on cardiac sympathetic nerve activity (CSNA) as evaluated by ^sup 123^I-metaiodobenzylguanidine (MIBG) ...
MIRD Continuing Education: Bystander and Low-Dose-Rate Effects: Are These Relevant to Radionuclide Therapy?*
Oct 01, 2007; ... Bystander and low-dose-rate effects influence the dose-response relationship in a manner not predicted by current dosimetric methodologies. Radiation-induced bystander effects refer to biologic responses in cells that are not traversed by an ionizing radiation track and, thus, not subject to ...
Imaging of Weak-Source Distributions in LSO-Based Small-Animal PET Scanners
Oct 01, 2007; ... Lutetium oxyorthosilicate (LSO)- or lutetium-yttrium oxyorthosilicate (LYSO)-based PET scanners have intrinsic radioactivity in the scintillator crystals due to the presence of ^sup 176^Lu, which decays by β-emission followed by one or more prompt γ-ray emissions. This leads to ...
PET Imaging of CCND1 mRNA in Human MCF7 Estrogen Receptor-Positive Breast Cancer Xenografts with Oncogene-Specific [^sup 64^Cu]Chelator-Peptide Nucleic Acid-IGF1 Analog Radiohybridization Probes
Oct 01, 2007; ... Treatment of breast cancer is hampered by a large unmet need for rapid, sensitive, specific staging and stratification of palpable and nonpalpable abnormalities. Mammography and physical examination miss many early breast cancers, yet detect many benign lesions. Cyclin D1, encoded by CCND1 ...
Dynamic Tracking During Intracoronary Injection of ^sup 18^F-FDG-Labeled Progenitor Cell Therapy for Acute Myocardial Infarction
Oct 01, 2007; ... We assessed the feasibility of dynamic 3-dimensional (3D) PET/CT tracking of ^sup 18^F-FDG-labeled circulating progenitor cell (CPC) therapy during intracoronary injection, using a porcine model of acute myocardial infarction (MI). Methods: Human and porcine CPC were radiolabeled with ^sup ...
Comparison of Uptake of Multiple Clinical Radiotracers into Brown Adipose Tissue Under Cold-Stimulated and Nonstimulated Conditions
Oct 01, 2007; ... Our objective was to determine whether multiple clinically useful radiotracers accumulate in brown adipose tissue (BAT) and to assess their uptake in rats kept at room temperature or exposed to a cold environment. Methods: The following radiotracers were injected intravenously into groups of 6 ...
PET Studies of d-Methamphetamine Pharmacokinetics in Primates: Comparison with l-Methamphetamine and ( - )-Cocaine
Oct 01, 2007; ... The methamphetamine molecule has a chiral center and exists as 2 enantiomers, d-methamphetamine (the more active enantiomer) and l-methamphetamine (the less active enantiomer). d-Methamphetamine is associated with more intense stimulant effects and higher abuse liability. The objective of this ...
Presence of Specific ^sup 11^C-meta-Hydroxyephedrine Retention in Heart, Lung, Pancreas, and Brown Adipose Tissue
Oct 01, 2007; ... ^sup 11^C-meta-Hydroxyephedrine (HED) is used in cardiac PET as an index of norepinephrine (NE) reuptake transporter (NET) density and synaptic NE levels. Whereas cardiac uptake is well documented, tracer retention in other tissues with rich noradrenergic innervation is unclear. Dysfunctional ...
Processing of Generator-Produced ^sup 68^Ga for Medical Application
Oct 01, 2007; ... The ^sup 68^Ge/^sup 68^Ga generator provides an excellent source of positron-emitting ^sup 68^Ga. However, newly available "ionic" ^sup 68^Ge/^sup 68^Ga radionuclide generators are not necessarily optimized for the synthesis of ^sup 68^Ga-labeled radiopharmaceuticals. The eluates have rather ...
Beyond Knowing: Mysteries and Messages of Death and Life from a Forensic Pathologist
Oct 01, 2007; ... Beyond Knowing: Mysteries and Messages of Death and Life from a Forensic Pathologist J. Amatuzio Novato, CA: New World Library, 2006, 204 pages, $21.95 Dr. Janis Amatuzio has been a pathologist and medical examiner in Minnesota for over 25 years, performing hundreds of autopsies per year ...
PET Chemistry: The Driving Force in Molecular Imaging
Oct 01, 2007; ... PET Chemistry: The Driving Force in Molecular Imaging P.A. Schubiger, L. Lehmann, and M. Friebe, eds. New York, NY: Springer, 2006, 339 pages, $119 PET Chemistry: The Driving Force in Molecular Imaging describes the development of radiochemicals as concepts move from bench work to ...
^sup 18^F-FDG PET in Detecting Primary Breast Cancer/REPLY
Oct 01, 2007; ... TO THE EDITOR: We read the article by Moy et al. (1) with great interest. This is one of die few studies that have investigated the role of PET/MRI in evaluating primary breast cancer. Several investigators have assessed the role of ^sup 18^F-FDG PET in the comprehensive detection of primary ...