The Journal of Nuclear Medicine back issues from December 2007:
NRC Issues Transition Plan on New Regulatory Authority
Dec 01, 2007; ... On October 18, the U.S. Nuclear Regulatory Commission (NRC) published its transition plan for assuming regulatory authority over certain radioactive materials under provisions of the Energy Policy Act of 2005. The act expanded the definition of "byproduct material" subject to NRC regulatory ...
MI Abstracts for Annual Meeting
Dec 01, 2007; ... MOLECULAR IMAGING UPDATE A new track for abstract presentations, "Novel Approaches to Molecular Imaging," has been added to the scientific program for the 2008 SNM Annual Meeting. While the scope of nuclear medicine includes much of what is understood to be "molecular imaging," the MI ...
Advocating for PET/CT
Dec 01, 2007; ... SNM LEADERSHIP UPDATE The publication of "Is PET an Endangered Species?"an article by Richard Black, DO, on AuntMinnie. com-raises a number of interesting observations regarding the challenges facing the nuclear medicine/ molecular imaging community. Black's hypothesis is that recent ...
Downturn in Non-PET NM Patient Visits
Dec 01, 2007; ... A report released on October 17 by IMV Medical Information Division (Des Plaines, IL), an international marketing research company, described an unexpected downturn in total numbers of non-PET nuclear medicine patient visits. In 2006, an estimated 17.7 million nuclear medicine procedures were ...
SNM Actions to Restore Basic Research Funding
Dec 01, 2007; ... HEALTH POLICY & REGULATORY AFFAIRS UPDATE In late October, Representative Carolyn Maloney (D-NY) distributed a letter to her colleagues in the U.S. House of Representatives asking Appropriations Committee leaders to agree with the Senate language and numbers that restore funding for ...
GE Discontinues Some Radioisotope Production
Dec 01, 2007; ... GE Healthcare (Waukesha, WI) announced on October 19 that it will discontinue production of all products with the short-lived radioisotopes 32P, ^sup 33^P, ^sup 35^S, and ^sup 125^I. This includes nucleotides, nucleosides, amino acids, receptor ligands, and custom products labeled with these ...
New Potency Rules for Thyroid Drugs
Dec 01, 2007; ... The U.S. Food and Drug Administration (FDA) announced on October 3 that it would tighten potency specifications for levothyroxine sodium, used by more than 13 million patients, to ensure that the drug retains its potency over its entire shelf life. This action was taken in response to concerns ...
DOE Office of Science Looks Ahead
Dec 01, 2007; ... On October 11, the U.S. Department of Energy (DOE) Office of Science released a comprehensive update of its 2003 publication, Facilities for the Future of Science: A TwentyYear Outlook, reporting that the agency has made "significant progress" in deploying these scientific facilities and ...
Petition to Alter NRC Training Regs Denied
Dec 01, 2007; ... The U.S. Nuclear Regulatory Commission (NRC) announced in the Federal Register on October 24 that it had denied a petition for rulemaking (PRM35-19) originally submitted by William Stein, III, MD (Metairie, LA), on June 14, 2006. Stein had requested that the NRC amend Title 10 Code of Federal ...
NIBIB Invests in Quantum Research
Dec 01, 2007; ... The National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the National Institutes of Health (NIH), announced on October 4 the award of more than $12 million in grants to 4 investigators developing groundbreaking technologies, including disposable microchips for the ...
NRC Creates Panel on Licensing Vulnerabilities
Dec 01, 2007; ... The U.S. Nuclear Regulatory Commission (NRC) announced on October 5 the establishment of a special advisory panel, the Independent External Review Panel to Identify Vulnerabilities in the U.S. NRC's Material Licensing Program, in response to criticism of the agency's licensing process in 3 ...
U.S. Dementia Numbers Growing
Dec 01, 2007; ... A new analysis suggests that about 3.4 million Americans ages 71 and older (1 in 7 in that age group) have dementia and that 2.4 million of these individuals (more than 2/3) have Alzheimer's disease (AD). The study, supported by the National Institutes of Health (NIH), is the latest in a series ...
SLN and ALND in Breast Cancer
Dec 01, 2007; ... DIAGNOSIS Members of the multicenter National Surgical Adjuvant Breast and Bowel Project (NSABP) reported in the October issue of Lancet Oncology (2007;8:881-888) on a subset of studies in a randomized phase III trial to assess therapeutic outcomes and attendant side effects of sentinel ...
Arm Morbidity and SLN
Dec 01, 2007; ... In an article e-published on October 8 ahead of print in Breast, Husted Madsen and the Danish Breast Cancer Cooperative Group reported on a study of arm morbidity after sentinel lymph node (SLN) biopsy or axillary lymph node dissection (ALND). The multicenter study included 395 patients with ...
Type 1 Diabetes and ^sup 99m^Tc-Interleukin Scintigraphy
Dec 01, 2007; ... Chianelli et al. from the Regina Apostolorum Hospital (Albano Laziale, Italy) reported on October 5 ahead of print in Diabetes/Metabolism Research and Reviews on the clinical utility of 99mTc-interleukin-2 scintigraphy to identify pancreatic inflammation in patients with newly diagnosed type 1 ...
P-gp Expression and Sestamibi Washout
Dec 01, 2007; ... In an article e-published on October 10 ahead of print in the British Journal of Surgery, Gupta et al. from the Addenbrooke's Hospital (Cambridge, UK) reported on an investigation of the relationship between sestamibi accumulation and multidrug resistance (MDR)-related P-glycoprotein expression ...
Modulating Myocardial Metabolism in Diabetes
Dec 01, 2007; ... Peterson et al. from the Washington University School of Medicine (St. Louis, MO) reported on October 3 ahead of print in Diabetes on a study designed to test the hypothesis that myocardial glucose and fatty acids can be manipulated in individuals with type 1 diabetes by altering plasma free ...
Functional Neuroimaging of Anxiety
Dec 01, 2007; ... In an article published in the October issue of the American Journal of Psychiatry (2007;164:1476-1488), Etkin and Wager of the Stanford University School of Medicine (CA) reported on the functional neuroimaging of anxiety in a meta-analysis of emotional processing in posttraumatic stress ...
^sup 111^In-Peptide for Breast Carcinoma Targeting and Imaging
Dec 01, 2007; ... Kumar et al. from the University of Missouri-Columbia and Harry S. Truman Veterans Hospital (MO) reported in the October 15 issue of Clinical Cancer Research (2007;13:6070-6079) on an evaluation of the cellular targeting and tumor imaging properties of a novel ErbB-2-avid peptide in human breast ...
Mitochondrial Bioenergetic Capacity and Glucose Avidity
Dec 01, 2007; ... MOLECULAR IMAGING López-Ríos et al. from the Universidad Autonoma de Madrid-Consejo Superior de Investigaciones Cientificas (Madrid, Spain) reported in the October 1 issue of Cancer Research (2007;67: 9013-9017) on the relationship between in vivo tumor glucose uptake in lung carcinomas ...
SPECT/CT of Tumor Oncolytic Adenovirus Propagation
Dec 01, 2007; ... In an article e-published on October 25 ahead of print in Gene Therapy, Merron et al. from the Queen Mary's School of Medicine and Dentistry (London, UK) reported on small animal SPECT/CT imaging of oncolytic adenovirus propagation in tumors using the human sodium iodide symporter (hNIS) as a ...
Real-Time Imaging of ß-Catenin Dynamics
Dec 01, 2007; ... Naik and Piwnica-Worms from the Washington University School of Medicine (St. Louis, MO) reported on October 22 ahead of print in the Proceedings of the National Academy of Sciences USA on real-time imaging of β-catenin (a key signaling component of the canonical Wnt signaling pathway as ...
Molecular Imaging of Collagen in Atherosclerosis
Dec 01, 2007; ... Megens and researchers from the Netherlands reported in the October-December issue of Molecular Imaging (2007;6:247-260) on an investigation of collagen imaging in intact, viable healthy and atherosclerotic arteries using the fluorescent-labeled collagen-binding protein CNA35 and 2-photon ...
Functional Imaging of Tumor Fibroblasts
Dec 01, 2007; ... In an article published in the October 1 issue of Cancer Research (2007;67:9180-9189), Granot et al. from the Weizmann Institute (Rehovot, Israel) reported on in vivo MR and optical imaging of the systemic recruitment of fibroblasts to the angiogenic rim of ovarian tumors in vivo in a mouse ...
Imaging Musculoskeletal Bacterial Infections
Dec 01, 2007; ... Diaz et al. from the Howard Hughes Medical Institute and John Hopkins University Hospitals (Baltimore, MD) reported in the October 10 online issue of PLoS ONE on a study using ^sup 124^I-FIAU PET/CT in imaging suspected musculoskeletal bacterial infections. The study included 8 individuals with ...
Antibody-Based RIT in SCLC
Dec 01, 2007; ... THERAPY Krug et al. from the Memorial Sloan-Kettering Cancer Center and Weill Medical College at Cornell University (New York, NY) reported in the October issue of the Journal of Thoracic Oncology (2007;2:947-952) on a pilot trial assessing the use of a humanized monoclonal antibody ...
PET/CT Target Delineation in NSCLC
Dec 01, 2007; ... Klopp et al. from the University of Texas M.D. Anderson Cancer Center (Houston, TX) reported on September 26 ahead of print in the International Journal of Radiation Oncology, Biology, Physics on patterns of treatment failure in patients treated for non-small cell lung cancer (NSCLC) according ...
Image-Guided Adenovirus-Mediated RT of MTC
Dec 01, 2007; ... In an article published in the October issue of Human Gene Therapy (2007;18:916-924), Spitzweg et al. from the Ludwig-Maximilians University (Munich, Germany) reported on a study of the feasibility of image-guided radioiodide therapy of medullary thyroid cancer (MTC) after human sodium iodide ...
"Focus on Molecular Imaging"
Dec 01, 2007; ... This issue introduces "Focus on Molecular Imaging" as a new monthly feature of The Journal of Nuclear Medicine (JNM). Molecular imaging aims to visualize and measure fundamental biologic processes at the molecular, subcellular, and cellular levels. Molecular imaging promises not only to deepen ...
Comparison of Imaging Techniques for Tracking Cardiac Stem Cell Therapy
Dec 01, 2007; ... A growing number of exciting animal and preclinical studies are beginning to reveal the immense potential in stem cell-based therapies, particularly in the area of treating cardiovascular diseases. However, to evaluate the efficacy of these treatments in clinical trials, the transplanted stem ...
PET/CT in Evaluating Pediatric Malignancies: A Clinician's Perspective
Dec 01, 2007; ... The introduction of combined CT with the functional imaging modality of PET has been an advancement in diagnostic imaging that has been welcomed by radiologists, nuclear medicine specialists, and oncologists. PET/CT has been used successfully in the diagnosis, staging, monitoring of response to ...
^sup 18^F-FDG PET/CT in Evaluating Non-CNS Pediatric Malignancies
Dec 01, 2007; ... We reviewed our experience of ^sup 18^F-FDG PET/CT in noncentral nervous system (CNS) pediatric malignancies and evaluated if PET/CT provided additional information to conventional imaging (CI) examinations to determine the efficacy of this new imaging modality in the clinical setting. Methods: ...
Significant Benefit of Multimodal Imaging: PET/CT Compared with PET Alone in Staging and Follow-up of Patients with Ewing Tumors
Dec 01, 2007; ... Hybrid PET/CT was compared with PET alone in the staging and restaging of patients with Ewing tumor to assess the benefit of the combined imaging technique. Methods: A total of 163 ^sup 18^F-FDG PET/CT studies performed in 53 patients (age: range, 4-38 y; median, 16.5 y) with histopathologically ...
Usefulness of Standardized Uptake Values for Distinguishing Adrenal Glands with Pheochromocytoma from Normal Adrenal Glands by Use of 6-^sup 18^F-Fluorodopamine PET
Dec 01, 2007; ... 6-^sup 18^F-Fluorodopamine (^sup 18^F-FDA) PET is a highly sensitive tool for the localization of pheochromocytoma (PHEO). The aim of this study was to establish cutoff values for pathologic and physiologic adrenal gland tracer uptake. Methods: ^sup 18^F-FDA PET with CT coregistration was ...
Imaging Gastric Cancer with PET and the Radiotracers ^sup 18^F-FLT and ^sup 18^F-FDG: A Comparative Analysis
Dec 01, 2007; ... In this pilot study, we evaluated 3'-deoxy-3'-^sup 18^F-fluorothymidine (FLT) PET for the detection of gastric cancer and compared the diagnostic accuracy with that of ^sup 18^F-FDG PET. Methods: Forty-five patients (31 male and 14 female) with histologically proven locally advanced gastric ...
Impact of Acquisition Geometry, Image Processing, and Patient Size on Lesion Detection in Whole-Body ^sup 18^F-FDG PET
Dec 01, 2007; ... The aim of this work was to develop a rigorous evaluation methodology to assess performance of different acquisition and processing methods for variable patient sizes in the context of lesion detection in whole-body ^sup 18^F-FDG PET. Methods: Fifty-nine bed positions were acquired in 32 ...
Comparison of ^sup 18^F-FDG PET and Optimized Voxel-Based Morphometry for Detection of Alzheimer's Disease: Aging Effect on Diagnostic Performance
Dec 01, 2007; ... The aim of this study was to compare optimized voxel-based morphometry (VBM) and ^sup 18^F-FDG PET for discrimination between patients with Alzheimer's disease (AD) and healthy subjects in relation to age. Methods: The study population consisted of 2 groups; the first group (27 AD patients and ...
Evaluation of Primary Brain Tumors Using ^sup 11^C-Methionine PET with Reference to a Normal Methionine Uptake Map
Dec 01, 2007; ... ^sup 11^C-Methionine PET is a well-established technique for evaluating tumor extent for diagnosis and treatment planning in neurooncology. Image interpretation is typically performed using the ratio of uptake within the tumor to a reference region. The precise location of this reference region ...
Striatal D^sub 2^ Receptor Availability After Shunting in Idiopathic Normal Pressure Hydrocephalus
Dec 01, 2007; ... Gait disturbance in idiopathic normal pressure hydrocephalus (iNPH) is reminiscent of parkinsonism. Our recent PET study showed reduction in postsynaptic D^sub 2^ receptor binding concomitant with a normality of presynaptic dopamine transporter binding. Here, we investigated the plasticity of ...
Microvascular Function in Viable Myocardium After Chronic Infarction Does Not Influence Fractional Flow Reserve Measurements
Dec 01, 2007; ... Fractional flow reserve (FFR) is an index of coronary stenosis severity. FFR is the ratio of hyperemic myocardial flow in the stenotic area to maximal flow in that same territory without stenosis and can be measured with a pressure wire. In patients with prior infarction, measuring FFR in ...
Additive Effects of Spironolactone and Candesartan on Cardiac Sympathetic Nerve Activity and Left Ventricular Remodeling in Patients with Congestive Heart Failure
Dec 01, 2007; ... The activation of the renin-angiotensin-aldosterone system prevents the uptake of norepinephrine in the myocardium. However, the additive effects of combined spironolactone and candesartan on cardiac sympathetic nerve activity (CSNA) have not been determined. We investigated the effects of the ...
Nuclear Imaging in Cardiac Resynchronization Therapy*
Dec 01, 2007; ... Recently, cardiac resynchronization therapy (CRT) has become implemented in the treatment of patients with severe heart failure. Although the improvement in systolic function after CRT implantation can be considerable, 20%-30% of patients do not respond to CRT. Evidence is accumulating that the ...
Imaging of Mesenchymal Stem Cell Transplant by Bioluminescence and PET
Dec 01, 2007; ... Dynamic measurements of infused stem cells generally require animal euthanasia for single-time-point determinations of engraftment. In this study, we used a triple-fusion reporter system for multimodal imaging to monitor human mesenchymal stem cell (hMSC) transplants. Methods: hMSCs were ...
Errata
Dec 01, 2007; ... The article "Lung Toxicity in Radioiodine Therapy of Thyroid Carcinoma: Development of a Dose-Rate Method and Dosimetric Implications of the 80-mCi Rule," by Sgouros et al. (J Nucl Med. 2006;47:1977-1984), contained substantive errors in the reported data. A corrected PDF version is available ...
Biodistribution and Predictive Value of ^sup 18^F-Fluorocyclophosphamide in Mice Bearing Human Breast Cancer Xenografts
Dec 01, 2007; ... In mice bearing human breast cancer xenografts, we examined the biodistribution of ^sup 18^F-fluorocyclophosphamide (^sup 18^F-F-CP) to evaluate its potential as a noninvasive prognostic tool for predicting the resistance of tumors to cyclophosphamide therapy. Methods: ^sup 18^F-F-CP was ...
Noninvasive Imaging of Human Telomerase Reverse Transcriptase (hTERT) Messenger RNA with ^sup 99m^Tc-Radiolabeled Antisense Probes in Malignant Tumors
Dec 01, 2007; ... The expression of human telomerase reverse transcriptase (hTERT) is present in most malignant cells (>85%) but is undetectable in most normal somatic cells. Visualization of hTERT expression using radionuclide targeting can provide important diagnostic information in malignant tumors. The ...
L-3-^sup 11^C-Lactate as a PET Tracer of Myocardial Lactate Metabolism: A Feasibility Study
Dec 01, 2007; ... Lactate is a key myocardial energy source. Lactate metabolism is altered in a variety of conditions, such as exercise and diabetes mellitus. However, to our knowledge, noninvasive quantitative measurements of myocardial lactate metabolism have never been performed because of the lack of an ...
Differential Uptake of O-(2-^sup 18^F-Fluoroethyl)-L-Tyrosine, L-^sup 3^H-Methionine, and ^sup 3^H-Deoxyglucose in Brain Abscesses
Dec 01, 2007; ... The amino acid O-(2-^sup 18^F-fluoroethyl)-L-tyrosine (^sup 18^F-FET) has been shown to be a useful tracer for brain tumor imaging. Experimental studies demonstrated no uptake of ^sup 18^F-FET in inflammatory cells but increased uptake has been reported in single cases of human brain abscesses ....
Computed Tomography and Magnetic Resonance of the Thorax
Dec 01, 2007; ... Computed Tomography and Magnetic Resonance of the Thorax D.P Naidich, W.R. Webb, N.L. Müller, I. Vlahos, and G.A. Krinsky Philadelphia, PA: Lippincott Williams and Wilkins, 2007, 897 pages, $149 This textbook, CT and Magnetic Resonance of the Thorax, was first published 21 years ago, and ...
Molecular and Cellular MR Imaging
Dec 01, 2007; ... Molecular and Cellular MR Imaging M.M.J. Modo and J.W.M. Bulte, eds. Boca Raton, FL: CRC Press, 2007, 421 pages, $169.95 The application of histology and molecular biology in humans is very restricted. Neither can provide a satisfactory noninvasive deep-tissue visualization of molecules ...
Radiation Dosimetry and Biodistribution in Monkey and Man of ^sup 11^C-PBR28: A PET Radioligand to Image Inflammation
Dec 01, 2007; ... ^sup 11^C-PBR28 ([methyl-^sup 11^C]N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine) is a recently developed radioligand to image peripheral benzodiazepine receptors (PBRs) in brain. The aim of this study was to estimate the human radiation doses of ^sup 11^C-PBR28 based on biodistribution ...
Posttherapy Radiation Safety Considerations in Radiomicrosphere Treatment with ^sup 90^Y-Microspheres
Dec 01, 2007; ... Radiomicrosphere treatment involves the intrahepatic arterial administration of ^sup 90^Y-resin or ^sup 90^Y-glass microspheres. The microspheres are biocompatible, but not biodegradable, and little to no ^sup 90^Y leaches from the microspheres. Without any bioelimination, the β-dose ...
L-Type Amino Acid Transporters LAT1 and LAT4 in Cancer: Uptake of 3-O-Methyl-6-^sup 18^F-Fluoro-L-Dopa in Human Adenocarcinoma and Squamous Cell Carcinoma In Vitro and In Vivo
Dec 01, 2007; ... Expression of system L amino acid transporters (LAT) is strongly increased in many types of tumor cells. The purpose of this study was to demonstrate that ^sup 18^F-labeled amino acids, for example, 3-O-methyl-6-^sup 18^F-fluoro-L-dopa (^sup 18^F-OMFD), that accumulate in tumors via LAT ...
MOC: Frequently Asked Questions
Dec 01, 2007; ... MAINTENANCE OF CERTIFICATION The American Board of Nuclear Medicine (ABNM) recognizes that its diplomates have many questions about Maintenance of Certification (MOC) requirements. The board has done its best to answer these questions; however, as these requirements evolve, changes in ...
Survey of Patient Release Information on Radiation and Security Checkpoints
Dec 01, 2007; ... Patients who receive radiopharmaceuticals in the course of diagnosis or treatment are often released when their bodies still contain elevated amounts of radioactive material. These amounts are sufficiently high to be detected by sensitive radiation monitors for days or even weeks after ...