The Journal of Nuclear Medicine back issues from January 2008:
Molecular Imaging in the Spotlight at RSNA 2007
Jan 01, 2008; ... Molecular imaging was both a highlighted topic and an integral part of many of the scientific presentations and exhibits, educational offerings, and technologic advances on display at the 93rd Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA), held ...
Optical Imaging Shines In Vivo
Jan 01, 2008; ... Noninvasive molecular imaging can be employed to quantitatively assess numerous physiological processes in vivo and is, therefore, an ideal metric to rapidly profile the initiation and progression of disease and its response to therapy. The entire field of molecular imaging has ...
Sudden Radioisotope Shortage Threatens Patient Care
Jan 01, 2008; ... In what members of the nuclear medicine community referred to as a "devastating" and "catastrophic" series of events, the Canadian supplier of more than 50% of the world's marketed radioisotopes shut down its reactor in late November. The result was an immediate shortage of ^sup 99m^Tc ...
Professional Resolutions
Jan 01, 2008; ... With a broader mission to be the leader in nuclear medicine and to advance molecular imaging and therapy, SNM is more diverse today than at any time in the past-a rich tapestry that comprises individuals with countless different medical backgrounds. SNM offers bold, innovative, and high-quality ...
MOC Fees: An Inconvenient Truth
Jan 01, 2008; ... A common complaint about meeting maintenance of certification (MOC) requirements is that physicians must pay not only MOC fees and examination fees to the American Board of Nuclear Medicine (ABNM) but also fees for continuing medical education (CME) and selfassessment modules to other ...
SNM Offers Fellowships for Japanese Physicians
Jan 01, 2008; ... SNM announced in early November the introduction of a 2-year, $24,000 fellowship program in the United States for Japanese physicians in the early stages of their careers. "The SNM Wagner-Torizuka Fellowship will advance fellows' research and clinical experience, as well as facilitate ...
ABMS Launches Certification PSA
Jan 01, 2008; ... The American Board of Medical Specialties (ABMS) announced on November 23 the launch of a television public service announcement (PSA) campaign to educate Americans about the significance of physician board certification as a credential to consider when selecting a physician. The "Certification ...
PET and PET/CT in the UK
Jan 01, 2008; ... In a monograph released in November. Karen Facey, PhD, and colleagues from the United Kingdom and New Zealand reported on a comprehensive survey of UK PET facilities to determine the clinical effectiveness of ^sup 18^F-FDG PET in breast, colorectal, head and neck, lung, lymphoma, melanoma, ...
FDA Advisory Committee Process Changes
Jan 01, 2008; ... The Food and Drug Administration (FDA) announced on November 15 steps to strengthen its advisory committee processes in response to recent recommendations from the Institute of Medicine. The measures include proposed new guidance or procedures on advisory committee voting, on disclosing ...
PET to Monitor Immune Response to Melanoma
Jan 01, 2008; ... Scientists at the University of California at Los Angeles (UCLA) Jonsson Comprehensive Cancer Center and at other institutions in Los Angeles announced on November 15 a $1.8 million grant from the W.M. Keck Foundation to fund collaborative research to genetically engineer the human immune system ...
IAEA and Molecular Nuclear Medicine
Jan 01, 2008; ... From November 10 through 14, almost 400 delegates from 82 countries attended the first International Conference on Clinical PET and Molecular Nuclear Medicine, held in at the Chulabhorn Research Institute in Bangkok, Thailand, and sponsored by the International Atomic Energy Agency (IAEA). The ...
HRSA Provider-Patient Communication Tool
Jan 01, 2008; ... The Health Research Services Administration (HRSA) announced on November 21 the launch of a new Web-based health communications training tool designed to improve interaction between health care providers and their patients. The interactive training course, "Unified Health Communication: ...
^sup 99m^Tc-Aprotinin Imaging in Amyloidosis
Jan 01, 2008; ... DIAGNOSIS In an article e-published on November 5 ahead of print in the European Journal of Haematology, Han et al. from the Royal Infirmary (Glasgow, UK), reported on a study designed to assess the effectiveness of 99mTc-aprotinin scintigraphy in systemic amyloidosis. The retrospective ...
Molecular Imaging Funded at Washington University
Jan 01, 2008; ... Washington University School of Medicine (St. Louis, MO) announced on November 8 that its innovative, multidisciplinary molecular imaging center had received a 5-year, $10 million grant from the National Cancer Institute (NCI). The grant will fund a second cycle of research at the Washington ...
CMS Posts HOPPS 2008 Final Rule
Jan 01, 2008; ... On November 1, the Centers for Medicare & Medicaid Services (CMS) posted an advance copy of the Hospital Outpatient Prospective Payment System (HOPPS) final 2008 rule. This final rule implements significant policy changes affecting hospital outpatient services paid under the HOPPS system ...
Second Primary Risk in Thyroid Ca Survivors
Jan 01, 2008; ... Subramanian et al. from Stanford University (Palo Alto, CA) reported on November 16 ahead of print in Thyroid on a systematic review and metaanalysis of the risk of second primary malignancies (SPMs) in thyroid cancer survivors. The authors screened relevant citations and reviewed 13 full-text ...
Hashimoto's Thyroiditis and Thyroid Cancer
Jan 01, 2008; ... In an article e-published on October 29 ahead of print in the Journal of Surgical Research, Repplinger et al. from the University of Wisconsin (Madison) reported on a retrospective study designed to determine whether a correlation exists between Hashimoto's thyroiditis (HT) and papillary thyroid ...
Novel Radioligand for PET in Neuroinflammation
Jan 01, 2008; ... Boulin et al. from the Laboratoire d'Imagerie Moléculaire Expérimentale (Orsay, France), a part of the Commissariat à l'Énergie Atomique, reported in the November 1 issue of Glia (2007; 55:1459-1468) on a new peripheral benzodiazepine receptor (PBR) ligand proposed as an alternative to PK11195 ...
Model for Bimodal Imaging of SSTR Expression
Jan 01, 2008; ... THERAPY In an article e-published on November 16 ahead of print in Neumendocrinology, Stelter et al. from the Universitätsmedizin Berlin (Germany) reported on an orthotopic mouse model of pancreatic somatostatin receptor (SSTR)-positive tumors that facilitates MR and PET imaging of SSTR ...
PET and Effects of Cardiac Resynchronization
Jan 01, 2008; ... In an article e-published on October 25 ahead of print in the Journal of Cardiovascular Electrophysiology, Christenson et al. from the Mayo Clinic and Mayo Clinic College of Medicine (Rochester, MI) reported on a study using ^sup 11^C-acetate PET and echocardiography to explore the effects of ...
Direct Implantation of Bone Marrow Cells in CAD
Jan 01, 2008; ... Tse et al. from the Queen Mary Hospital (Hong Kong) reported on November 5 ahead of print in the European Heart Journal on early results from a prospective randomized trial of direct endomyocardial implantation of bone marrow cells for therapeutic angiogenesis of severe coronary artery disease ...
PET Monitoring of Hypoxia
Jan 01, 2008; ... In an article published in the November 15 issue of the International Journal of Radiation Oncology, Biology, Physics (2007;69:1024-1031), Evans et al. from the University of Pennsylvania (Philadelphia) reported on the use of EF5, a 2-nitroimidazole hypoxia marker, to study the levels and ...
PET and Alcohol Detox
Jan 01, 2008; ... In another of their groundbreaking collaborations elucidating the neurologic mechanisms of addiction, Volkow et al. from the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism (Bethesda, MD) and Wang et al. from the Brookhaven National Laboratory (Upton, ...
E Coli Tumor-Targeting and Imaging
Jan 01, 2008; ... In an article e-published on November 10 ahead of print in Molecular Imaging and Biology, Min et al. from the Chonnam National University Medical School (Gwangju, South Korea) reported on noninvasive real-time imaging using tumor-targeting, light-emitting Escherichia coli. The studies were ...
Targeting Cancer as an Infectious Disease
Jan 01, 2008; ... Wang et al. from the Albert Einstein College of Medicine (Bronx, NY) reported on October 31 in PLoS One (2007;2:e114) on a study assessing the potential use of viral antigens as novel targets for both direct and prophylactic radioimmunotherapy (RIT) of cancers with viral etiologies (nearly 20% ...
Zevalin with Stem Cell Transplantation
Jan 01, 2008; ... In a study published in the November issue of the British Journal of Haematology (2007,139:590-599), Ferrucci et al. from the European Institute of Oncology (Milan, Italy) reported on a feasibility and toxicity pilot study of different levels of ^sup 90^Y-ibritumomab tiuxetan (Zevalin) ...
Multimodal SSTR Imaging
Jan 01, 2008; ... MOLECULAR IMAGING In an article e-published on November 20 ahead of print in Bioconjugale Chemistry, Edwards et al. from the Mallinckrodt Institute of Radiology at Washington University (St. Louis, MO) reported on the synthesis of a novel monomolecular agent for multimodel optical and ...
Modulating Prostate Ca Metastasis
Jan 01, 2008; ... Brakenhielm et al. from the University of California at Los Angeles reported in the November 15 issue of the International Journal of Cancer (2007;121:2153-2161) on a study investigating the possibility of modulating prostate cancer metastasis by the use of alymphangiogenic "switch" and the ...
Molecular Imaging of EGFR Expression
Jan 01, 2008; ... Barrett et al. from the National Institutes of Health (Bethesda, MD) and the University of Tokyo (Japan) reported in the November 15 issue of Clinical Cancer Research (2007;13: 6639-6648) on the use of a "cocktail" of optically labeled monoclonal antibodies for in vivo assessment of epidermal ...
Contrast US in Breast Cancer
Jan 01, 2008; ... In an article published in the November issue of the Journal of Ultrasound in Medicine (2007;26:15751586), Lyshchik et al. from Vanderbilt University Medical Center (Nashville, TN) reported on an investigation of the use of targeted contrast-enhanced highfrequency ultrasound for molecular ...
Optical Imaging: Current Applications and Future Directions
Jan 01, 2008; ... Optical techniques, such as bioluminescence and fluorescence, are emerging as powerful new modalities for molecular imaging in disease and therapy. Combining innovative molecular biology and chemistry, researchers have developed optical methods for imaging a variety of cellular and molecular ...
Don't Bury the V/Q Scan: It's as Good as Multidetector CT Angiograms with a Lot Less Radiation Exposure
Jan 01, 2008; ... Within the past decade, advances in CT technology have allowed superb angiographic studies for pulmonary embolism (PE) diagnosis. This has been embraced by clinicians and most diagnostic radiologists who are more comfortable with an anatomic demonstration of whether a clot is present or not as ...
^sup 18^F-FDG PET as a Routine Test for Posttherapy Assessment of Hodgkin's Disease and Aggressive Non-Hodgkin's Lymphoma: Where Is the Evidence?
Jan 01, 2008; ... The recently published 2 reports of the International Harmonization Project (IHP) in Lymphoma recommended the routine use of ^sup 18^F-FDG PET for posttherapy assessment of patients with Hodgkin's disease (HD) and diffuse large B-cell lymphoma, the most common and potentially curable form of ...
^sup 18^F-FDG PET for Posttherapy Assessment of Hodgkin's Disease and Aggressive Non-Hodgkin's Lymphoma: A Systematic Review
Jan 01, 2008; ... Although studies have shown that ^sup 18^F-FDG PET, when used to assess the response of malignant lymphoma after treatment, has a strong ability to predict relapse, its diagnostic accuracy in clinical practice remains unclear. The aim of this study was to systematically review the diagnostic ...
Comparison of Integrin ¿^sub v^ß^sub 3^ Expression and Glucose Metabolism in Primary and Metastatic Lesions in Cancer Patients: A PET Study Using ^sup 18^F-Galacto-RGD and ^sup 18^F-FDG
Jan 01, 2008; ... The expression of α^sub v^β^sub 3^ and glucose metabolism are upregulated in many malignant lesions, and both are known to correlate with an aggressive phenotype. We evaluated whether assessment of α^sub v^β^sub 3^ expression and of glucose metabolism with PET using ^sup ...
Clinical Experience with ¿-Particle-Emitting ^sup 211^At: Treatment of Recurrent Brain Tumor Patients with ^sup 211^At-Labeled Chimeric Antitenascin Monoclonal Antibody 81C6
Jan 01, 2008; ... α-Particle-emitting radionuclides, such as ^sup 211^At, with a 7.2-h half-life, may be optimally suited for the molecularly targeted radiotherapy of strategically sensitive tumor sites, such as those in the central nervous system. Because of the much shorter range and more potent ...
Probabilistic Anatomic Mapping of Cerebral Blood Flow Distribution of the Middle Cerebral Artery
Jan 01, 2008; ... Probabilistic atlases are more representative of the population than single brain atlases. They allow anatomic and functional labeling of the results of group studies in stereotactic space and, hence, the automated anatomic labeling of individual brain imaging data. Methods: In the current ...
Cortical Flattening Applied to High-Resolution ^sup 18^F-FDG PET
Jan 01, 2008; ... Group studies using PET and other types of neuroimaging require some means to achieve congruence of brain structures across subjects, such that scans from individuals varying in brain shape and gyral anatomy can be analyzed together. Volume registration methods are the most widely used approach ...
Quantification of Cerebral Blood Flow and Oxygen Metabolism with 3-Dimensional PET and ^sup 15^O: Validation by Comparison with 2-Dimensional PET
Jan 01, 2008; ... Quantitative PET with ^sup 15^O provides absolute values for cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral metabolic rate of oxygen (CMRO^sub 2^), and oxygen extraction fraction (OEF), which are used for assessment of brain pathophysiology. Absolute quantification relies on ...
Cochlear Implant Benefits in Deafness Rehabilitation: PET Study of Temporal Voice Activations
Jan 01, 2008; ... Cochlear implants may improve the medical and social prognosis of profound deafness. Nevertheless, some patients have experienced poor results without any clear explanations. One correlate may be an alteration in cortical voice processing. To test this hypothesis, we studied the activation of ...
Skeletal PET with ^sup 18^F-Fluoride: Applying New Technology to an Old Tracer*
Jan 01, 2008; ... Although ^sup 18^F-labeled NaF was the first widely used agent for skeletal scintigraphy, it quickly fell into disuse after the introduction of ^sup 99m^Tc-labeled bone-imaging agents. Recent comparative studies have demonstrated that ^sup 18^F-fluoride PET is more accurate than ^sup ...
A Feasibility Study of a Prototype PET Insert Device to Convert a General-Purpose Animal PET Scanner to Higher Resolution
Jan 01, 2008; ... We developed a prototype system to evaluate the feasibility of using a PET insert device to achieve higher resolution from a general-purpose animal PET scanner. Methods: The system consists of a high-resolution PET detector, a computer-controlled rotation stage, and a custom mounting plate. The ...
SPECT Low-Field MRI System for Small-Animal Imaging
Jan 01, 2008; ... Localization of regions with increased uptake of radiotracer in small-animal SPECT is greatly facilitated when using coregistration with anatomic images of the same animal. As MRI has several advantages compared with CT (soft-tissue contrast and lack of ionizing radiation) we developed a ...
Imaging of Gene Expression in Live Pancreatic Islet Cell Lines Using Dual-Isotope SPECT
Jan 01, 2008; ... We are combining nuclear medicine with molecular biology to establish a sensitive, quantitative, and tomographic method with which to detect gene expression in pancreatic islet cells in vivo. Dual-isotope SPECT can be used to image multiple molecular events simultaneously, and coregistration of ...
In Vivo Imaging of ^sup 64^Cu-Labeled Polymer Nanoparticles Targeted to the Lung Endothelium
Jan 01, 2008; ... Nanoparticles (NPs) targeting the intercellular adhesion molecule 1 (ICAM-1) hold promise as a mean of delivering therapeutics to the pulmonary endothelium in patients with acute and chronic respiratory diseases. As these new materials become available, strategies are needed to understand their ...
PET Imaging of VPAC1 Expression in Experimental and Spontaneous Prostate Cancer
Jan 01, 2008; ... Among U.S. men, prostate cancer (PC) accounts for 29% of all newly diagnosed cancers. A reliable scintigraphic agent to image PC and its metastatic or recurrent lesions and to determine the effectiveness of its treatment will contribute to the management of this disease. All PC overexpresses ...
^sup 99m^Tc-GSA Scintigraphy with SPECT for Assessment of Hepatic Function and Functional Volume During Liver Regeneration in a Rat Model of Partial Hepatectomy
Jan 01, 2008; ... Small-animal models are crucial to gain insights in the complex recovery mechanisms of liver function during liver regeneration. ^sup 99m^Tc-Mebrofenin hepatobiliary scintigraphy (HBS) has been introduced for noninvasive assessment of liver function in the clinical setting as well as in ...
Preclinical Efficacy of the c-Met Inhibitor CE-355621 in a U87 MG Mouse Xenograft Model Evaluated by ^sup 18^F-FDG Small-Animal PET
Jan 01, 2008; ... The purpose of this study was to evaluate the efficacy of CE-355621, a novel antibody against c-Met, in a subcutaneous U87 MG xenograft mouse model using ^sup 18^F-FDG small-animal PET. Methods: CE-355621 or control vehicle was administered intraperitoneally into nude mice (drug-treated group, n ...
Usefulness of ^sup 11^C-Methionine for Differentiating Tumors from Granulomas in Experimental Rat Models: A Comparison with ^sup 18^F-FDG and ^sup 18^F-FLT
Jan 01, 2008; ... Many clinical PET studies have shown that increased ^sup 18^F-FDG uptake is not specific to malignant tumors. ^sup 18^F-FDG is also taken up in inflammatory lesions, particularly in granulomatous lesions such as sarcoidosis or active inflammatory processes after chemoradiotherapy, making it ...
Generation of Destabilized Herpes Simplex Virus Type 1 Thymidine Kinase as Transcription Reporter for PET Reporter Systems in Molecular-Genetic Imaging
Jan 01, 2008; ... Herpes simplex virus type 1 thymidine kinase (HSV1-TK) is a widely used reporter for in vivo noninvasive monitoring of therapeutic gene expression, immune cell trafficking, and protein-protein interactions in various animal systems. However, the stability of HSV1-TK limits its application in ...
CELLDOSE: A Monte Carlo Code to Assess Electron Dose Distribution-S Values for ^sup 131^I in Spheres of Various Sizes
Jan 01, 2008; ... Monte Carlo simulation can be particularly suitable for modeling the microscopic distribution of energy received by normal tissues or cancer cells and for evaluating the relative merits of different radiopharmaceuticals. We used a new code, CELLDOSE, to assess electron dose for isolated spheres ...
Multifunctional Antibodies by the Dock-and-Lock Method for Improved Cancer Imaging and Therapy by Pretargeting
Jan 01, 2008; ... The Dock-and-Lock (DNL) method, which makes bioactive molecules with multivalency and multifunctionality, is a new approach to develop targeting molecules for improved cancer imaging and therapy. It involves the use of a pair of distinct protein domains involved in the natural association ...
Computed Tomography of the Lung: A Pattern Approach
Jan 01, 2008; ... Computed Tomography of the Lung: A Pattern Approach J.A. Verschakelen and W. De Wever Berlin, Germany: Springer-Verlag, 2007, 191 pages, $129 The purpose of this book is to present a pattern approach, using high-resolution CT, to evaluate the pulmonary parenchyma in normal and diseased ...
Diseases of the Heart, Chest and Breast: Diagnostic Imaging and Interventional Techniques
Jan 01, 2008; ... Diseases of the Heart, Chest and Breast: Diagnostic Imaging and Interventional Techniques J. Hodler, G.K. von Schulthess, and C.L. Zollikofer, eds. New York, NY: Springer, 2007, 222 pages, $99 This book is a condensed syllabus for the 39th International Diagnostic Course in Davos (IDKD), ...
Radioiodine Ablation Outcomes After Imaging with ^sup 123^I or ^sup 131^I: Is No News Good News?/REPLY
Jan 01, 2008; ... TO THE EDITOR: In a recent paper (1), Silberstein reported data from his study assessing outcomes of radioiodine ablation in patients with differentiated thyroid carcinoma after imaging with 2 different isotopes. This study analyzed the results from 49 patients, 26 of whom received ^sup 123^I ...
Merits of V/Q SPECT Scintigraphy Compared with CTPA in Imaging of Pulmonary Embolism/REPLY
Jan 01, 2008; ... TO THE EDITOR: We refer to the recent Invited Perspective which proposes that there is now a reduced role for V/Q scintigraphy in the detection of pulmonary embolism (PE) given the emergence of CT pulmonary angiography (CTPA) (1). Although the article addressed many of the strengths and ...
^sup 18^F-Galacto-RGD PET for [alpha]^sub v^[beta]^sub 3^ Imaging
Jan 01, 2008; ... Beer et al. from the Technische Universität München (Germany) and the Medizinische Universität Innsbruck (Austria) reported in the November 15 issue of Clinical Cancer Research (2007;13:6610-6616) on the use of ^sup 18^F-galacto-RGD PET for imaging α^sub v^β^sub 3^ expression in ...
USA TODAY Questions ^sup 131^I Patient Release Safety
Jan 01, 2008; ... Nuclear medicine practitioners across the United States found themselves answering numerous questions from concerned patients and families after a November 19 article in USA TODAY with a headline that asked, "It Kills Thyroid Cancer, But Is Radiation Safe?" The article focused on guidelines for ...
IN MEMORIAM: Eugene Lange Saenger, MD
Jan 01, 2008; ... Eugene Lange Saenger was born March 5, 1917, in Cincinnati, OH, and died there on September 30, 2007. He was predeceased by his daughter, Katherine, and wife, Sue Reis Saenger. He leaves a son, Eugene L. Saenger, Jr., and 4 grandchildren. He lived a rich, honorable life and led his medical ...