The Journal of Nuclear Medicine back issues from February 2008:
Meeting Needs of Today, Tomorrow
Feb 01, 2008; ... This past year, SNM grew and adapted to meet the changing needs of health care, our members, and the profession. The society adhered to its strategic plan and underwent rebranding, a process in which SNM and SNMTS officers reviewed all of the elements of our brand and took action to ...
Molecular Imaging: The State of the Science
Feb 01, 2008; ... We may not yet have reached a watershed, but 2007 was a significant year for molecular imaging. The concept of molecular imaging is percolating throughout the medical imaging community. We are seeing recognition of nuclear medicine as the original molecular imaging modality as well as a ...
Our Future Takes Shape
Feb 01, 2008; ... Health-related concerns top the list of promises many of us make to ourselves with each new calendar year-and it's no different with SNMTS. To remain strong and healthy, the Technologist Section has made the following resolutions for the new year and beyond. SNMTS will continue to ...
Continuing and Accumulating Successes
Feb 01, 2008; ... SNM has accomplished a great deal this past year-for our patients, for the public, and for the profession. These successes have occurred in the halls of Congress, with regulatory agencies, and with our professional colleagues. We have voiced concerns in the national media about critical ...
Physics Applications in Nuclear Medicine: 2007
Feb 01, 2008; ... The past year saw some revolutionary changes in methods and resources available for internal dose assessment, as well as excellent progress in instrumentation. Significant advances were seen in detector development and image analysis methods, and new tools and information for dosimetry became ...
The State of Nuclear Medicine, 2008
Feb 01, 2008; ... A Matter of Perspective Two themes emerged in reviewing the year's scientific and medical news in preparation for our annual retrospective issue of Newsline. Both themes ultimately have to do with scope or (because it is a term so much nearer to our daily experience) what we might call ...
From the SNM Brain Imaging Council
Feb 01, 2008; ... The SNM Brain Imaging Council provided an exceptional program of educational activities at both the 2007 Mid-Winter and Annual meetings of the SNM. Both programs were very well attended and stimulated renewed interest in brain imaging and enthusiasm for the future. To build upon this momentum, ...
From the SNM Nuclear Oncology Council
Feb 01, 2008; ... The SNM Nuclear Oncology Council (NOC) brings together individuals with special interest in nuclear oncology and radioisotope therapy to provide an opportunity for the integration of the practice of nuclear medicine as applied to superior patient care by facilitating excellence in education and ...
From the SNM Gastrointestinal Council
Feb 01, 2008; ... The SNM Gastrointestinal (GI) Council, established in 2007, was created to increase awareness and promote utilization of a wide range of GI scintigraphic studies and to develop more universal standardization for these procedures. The council proposes to achieve these goals through educational ...
From the SNM Correlative Imaging Council
Feb 01, 2008; ... The SNM Correlative Imaging Council had a very busy and productive year. The first Walter Wolf Young Investigator's Award in Correlative Imaging was presented at the 54th SNM Annual Meeting in Washington, DC, to Jan Soyka, MD, of the University Hospital in Zurich, Switzerland, for his abstract, ...
From the SNM Academic Council
Feb 01, 2008; ... The SNM Academic Council's mission includes helping residency directors fulfill Accreditation Council of Graduate Medical Education (ACGME) regulations, helping teachers teach more effectively, improving the educational experience of our residents, keeping program directors informed of changes ...
SNM Education Committee
Feb 01, 2008; ... The SNM Committee on Education has had a busy year developing online educational materials and organizing workshops to meet the educational needs of physicians, technologists, scientists, pharmacists, and other members. The SNM Web site was redesigned to provide faster and easier access to ...
From the SNM MIRD Committee
Feb 01, 2008; ... The mission of the SNM Medical Internal Radiation Dose (MIRD) Committee is to develop standard methods, models, and mathematical schema for assessing internal radiation dose from administered radiopharmaceuticals. Some of the objectives are to provide basic tools, methods, and guidance for ...
From the MICoE: Translating Molecular Imaging Techniques into Practical Medicine
Feb 01, 2008; ... SNM is firmly committed to a leadership role in the evolution of nuclear medicine by establishing the Molecular Imaging Center of Excellence (MICoE). In the past year, the MICoE has made remarkable progress toward the ambitious goals that were set at 2 summit meetings called to explore the ...
Maintenance of Certification: The Year in Review
Feb 01, 2008; ... Since the inception of the maintenance of certification (MOC) principle in 2001, the American Board of Medical Specialties (ABMS) has led and overseen the development of MOC programs for all 24 of its member boards. The development of MOC programs by member boards was not an option and was a ...
Action Plan for Emerging Molecular Imaging Technologies
Feb 01, 2008; ... As a major element of its ongoing molecular imaging campaign, SNM convened a retreat on June 23 and 24, 2007, in Reston, VA, to address issues related to the utilization of current PET probes, to the development of the next generation of molecular imaging probes and technologies, and to their ...
Released Nuclear Medicine Patients, Security Checkpoints, and the NRC/KATZ AND ANSARI RESPOND
Feb 01, 2008; ... TO THE JNM NEWSLINE EDITOR: We read with interest the Newsline article by Katz and Ansari (1) that appeared in the December 2007 issue of The Journal of Nuclear Medicine (JNM) concerning nuclear medicine patients potentially triggering radiation detectors. According to this article, many ...
Funding for Basic Nuclear Medicine Research Restored
Feb 01, 2008; ... On December 26, President Bush signed an omnibus appropriations package for fiscal year 2008. The bill contains $411,273,000 for biological research at the Department of Energy (DOE) Office of Science, including $31.5 million for Medical Applications and Measurement Science. This is an increase ...
Restored Funding for Nuclear Medicine Research
Feb 01, 2008; ... On December 26, President Bush signed an omnibus appropriations package for fiscal year 2008. The bill contains more than $411 million for biological research at the Department of Energy (DOE) Office of Science, including $31.5 million for medical applications and measurement science. This is an ...
Canadian Reactor Restarts
Feb 01, 2008; ... Under pressure from the Canadian government and through a special enforcement allowance from the country's nuclear regulatory agency, Atomic Energy of Canada, Ltd. (AECL) announced on December 13 that it would restart a nuclear reactor shut down for almost 1 month. The shutdown caused widespread ...
FDA Science and Research Criticized
Feb 01, 2008; ... An investigative report released on December 5 by a subcommittee of the Science Board, which advises the U.S. Food and Drug Administration (FDA), catalogued a lengthy list of shortcomings in technology, science, and research capacities, many of which were attributed to increased demands and ...
NRC Orders Fingerprints, Criminal Histories for Some Licensees
Feb 01, 2008; ... The Nuclear Regulatory Commission (NRC) issued an order on December 5 to almost 1,000 licensees to begin fingerprinting of and criminal history checks on all persons granted unescorted access to certain radioactive materials. The order applies to NRC licensees in industry, academia, and medicine ...
NCRP on Radionuclide Therapy Patients
Feb 01, 2008; ... The National Council on Radiation Protection and Measurements (NCRP) announced on November 26 the release of NCRP Report No. 155, Management of Radionuclide Therapy Patients, intended for use by physicians, medical physicists, health physicists, administrators, nurses, other professional and ...
NIH Launches Human Microbiome Project
Feb 01, 2008; ... The National Institutes of Health (NIH) announced on December 19 the official launch of the Human Microbiome Project, which will attempt to sequence the collective genomes of all microorganisms present in or on the human body. "The human microbiome is largely unexplored," said NIH Director Elias ...
IAEA Designates Nuclear Trafficking a Global Challenge
Feb 01, 2008; ... The illicit trafficking of nuclear material and the potential threat it poses continue to be issues of international concern, and steps to establish effective technical and administrative systems to prevent the unauthorized movement of nuclear and other radioactive materials must continue to be ...
National Biodefense Science Board Named
Feb 01, 2008; ... U.S. Department of Health and Human Services secretary Mike Leavitt announced on December 17 the names of members of the newly formed National Biodefense Science Board (NBSB). The NBSB will provide expert advice and guidance on scientific, technical, and other matters of special interest ...
Plasma Aminothiol Compounds in AD and MCI
Feb 01, 2008; ... DIAGNOSIS Hernanz et al. from the Hospital Universitario La Paz (Madrid, Spain) reported on December 5 ahead of print in Neuroimmunomodulation on blood chemistry and imaging studies designed to identify correlates of cognitive impairment in individuals with Alzheimer's disease (AD) and ...
PET and Donepezil Binding in AD
Feb 01, 2008; ... In an article e-published on December 7 ahead of print in the British Journal of Clinical Pharmacology, Okamura et al. from the Tohoku University Graduate School of Medicine (Sendai, Japan) reported on in vivo visualization of donepezil binding in the brains of patients with Alzheimer's disease ...
Optimal Node Numbers for Breast SLN Biopsy
Feb 01, 2008; ... Zakaris et al. from the Mayo Clinic (Rochester, MN) reported in the December 1 issue of the Journal of Surgical Oncology (2007;96:554-559) on a study designed to determine whether and how a surgeon can determine the optimal number of nodes in sentinel lymph node (SLN) biopsy for breast cancer ....
PET/CT Predictors in Ovarian Cancer
Feb 01, 2008; ... In an article e-published on December 3 ahead of print in Gynecologic Oncology, Risum et al. from the Copenhagen University Hospital (Denmark) reported on a study to identify the utility and specific applications of PET/ CT in predicting incomplete and/or suboptimal primary cytoreduction in ...
PET in Malignant Neoplasms of the Pancreas
Feb 01, 2008; ... Spelli et al. from the University of Padua (Italy) and the Castelfranco General Hospital (Treviso, Italy) reported in the December issue of the Annals of Surgery (2007;246:932-939) on a study assessing the ability of ^sup 18^F-FDG to distinguish benign from malignant intraductal papillary ...
SPECT and Ischemia in Hypertension
Feb 01, 2008; ... Lacourcière et al. from the Centre Hospitalier de l'Université Laval (Québec, Canada) and the Hôpital St-François D'Assise (Québec, Canada) reported in the December issue of the Journal of Clinical Hypertension (Greenwich) (2007;9:921-928) on a study designed to determine the ability of stress ...
Optimal Neck Exploration in Primary Hyperparathyroidism
Feb 01, 2008; ... Westerdahl and Bergenfelz from the Lund University Hospital (Sweden) reported in the December issue of the Annals of Surgery (2007;246:976-981) on a study comparing long-term outcomes in unilateral and bilateral neck exploration for primary hyperparathyroidism. The study included 91 patients ...
PET/CT in ^sup 131^I-Negative Recurrent DTC
Feb 01, 2008; ... Mirallié et al. from the Clinique de Chirurgie Digestive et Endocrinienne (Nantes. France) reported in the December issue of Surgery (2007; 142:952-958) on a study of outcomes in decision making based on ^sup 18^F-FDG PET/CT results in iodine-negative recurrence of differentiated thyroid ...
PET Staging in Pediatric Sarcoma
Feb 01, 2008; ... Völker et al. from the Charité-Universitätsmedizin Berlin (Germany) reported in the December 1 issue of the Journal of Clinical Oncology (2007;25: 5435-5441) on the results of a multicenter prospective trial to evaluate the impact of ^sup 18^F-FDG in initial staging and therapy planning in ...
RIT for Leptomeningeal Cancers
Feb 01, 2008; ... THERAPY Kramer et al. from the Memorial Sloan-Kettering Cancer Center (New York, NY) reported in the December 1 issue of the Journal of Clinical Oncology (2007;25:5465-5470) on the toxicity, pharmacokinetics, and dosimetry of intraventricular ^sup 131^labeled monoclonal antibody 3F8 ...
RIT in CNS Lymphoma
Feb 01, 2008; ... Iwamoto et al. from the Memorial Sloan-Kettering Cancer Center (New York, NY) reported in the December 1 issue of Cancer (2007;110:2528-2534) on research evaluating the feasibility of RIT delivery using an anti-CD20 antibody across the blood-brain barrier in refractory or recurrent primary ...
Nanoparticles and Stem Cell Engraftment
Feb 01, 2008; ... MOLECULAR IMAGING In an article e-published ahead of print on November 29 in Stem Cells, Maxwell et al. from the Washington University School of Medicine (St. Louis, MO) reported on the use of fluorophoreconjugated iron oxide nanoparticle labeling to characterize human hematopoietic stem ...
In Vivo Molecular Imaging to Subtype Tumors
Feb 01, 2008; ... Koyama et al. from the National Cancer Institute (Bethesda, MD) reported in the December issue of Neoplasia (2007;9:1021-1029) on a study of in vivo molecular imaging to diagnose and subtype tumors using receptor-targeted, optically labeled monoclonal antibodies. The researchers used multifilter ...
Functional Reactivity of Cerebral Capillaries
Feb 01, 2008; ... In an article e-published ahead of print on December 5 in the Journal of Cerebral Blood Flow and Metabolism, Stefanovic et al. from the National Institute of Neurological Disorders and Stroke (Bethesda, MD) reported on the use of photon laser scanning microscopy, in combination with intracranial ...
^sup 18^F-FLT PET in BRAF-Dependent Tumor Response
Feb 01, 2008; ... Solit et al. from the Memorial Sloan-Kettering Cancer Center (New York, NY) reported in the December 1 issue of Cancer Research (2007;67: 11463-11469) on the use of ^sup 18^F-fluorothymidine (^sup 18^F-FLT) PET to image the response of BRAF (v-raf murine sarcoma viral oncogene homolog ...
Multimodality Molecular Imaging with Combined Optical and SPECT/PET Modalities
Feb 01, 2008; ... Today's medical imaging technologies are expected to furnish anatomic, physiologic, molecular, and genomic information for accurate disease diagnosis, prediction of treatment response, and development of highly specific and sensitive drugs and imaging agents. However, none of the current imaging ...
A Potential Key Role for Radionuclide Imaging in the Prediction and Prevention of Sudden Arrhythmic Cardiac Death
Feb 01, 2008; ... Despite enormous progress over the past few decades in reducing deaths from cardiovascular disease, the ability to identify patients at risk for sudden cardiac death (SCD) remains a challenge. SCD accounts for about 350,000 deaths annually in the United States (1). Most SCDs are from ventricular ...
Revisiting an Old Issue: The Discrepancy Between Tissue Ratio-Derived Binding Parameters and Kinetic Modeling-Derived Parameters After a Bolus of the Serotonin Transporter Radioligand ^sup 123^I-ADAM
Feb 01, 2008; ... In vivo neuroreceptor imaging research based on radiolabeled probes has been performed in 2 imaging modalities-PET and SPECT. It is generally agreed that PET is the more quantitatively precise of the two (1) for a variety of reasons, such as the ease with which accurate attenuation correction ...
A Comparison of the Diagnostic Accuracy of ^sup 18^F-FDG PET and CT in the Characterization of Solitary Pulmonary Nodules
Feb 01, 2008; ... CT and PET are widely used to characterize solitary pulmonary nodules (SPNs). However, most CT accuracy studies have been performed with outdated technology and methods, and previous PET studies have been limited by small sample sizes and incomplete masking. Our objective was to compare CT and ...
A Multicenter Clinical Trial on the Diagnostic Value of Dual-Tracer PET/CT in Pulmonary Lesions Using 3'-Deoxy-3'-^sup 18^F-Fluorothymidine and ^sup 18^F-FDG
Feb 01, 2008; ... Some new radiotracers might add useful information and improve diagnostic confidence of ^sup 18^F-FDG imaging in tumors. A muiticenter clinical trial was designed to investigate the diagnostic performance of dual-tracer (^sup 18^F-FDG and 3'-deoxy3'-^sup 18^F-fluorothymidine [^sup 18^F-FLT]) ...
^sup 18^F-FDG PET/CT, ^sup 99m^Tc-MIBI, and MRI in Evaluation of Patients with Multiple Myeloma
Feb 01, 2008; ... New imaging techniques have been introduced to assess the extent and severity of disease in multiple myeloma (MM) patients. The aim of our study was to compare newer imaging modalities-such as ^sup 18^F-FDG PET/CT, ^sup 99m^Tc-methoxyisobutylisonitrite (^sup 99m^Tc-MIBI) scintigraphy, and MRI-to ...
Assessing Tumor Hypoxia in Cervical Cancer by PET with ^sup 60^Cu-Labeled Diacetyl-Bis(N^sup 4^-Methylthiosemicarbazone)
Feb 01, 2008; ... Tumor hypoxia indicates a poor prognosis. This study was undertaken to confirm our prior pilot results showing that pretreatment tumor hypoxia demonstrated by PET with ^sup 60^Cu-labeled diacetylbis(N^sup 4^-methylthiosemicarbazone) (^sup 60^Cu-ATSM) is a biomarker of poor prognosis in patients ...
1-^sup 11^C-Acetate Kinetics of Prostate Cancer
Feb 01, 2008; ... ^sup 18^F-FDG is in widespread use in cancer imaging but has limited utility in staging and monitoring of prostate cancer. 1-^sup 11^C-Labeled acetate, a substrate for the citric acid cycle, is superior. The kinetics of prostate tumors were investigated. Methods: Ten patients with primary ...
Diagnostic Performance of an Expert System for Interpretation of ^sup 99m^Tc MAG3 Scans in Suspected Renal Obstruction
Feb 01, 2008; ... The purpose of the study was to compare diuresis renography scan interpretation generated by a renal expert system with the consensus interpretation of 3 expert readers. Methods: The expert system was evaluated in 95 randomly selected furosemideaugmented patient studies (185 kidneys) obtained ...
Predicting the Need for an Implantable Cardioverter Defibrillator Using Cardiac Metaiodobenzylguanidine Activity Together with Plasma Natriuretic Peptide Concentration or Left Ventricular Function
Feb 01, 2008; ... Despite widespread use of implantable cardioverter defibrillators (ICDs), their cost and the fact that only a certain group of patients fully benefits from the devices require appropriate risk stratification of patients. This study investigated whether altered cardiac autonomic function is ...
Evidence for Pre- to Postsynaptic Mismatch of the Cardiac Sympathetic Nervous System in Ischemic Congestive Heart Failure
Feb 01, 2008; ... Pre- and postsynaptic cardiac sympathetic function is altered in ischemic congestive heart failure (CHF). Whether there is a presynaptic-to-postsynaptic mismatch or whether mismatch is related to adverse cardiac events is unknown. Methods: In 13 patients with ischemic CHF and 25 aged-matched ...
Shorter Examination Method for the Diagnosis of Misery Perfusion with Count-Based Oxygen Extraction Fraction Elevation in ^sup 15^O-Gas PET
Feb 01, 2008; ... ^sup 15^O-Gas PET is useful for evaluating hemodynamic status in patients with ischemic cerebrovascular disease. To reduce examination time and exposure to radioactive gas, we assessed a count-based method with shorter continuous ^sup 15^O^sub 2^ gas inhalation. Methods: Twenty-five patients (66 ...
Evaluation of the Serotonin Transporter Ligand ^sup 123^I-ADAM for SPECT Studies on Humans
Feb 01, 2008; ... Imaging serotonin transporters in the living human brain is important in several fields, such as normal psychophysiology, mood disorders, eating disorders, and neurodegenerative disorders. The aim of this study was to compare different kinetic and semiquantitative methods for assessing serotonin ...
Gastrin-Releasing Peptide Receptor Imaging in Human Breast Carcinoma Versus Immunohistochemistry
Feb 01, 2008; ... This study reports on the uptake of ^sup 99m^Tc-RP527 by human breast carcinoma and its relationship to gastrin-releasing peptide receptor (GRP-R) expression as measured by immunohistochemistry (IHC). Methods: Nine patients referred because of a clinical diagnosis suggestive of breast carcinoma ...
Uncommon Causes of Thyrotoxicosis*
Feb 01, 2008; ... Apart from the common causes of thyrotoxicosis, such as Graves' disease and functioning nodular goiters, there are more than 20 less common causes of elevated free thyroid hormones that produce the symptoms and signs of thyrotoxicosis. This review describes these rarer conditions and includes 14 ...
A Method to Correct for Radioactivity in Large Vessels That Overlap the Spine in Imaging-Based Marrow Dosimetry of Lumbar Vertebrae
Feb 01, 2008; ... Accurate marrow dosimetry for radionuclide therapy based on imaging methods has been challenging because of a variety of factors. One of the uncertainties in image quantification of lumbar vertebrae is correction for radioactivity in large blood vessels anterior to the vertebrae. We developed a ...
Development of a Dual-Luciferase Reporter System for In Vivo Visualization of MicroRNA Biogenesis and Posttranscriptional Regulation
Feb 01, 2008; ... MicroRNAs (miRNAs) function in mammalian cells via translational repression or messenger RNA (mRNA) cleavage of target genes by base-pairing with 3' untranslated regions (UTRs) of target mRNAs. Although miRNAs are involved in cell differentiation or organ development, posttranscritptional ...
Pulsed High-Intensity Focused Ultrasound Enhances Uptake of Radiolabeled Monoclonal Antibody to Human Epidermoid Tumor in Nude Mice
Feb 01, 2008; ... The aim of this study was to determine if pulsed high-intensity focused ultrasound (HIFU) exposures could enhance tumor uptake of ^sup 111^In-MX-B3, a murine IgG1κ monoclonal antibody directed against the Le^sup y^ antigen. Methods: MX-B3 was labeled with ^sup 111^In, purified, and ...
Changes in ^sup 18^F-FDG Uptake Within Minutes After Chemotherapy in a Rabbit VX2 Tumor Model
Feb 01, 2008; ... The purpose of this study was to investigate whether ^sup 18^F-FDG PET/CT can be used for in vivo chemosensitivity testing and to determine the optimal time point for observation. Methods: Forty-two rabbits with 84 implanted VX2 squamous cell tumors were randomized into a control group (n = 10) ...
SPECT Study of Folate Receptor-Positive Malignant and Normal Tissues in Mice Using a Novel ^sup 99m^Tc-Radiofolate
Feb 01, 2008; ... The folate receptor (FR) is overexpressed on epithelial cancers (FR-α) and on activated, but not resting, macrophages (FR-β) involved in a variety of inflammatory and autoimmune diseases. Therefore, folate-based radiopharmaceuticals have the potential to be used as imaging agents of ...
Bombesin Receptor Antagonists May Be Preferable to Agonists for Tumor Targeting
Feb 01, 2008; ... Two bombesin analogs, Demobesin 4 and Demobesin 1, were characterized in vitro as gastrin-releasing peptide (GRP) receptor agonist and antagonist, respectively, and were compared as ^sup 99m^Tc-labeled ligands for their in vitro and in vivo tumor-targeting properties. Methods: N^sub 4^-[Pro^sup ...
Pediatric Radiology Review
Feb 01, 2008; ... Pediatric Radiology Review M.D. Pappas, L.G. Yamamoto, and O. Anene, eds. Totowa, NJ: Humana Press, 2007, 174 pages, $90 Pediatric Radiology Review, written for an audience of nonradiologists (medical students, residents, and clinicians) involved in the medical care of children, consists ...
1-^sup 11^C-Acetate as a PET Radiopharmaceutical for Imaging Fatty Acid Synthase Expression in Prostate Cancer
Feb 01, 2008; ... Although it is accepted that the metabolic fate of 1-^sup 11^C-acetate is different in tumors than in myocardial tissue because of different clearance patterns, the exact pathway has not been fully elucidated. For decades, fatty acid synthesis has been quantified in vitro by the incubation of ...
Advances in Healthcare Technology: Shaping the Future of Medical Care
Feb 01, 2008; ... Advances in Healthcare Technology: Shaping the Future of Medical Care G. Spekowius and T. Wendler. eds. Dordrecht, The Netherlands: Springer, 2006, 538 pages, $159 In the mid 1960s Gordon Moore, cofounder of Intel Corp., professed that the number of transistors on an integrated circuit ...