The Journal of Nuclear Medicine back issues from April 2008:
Continued Fallout Over Canada Reactor Shutdown
Apr 01, 2008; ... Although routine shipments of medical radioisotopes have been restored after the Chalk River, Ontario, National Research Universal (NRU) reactor was restarted on December 16 under a special enforcement allowance from Canada's nuclear regulatory agency, debate and controversy continue. Much of ...
2009 Budget Recommendations/Physician Quality Consortium
Apr 01, 2008; ... The U.S. Department of Energy (DOE) released its budget recommendations for Fiscal Year (FY) 2009 in early February. The recommendations include $13.1 million for the Radiochemistry and Instrumentation program within the Biological and Environmental Research (BER) program in the Office of ...
MI at the Mid-Winter Meeting
Apr 01, 2008; ... At SNM's Mid-Winter Educational Symposium, held February 14-18 in Newport Beach, CA, 2 educational sessions focused on molecular imaging. The SNM Radiopharmaceutical Sciences Council, in collaboration with the Molecular Imaging Center of Excellence, sponsored a program titled "New ...
Strong North American SPECT/CT Market
Apr 01, 2008; ... Frost & Sullivan (Palo Alto, CA), a market growth consulting and research firm, released analysis on February 25 indicating that the North American nuclear medicine equipment market may recover more quickly than expected from the effects of the Deficit Reduction Act (DRA) of 2005. Driving ...
Speaking Out for What Is Right
Apr 01, 2008; ... The right drug for the right patient at the right time." It's a phrase heard often these days as issues of safety, efficacy, and the cost of health care dominate many discussions on the state of modern medicine. It is also a focus at SNM as we continue to spread the word-that nuclear medicine ...
Participating in MOC
Apr 01, 2008; ... The American Board of Nuclear Medicine (ABNM) is asked increasingly by state medical licensing boards, credentialing committees, and payers whether individual diplomates are participating in maintenance of certification (MOC). The ABMS expects that diplomates of all medical boards will be ...
2007 Annual Report: Funding the FUTURE
Apr 01, 2008; ... THE EDUCATION AND RESEARCH FOUNDATION FOR THE SOCIETY OF NUCLEAR MEDICINE The mission of the Foundation is to advance excellence in healthcare through the support of education and research in nuclear medicine and molecular imaging by provision of grants and awards. The vision of ...
AAPM Report on CT Radiation Dose
Apr 01, 2008; ... The American Association of Physicists in Medicine (AAPM) released in January a report on CT radiation dose management, providing information on the latest dose reduction technology and recommending standardized ways of reporting doses. The report, Measurement, Reporting, and Management of ...
FDA Draft Guidance on Industry Medical Publications
Apr 01, 2008; ... The U.S. Food and Drug Administration (FDA) on February 15 issued draft guidance on "Good Reprint Practices" for industry use in the distribution of medical or scientific journal articles and reference publications that involve unapproved uses of PDA-approved drugs and medical devices. "Articles ...
IOM Recommends National Health Product Review
Apr 01, 2008; ... A report released on January 24 by the Institute of Medicine (IOM), part of the National Academies, offered a blueprint for a national program that would assess the effectiveness of clinical services and provide unbiased information about which health care products are effective. Knowing What ...
CMS: Steady Growth in Health Spending
Apr 01, 2008; ... The Centers for Medicare and Medicaid Services (CMS) issued a report on February 26 estimating growth in health care spending in the United States to have been at 6.7% in 2007 and projecting that average annual growth would remain near that rate throughout the next decade. The analysis was ...
Better Medical Device Info Needed
Apr 01, 2008; ... Researchers from the University of California-San Francisco (UCSF) and other institutions provided perspectives and analyses in the January issue of the Journal of General Internal Medicine (2008;23[suppll]:1,57-63) on the current approval process for medical devices, noting that the process ...
Health Plans Target Imaging
Apr 01, 2008; ... The Center for Studying Health System Change (HSC; Washington, DC) released on February 21 the results of a study suggesting that health plans are increasing efforts to slow the proliferation of advanced imaging services, including CT, PET, MR, and nuclear cardiology studies. "Health plans are ...
NRC Special Inspection Focuses on Generators
Apr 01, 2008; ... The U.S. Nuclear Regulatory Commission (NRC) on February 1 issued a Confirmatory Action Letter to Mallinckrodt, Inc. (also known as Covidien Imaging Solutions; Maryland Heights, MO), and announced that a special inspection team had been formed to evaluate events surrounding problems with the ...
DOE Technology Transfer Policy
Apr 01, 2008; ... U.S. Secretary of Energy Samuel W. Bodman issued a policy statement on February 8 on Department of Energy (DOE) efforts to transfer stateof-the-art technologies from its national laboratories and facilities to the marketplace. The policy lays out guiding principles, responsibilities, and a ...
NRC Announces New Strategic Plan
Apr 01, 2008; ... On February 19, the Nuclear Regulatory Commission (NRC) issued its new Strategic Plan for Fiscal Years 2008 to 2013, establishing the ways in which the agency intends to carry out its mission by licensing and regulating the safe and secure use and management of radioactive materials. "This ...
PET and Moderate Alcohol Consumption
Apr 01, 2008; ... DIAGNOSIS In an article e-published on February 14 ahead of print in Psychiatry Research, Volkow and colleagues from the National Institute on Drug Abuse (Bethesda, MD), National Institute on Alcohol Abuse and Alcoholism (Bethesda), and Brookhaven National Laboratory (Upton, NY) reported ...
Mapping Selective Neuronal Loss
Apr 01, 2008; ... Giffard et al. from the INSERM at the University of Caen (France) and from the University of Cambridge (UK) reported on January 31 ahead of print in Stroke on an in vivo study of the feasibility of PET and MR imaging for mapping selective neuronal loss after focal ischemia and reperfusion. The ...
PET Metrics vs RECIST in Sarcoma Response
Apr 01, 2008; ... Evilevitch et al. from the University of Freiburg (Germany) and from the University of California at Los Angeles reported in the February 1 issue of Clinical Cancer Research (2008;14:715-720) on a study designed to determine whether ^sup 18^F-FDG PET imaging in patients with soft-tissue sarcomas ...
^sup 123^I-MIBG Cardiac Scintigraphy in MS
Apr 01, 2008; ... Lorberboym et al. from the Wolfson Medical Center (Holon, Israel) reported on February 20 ahead of print in the Journal of Neurology on a study assessing the ability of ^sup 123^I-MIBG cardiac scintigraphy to evaluate direct cardiac sympathetic denervation in patients with multiple sclerosis ...
Targeting Receptor-Mediated Signal Transduction
Apr 01, 2008; ... Bhattacharjee et al. from the National Institutes of Health (Bethesda, MD) reported on February 15 ahead of print in Psychopharmacology (Berlin) on animal studies with PET designed to image apomorphine stimulation of brain arachidonic acid signaling via D^sub 2^-like receptors. The study ...
Scintigraphy, Diabetes, and Nicotinamide Therapy
Apr 01, 2008; ... Chianelli et al. from the Regina Apostolorum Hospital (Albano Laziale, Italy) reported in the February issue of Diabetes/Metabolism Research and Reviews (2008;24:115-122) on the utility of ^sup 99m^Tc-interleukin-2 pancreatic scintigraphy to identify pancreatic inflammation at the time of ...
PET in Staging SCLC
Apr 01, 2008; ... Vinjamuri et al. from the West Virginia University Hospital (Morgantown) reported in the January issue of Clinical Lung Cancer (2008;9:30-34) on a study to determine the utility of PET in staging of small-cell lung cancer (SCLC). The study included the records of 51 patients who had undergone ...
Single-Dose ^sup 211^At RIT in Experimental Breast Tumor
Apr 01, 2008; ... THERAPY Robinson et al. from the Fox Chase Cancer Center (Philadelphia, PA) reported in the February 1 issue of Clinical Cancer Research (2008; 14: 875-882) on a study to determine whether the C6.5 diabody, a noncovalent anti-HER2 single-chain Friend virus dimer, would be a suitable ...
MAb RIT of Human Synovial Sarcoma
Apr 01, 2008; ... In an article in the February issue of Cancer Science ( 2008 ;99:452-440), Fukukawa et al. from the University of Tokyo (Japan) built on previous work with Frizzled homolog 10 (FZDlO), a promising therapeutic target for synovial sarcomas, by reporting on the development of a murine monoclonal ...
Tracking Human Embryonic Stem Cells
Apr 01, 2008; ... MOLECULAR IMAGING Li et al. from Stanford University (CA) reported on January 24 ahead of print in Stem Cells on a study comparing reporter gene and iron particle labeling and their respective imaging techniques for tracking the fate of human embryonic stem (hES) cells and differentiated ...
PET and NHL Response to Fractionated RIT
Apr 01, 2008; ... In an article e-published on February 11 ahead of print in Haematologica, Bodet-Milin et al. from University Hospital (Nantes, France) reported on a study designed to evaluate the efficacy of ^sup 18^F-FDG PET imaging in early prediction of response to radioimmunotherapy (RTT) in patients with ...
Imaging Transglutaminase Activity in Cardiac Healing
Apr 01, 2008; ... Nahrendorf et al. from the Massachusetts General Hospital and the Harvard Medical School (Boston, MA) reported in the February issue of the European Heart Journal (2008; 29:445-454) on the use of a novel molecular imaging technique in the assessment of the effects of transglutaminase-modulating ...
PET Monitoring of VEGF Expression
Apr 01, 2008; ... In an article e-published on February 4 ahead of print in Circulation, Willmann et al. from the Stanford University School of Medicine (CA) and the University of California at San Francisco reported on the use of ^sup 64^Culabeled vascular endothelial growth factor 121 (^sup 64^Cu-VEGF121) PET ...
Optical Imaging of Staphylococcus Aureus
Apr 01, 2008; ... A group of 9 researchers representing academic institutions across the United States and from China reported on February 9 ahead of print in Bioconjugate Chemistry on a study of optical imaging of Staphylococcus aureus infection in living mice. Leevy et al. described the development of a ...
Receptor Binding and Predisposition to Alcoholism
Apr 01, 2008; ... Underwood et al. from the New York State Psychiatric Institute (New York, NY) reported on January 30 ahead of print in Alcohol: Clinical and Experimental Research on post mortem investigations to determine whether 5-HT2A receptors are altered in the prefrontal cortex in alcoholics. The study ...
Advances in Anatomic, Functional, and Molecular Imaging of Angiogenesis
Apr 01, 2008; ... Angiogenesis is a fundamental process in various physiologic and pathologic processes. The ability to visualize and quantify angiogenesis will allow early diagnosis and monitoring for clinical determination of angiogenesis states before, during, and after adjuvant antiangiogenic and therapeutic ...
Correlative Imaging of Hypoxia and Angiogenesis in Oncology
Apr 01, 2008; ... Hypoxia plays a critical role in tumor development and aggressiveness and is an important prognostic factor for resistance to antineoplastic treatments. Hypoxie cells in tumors are about 3-fold more resistant to radiation therapy than their well-oxygenated counterparts (1). In the early stage of ...
Tumor Blood Flow Measured by PET Dynamic Imaging of First-Pass ^sup 18^F-FDG Uptake: A Comparison with ^sup 15^O-Labeled Water-Measured Blood Flow
Apr 01, 2008; ... PET molecular imaging of ^sup 15^O-labeled water is the gold standard for measuring blood flow in humans. However, this requires an on-site cyclotron to produce the short-lived ^sup 15^O tracer, which is cost-prohibitive for most clinical PET centers. The purpose of this study was to determine ...
^sup 18^F-Dihydroxyphenylalanine PET in Patients with Biochemical Evidence of Medullary Thyroid Cancer: Relation to Tumor Differentiation
Apr 01, 2008; ... Curative treatment for recurrent medullary thyroid cancer (MTC), diagnosed by rising serum calcitonin, is surgery, but tumor localization is difficult. Therefore, the value of ^sup 18^F-dihydroxyphenylanaline PET (^sup 18^F-DOPA PET), ^sup 18^F-FDG PET, ^sup 99m^Tc-V-di-mercaptosulfuricacid ...
Clinical Utility of ^sup 18^F-FDG PET/CT in Assessing the Neck After Concurrent Chemoradiotherapy for Locoregional Advanced Head and Neck Cancer
Apr 01, 2008; ... For patients with locoregional advanced head and neck squamous cell carcinoma (HNSCC), concurrent chemoradiotherapy is a widely accepted treatment, but the need for subsequent neck dissection remains controversial. We investigated the clinical utility of ^sup 18^F-FDG PET/CT in this setting ....
Scintigraphic Detection of ^sup 125^I Seeds After Permanent Brachytherapy for Prostate Cancer
Apr 01, 2008; ... The purpose of this investigation was to monitor the localization and migration of ^sup 125^I seeds after permanent brachytherapy for prostate cancer using a new scintigraphic technique that may overcome the drawbacks of conventional x-ray methods. Methods: ^sup 125^I seeds emit γ-rays with ...
Reducing the Incidence of ^sup 131^I-Induced Sialadenitis: The Role of Pilocarpine
Apr 01, 2008; ... The goal of this study was to reduce the salivary symptoms of pain and xerostomia caused by ^sup 131^I therapy for papillary and follicular thyroid carcinoma. Methods: In a single-blind controlled prospective study of 60 patients, we investigated whether pilocarpine, 5 mg orally every 8 h for 1 ...
Value and Limitations of Target-Vessel Ischemia in Predicting Late Clinical Events After Drug-Eluting Stent Implantation
Apr 01, 2008; ... Drug-eluting stents reduce clinical events related to restenosis but may be complicated by late stent-thrombosis. Whereas assessment of target-vessel ischemia by myocardial perfusion scintigraphy identifies relevant restenosis noninvasively, it is unknown whether this technique may also predict ...
Quantitative Measures of Coronary Stenosis Severity by 64-Slice CT Angiography and Relation to Physiologic Significance of Perfusion in Nonobese Patients: Comparison with Stress Myocardial Perfusion Imaging
Apr 01, 2008; ... Coronary stenosis severity by 64-slice CT angiography (CTA) is acceptably correlated with intravascular ultrasound. Stress myocardial perfusion imaging using SPECT is an established method for assessment of the functional significance of coronary stenosis. Our aim was to assess a clinical ...
Effect of Progenitor Cells on Myocardial Perfusion and Metabolism in Patients After Recanalization of a Chronically Occluded Coronary Artery
Apr 01, 2008; ... Even after recanalization of a chronic total coronary occlusion, functional recovery is incomplete and parts of the myocardium remain hypoperfused. In this randomized, placebo-controlled, and double-blinded study, we investigated relative changes in myocardial perfusion and glucose metabolism ...
6-L-^sup 18^F-Fluorodihydroxyphenylalanine PET in Neuroendocrine Tumors: Basic Aspects and Emerging Clinical Applications*
Apr 01, 2008; ... In recent years, 6-L-^sup 18^F-fluorodihydroxyphenylalanine (^sup 18^F-DOPA) PET has emerged as a new diagnostic tool for the imaging of neuroendocrine tumors. This application is based on the unique property of neuroendocrine tumors to produce and secrete various substances, a process that ...
Erratum
Apr 01, 2008; ... In the article "Disulfiram Inhibits Defluorination of ^sup 18^F-FCWAY, Reduces Bone Radioactivity, and Enhances Visualization of Radioligand Binding to ...
Modeling Considerations for ^sup 11^C-CUMI-101, an Agonist Radiotracer for Imaging Serotonin 1A Receptor In Vivo with PET
Apr 01, 2008; ... Several lines of evidence demonstrate involvement of serotonin 1A receptors (5-HT^sub 1A^Rs) in the pathophysiology of neuropsychiatrie disorders such as depression, suicidal behavior, schizophrenia, and Alzheimer's disease. We recently published the synthesis and initial evaluation of ...
Intratumoral Spatial Distribution of Hypoxia and Angiogenesis Assessed by ^sup 18^F-FAZA and ^sup 125^I-Gluco-RGD Autoradiography
Apr 01, 2008; ... The hypoxia-inducible factor-1α (HIF-1α) activates angiogenesis in response to cellular hypoxia, suggesting a spatial correlation between angiogenesis and tissue hypoxia. Methods: Using digital autoradiography of coinjected ^sup 18^F-labeled azomycin arabinoside (^sup 8^F-FAZA) ...
Spillover and Partial-Volume Correction for Image-Derived Input Functions for Small-Animal ^sup 18^F-FDG PET Studies
Apr 01, 2008; ... We present and validate a method to obtain an input function from dynamic image data and 0 or 1 blood sample for small-animal ^sup 18^F-FDG PET studies. The method accounts for spillover and partial-volume effects via a physiologic model to yield a model-corrected input function (MCIF). Methods: ...
Pemetrexed Improves Tumor Selectivity of ^sup 111^In-DTPA-Folate in Mice with Folate Receptor-Positive Ovarian Cancer
Apr 01, 2008; ... Folate-based radiopharmaceuticals can be used as imaging agents and for potential radiotherapy of folate receptor (FR)-positive malignant tissue (e.g., ovarian carcinomas). However, substantial FR expression in the kidneys results in undesired renal retention of radioactivity. Recently, we found ...
Cancer Detection Using a PET Tracer, ^sup 11^C-Glycylsarcosine, Targeted to H+/Peptide Transporter
Apr 01, 2008; ... H+/peptide transporter, PEPT1, is functionally expressed in some human cancer cell lines and might be a candidate molecular target for detection of cancers in vivo using PET. The aim of the present study was to establish a novel tumor-imaging technology using a PET tracer targeted to H+/peptide ...
Initial Characterization of an ^sup 18^F-Labeled Myocardial Perfusion Tracer
Apr 01, 2008; ... PET allows for quantitative, regional myocardial perfusion imaging. The short half-lives of the perfusion tracers currently in use limit their clinical applicability. Here, the biodistribution and imaging quality of a new ^sup 18^F-labeled myocardial perfusion agent (^sup 18^F-BMS-747158-02) in ...
^sup 11^C-Loperamide and Its N-Desmethyl Radiometabolite Are Avid Substrates for Brain Permeability-Glycoprotein Efflux
Apr 01, 2008; ... Loperamide, an opiate receptor agonist, does not cross the blood-brain barrier because it is a substrate for the permeability-glycoprotein (P-gp) efflux pump. We evaluated ^sup 11^C-loperamide as a PET radiotracer to measure P-gp function in vivo. Methods: Monkeys were injected with ^sup ...
PET Image Denoising Using a Synergistic Multiresolution Analysis of Structural (MRI/CT) and Functional Datasets
Apr 01, 2008; ... PET allows the imaging of functional properties of the living tissue, whereas other modalities (CT, MRI) provide structural information at significantly higher resolution and better image quality. Constraints for injected radioactivity, technologic limitations of current instrumentation, and ...
Imaging of HSV-tk Reporter Gene Expression: Comparison Between [^sup 18^F]FEAU, [^sup 18^F]FFEAU, and Other Imaging Probes
Apr 01, 2008; ... Herpes virus type 1 thymidine kinase (HSV1-tk) and the mutant HSV1-sr39tk are the 2 most widely used "reporter genes" for radiotracer-based imaging. Two pyrimidine nucleoside analogs, [^sup 18^F]FEAU (1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-ethyluridine) and [^sup 18^F]FFEAU ...
In Vitro Evaluation of Radioprotective and Radiosensitizing Effects of Rituximab
Apr 01, 2008; ... Clinical radioimmunotherapies with anti-CD20 monoclonal antibodies involve administering a predose of unlabeled anti-CD20 antibodies to favorably alter the biodistribution profile of the subsequently administered radiolabeled antibodies and mediate antitumor effects. Prior in vitro data ...
Imaging of VEGF Receptor in a Rat Myocardial Infarction Model Using PET
Apr 01, 2008; ... Myocardial infarction (MI) leads to left ventricular (LV) remodeling, which leads to the activation of growth factors such as vascular endothelial growth factor (VEGF). However, the kinetics of a growth factor's receptor expression, such as VEGF, in the living subject has not yet been described ....
New Technologies in Radiation Oncology
Apr 01, 2008; ... New Technologies in Radiation Oncology W. Schlegel, T. Bortfeld, and A.-L. Grosu, eds. New York, NY: Springer, 2006, 459 pages, $269 New Technologies in Radiation Oncology provides an excellent overview of recent technologic developments in the field of radiation oncology. This book is ...
PET/CT in Clinical Practice
Apr 01, 2008; ... PET/CT in Clinical Practice T.B. Lynch New York, NY: Springer, 2007, 241 pages, $39.95 PET/CT has an ability that has revolutionized the detection and staging of various tumors: the ability to accurately identify the anatomic location of abnormal metabolic activity. This new technology ...
Can LV Dyssynchrony as Assessed with Phase Analysis on Gated Myocardial Perfusion SPECT Preferably Predict Response to CRT?/REPLY
Apr 01, 2008; ... TO THE EDITOR: I read with great interest the study by Henneman et al. (J) suggesting that response to cardiac resynchronization therapy (CRT) is related to the presence of left ventricular (LV) dyssynchrony as assessed by phase analysis with gated myocardial perfusion SPECT. The study confirmed ...
PET-MR Fusion in Thyroid Cancer
Apr 01, 2008; ... Seiboth et al. from the Washington Hospital Center (DC) reported in the February issue of Thyroid (2008; 18: 103-111) on a study assessing the incremental clinical utility of fused PET and MR imaging of the neck in detection of recurrent or persistent thyroid cancer. The study included 34 ...
Estimation of the [beta]+ Dose to the Embryo Resulting from ^sup 18^F-FDG Administration During Early Pregnancy
Apr 01, 2008; ... Although ^sup 18^F-FDG examinations are widely used, data are lacking on the dose to human embryo tissues in cases of exposure in early pregnancy. Although the photon component can easily be estimated from available data on the pharmacokinetics of ^sup 18^F-FDG in female organs and from phantom ...
Monitoring [alpha]^sub 4^[beta]^sub 1^ Integrin
Apr 01, 2008; ... Peng et al. from the University of California Davis (UC-Davis) Cancer Center (Sacramento) reported in the February issue of Molecular Cancer Therapeutics (2008;7:432-437) on in vivo optical imaging of human lymphoma xenografts using a libraryderived peptidomimetic against α^sub 4^β^sub ...
Imaging [alpha]^sub v^[beta]^sub 3^ Integrin Expression After MI
Apr 01, 2008; ... In an article e-published on February 6 ahead of print in Cardiovascular Research, Higuchi et al. from the Technischen Universität München (Germany) reported on a new PET approach for imaging of α^sub v^β^sub 3^ integrin expression after myocardial infarction in a rat model. The study ...